{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:20:52Z","timestamp":1794324052655,"version":"4.9.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.ajo.2017.03.003","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T22:52:03Z","timestamp":1489445523000},"page":"175-181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy"],"prefix":"10.1016","volume":"177","author":[{"given":"Jonathan A.","family":"Micieli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinda","family":"Najem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Margolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ajo.2017.03.003_bib1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0002-9394(14)70999-7","article-title":"Incidence of nonarteritic anterior ischemic optic neuropathy","volume":"123","author":"Hattenhauer","year":"1997","journal-title":"Am J Ophthalmol"},{"issue":"25","key":"10.1016\/j.ajo.2017.03.003_bib2","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1056\/NEJMra1413352","article-title":"Ischemic optic neuropathies","volume":"372","author":"Biousse","year":"2015","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ajo.2017.03.003_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.survophthal.2009.06.008","article-title":"Treatment of nonarteritic anterior ischemic optic neuropathy","volume":"55","author":"Atkins","year":"2010","journal-title":"Surv Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2017.03.003_bib4","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/WNO.0b013e31814b273d","article-title":"Treatment of nonarteritic anterior ischemic optic neuropathy with intravitreal bevacizumab","volume":"27","author":"Bennett","year":"2007","journal-title":"J Neuroophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2017.03.003_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/WNO.0b013e318240596e","article-title":"Is intravitreal bevacizumab an effective treatment option for nonarteritic anterior ischemic optic neuropathy?","volume":"32","author":"Prescott","year":"2012","journal-title":"J Neuroophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2017.03.003_bib6","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/eye.2012.296","article-title":"Intravitreal bevacizumab for the treatment of nonarteritic anterior ischemic optic neuropathy: a prospective trial","volume":"27","author":"Rootman","year":"2013","journal-title":"Eye (Lond)"},{"issue":"5","key":"10.1016\/j.ajo.2017.03.003_bib7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1089\/jop.2010.0053","article-title":"Intravitreal ranibizumab injection for nonarteritic ischemic optic neuropathy","volume":"26","author":"Pece","year":"2010","journal-title":"J Ocul Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.ajo.2017.03.003_bib8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1444-0938.2010.00570.x","article-title":"Single intravitreal ranibizumab injection in eyes with acute non-arteritic anterior ischaemic optic neuropathy","volume":"94","author":"Bajin","year":"2011","journal-title":"Clin Exp Optom"},{"issue":"Sep 30","key":"10.1016\/j.ajo.2017.03.003_bib9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2174\/1874364101307010058","article-title":"Efficacy of intravitreal ranibizumab injection in acute nonarteritic ischemic optic neuropathy: a long-term follow up","volume":"7","author":"Saatci","year":"2013","journal-title":"Open Ophthalmol J"},{"key":"10.1016\/j.ajo.2017.03.003_bib10","first-page":"783241","article-title":"Single intravitreal aflibercept injection for unilateral acute nonarteritic ischemic optic neuropathy","volume":"2015","author":"Ayhan","year":"2015","journal-title":"Case Rep Ophthalmol Med"},{"issue":"5","key":"10.1016\/j.ajo.2017.03.003_bib11","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00417-006-0332-4","article-title":"Intravitreal triamcinolone acetonide for treatment of acute nonarteritic anterior ischemic optic neuropathy","volume":"245","author":"Jonas","year":"2007","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2017.03.003_bib12","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/WNO.0b013e31814a5a9a","article-title":"Intravitreal triamcinolone improves recovery of visual acuity in nonarteritic anterior ischemic optic neuropathy","volume":"27","author":"Kaderli","year":"2007","journal-title":"J Neuroophthalmol"},{"issue":"6","key":"10.1016\/j.ajo.2017.03.003_bib13","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1444-0938.2008.00287.x","article-title":"Intravitreal triamcinolone acetonide injection for acute non-arteritic anterior ischaemic optic neuropathy","volume":"91","author":"Yaman","year":"2008","journal-title":"Clin Exp Optom"},{"issue":"2","key":"10.1016\/j.ajo.2017.03.003_bib14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00417-013-2499-9","article-title":"Intravitreal triamcinolone injections in non-arteritic anterior ischemic optic