{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:44:52Z","timestamp":1779907492602,"version":"3.53.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Glaxo"},{"DOI":"10.13039\/501100010313","name":"Heidelberg Engineering","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010313","id-type":"DOI","asserted-by":"crossref"}]},{"name":"GmbH"},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Optovue, Inc"},{"name":"Pfizer, Inc"},{"name":"Topcon Medical Systems, Inc"},{"DOI":"10.13039\/501100002806","name":"Carl Zeiss Meditec, Inc","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002806","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Diopsys, Inc"},{"name":"Optovue, Inc"},{"name":"Pfizer, Inc"},{"name":"Alcon Laboratories, Inc"},{"name":"Merck, Inc"},{"name":"Allergan, Inc"},{"name":"Topcon Medical Systems, Inc"},{"name":"Glaukos, Inc"},{"name":"National Eye Institute, National Institutes of Health"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Merck Research Laboratories"},{"name":"Pfizer, Inc"},{"name":"Research to Prevent Blindness, Inc"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.ajo.2013.01.020","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T12:04:11Z","timestamp":1363262651000},"page":"971-982","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Rate of Structural Change: The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study"],"prefix":"10.1016","volume":"155","author":[{"given":"Linda M.","family":"Zangwill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keri","family":"Dirkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe A.","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary L.","family":"Trick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Cioffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Liebmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody R.","family":"Piltz-Seymour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mae O.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Kass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Weinreb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ajo.2013.01.020_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/eye.2010.202","article-title":"Assessment of rates of structural change in glaucoma using imaging technologies","volume":"25","author":"Mansouri","year":"2011","journal-title":"Eye (Lond)"},{"issue":"8","key":"10.1016\/j.ajo.2013.01.020_bib2","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1167\/iovs.08-2844","article-title":"The spatial pattern of neuroretinal rim loss in ocular hypertension","volume":"50","author":"Strouthidis","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.ajo.2013.01.020_bib3","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s00417-005-0094-4","article-title":"Ten-year results: detection of long-term progressive optic disc changes with confocal laser tomography","volume":"244","author":"Philippin","year":"2006","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"9","key":"10.1016\/j.ajo.2013.01.020_bib4","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1136\/bjo.84.9.993","article-title":"Use of sequential Heidelberg retina tomograph images to identify changes at the optic disc in ocular hypertensive patients at risk of developing glaucoma","volume":"84","author":"Kamal","year":"2000","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2013.01.020_bib5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1136\/bjo.83.3.290","article-title":"Detection of optic disc change with the Heidelberg retina tomograph before confirmed visual field change in ocular hypertensives converting to early glaucoma","volume":"83","author":"Kamal","year":"1999","journal-title":"Br J Ophthalmol"},{"issue":"9","key":"10.1016\/j.ajo.2013.01.020_bib6","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1001\/archopht.123.9.1188","article-title":"Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study","volume":"123","author":"Zangwill","year":"2005","journal-title":"Arch Ophthalmol"},{"issue":"9","key":"10.1016\/j.ajo.2013.01.020_bib7","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.ophtha.2010.03.044","article-title":"Predicting the onset of glaucoma: the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study","volume":"117","author":"Weinreb","year":"2010","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.ajo.2013.01.020_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1001\/archopht.122.1.22","article-title":"Racial differences in optic disc topography: baseline results from the confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study","volume":"122","author":"Zangwill","year":"2004","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2013.01.020_bib9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ajo.2003.08.031","article-title":"The confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study: study design and baseline factors","volume":"137","author":"Zangwill","year":"2004","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajo.2013.01.020_bib10","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/archopht.120.6.714","article-title":"The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma","volume":"120","author":"Gordon","year":"2002","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2013.01.020_bib11","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2307\/2529876","article-title":"Random-effects models for longitudinal data","volume":"38","author":"Laird","year":"1982","journal-title":"Biometrics"},{"issue":"10","key":"10.1016\/j.ajo.2013.01.020_bib12","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1001\/archopht.123.10.1351","article-title":"Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma","volume":"123","author":"Medeiros","year":"2005","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2013.01.020_bib13","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1167\/iovs.08-2712","article-title":"Detection of progressive retinal nerve fiber layer loss in glaucoma using scanning laser polarimetry with variable corneal compensation","volume":"50","author":"Medeiros","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"10.1016\/j.ajo.2013.01.020_bib14","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.ophtha.2008.12.062","article-title":"The relationship between intraocular pressure and progressive retinal nerve fiber layer loss in glaucoma","volume":"116","author":"Medeiros","year":"2009","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.ajo.2013.01.020_bib15","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ajo.2009.01.021","article-title":"Impact of atypical retardation patterns on detection of glaucoma progression using the GDx with variable corneal compensation","volume":"148","author":"Medeiros","year":"2009","journal-title":"Am J Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajo.2013.01.020_bib16","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1001\/archophthalmol.2009.276","article-title":"Prediction of functional loss in glaucoma from progressive optic disc damage","volume":"127","author":"Medeiros","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2013.01.020_bib17","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1167\/iovs.09-4350","article-title":"A comparison of rates of change in neuroretinal rim area and retinal nerve fiber layer thickness in progressive glaucoma","volume":"51","author":"Alencar","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.ajo.2013.01.020_bib18","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ophtha.2009.08.012","article-title":"Agreement for detecting glaucoma progression with the GDx guided progression analysis, automated perimetry, and optic disc photography","volume":"117","author":"Alencar","year":"2010","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.ajo.2013.01.020_bib19","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.ajo.2010.01.010","article-title":"Rates of progressive retinal nerve fiber layer loss in glaucoma measured by scanning laser polarimetry","volume":"149","author":"Medeiros","year":"2010","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2013.01.020_bib20","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.ophtha.2008.12.005","article-title":"Rates of neuroretinal rim and peripapillary atrophy area change: a comparative study of glaucoma patients and normal controls","volume":"116","author":"See","year":"2009","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1016\/j.ajo.2013.01.020_bib21","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.ophtha.2010.12.035","article-title":"Evaluation of retinal nerve fiber layer progression in glaucoma a prospective analysis with neuroretinal rim and visual field progression","volume":"118","author":"Leung","year":"2011","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.ajo.2013.01.020_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ophtha.2004.07.029","article-title":"Differences in optic disc topography between black and white normal subjects","volume":"112","author":"Girkin","year":"2005","journal-title":"Ophthalmology"},{"issue":"10","key":"10.1016\/j.ajo.2013.01.020_bib23","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/S0161-6420(01)00760-6","article-title":"Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS)","volume":"108","author":"Brandt","year":"2001","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.ajo.2013.01.020_bib24","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/archopht.122.6.813","article-title":"The Ocular Hypertension Treatment Study: topical medication delays or prevents primary open-angle glaucoma in African American individuals","volume":"122","author":"Higginbotham","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajo.2013.01.020_bib25","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1001\/archophthalmol.2011.337","article-title":"The 10-year incidence of glaucoma among patients with treated and untreated ocular hypertension","volume":"129","author":"Gordon","year":"2011","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2013.01.020_bib26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1136\/bjo.78.2.99","article-title":"Shape of the neuroretinal rim and position of the central retinal vessels in glaucoma","volume":"78","author":"Jonas","year":"1994","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2013.01.020_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1364\/JOSAA.19.000197","article-title":"Imaging of the optic disc and retinal nerve fiber layer: the effects of age, optic disc area, refractive error, and gender","volume":"19","author":"Bowd","year":"2002","journal-title":"J Opt Soc Am A Opt Image Sci Vis"},{"issue":"6","key":"10.1016\/j.ajo.2013.01.020_bib28","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.ophtha.2009.01.004","article-title":"Effects of age on optical coherence tomography measurements of healthy retinal nerve fiber layer, macula, and optic nerve head","volume":"116","author":"Sung","year":"2009","journal-title":"Ophthalmology"},{"issue":"10","key":"10.1016\/j.ajo.2013.01.020_bib29","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1136\/bjo.81.10.840","article-title":"Aging changes of the optic nerve head in relation to open angle glaucoma","volume":"81","author":"Garway-Heath","year":"1997","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2013.01.020_bib30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S0002-9394(00)00488-8","article-title":"Optic disk topography after medical treatment to reduce intraocular pressure","volume":"130","author":"Bowd","year":"2000","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"10.1016\/j.ajo.2013.01.020_bib31","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.ophtha.2008.02.001","article-title":"Changes in central corneal thickness over time: the ocular hypertension treatment study","volume":"115","author":"Brandt","year":"2008","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.ajo.2013.01.020_bib32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/01.ijg.0000133151.82804.e3","article-title":"Reversal of disc cupping after intraocular pressure reduction in topographic image series","volume":"13","author":"Tan","year":"2004","journal-title":"J Glaucoma"},{"issue":"5","key":"10.1016\/j.ajo.2013.01.020_bib33","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/archopht.1993.01090050070031","article-title":"Effect of repetitive imaging on topographic measurements of the optic nerve head","volume":"111","author":"Weinreb","year":"1993","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2013.01.020_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0002-9394(14)72836-3","article-title":"Test-retest variability of topographic measurements with confocal scanning laser tomography in patients with glaucoma and control subjects","volume":"118","author":"Chauhan","year":"1994","journal-title":"Am J Ophthalmol"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939413000767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939413000767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:08:44Z","timestamp":1757596124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939413000767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0002939413000767"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2013.01.020","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717995528.793481640","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717995528.793474873","asserted-by":"object"}]},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Rate of Structural Change: The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2013.01.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}