{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:41:11Z","timestamp":1767919271820,"version":"3.49.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.ajo.2015.03.002","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T12:19:47Z","timestamp":1425557987000},"page":"1065-1074.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC"],"prefix":"10.1016","volume":"159","author":[{"given":"Frederick A.","family":"Jakobiec","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Kool","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Stagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan M.","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph C.","family":"Eagle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan D.","family":"Proia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Korshunov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ajo.2015.03.002_bib1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0002-9394(14)77739-6","article-title":"A clinicopathologic study of 56 cases of intraocular medulloepitheliomas","volume":"85","author":"Broughton","year":"1978","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2015.03.002_bib2","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1016\/j.ophtha.2013.05.015","article-title":"Ciliary body medulloepithelioma: analysis of 41 cases","volume":"120","author":"Kaliki","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2015.03.002_bib3","first-page":"210","article-title":"Verhoeff's \u201cterato-neuroma\u201d a critical reappraisal in light of new observations and current concepts of embryonic tumors","volume":"69","author":"Zimmerman","year":"1971","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.ajo.2015.03.002_bib4","series-title":"Russell and Rubenstein's Pathology of Tumors of the Nervous System","first-page":"635","article-title":"Tumors of the retina","author":"Cummings","year":"2006"},{"key":"10.1016\/j.ajo.2015.03.002_bib5","series-title":"Russell and Rubenstein's Pathology of Tumors of the Nervous System","first-page":"287","article-title":"Medulloepithelioma","author":"Giangaspero","year":"2006"},{"key":"10.1016\/j.ajo.2015.03.002_bib6","series-title":"WHO classification of tumors of the central nervous system","first-page":"143","article-title":"Central nervous system primitive neuroectodermal tumors","author":"McLendon","year":"2007"},{"issue":"2","key":"10.1016\/j.ajo.2015.03.002_bib7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00688777","article-title":"Cerebral medulloepithelioma","volume":"22","author":"Jellinger","year":"1972","journal-title":"Acta Neuropathol"},{"issue":"3","key":"10.1016\/j.ajo.2015.03.002_bib8","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3171\/jns.1996.84.3.0430","article-title":"Central nervous system medulloepithelioma: a series of eight cases including two arising in the pons","volume":"84","author":"Molloy","year":"1996","journal-title":"J Neurosurg"},{"issue":"1","key":"10.1016\/j.ajo.2015.03.002_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00294231","article-title":"Cerebral medulloepithelioma\u2013electron microscopy and immunohistochemistry","volume":"80","author":"Troost","year":"1990","journal-title":"Acta Neuropathol"},{"issue":"3","key":"10.1016\/j.ajo.2015.03.002_bib10","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/00005072-198305000-00004","article-title":"Cerebral medulloepithelioma with bone, cartilage, and striated muscle. Light microscopic and immunohistochemical study","volume":"42","author":"Auer","year":"1983","journal-title":"J Neuropathol Exp Neurol"},{"issue":"6","key":"10.1016\/j.ajo.2015.03.002_bib11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3928\/01913913-20041101-05","article-title":"Pigmented malignant medulloepithelioma of the ciliary body","volume":"41","author":"Gopal","year":"2004","journal-title":"J Pediatr Ophthalmol Strabismus"},{"issue":"1-2","key":"10.1016\/j.ajo.2015.03.002_bib12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s003810050179","article-title":"Pigmented medulloepithelioma: report of a case and review of the literature","volume":"14","author":"Sharma","year":"1998","journal-title":"Childs Nerv Syst"},{"issue":"3","key":"10.1016\/j.ajo.2015.03.002_bib13","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/1097-0142(197209)30:3<817::AID-CNCR2820300334>3.0.CO;2-E","article-title":"Rhabdomyosarcomatous differentiation in malignant intraocular medulloepitheliomas","volume":"30","author":"Zimmerman","year":"1972","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.ajo.2015.03.002_bib14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1440-1789.2009.01040.x","article-title":"Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation","volume":"30","author":"Buccoliero","year":"2010","journal-title":"Neuropathology"},{"issue":"1","key":"10.1016\/j.ajo.2015.03.002_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.5414\/NP300636","article-title":"Embryonal tumor with multilayered rosettes: diagnostic tools update and review of the literature","volume":"33","author":"Ceccom","year":"2014","journal-title":"Clin