{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:58:37Z","timestamp":1791478717189,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY011008"],"award-info":[{"award-number":["EY011008"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY14267"],"award-info":[{"award-number":["EY14267"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY019869"],"award-info":[{"award-number":["EY019869"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["15K21335"],"award-info":[{"award-number":["15K21335"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["16KK0208"],"award-info":[{"award-number":["16KK0208"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000350","name":"core","doi-asserted-by":"publisher","award":["P30EY022589"],"award-info":[{"award-number":["P30EY022589"]}],"id":[{"id":"10.13039\/501100000350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.ajo.2017.07.011","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T01:46:49Z","timestamp":1500515209000},"page":"107-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":187,"special_numbering":"C","title":["Progressive Macula Vessel Density Loss in Primary Open-Angle Glaucoma: A Longitudinal Study"],"prefix":"10.1016","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5464-2573","authenticated-orcid":false,"given":"Takuhei","family":"Shoji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M.","family":"Zangwill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamichi","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke J.","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeleh","family":"Yarmohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Isabel C.","family":"Manalastas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaella C.","family":"Penteado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Weinreb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9422","key":"10.1016\/j.ajo.2017.07.011_bib1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ajo.2017.07.011_bib2","series-title":"Ocular Blood Flow in Glaucoma","author":"Weinreb","year":"2009"},{"issue":"4","key":"10.1016\/j.ajo.2017.07.011_bib3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1350-9462(02)00008-3","article-title":"The impact of ocular blood flow in glaucoma","volume":"21","author":"Flammer","year":"2002","journal-title":"Prog Retin Eye Res"},{"issue":"Suppl 2","key":"10.1016\/j.ajo.2017.07.011_bib4","doi-asserted-by":"crossref","first-page":"S144","DOI":"10.1016\/j.survophthal.2007.08.010","article-title":"What is the link between vascular dysregulation and glaucoma?","volume":"52","author":"Grieshaber","year":"2007","journal-title":"Surv Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2017.07.011_bib5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ohc.2005.04.001","article-title":"The role of optic nerve blood flow in the pathogenesis of glaucoma","volume":"18","author":"Harris","year":"2005","journal-title":"Ophthalmol Clin North Am"},{"issue":"10","key":"10.1016\/j.ajo.2017.07.011_bib6","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1080\/17434440.2016.1230014","article-title":"Optical coherence tomography angiography and glaucoma: searching for the missing link","volume":"13","author":"Mansouri","year":"2016","journal-title":"Expert Rev Med Devices"},{"issue":"2","key":"10.1016\/j.ajo.2017.07.011_bib7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1001\/archopht.122.2.195","article-title":"Fluorescein filling defects and quantitative morphologic analysis of the optic nerve head in glaucoma","volume":"122","author":"Plange","year":"2004","journal-title":"Arch Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2017.07.011_bib8","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0002-9394(14)71078-5","article-title":"Indocyanine green angiography of the peripapillary region in glaucomatous eyes by confocal scanning laser ophthalmoscopy","volume":"123","author":"O'Brart","year":"1997","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajo.2017.07.011_bib9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1076\/ceyr.27.6.329.18193","article-title":"An update on retinal circulation assessment technologies","volume":"27","author":"Rechtman","year":"2003","journal-title":"Curr Eye Res"},{"issue":"6","key":"10.1016\/j.ajo.2017.07.011_bib10","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0002-9394(14)70373-3","article-title":"Scanning laser Doppler flowmeter study of retinal and optic disk blood flow in glaucomatous patients","volume":"122","author":"Nicolela","year":"1996","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2017.07.011_bib11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00061198-199604000-00004","article-title":"Principle, validity, and reliability of scanning laser Doppler flowmetry","volume":"5","author":"Michelson","year":"1996","journal-title":"J Glaucoma"},{"issue":"4","key":"10.1016\/j.ajo.2017.07.011_bib12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0002-9394(98)00437-1","article-title":"Laser Doppler flowmetry and optic nerve head blood flow","volume":"127","author":"Petrig","year":"1999","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajo.2017.07.011_bib13","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0002-9394(00)00382-2","article-title":"Measurement of microcirculation in the optic nerve head by laser speckle flowgraphy and