{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:07:09Z","timestamp":1773774429881,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.ajo.2016.02.030","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T17:40:33Z","timestamp":1457026833000},"page":"94-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Photoactivated Chromophore for Moderate to Severe Infectious Keratitis as an Adjunct Therapy: A Randomized Controlled Trial"],"prefix":"10.1016","volume":"165","author":[{"given":"Ngamjit","family":"Kasetsuwan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usanee","family":"Reinprayoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vannarut","family":"Satitpitakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ajo.2016.02.030_bib1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/01.icu.0000233954.86723.25","article-title":"Crosslinking treatment of progressive keratoconus: new hope","volume":"17","author":"Wollensak","year":"2006","journal-title":"Curr Opin Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2016.02.030_bib2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/BF01121647","article-title":"Effect of alkylated and intercalated DNA on the generation of superoxide anion by riboflavin","volume":"8","author":"Naseem","year":"1988","journal-title":"Biosci Rep"},{"issue":"6","key":"10.1016\/j.ajo.2016.02.030_bib3","first-page":"1163","article-title":"Scavenging activity of \u201cbeta catechin\u201d on reactive oxygen species generated by photosensitization of riboflavin","volume":"38","author":"Kumari","year":"1996","journal-title":"Biochem Mol Biol Int"},{"key":"10.1016\/j.ajo.2016.02.030_bib4","first-page":"15","article-title":"Riboflavin and UV-light based pathogen reduction: extent and consequence of DNA damage at the molecular level","volume":"80","author":"Kumar","year":"2004","journal-title":"Photochem Photobiol"},{"issue":"1","key":"10.1016\/j.ajo.2016.02.030_bib5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/02713680490513182","article-title":"Increased resistance of crosslinked cornea against enzymatic digestion","volume":"29","author":"Spoerl","year":"2004","journal-title":"Curr Eye Res"},{"issue":"1","key":"10.1016\/j.ajo.2016.02.030_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1869-5760-3-47","article-title":"Corneal cross linking and infectious keratitis: a systematic review with a meta-analysis of reported cases","volume":"3","author":"Alio","year":"2013","journal-title":"J Ophthalmic Inflamm Infect"},{"issue":"7","key":"10.1016\/j.ajo.2016.02.030_bib7","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.ophtha.2014.01.011","article-title":"Collagen cross-linking with photoactivated riboflavin (PACK-CXL) for the treatment of advanced infectious keratitis with corneal melting","volume":"121","author":"Said","year":"2014","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.ajo.2016.02.030_bib8","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/ICO.0000000000000375","article-title":"Ultraviolet A\/riboflavin collagen cross-linking for treatment of moderate bacterial corneal ulcers","volume":"34","author":"Bamdad","year":"2015","journal-title":"Cornea"},{"issue":"1","key":"10.1016\/j.ajo.2016.02.030_bib9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ajo.2015.03.024","article-title":"Corneal cross-linking as an adjuvant therapy in the management of recalcitrant deep stromal fungal keratitis: a randomized trial","volume":"160","author":"Uddaraju","year":"2015","journal-title":"Am J Ophthalmol"},{"issue":"8","key":"10.1016\/j.ajo.2016.02.030_bib10","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0161-6420(81)34943-4","article-title":"Decision-making in the management of microbial keratitis","volume":"88","author":"Jones","year":"1981","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1016\/j.ajo.2016.02.030_bib11","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1167\/iovs.07-1592","article-title":"Antimicrobial efficacy of riboflavin\/UVA combination (365\u00a0nm) in\u00a0vitro for bacterial and fungal isolates: a potential new treatment for infectious keratitis","volume":"49","author":"Martins","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"10.1016\/j.ajo.2016.02.030_bib12","first-page":"S799","article-title":"In\u00a0vitro antimicrobial efficacy of riboflavin and ultraviolet light on Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Pseudomonas aeruginosa","volume":"25","author":"Schrier","year":"2009","journal-title":"J Refract Surg"},{"issue":"8","key":"10.1016\/j.ajo.2016.02.030_bib13","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1167\/iovs.09-4013","article-title":"In\u00a0vitro efficacy of antifungal treatment using riboflavin\/UV-A (365\u00a0nm) combination and amphotericin B","volume":"51","author":"Sauer","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.ajo.2016.02.030_bib14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ajo.2011.07.025","article-title":"Evaluation of in\u00a0vitro efficacy of combined riboflavin and ultraviolet a for Acanthamoeba isolates","volume":"153","author":"del Buey","year":"2012","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2016.02.030_bib15","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/aos.12301","article-title":"The efficiency of cross-linking methods in eradication of bacteria is influenced by the riboflavin concentration and the irradiation time of ultraviolet light","volume":"92","author":"Backman","year":"2014","journal-title":"Acta Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2016.02.030_bib16","first-page":"205","article-title":"Evaluation of the in\u00a0vitro antimicrobial properties of ultraviolet A\/riboflavin mediated crosslinking on Candida albicans and Fusarium solani","volume":"7","author":"Sun","year":"2014","journal-title":"Int J Ophthalmol"},{"issue":"Suppl 1","key":"10.1016\/j.ajo.2016.02.030_bib17","first-page":"S70","article-title":"Bacteriological findings and antimicrobial susceptibility pattern of isolated pathogens from visual threatening ocular infections","volume":"98","author":"Reinprayoon","year":"2015","journal-title":"J Med Assoc Thai"},{"issue":"Suppl 1","key":"10.1016\/j.ajo.2016.02.030_bib18","first-page":"S217","article-title":"Infectious keratitis at King Chulalongkorn Memorial Hospital: a 12-year retrospective study of 391 cases","volume":"85","author":"Boonpasart","year":"2002","journal-title":"J Med Assoc Thai"},{"issue":"4","key":"10.1016\/j.ajo.2016.02.030_bib19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/ICU.0b013e32833a8e23","article-title":"Therapeutic keratoplasty for microbial keratitis","volume":"21","author":"Sharma","year":"2010","journal-title":"Curr Opin Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2016.02.030_bib20","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1016\/j.ophtha.2014.06.044","article-title":"Author reply: to PMID 24576886","volume":"121","author":"Said","year":"2014","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ajo.2016.02.030_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2165\/00002018-199512030-00004","article-title":"Antibiotic-induced release of endotoxin. A therapeutic paradox","volume":"12","author":"Hurley","year":"1995","journal-title":"Drug Saf"},{"issue":"6","key":"10.1016\/j.ajo.2016.02.030_bib22","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/ICO.0b013e318226da53","article-title":"Peripheral sterile corneal ring infiltrate after riboflavin-UVA collagen cross-linking in keratoconus","volume":"31","author":"Ghanem","year":"2012","journal-title":"Cornea"},{"issue":"3","key":"10.1016\/j.ajo.2016.02.030_bib23","doi-asserted-by":"crossref","first-page":"320","DOI":"10.5301\/ejo.5000424","article-title":"Anterior segment optical coherence tomography in evaluation of severe fungal keratitis infections treated by corneal crosslinking","volume":"24","author":"Abbouda","year":"2014","journal-title":"Eur J Ophthalmol"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939416300800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939416300800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:31:49Z","timestamp":1757597509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939416300800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":23,"alternative-id":["S0002939416300800"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2016.02.030","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Photoactivated Chromophore for Moderate to Severe Infectious Keratitis as an Adjunct Therapy: A Randomized Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2016.02.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}