Neuropathol"},{"issue":"2","key":"10.1016\/j.ajo.2015.03.002_bib16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/PAS.0b013e318186235b","article-title":"Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor","volume":"33","author":"Gessi","year":"2009","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.ajo.2015.03.002_bib17","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00401-013-1228-0","article-title":"Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity","volume":"128","author":"Korshunov","year":"2014","journal-title":"Acta Neuropathol"},{"issue":"2","key":"10.1016\/j.ajo.2015.03.002_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00401-014-1291-1","article-title":"CNS-PNETs with C19MC amplification and\/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity","volume":"128","author":"Spence","year":"2014","journal-title":"Acta Neuropathol"},{"issue":"2","key":"10.1016\/j.ajo.2015.03.002_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00401-010-0688-8","article-title":"Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes","volume":"120","author":"Korshunov","year":"2010","journal-title":"Acta Neuropathol"},{"issue":"6","key":"10.1016\/j.ajo.2015.03.002_bib20","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00401-012-1068-3","article-title":"LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)","volume":"124","author":"Korshunov","year":"2012","journal-title":"Acta Neuropathol"},{"issue":"5","key":"10.1016\/j.ajo.2015.03.002_bib21","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1750-3639.2012.00574.x","article-title":"Analysis of chromosome 19q13.42 amplification in embryonal brain tumors with ependymoblastic multilayered rosettes","volume":"22","author":"Nobusawa","year":"2012","journal-title":"Brain Pathol"},{"issue":"4","key":"10.1016\/j.ajo.2015.03.002_bib22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00401-008-0467-y","article-title":"Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes","volume":"117","author":"Pfister","year":"2009","journal-title":"Acta Neuropathol"},{"issue":"7","key":"10.1016\/j.ajo.2015.03.002_bib23","doi-asserted-by":"crossref","first-page":"e40008","DOI":"10.1371\/journal.pone.0040008","article-title":"Lin28 mediates paclitaxel resistance by modulating p21, Rb and Let-7a miRNA in breast cancer cells","volume":"7","author":"Lv","year":"2012","journal-title":"PLoS One"},{"issue":"5872","key":"10.1016\/j.ajo.2015.03.002_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1154040","article-title":"Selective blockade of microRNA processing by Lin28","volume":"320","author":"Viswanathan","year":"2008","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.ajo.2015.03.002_bib25","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jaapos.2013.02.005","article-title":"Malignant teratoid medulloepithelioma with retinoblastic and rhabdomyoblastic differentiation","volume":"17","author":"Earl","year":"2013","journal-title":"J AAPOS"},{"issue":"6","key":"10.1016\/j.ajo.2015.03.002_bib26","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.ajo.2014.08.036","article-title":"New insights into the development of infantile intraocular medulloepithelioma","volume":"158","author":"Jakobiec","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2015.03.002_bib27","article-title":"Immunohistochemical investigations of adult intraocular medulloepitheliomas","author":"Jakobiec","year":"2014","journal-title":"Clin Experiment Ophthalmol"},{"key":"10.1016\/j.ajo.2015.03.002_bib28","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0076-6879(95)54024-5","article-title":"Detection of chromosomal aberrations by means of molecular cytogenetics: painting of chromosomes and chromosomal subregions and comparative genomic hybridization","volume":"254","author":"Lichter","year":"1995","journal-title":"Methods Enzymol"},{"issue":"2","key":"10.1016\/j.ajo.2015.03.002_bib29","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.survophthal.2014.12.002","article-title":"Malignant rhabdoid transformation of a longstanding recurrent orbital angiomyxoma","volume":"60","author":"Jakobiec","year":"2015","journal-title":"Surv Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2015.03.002_bib30","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0165-4608(96)00157-4","article-title":"Cytogenetic analysis in a case of intraocular medulloepithelioma","volume":"92","author":"Betts","year":"1996","journal-title":"Cancer Genet Cytogenet"},{"issue":"4","key":"10.1016\/j.ajo.2015.03.002_bib31","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.stem.2013.03.005","article-title":"Lin28: primal regulator of growth and metabolism in stem cells","volume":"12","author":"Shyh-Chang","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.ajo.2015.03.002_bib32","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.survophthal.2012.08.006","article-title":"Ciliary body medulloepithelioma in an adult","volume":"58","author":"Ali","year":"2013","journal-title":"Surv Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2015.03.002_bib33","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/j.humpath.2011.02.020","article-title":"Medulloepithelioma