scanning laser Doppler flowmetry","volume":"129","author":"Yaoeda","year":"2000","journal-title":"Am J Ophthalmol"},{"issue":"18","key":"10.1016\/j.ajo.2017.07.011_bib14","doi-asserted-by":"crossref","first-page":"E2395","DOI":"10.1073\/pnas.1500185112","article-title":"Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye","volume":"112","author":"Jia","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.ajo.2017.07.011_bib15","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.ophtha.2014.01.021","article-title":"Optical coherence tomography angiography of optic disc perfusion in glaucoma","volume":"121","author":"Jia","year":"2014","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.ajo.2017.07.011_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/jamaophthalmol.2014.3616","article-title":"Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography","volume":"133","author":"Spaide","year":"2015","journal-title":"JAMA Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2017.07.011_bib17","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1364\/OE.20.004710","article-title":"Split-spectrum amplitude-decorrelation angiography with optical coherence tomography","volume":"20","author":"Jia","year":"2012","journal-title":"Opt Express"},{"issue":"9","key":"10.1016\/j.ajo.2017.07.011_bib18","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1001\/jamaophthalmol.2015.2225","article-title":"Optical coherence tomography angiography of the peripapillary retina in glaucoma","volume":"133","author":"Liu","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ajo.2017.07.011_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ajo.2016.02.018","article-title":"In\u00a0vivo assessment of macular vascular density in healthy human eyes using optical coherence tomography angiography","volume":"165","author":"Shahlaee","year":"2016","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"10.1016\/j.ajo.2017.07.011_bib20","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.15-18944","article-title":"Optical coherence tomography angiography vessel density in healthy, glaucoma suspect, and glaucoma eyes","volume":"57","author":"Yarmohammadi","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2017.07.011_bib21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ajo.2016.06.009","article-title":"Microvascular density in glaucomatous eyes with hemifield visual field defects: an optical coherence tomography angiography study","volume":"168","author":"Akagi","year":"2016","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2017.07.011_bib22","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1016\/j.ophtha.2016.08.041","article-title":"Relationship between optical coherence tomography angiography vessel density and severity of visual field loss in glaucoma","volume":"123","author":"Yarmohammadi","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2017.07.011_bib23","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.preteyeres.2013.07.001","article-title":"Retinal ganglion cells: energetics, compartmentation, axonal transport, cytoskeletons and vulnerability","volume":"36","author":"Yu","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ajo.2017.07.011_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.preteyeres.2014.02.001","article-title":"Functional and morphological characteristics of the retinal and choroidal vasculature","volume":"40","author":"Yu","year":"2014","journal-title":"Prog Retin Eye Res"},{"issue":"7","key":"10.1016\/j.ajo.2017.07.011_bib25","first-page":"1774","article-title":"Scaling the hill of vision: the physiological relationship between light sensitivity and ganglion cell numbers","volume":"41","author":"Garway-Heath","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.ajo.2017.07.011_bib26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/cne.903000103","article-title":"Topography of ganglion cells in human retina","volume":"300","author":"Curcio","year":"1990","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.ajo.2017.07.011_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ajo.2016.08.030","article-title":"Regional comparisons of optical coherence tomography angiography vessel density in primary open-angle glaucoma","volume":"171","author":"Rao","year":"2016","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"10.1016\/j.ajo.2017.07.011_bib28","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/archophthalmol.2009.187","article-title":"The African Descent and Glaucoma Evaluation Study (ADAGES): design and baseline data","volume":"127","author":"Sample","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2017.07.011_bib29","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1364\/BOE.3.003127","article-title":"Quantitative OCT angiography of optic nerve head blood flow","volume":"3","author":"Jia","year":"2012","journal-title":"Biomed Opt Express"},{"issue":"11","key":"10.1016\/j.ajo.2017.07.011_bib30","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1097\/IAE.0000000000000881","article-title":"Optical coherence tomography angiography","volume":"35","author":"Spaide","year":"2015","journal-title":"Retina"},{"issue":"5","key":"10.1016\/j.ajo.2017.07.011_bib31","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1167\/iovs.14-16270","article-title":"Macular perfusion in healthy Chinese: an optical coherence tomography