{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:54:38Z","timestamp":1784105678588,"version":"3.55.0"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.ajo.2017.03.032","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T23:03:57Z","timestamp":1491260637000},"page":"157-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["The Utility of Repeat Culture in Fungal Corneal Ulcer Management: A Secondary Analysis of the MUTT-I Randomized Clinical Trial"],"prefix":"10.1016","volume":"178","author":[{"given":"Kathryn J.","family":"Ray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajna","family":"Lalitha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Venkatesh","family":"Prajna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revathi","family":"Rajaraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiruvengada","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthiah","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ryg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"McLeod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha R.","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Lietman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4905-2528","authenticated-orcid":false,"given":"Jennifer","family":"Rose-Nussbaumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ajo.2017.03.032_bib1","first-page":"214","article-title":"Corneal blindness: a global perspective","volume":"79","author":"Whitcher","year":"2001","journal-title":"Bull World Health Organ"},{"issue":"8","key":"10.1016\/j.ajo.2017.03.032_bib2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1136\/bjo.82.8.919","article-title":"Randomised trial of 0.2% chlorhexidine gluconate and 2.5% natamycin for fungal keratitis in Bangladesh","volume":"82","author":"Rahman","year":"1998","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2017.03.032_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0161-6420(96)30738-0","article-title":"The role of smears, cultures, and antibiotic sensitivity testing in the management of suspected infectious keratitis","volume":"103","author":"McLeod","year":"1996","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1016\/j.ajo.2017.03.032_bib4","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/sj.eye.6700557","article-title":"Fungal infections of the cornea","volume":"17","author":"Thomas","year":"2003","journal-title":"Eye (Lond)"},{"issue":"3","key":"10.1016\/j.ajo.2017.03.032_bib5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12281-013-0150-1","article-title":"Current thoughts in fungal keratitis: diagnosis and treatment","volume":"7","author":"Ansari","year":"2013","journal-title":"Curr Fungal Infect Rep"},{"issue":"3","key":"10.1016\/j.ajo.2017.03.032_bib6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/1469-0691.12126","article-title":"Mycotic keratitis: epidemiology, diagnosis and management","volume":"19","author":"Thomas","year":"2013","journal-title":"Clin Microbiol Infect"},{"issue":"4","key":"10.1016\/j.ajo.2017.03.032_bib7","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00417-007-0719-x","article-title":"Antifungal chemotherapy for fungal keratitis guided by in\u00a0vivo confocal microscopy","volume":"246","author":"Shi","year":"2008","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2017.03.032_bib8","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1001\/jamaophthalmol.2013.1718","article-title":"Fluoroquinolone treatment and susceptibility of isolates from bacterial keratitis","volume":"131","author":"Ray","year":"2013","journal-title":"JAMA Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2017.03.032_bib9","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1167\/iovs.12-11246","article-title":"Moxifloxacin susceptibility mediates the relationship between causative organism and clinical outcome in bacterial keratitis","volume":"54","author":"Oldenburg","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"10.1016\/j.ajo.2017.03.032_bib10","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1093\/cid\/cis189","article-title":"Relationship of in\u00a0vitro susceptibility and in\u00a0vivo clinical outcome in bacterial keratitis","volume":"54","author":"Prajna","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"11","key":"10.1016\/j.ajo.2017.03.032_bib11","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1136\/bjophthalmol-2014-306414","article-title":"Comparison of culture-negative and culture-positive microbial keratitis: cause of culture negativity, clinical features and final outcome","volume":"99","author":"Bhadange","year":"2015","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2017.03.032_bib12","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1001\/jamaophthalmol.2013.1497","article-title":"The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole","volume":"131","author":"Prajna","year":"2013","journal-title":"JAMA Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajo.2017.03.032_bib13","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1093\/cid\/cis189","article-title":"Relationship of in vitro susceptibility to moxifloxacin and in vivo clinical outcome in bacterial keratitis","volume":"54","author":"Lalitha","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"3","key":"10.1016\/j.ajo.2017.03.032_bib14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ophtha.2006.09.006","article-title":"The prognostic role of donor corneoscleral rim cultures in corneal transplantation","volume":"114","author":"Wilhelmus","year":"2007","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.ajo.2017.03.032_bib15","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0197-2456(01)00153-2","article-title":"Considerations in the evaluation of surrogate endpoints in clinical trials. Summary of a National Institutes of Health workshop","volume":"22","author":"De Gruttola","year":"2001","journal-title":"Control Clin Trials"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939417301459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939417301459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:34:27Z","timestamp":1757597667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939417301459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":15,"alternative-id":["S0002939417301459"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2017.03.032","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Utility of Repeat Culture in Fungal Corneal Ulcer Management: A Secondary Analysis of the MUTT-I Randomized Clinical Trial","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2017.03.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}