{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:30:23Z","timestamp":1788413423038,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.ajo.2015.08.032","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T10:46:07Z","timestamp":1441277167000},"page":"1269-1275.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Retinal Architecture in \u200bRGS9- and \u200bR9AP-Associated Retinal Dysfunction (Bradyopsia)"],"prefix":"10.1016","volume":"160","author":[{"given":"Rupert W.","family":"Strauss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Dubis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6301-2899","authenticated-orcid":false,"given":"Rola","family":"Ba-Abbad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony T.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Dubra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Michaelides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3-4","key":"10.1016\/j.ajo.2015.08.032_bib1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF00165687","article-title":"Prolonged electro-retinal response suppression (PERRS) in patients with stationary subnormal visual acuity and photophobia","volume":"78","author":"Kooijman","year":"1991","journal-title":"Doc Ophthalmol"},{"issue":"6969","key":"10.1016\/j.ajo.2015.08.032_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature02170","article-title":"Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation","volume":"427","author":"Nishiguchi","year":"2004","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ajo.2015.08.032_bib3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ophtha.2009.06.011","article-title":"Novel mutations and electrophysiologic findings in RGS9- and R9AP-associated retinal dysfunction (Bradyopsia)","volume":"117","author":"Michaelides","year":"2010","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1016\/j.ajo.2015.08.032_bib4","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1016\/j.ophtha.2007.04.057","article-title":"Six patients with bradyopsia (slow vision): clinical features and course of the disease","volume":"114","author":"Hartong","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2015.08.032_bib5","article-title":"The cone dysfunction syndromes","author":"Aboshiha","year":"2015","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2015.08.032_bib6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1136\/bjo.2003.028142","article-title":"Oligocone trichromacy: a rare and unusual cone dysfunction syndrome","volume":"88","author":"Michaelides","year":"2004","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2015.08.032_bib7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1167\/iovs.09-3988","article-title":"Oligocone trichromacy: clinical and molecular genetic investigations","volume":"51","author":"Andersen","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.ajo.2015.08.032_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10633-014-9473-7","article-title":"ISCEV Standard for full-field clinical electroretinography (2015 update)","volume":"130","author":"McCulloch","year":"2015","journal-title":"Doc Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2015.08.032_bib9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10633-007-9053-1","article-title":"ISCEV standard for clinical pattern electroretinography\u20132007 update","volume":"114","author":"Holder","year":"2007","journal-title":"Doc Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2015.08.032_bib10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/IAE.0b013e31827e2306","article-title":"Pathognomonic (diagnostic) ERGs. A review and update","volume":"33","author":"Vincent","year":"2013","journal-title":"Retina"},{"issue":"7","key":"10.1016\/j.ajo.2015.08.032_bib11","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1167\/iovs.10-6659","article-title":"Integrity of the cone photoreceptor mosaic in oligocone trichromacy","volume":"52","author":"Michaelides","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.ajo.2015.08.032_bib12","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1364\/JOSAA.24.001358","article-title":"Automated identification of cone photoreceptors in adaptive optics retinal images","volume":"24","author":"Li","year":"2007","journal-title":"J Opt Soc Am A Opt Image Sci Vis"},{"issue":"8","key":"10.1016\/j.ajo.2015.08.032_bib13","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.visres.2010.02.003","article-title":"Arrested development: high-resolution imaging of foveal morphology in albinism","volume":"50","author":"McAllister","year":"2010","journal-title":"Vision Res"},{"issue":"13","key":"10.1016\/j.ajo.2015.08.032_bib14","doi-asserted-by":"crossref","first-page":"8006","DOI":"10.1167\/iovs.12-11087","article-title":"The effect of cone opsin mutations on retinal structure and the integrity of the photoreceptor