angiogram study","volume":"56","author":"Yu","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.ajo.2017.07.011_bib32","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1001\/archophthalmol.2010.58","article-title":"African Descent and Glaucoma Evaluation Study (ADAGES): III. Ancestry differences in visual function in healthy eyes","volume":"128","author":"Racette","year":"2010","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2017.07.011_bib33","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1016\/j.ophtha.2009.05.025","article-title":"Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography","volume":"116","author":"Tan","year":"2009","journal-title":"Ophthalmology"},{"issue":"7","key":"10.1016\/j.ajo.2017.07.011_bib34","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1167\/iovs.09-4350","article-title":"A comparison of rates of change in neuroretinal rim area and retinal nerve fiber layer thickness in progressive glaucoma","volume":"51","author":"Alencar","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.ajo.2017.07.011_bib35","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1167\/iovs.08-2712","article-title":"Detection of progressive retinal nerve fiber layer loss in glaucoma using scanning laser polarimetry with variable corneal compensation","volume":"50","author":"Medeiros","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.ajo.2017.07.011_bib36","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1167\/iovs.15-18287","article-title":"Quantification of vessel density in retinal optical coherence tomography angiography images using local fractal dimension","volume":"57","author":"Gadde","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"10.1016\/j.ajo.2017.07.011_bib37","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1136\/bjophthalmol-2016-309160","article-title":"Association between outer retinal alterations and microvascular changes in intermediate stage age-related macular degeneration: an optical coherence tomography angiography study","volume":"101","author":"Toto","year":"2017","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2017.07.011_bib38","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ophtha.2011.08.022","article-title":"Progression detection capability of macular thickness in advanced glaucomatous eyes","volume":"119","author":"Sung","year":"2012","journal-title":"Ophthalmology"},{"issue":"13","key":"10.1016\/j.ajo.2017.07.011_bib39","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.1167\/iovs.16-20045","article-title":"Retinal capillary density and foveal avascular zone area are age-dependent: quantitative analysis using optical coherence tomography angiography","volume":"57","author":"Iafe","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"10.1016\/j.ajo.2017.07.011_bib40","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.15-18793","article-title":"Normative data for vascular density in superficial and deep capillary plexuses of healthy adults assessed by optical coherence tomography angiography","volume":"57","author":"Coscas","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.ajo.2017.07.011_bib41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ajo.2009.03.002","article-title":"Effect of signal strength and improper alignment on the variability of stratus optical coherence tomography retinal nerve fiber layer thickness measurements","volume":"148","author":"Vizzeri","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2017.07.011_bib42","article-title":"Repeatability of vessel density measurements of optical coherence tomography angiography in normal and glaucoma eyes","author":"Venugopal","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2017.07.011_bib43","doi-asserted-by":"crossref","DOI":"10.1136\/bjophthalmol-2016-309441","article-title":"Interchangeability and reliability of macular perfusion parameter measurements using optical coherence tomography angiography","author":"Dong","year":"2017","journal-title":"Br J Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2017.07.011_bib44","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1167\/iovs.08-2970","article-title":"Macular thickness measurements in healthy eyes using six different optical coherence tomography instruments","volume":"50","author":"Wolf-Schnurrbusch","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.ajo.2017.07.011_bib45","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.ophtha.2009.08.039","article-title":"Reproducibility of retinal nerve fiber layer and macular thickness measurement with the RTVue-100 optical coherence tomograph","volume":"117","author":"Garas","year":"2010","journal-title":"Ophthalmology"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939417303069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939417303069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:35:57Z","timestamp":1757597757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939417303069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":45,"alternative-id":["S0002939417303069"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2017.07.011","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progressive Macula Vessel Density Loss in Primary Open-Angle Glaucoma: A Longitudinal Study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2017.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}