neuropathy","volume":"252","author":"Radoi","year":"2014","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2017.03.003_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3341\/kjo.2009.23.1.59","article-title":"The effect of an intravitreal triamcinolone acetonide injection for acute nonarteritic anterior ischemic optic neuropathy","volume":"23","author":"Sohn","year":"2009","journal-title":"Korean J Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2017.03.003_bib16","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00417-008-0805-8","article-title":"Non-arteritic anterior ischemic optic neuropathy: role of systemic corticosteroid therapy","volume":"246","author":"Hayreh","year":"2008","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2017.03.003_bib17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00417-012-1995-7","article-title":"Visual and anatomical outcomes of non-arteritic anterior ischemic optic neuropathy with high-dose systemic corticosteroids","volume":"251","author":"Rebolleda","year":"2013","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajo.2017.03.003_bib18","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s00417-016-3451-6","article-title":"The effect of high-dose steroids, and normobaric oxygen therapy, on recent onset non-arteritic anterior ischemic optic neuropathy: a randomized clinical trial","volume":"254","author":"Pakravan","year":"2016","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2017.03.003_bib19","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1136\/bjo.2004.046524","article-title":"Elevated plasma levels of interleukin 8 in patients with acute anterior ischaemic optic neuropathy","volume":"88","author":"Goldenberg-Cohen","year":"2004","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2017.03.003_bib20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0002-9394(01)01269-7","article-title":"Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema","volume":"133","author":"Funatsu","year":"2002","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2017.03.003_bib21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1515\/jbcpp-2013-0121","article-title":"Cerebral stroke injury: the role of cytokines and brain inflammation","volume":"25","author":"Siniscalchi","year":"2014","journal-title":"J Basic Clin Physiol Pharmacol"},{"issue":"4","key":"10.1016\/j.ajo.2017.03.003_bib22","doi-asserted-by":"crossref","first-page":"e0125329","DOI":"10.1371\/journal.pone.0125329","article-title":"Study of 27 aqueous humor cytokines in type 2 diabetic patients with or without macular edema","volume":"10","author":"Dong","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ajo.2017.03.003_bib23","first-page":"1734","article-title":"Study of 27 aqueous humor cytokines in patients with type 2 diabetes with or without retinopathy","volume":"19","author":"Dong","year":"2013","journal-title":"Mol Vis"},{"issue":"10","key":"10.1016\/j.ajo.2017.03.003_bib24","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1097\/IAE.0b013e3182576d07","article-title":"Cytokine concentration in aqueous humor of eyes with diabetic macular edema","volume":"32","author":"Jonas","year":"2012","journal-title":"Retina"},{"issue":"1","key":"10.1016\/j.ajo.2017.03.003_bib25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00417-004-0950-7","article-title":"Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients","volume":"243","author":"Funatsu","year":"2005","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2017.03.003_bib26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1177\/112067211002000222","article-title":"Aqueous humor levels of vasoactive molecules correlate with vitreous levels and macular edema in central retinal vein occlusion","volume":"20","author":"Noma","year":"2010","journal-title":"Eur J Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2017.03.003_bib27","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1167\/iovs.14-15999","article-title":"Efficacy of intravitreal injections of antivascular endothelial growth factor agents in a rat model of anterior ischemic optic neuropathy","volume":"56","author":"Huang","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.ajo.2017.03.003_bib28","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2337\/diabetes.48.5.1131","article-title":"Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells","volume":"48","author":"Marumo","year":"1999","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.ajo.2017.03.003_bib29","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1016\/j.biomaterials.2014.01.030","article-title":"Monitoring the VEGF level in aqueous humor of patients with ophthalmologically relevant diseases via ultrahigh sensitive paper-based ELISA","volume":"35","author":"Hsu","year":"2014","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.ajo.2017.03.003_bib30","doi-asserted-by":"crossref","first-page":"905","DOI":"10.4103\/0301-4738.176031","article-title":"Intraocular