{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:15:26Z","timestamp":1791980126551,"version":"4.4.0"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.ajo.2017.08.017","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T22:17:06Z","timestamp":1504649826000},"page":"158-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"special_numbering":"C","title":["Blau Syndrome\u2013Associated Uveitis: Preliminary Results From an International Prospective Interventional Case Series"],"prefix":"10.1016","volume":"187","author":[{"given":"Inge L.","family":"Sarens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingele","family":"Casteels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Anton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Bader-Meunier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Brissaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelle","family":"Ch\u00e9deville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Cimaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciella","family":"Espada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Fernandez-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Guly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hachulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Harjacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju","family":"Khubchandani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Mackensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Modesto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Naranjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Oliveira-Knupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seza","family":"\u00d6zen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Pajot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athimalaipet V.","family":"Ramanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Susic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akaluck","family":"Thatayatikom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Thom\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan","family":"Vastert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bertin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan I.","family":"Arostegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos D.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine H.","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ajo.2017.08.017_bib1","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.autrev.2014.08.010","article-title":"Caveats and truths in genetic, clinical, autoimmune and autoinflammatory issues in Blau syndrome and early onset sarcoidosis","volume":"13","author":"Caso","year":"2014","journal-title":"Autoimmun Rev"},{"issue":"6","key":"10.1016\/j.ajo.2017.08.017_bib2","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1093\/rheumatology\/keu437","article-title":"Blau syndrome: cross-sectional data from a multicentre study of clinical, radiological and functional outcomes","volume":"54","author":"Rose","year":"2015","journal-title":"Rheumatology"},{"issue":"5","key":"10.1016\/j.ajo.2017.08.017_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/BOR.0b013e328349c430","article-title":"Blau syndrome revisited","volume":"23","author":"Rose","year":"2011","journal-title":"Curr Opin Rheumatol"},{"issue":"5","key":"10.1016\/j.ajo.2017.08.017_bib4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0022-3476(85)80394-2","article-title":"Familial granulomatous arthritis, iritis, and rash","volume":"107","author":"Blau","year":"1985","journal-title":"J Pediatr"},{"issue":"6","key":"10.1016\/j.ajo.2017.08.017_bib5","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0002-9394(02)01709-9","article-title":"Multifocal choroiditis in patients with familial juvenile systemic granulomatosis","volume":"134","author":"Latkany","year":"2002","journal-title":"Am J Ophthalmol"},{"issue":"11","key":"10.1016\/j.ajo.2017.08.017_bib6","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1002\/art.22966","article-title":"NOD2 gene-associated pediatric granulomatous arthritis: clinical diversity, novel and recurrent mutations, and evidence of clinical improvement with Interleukin-1 blockade in a Spanish cohort","volume":"56","author":"Arostegui","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.ajo.2017.08.017_bib7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/aos.12544","article-title":"Optic nerve and retinal features in uveitis associated with juvenile systemic granulomatous disease (Blau syndrome)","volume":"93","author":"Carreno","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.ajo.2017.08.017_bib8","first-page":"509","article-title":"Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop","volume":"140","year":"2005","journal-title":"J Ophthalmol"},{"key":"10.1016\/j.ajo.2017.08.017_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1741-7015-4-7","article-title":"Revision of visual impairment definitions in the International Statistical Classification of Diseases","volume":"4","author":"Dandona","year":"2006","journal-title":"BMC Med"},{"issue":"4","key":"10.1016\/j.ajo.2017.08.017_bib10","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0161-6420(85)34001-0","article-title":"Standardization of vitreal inflammatory activity in intermediate and posterior uveitis","volume":"92","author":"Nussenblatt","year":"1985","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2017.08.017_bib11","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/S0161-6420(03)00717-6","article-title":"Ocular manifestations in Blau syndrome associated with a CARD15\/NOD2 mutation","volume":"110","author":"Kurokawa","year":"2003","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.ajo.2017.08.017_bib12","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0002-9343(85)90286-4","article-title":"Familial granulomatous synovitis, uveitis and cranial neuropathies","volume":"78","author":"Jabs","year":"1985","journal-title":"Am J Med"},{"key":"10.1016\/j.ajo.2017.08.017_bib13","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.ajo.2006.06.064","article-title":"Blau syndrome associated with a CARD15\/NOD2 mutation","volume":"142","author":"Snyers","year":"2006","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2017.08.017_bib14","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/art.37776","article-title":"Clinical and transcriptional response to the long-acting interleukin-1 blocker canakinumab in Blau syndrome-related uveitis","volume":"65","author":"Simonini","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.ajo.2017.08.017_bib15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/art.22381","article-title":"Prevalence, risk factors, and outcome of uveitis in juvenile idiopathic arthritis: a long-term follow-up study","volume":"56","author":"Saurenmann","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.ajo.2017.08.017_bib16","first-page":"1139","article-title":"Prevalence and outcome\u00a0of juvenile idiopathic arthritis-associated uveitis and relation to articular disease","volume":"34","author":"Grassi","year":"2007","journal-title":"J Rheumatol"},{"issue":"6","key":"10.1016\/j.ajo.2017.08.017_bib17","first-page":"92","article-title":"Uveitis in juvenile idiopathic arthritis","volume":"112","author":"Heiligenhaus","year":"2015","journal-title":"Dtsch Artzebl Int"},{"key":"10.1016\/j.ajo.2017.08.017_bib18","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/art.24134","article-title":"Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis","volume":"60","author":"Okafuji","year":"2009","journal-title":"Arthritis Rheum"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939417303719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939417303719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:36:10Z","timestamp":1757597770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939417303719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":18,"alternative-id":["S0002939417303719"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2017.08.017","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blau Syndrome\u2013Associated Uveitis: Preliminary Results From an International Prospective Interventional Case Series","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2017.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2017.12.006","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}