mosaic","volume":"53","author":"Carroll","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"49","key":"10.1016\/j.ajo.2015.08.032_bib15","doi-asserted-by":"crossref","first-page":"20948","DOI":"10.1073\/pnas.0910128106","article-title":"Cone photoreceptor mosaic disruption associated with Cys203Arg mutation in the M-cone opsin","volume":"106","author":"Carroll","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.ajo.2015.08.032_bib16","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1364\/BOE.2.001757","article-title":"Reflective afocal broadband adaptive optics scanning ophthalmoscope","volume":"2","author":"Dubra","year":"2011","journal-title":"Biomed Opt Express"},{"issue":"11","key":"10.1016\/j.ajo.2015.08.032_bib17","doi-asserted-by":"crossref","first-page":"7303","DOI":"10.1167\/iovs.14-14225","article-title":"Genotype-dependent variability in residual cone structure in achromatopsia: toward developing metrics for assessing cone health","volume":"55","author":"Dubis","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"10.1016\/j.ajo.2015.08.032_bib18","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1364\/BOE.2.001864","article-title":"Noninvasive imaging of the human rod photoreceptor mosaic using a confocal adaptive optics scanning ophthalmoscope","volume":"2","author":"Dubra","year":"2011","journal-title":"Biomed Opt Express"},{"issue":"5","key":"10.1016\/j.ajo.2015.08.032_bib19","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/OPX.0b013e3182540562","article-title":"Repeatability of in\u00a0vivo parafoveal cone density and spacing measurements","volume":"89","author":"Garrioch","year":"2012","journal-title":"Optom Vis Sci"},{"issue":"4","key":"10.1016\/j.ajo.2015.08.032_bib20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/cne.902920402","article-title":"Human photoreceptor topography","volume":"292","author":"Curcio","year":"1990","journal-title":"J Comp Neurol"},{"issue":"12","key":"10.1016\/j.ajo.2015.08.032_bib21","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1167\/iovs.10-5499","article-title":"Intersubject variability of foveal cone photoreceptor density in relation to eye length","volume":"51","author":"Li","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"10.1016\/j.ajo.2015.08.032_bib22","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1167\/iovs.13-13217","article-title":"Relationship between foveal cone specialization and pit morphology in albinism","volume":"55","author":"Wilk","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2015.08.032_bib23","first-page":"71","article-title":"RGS9-1 is required for normal inactivation of mouse cone phototransduction","volume":"7","author":"Lyubarsky","year":"2001","journal-title":"Mol Vis"},{"issue":"3","key":"10.1016\/j.ajo.2015.08.032_bib24","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1001\/archopthalmol.2011.1490","article-title":"Subclinical photoreceptor disruption in response to severe head trauma","volume":"130","author":"Stepien","year":"2012","journal-title":"Arch Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajo.2015.08.032_bib25","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1097\/IAE.0000000000000169","article-title":"Outer retinal structure after closed-globe blunt ocular trauma","volume":"34","author":"Flatter","year":"2014","journal-title":"Retina"},{"issue":"7","key":"10.1016\/j.ajo.2015.08.032_bib26","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1167\/iovs.14-14542","article-title":"In\u00a0vivo imaging of human cone photoreceptor inner segments","volume":"55","author":"Scoles","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6769","key":"10.1016\/j.ajo.2015.08.032_bib27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/35000601","article-title":"Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1","volume":"403","author":"Chen","year":"2000","journal-title":"Nature"},{"issue":"27","key":"10.1016\/j.ajo.2015.08.032_bib28","doi-asserted-by":"crossref","first-page":"24376","DOI":"10.1074\/jbc.M203237200","article-title":"Specific binding of RGS9-Gbeta 5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity","volume":"277","author":"Lishko","year":"2002","journal-title":"J Biol Chem"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939415005395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939415005395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:16:06Z","timestamp":1757596566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939415005395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0002939415005395"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2015.08.032","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinal Architecture in \u200bRGS9- and \u200bR9AP-Associated Retinal Dysfunction (Bradyopsia)","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2015.08.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}