{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:06:22Z","timestamp":1793034382552,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.ajo.2013.09.020","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T01:06:33Z","timestamp":1386205593000},"page":"451-457.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":282,"title":["Atropine for the Treatment of Childhood Myopia: Changes after Stopping Atropine 0.01%, 0.1% and 0.5%"],"prefix":"10.1016","volume":"157","author":[{"given":"Audrey","family":"Chia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Han","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yar Yen","family":"Goon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ajo.2013.09.020_bib1","first-page":"527","article-title":"The control of myopia with atropine","volume":"8","author":"Gimbel","year":"1973","journal-title":"Can J Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajo.2013.09.020_bib2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1136\/bjo.59.10.529","article-title":"Clinical assessment of the arrest of myopia","volume":"59","author":"Kelly","year":"1975","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2013.09.020_bib3","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0161-6420(79)35455-0","article-title":"The effects of atropine on myopia","volume":"86","author":"Bedrossian","year":"1979","journal-title":"Ophthalmology"},{"issue":"11","key":"10.1016\/j.ajo.2013.09.020_bib4","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0161-6420(84)34138-0","article-title":"The treatment of myopia with atropine and bifocals: a long-term prospective study","volume":"91","author":"Brodstein","year":"1984","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.ajo.2013.09.020_bib5","first-page":"137","article-title":"Further observations on use of atropine in the treatment of myopia","volume":"17","author":"Brenner","year":"1985","journal-title":"Ann Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2013.09.020_bib6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/jop.1997.13.61","article-title":"The effectiveness of 0.5% atropine in controlling high myopia in children","volume":"13","author":"Chou","year":"1997","journal-title":"J\u00a0Ocul Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.ajo.2013.09.020_bib7","first-page":"257","article-title":"Management of progressive school myopia with topical atropine eyedrops and photochromic bifocal spectacles","volume":"15","author":"Romano","year":"2000","journal-title":"Binocul Vis Strabismus Q"},{"issue":"3\u00a0suppl","key":"10.1016\/j.ajo.2013.09.020_bib8","first-page":"281","article-title":"Reducing the progression of myopia with atropine: a long term cohort study of Olmsted County students","volume":"15","author":"Kennedy","year":"2000","journal-title":"Binocul Vis Strabismus Q"},{"issue":"3","key":"10.1016\/j.ajo.2013.09.020_bib9","first-page":"209","article-title":"Treatment of childhood myopia with atropine eyedrops and bifocal spectacles","volume":"16","author":"Chiang","year":"2001","journal-title":"Binocul Vis Strabismus Q"},{"issue":"3","key":"10.1016\/j.ajo.2013.09.020_bib10","first-page":"203","article-title":"Atropine and bifocals can slow the progression of myopia in children","volume":"16","author":"Syniuta","year":"2001","journal-title":"Binocul Vis Strabismus Q"},{"issue":"1","key":"10.1016\/j.ajo.2013.09.020_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1089\/jop.2006.22.41","article-title":"Prevention of myopia progression with 0.05% atropine solution","volume":"22","author":"Lee","year":"2006","journal-title":"J Ocul Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.ajo.2013.09.020_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10384-006-0380-7","article-title":"Topical atropine in retarding myopic progression and axial length growth in children with moderate to severe myopia: a pilot study","volume":"51","author":"Fan","year":"2007","journal-title":"Jpn J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2013.09.020_bib13","first-page":"180","article-title":"Comparison of the effect of atropine and cyclopentolate on myopia","volume":"21","author":"Yen","year":"1989","journal-title":"Ann Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2013.09.020_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1089\/jop.1999.15.85","article-title":"Effects of different concentrations of atropine on controlling myopia in myopic children","volume":"15","author":"Shih","year":"1999","journal-title":"J Ocul Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.ajo.2013.09.020_bib15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1034\/j.1600-0420.2001.790304.x","article-title":"An intervention trial on efficacy of atropine and multi-focal glasses in controlling myopic progression","volume":"79","author":"Shih","year":"2001","journal-title":"Acta Ophthalmol Scand"},{"issue":"12","key":"10.1016\/j.ajo.2013.09.020_bib16","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.ophtha.2006.05.062","article-title":"Atropine for the treatment of childhood myopia","volume":"113","author":"Chua","year":"2006","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.ajo.2013.09.020_bib17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ctim.2008.04.007","article-title":"A combined therapy using stimulating auricular acupoints enhances lower-level atropine eyedrops when used for myopia control in school-aged children evaluated by a pilot randomized controlled clinical trial","volume":"16","author":"Liang","year":"2008","journal-title":"Complement Ther Med"},{"issue":"3","key":"10.1016\/j.ajo.2013.09.020_bib18","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ophtha.2008.10.020","article-title":"Atropine for the treatment of childhood myopia: effect on myopia progression after cessation of atropine","volume":"116","author":"Tong","year":"2009","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.ajo.2013.09.020_bib19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ophtha.2011.07.031","article-title":"Atropine for the treatment of childhood myopia: safety and efficacy of 0.5%, 0.1%, and 0.01% doses (ATOM2)","volume":"119","author":"Chia","year":"2012","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.ajo.2013.09.020_bib20","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.0006-341X.2000.00645.x","article-title":"A note on robust variance estimation for cluster-correlated data","volume":"56","author":"Williams","year":"2000","journal-title":"Biometrics"},{"key":"10.1016\/j.ajo.2013.09.020_bib21","first-page":"680","article-title":"Molecular mechanism of muscarinic receptors in mouse scleral fibroblast: prior to and after induction of experimental myopia with atropine treatment","volume":"17","author":"Barathi","year":"2011","journal-title":"Mol Vis"},{"issue":"7-8","key":"10.1016\/j.ajo.2013.09.020_bib22","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/02713680600770609","article-title":"The presence of m1 to m5 receptors in human sclera: evidence of the sclera as potential sites of action for muscarinic receptor antagonist","volume":"31","author":"Qu","year":"2006","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.ajo.2013.09.020_bib23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-3-642-23274-9_12","article-title":"Muscarinic receptor agonists and antagonist: effects on ocular function","volume":"208","author":"Mitchelson","year":"2012","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.ajo.2013.09.020_bib24","first-page":"1277","article-title":"Expression of muscarinic receptors in human and mouse sclera and their role in regulation of scleral fibroblast proliferation","volume":"15","author":"Barathi","year":"2009","journal-title":"Mol Vis"},{"key":"10.1016\/j.ajo.2013.09.020_bib25","doi-asserted-by":"crossref","first-page":"e18326","DOI":"10.1371\/journal.pone.0018326","article-title":"Transglutaminases (TGs) in ocular and periocular tissues; effect of muscarinic agents on TGs in scleral fibroblast","volume":"6","author":"Barathi","year":"2011","journal-title":"PloS One"},{"issue":"5","key":"10.1016\/j.ajo.2013.09.020_bib26","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1475-1313.2011.00841.x","article-title":"The M4 muscarinic antagonist MT-3 inhibits myopia in chick: evidence for site of action","volume":"31","author":"McBrien","year":"2011","journal-title":"Ophthal Physiol Opt"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939413006429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939413006429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:11:05Z","timestamp":1757596265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939413006429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0002939413006429"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2013.09.020","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718201623.793490275","asserted-by":"object"}]},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atropine for the Treatment of Childhood Myopia: Changes after Stopping Atropine 0.01%, 0.1% and 0.5%","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2013.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}