of the optic disc","volume":"42","author":"Correa","year":"2011","journal-title":"Hum Pathol"},{"issue":"6","key":"10.1016\/j.ajo.2015.03.002_bib34","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1001\/archopht.1974.03900060465007","article-title":"Malignant teratoid medulloepithelioma of the optic nerve","volume":"91","author":"Green","year":"1974","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2015.03.002_bib35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/01676830903421200","article-title":"Malignant transformation of a medulloepithelioma of the optic nerve","volume":"29","author":"Lindegaard","year":"2010","journal-title":"Orbit"},{"issue":"8","key":"10.1016\/j.ajo.2015.03.002_bib36","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1136\/bjophthalmol-2012-303019","article-title":"Ciliary body medulloepithelioma associated with pleuropulmonary blastoma","volume":"97","author":"Laird","year":"2013","journal-title":"Br J Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2015.03.002_bib37","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1136\/bjo.2010.189779","article-title":"Ciliary body medulloepithelioma: four cases associated with pleuropulmonary blastoma\u2013a report from the International Pleuropulmonary Blastoma Registry","volume":"95","author":"Priest","year":"2011","journal-title":"Br J Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2015.03.002_bib38","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/eye.2013.87","article-title":"Medulloepithelioma in DICER1 syndrome treated with resection","volume":"27","author":"Ramasubramanian","year":"2013","journal-title":"Eye (Lond)"},{"issue":"11","key":"10.1016\/j.ajo.2015.03.002_bib39","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1001\/jamaophthalmol.2014.2356","article-title":"Human ciliary epithelium as a source of synthesis and secretion of vascular endothelial growth factor in neovascular glaucoma","volume":"132","author":"Chalam","year":"2014","journal-title":"JAMA Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajo.2015.03.002_bib40","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/bjo.72.10.764","article-title":"Medulloepithelioma (diktyoma)","volume":"72","author":"Canning","year":"1988","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2015.03.002_bib41","series-title":"The Development of the Human Eye","first-page":"36","volume":"18","author":"Mann","year":"1928"},{"key":"10.1016\/j.ajo.2015.03.002_bib42","first-page":"317","article-title":"Intraocular diktyoma and glioneuroma","volume":"47","author":"Fralick","year":"1949","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"12","key":"10.1016\/j.ajo.2015.03.002_bib43","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/S0161-6420(89)32652-2","article-title":"Glioneuroma associated with colobomatous dysplasia of the anterior uvea and retina. A case simulating medulloepithelioma","volume":"96","author":"Kivela","year":"1989","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.ajo.2015.03.002_bib44","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/archopht.1973.01000040384006","article-title":"Neuroectodermal tumor of anterior lip of the optic cup. Glioneuroma transitional to teratoid medullo-epithelioma","volume":"89","author":"Manz","year":"1973","journal-title":"Arch Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2015.03.002_bib45","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/archopht.1973.01000040389007","article-title":"Glioneuroma (choristomatous malformation of the optic cup margin). A report of two cases","volume":"89","author":"Spencer","year":"1973","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2015.03.002_bib46","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/ICB.0000000000000089","article-title":"Choroid plexus in the eye: a case study","volume":"9","author":"Todorich","year":"2015","journal-title":"Retin Cases Brief Rep"},{"issue":"1","key":"10.1016\/j.ajo.2015.03.002_bib47","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.exer.2008.09.020","article-title":"A comparison of epithelial and neural properties in progenitor cells derived from the adult human ciliary body and brain","volume":"88","author":"Moe","year":"2009","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajo.2015.03.002_bib48","doi-asserted-by":"crossref","first-page":"531579","DOI":"10.1155\/2013\/531579","article-title":"Does the adult human ciliary body epithelium contain \u201ctrue\u201d retinal stem cells?","volume":"2013","author":"Froen","year":"2013","journal-title":"Biomed Res Int"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939415001075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939415001075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:14:13Z","timestamp":1757596453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939415001075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0002939415001075"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2015.03.002","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2015.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}