{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:28:39Z","timestamp":1790634519966,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.ajo.2016.09.017","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T03:01:37Z","timestamp":1474340497000},"page":"104-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Gevokizumab in the Treatment of Autoimmune Non-necrotizing Anterior Scleritis: Results of a Phase I\/II Clinical Trial"],"prefix":"10.1016","volume":"172","author":[{"given":"Jared E.","family":"Knickelbein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirali","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Armbrust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Valent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Obiyor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Nussenblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Nida","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ajo.2016.09.017_bib1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/ICU.0b013e32833f1060","article-title":"An update on the cause and treatment of scleritis","volume":"21","author":"Rachitskaya","year":"2010","journal-title":"Curr Opin Ophthalmol"},{"issue":"11","key":"10.1016\/j.ajo.2016.09.017_bib2","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1016\/j.ophtha.2009.04.020","article-title":"Methotrexate for ocular inflammatory diseases","volume":"116","author":"Gangaputra","year":"2009","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.ajo.2016.09.017_bib3","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ajo.2009.05.008","article-title":"Azathioprine for ocular inflammatory diseases","volume":"148","author":"Pasadhika","year":"2009","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"10.1016\/j.ajo.2016.09.017_bib4","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/S0161-6420(03)00570-0","article-title":"Mycophenolate mofetil for the treatment of scleritis","volume":"110","author":"Sen","year":"2003","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1016\/j.ajo.2016.09.017_bib5","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.ophtha.2005.02.020","article-title":"Mycophenolate mofetil therapy for inflammatory eye disease","volume":"112","author":"Thorne","year":"2005","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ajo.2016.09.017_bib6","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ophtha.2009.08.010","article-title":"Cyclosporine for ocular inflammatory diseases","volume":"117","author":"Kacmaz","year":"2010","journal-title":"Ophthalmology"},{"issue":"7","key":"10.1016\/j.ajo.2016.09.017_bib7","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1136\/bjo.2008.147157","article-title":"Rituximab for treatment of scleritis associated with rheumatoid arthritis","volume":"93","author":"Chauhan","year":"2009","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2016.09.017_bib8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1136\/bjo.2007.133173","article-title":"Rituximab for treatment of ocular inflammatory disease: a series of four cases","volume":"93","author":"Kurz","year":"2009","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2016.09.017_bib9","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.3129\/i09-061","article-title":"Infliximab for the treatment of active scleritis","volume":"44","author":"Sen","year":"2009","journal-title":"Can J Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajo.2016.09.017_bib10","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.ophtha.2014.04.044","article-title":"Rituximab therapy for refractory scleritis: results of a phase I\/II dose-ranging, randomized, clinical trial","volume":"121","author":"Suhler","year":"2014","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.ajo.2016.09.017_bib11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10067-009-1368-8","article-title":"Successful treatment of severe nodular scleritis with adalimumab","volume":"29","author":"Restrepo","year":"2010","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.ajo.2016.09.017_bib12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.preteyeres.2013.02.004","article-title":"Scleritis: immunopathogenesis and molecular basis for therapy","volume":"35","author":"Wakefield","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ajo.2016.09.017_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-3083.1992.tb01644.x","article-title":"Serum interleukin (IL-1 beta) in patients with diffuse scleritis","volume":"11","author":"Palexas","year":"1992","journal-title":"Scand J Immunol Suppl"},{"issue":"6","key":"10.1016\/j.ajo.2016.09.017_bib14","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/rheumatology\/kem052","article-title":"Efficacy of the IL-1 receptor antagonist, anakinra, for the treatment of diffuse anterior scleritis in rheumatoid arthritis. Report of two cases","volume":"46","author":"Botsios","year":"2007","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"10.1016\/j.ajo.2016.09.017_bib15","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ophtha.2010.08.027","article-title":"A standardized grading system for scleritis","volume":"118","author":"Sen","year":"2011","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.ajo.2016.09.017_bib16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/nrrheum.2016.166","article-title":"Interleukin-1 function and role in rheumatic disease","volume":"12","author":"Schett","year":"2016","journal-title":"Nat Rev Rheumatol"},{"issue":"25","key":"10.1016\/j.ajo.2016.09.017_bib17","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1056\/NEJMoa1205099","article-title":"Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis","volume":"367","author":"Ruperto","year":"2012","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.ajo.2016.09.017_bib18","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s10067-015-3004-0","article-title":"Efficacy and safety profile of anti-interleukin-1 treatment in Behcet's disease: a multicenter retrospective study","volume":"35","author":"Emmi","year":"2016","journal-title":"Clin Rheumatol"},{"issue":"4","key":"10.1016\/j.ajo.2016.09.017_bib19","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1136\/annrheumdis-2011-155143","article-title":"Interleukin-1beta-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behcet's disease: an open-label pilot study","volume":"71","author":"Gul","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ajo.2016.09.017_bib20","first-page":"1","article-title":"Safety and efficacy of gevokizumab in patients with behcet's disease uveitis: results of an exploratory phase 2 study","author":"Tugal-Tutkun","year":"2016","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.ajo.2016.09.017_bib21","series-title":"Gevokizumab (XOMA 052) Investigator's Brochure (version 9)","year":"2012"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939416304597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939416304597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:32:26Z","timestamp":1757597546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939416304597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":21,"alternative-id":["S0002939416304597"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2016.09.017","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gevokizumab in the Treatment of Autoimmune Non-necrotizing Anterior Scleritis: Results of a Phase I\/II Clinical Trial","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2016.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}