cytokines in retinal vein occlusion and its relation to the efficiency of anti-vascular endothelial growth factor therapy","volume":"63","author":"Shchuko","year":"2015","journal-title":"Indian J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2017.03.003_bib31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/sj.eye.6702498","article-title":"Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion","volume":"22","author":"Noma","year":"2008","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.ajo.2017.03.003_bib32","article-title":"Aqueous humor cytokine levels as biomarkers of disease severity in diabetic macular edema","author":"Hillier","year":"2016","journal-title":"Retina"},{"issue":"10","key":"10.1016\/j.ajo.2017.03.003_bib33","doi-asserted-by":"crossref","first-page":"4144","DOI":"10.1167\/iovs.16-19772","article-title":"The intraocular cytokine profile and therapeutic response in persistent neovascular age-related macular degeneration","volume":"57","author":"Rezar-Dreindl","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"10.1016\/j.ajo.2017.03.003_bib34","doi-asserted-by":"crossref","first-page":"e647","DOI":"10.1097\/IJG.0000000000000242","article-title":"Vascular endothelial growth factor is increased in aqueous humor of acute primary angle-closure eyes","volume":"25","author":"Huang","year":"2016","journal-title":"J Glaucoma"},{"issue":"1","key":"10.1016\/j.ajo.2017.03.003_bib35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ophtha.2008.09.034","article-title":"Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion","volume":"116","author":"Noma","year":"2009","journal-title":"Ophthalmology"},{"issue":"7","key":"10.1016\/j.ajo.2017.03.003_bib36","doi-asserted-by":"crossref","first-page":"e68149","DOI":"10.1371\/journal.pone.0068149","article-title":"Differences in aqueous concentrations of cytokines in macular edema secondary to branch and central retinal vein occlusion","volume":"8","author":"Feng","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.ajo.2017.03.003_bib37","first-page":"1124","article-title":"Aqueous concentrations of VEGF and soluble VEGF receptor-1 in diabetic retinopathy patients","volume":"17","author":"Javanmard","year":"2012","journal-title":"J Res Med Sci"},{"issue":"1","key":"10.1016\/j.ajo.2017.03.003_bib38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.preteyeres.2008.11.002","article-title":"Ischemic optic neuropathy","volume":"28","author":"Hayreh","year":"2009","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"10.1016\/j.ajo.2017.03.003_bib39","doi-asserted-by":"crossref","first-page":"e246","DOI":"10.1111\/j.1755-3768.2011.02219.x","article-title":"IL-2 may possess neuroprotective properties in glaucomatous optic neuropathy","volume":"90","author":"Hautala","year":"2012","journal-title":"Acta Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2017.03.003_bib40","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0002-9394(00)00862-X","article-title":"T cell subsets and sIL-2R\/IL-2 levels in patients with glaucoma","volume":"131","author":"Yang","year":"2001","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2017.03.003_bib41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0022-2143(96)90005-0","article-title":"In\u00a0vivo, in\u00a0vitro, and molecular aspects of interleukin-8 and the interleukin-8 receptors","volume":"128","author":"Hoch","year":"1996","journal-title":"J Lab Clin Med"},{"issue":"7","key":"10.1016\/j.ajo.2017.03.003_bib42","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJM199802123380706","article-title":"Chemokines\u2013chemotactic cytokines that mediate inflammation","volume":"338","author":"Luster","year":"1998","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.ajo.2017.03.003_bib43","first-page":"1065","article-title":"Slowly progressive ischemic optic neuropathy. A clinicopathologic case report","volume":"75","author":"Knox","year":"1971","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"issue":"4","key":"10.1016\/j.ajo.2017.03.003_bib44","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1001\/archopht.1996.01100130484027","article-title":"Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy","volume":"114","author":"Levin","year":"1996","journal-title":"Arch Ophthalmol"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293941730106X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293941730106X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:34:30Z","timestamp":1757597670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000293941730106X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":44,"alternative-id":["S000293941730106X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2017.03.003","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2017.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}