{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:10:48Z","timestamp":1792512648316,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.ajo.2018.01.030","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T18:34:18Z","timestamp":1517942058000},"page":"131-140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Vancomycin-Associated Hemorrhagic Occlusive Retinal Vasculitis: A Clinical-Pathophysiological Analysis"],"prefix":"10.1016","volume":"188","author":[{"given":"Bozho","family":"Todorich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Faia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristomenis","family":"Thanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0558-2615","authenticated-orcid":false,"given":"Mitual","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0602-7311","authenticated-orcid":false,"given":"Robert","family":"Folberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2781-7152","authenticated-orcid":false,"given":"Jeremy D.","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista M.","family":"Todorich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthemios","family":"Raphtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Ruby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek S.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajo.2018.01.030_bib1","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.jcrs.2011.06.018","article-title":"Prevention, diagnosis, and management of acute postoperative bacterial endophthalmitis","volume":"37","author":"Packer","year":"2011","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.ajo.2018.01.030_bib2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1001\/archopht.123.5.613","article-title":"Acute endophthalmitis following cataract surgery: a systematic review of the literature","volume":"123","author":"Taban","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajo.2018.01.030_bib3","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.jcrs.2007.02.032","article-title":"Prophylaxis of postoperative endophthalmitis following cataract surgery: results of the ESCRS multicenter study and identification of risk factors","volume":"33","year":"2007","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.ajo.2018.01.030_bib4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jcrs.2009.08.023","article-title":"Effectiveness of intracameral cefuroxime in preventing endophthalmitis after cataract surgery Ten-year comparative study","volume":"36","author":"Garcia-Saenz","year":"2010","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.ajo.2018.01.030_bib5","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/j.jcrs.2013.05.036","article-title":"Efficacy and safety of prophylactic intracameral moxifloxacin injection in Japan","volume":"39","author":"Matsuura","year":"2013","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.ajo.2018.01.030_bib6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2147\/OPTH.S9546","article-title":"Intracameral vancomycin following cataract surgery: an eleven-year study","volume":"4","author":"Anijeet","year":"2010","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.ajo.2018.01.030_bib7","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1136\/bjo.2006.112060","article-title":"Pharmacokinetics of vancomycin following intracameral bolus injection in patients undergoing phacoemulsification cataract surgery","volume":"91","author":"Murphy","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2018.01.030_bib8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2147\/OPTH.S74249","article-title":"Toxic anterior segment syndrome after uncomplicated cataract surgery possibly associated with intracamaral use of cefuroxime","volume":"9","author":"Cakir","year":"2015","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.ajo.2018.01.030_bib9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1177\/112067211002000232","article-title":"Cefuroxime dilution error","volume":"20","author":"Sakarya","year":"2010","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ajo.2018.01.030_bib10","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.jcrs.2007.07.009","article-title":"Prophylaxis of postoperative endophthalmitis after cataract surgery: results of the 2007 ASCRS member survey","volume":"33","author":"Chang","year":"2007","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.ajo.2018.01.030_bib11","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1016\/j.jcrs.2014.10.010","article-title":"Intracameral antibiotics: safety, efficacy, and preparation","volume":"40","author":"Braga-Mele","year":"2014","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.ajo.2018.01.030_bib12","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.ophtha.2015.03.016","article-title":"Postoperative hemorrhagic occlusive retinal vasculitis: expanding the clinical spectrum and possible association with vancomycin","volume":"122","author":"Witkin","year":"2015","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.ajo.2018.01.030_bib13","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ophtha.2016.11.042","article-title":"Vancomycin-associated hemorrhagic occlusive retinal vasculitis: clinical characteristics of 36 eyes","volume":"124","author":"Witkin","year":"2017","journal-title":"Ophthalmology"},{"issue":"Suppl 1","key":"10.1016\/j.ajo.2018.01.030_bib14","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.1097\/ICB.0000000000000389","article-title":"Hemorrhagic occlusive retinal vasculitis and nonhemorrhagic vasculitis after uncomplicated cataract surgery with intracameral vancomycin","volume":"11","author":"Ehmann","year":"2017","journal-title":"Retin Cases Brief Rep"},{"key":"10.1016\/j.ajo.2018.01.030_bib15","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3928\/23258160-20160808-10","article-title":"Hemorrhagic occlusive retinal vasculitis after first eye cataract surgery without subsequent second eye involvement","volume":"47","author":"Balducci","year":"2016","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"10.1016\/j.ajo.2018.01.030_bib16","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1016\/j.jcrs.2016.09.013","article-title":"Postoperative hemorrhagic occlusive retinal vasculitis associated with intracameral vancomycin prophylaxis during cataract surgery","volume":"42","author":"Miller","year":"2016","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.ajo.2018.01.030_bib17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1755-3768.1974.tb00366.x","article-title":"Retinoblastoma with necrosis of central retinal artery and vein and partial spontaneous regression","volume":"52","author":"Andersen","year":"1974","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.ajo.2018.01.030_bib18","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/ajh.23960","article-title":"Drug-induced thrombotic microangiopathy: experience of the Oklahoma Registry and the Blood Center of Wisconsin","volume":"90","author":"Reese","year":"2015","journal-title":"Am J Hematol"},{"key":"10.1016\/j.ajo.2018.01.030_bib19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1182\/blood-2014-11-611335","article-title":"Drug-induced thrombotic microangiopathy: a systematic review of published reports","volume":"125","author":"Al-Nouri","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.ajo.2018.01.030_bib20","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2500\/108854196778645029","article-title":"Vancomycin-induced Stevens-Johnson syndrome","volume":"17","author":"Alexander","year":"1996","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.ajo.2018.01.030_bib21","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1177\/106002809202601206","article-title":"Stevens-Johnson-type reaction with vancomycin treatment","volume":"26","author":"Laurencin","year":"1992","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.ajo.2018.01.030_bib22","first-page":"157","article-title":"Early diagnosis is key in vancomycin-induced linear IgA bullous dermatosis and Stevens-Johnson syndrome","volume":"104","author":"Jones","year":"2004","journal-title":"J Am Osteopath Assoc"},{"key":"10.1016\/j.ajo.2018.01.030_bib23","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1365-2230.2004.01649.x","article-title":"Vancomycin-induced linear IgA bullous disease presenting as toxic epidermal necrolysis","volume":"29","author":"Waldman","year":"2004","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.ajo.2018.01.030_bib24","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/S0002-9440(10)64676-7","article-title":"Time course of endothelial cell proliferation and microvascular remodeling in chronic inflammation","volume":"158","author":"Ezaki","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajo.2018.01.030_bib25","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajo.2018.01.030_bib26","first-page":"580","article-title":"Induction of endothelial cell proliferation in rat retinal venules by chemical and indirect physical trauma","volume":"13","author":"Deem","year":"1974","journal-title":"Invest Ophthalmol"},{"key":"10.1016\/j.ajo.2018.01.030_bib27","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ajo.2018.01.030_bib28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0065-230X(09)02002-8","article-title":"PI3K\/PTEN signaling in angiogenesis and tumorigenesis","volume":"102","author":"Jiang","year":"2009","journal-title":"Adv Cancer Res"},{"key":"10.1016\/j.ajo.2018.01.030_bib29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/01.RES.0000253094.03023.3f","article-title":"Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2","volume":"100","author":"Li","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.ajo.2018.01.030_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4889(00)00041-0","article-title":"Endothelial cell responses to hypoxia: initiation of a cascade of cellular interactions","volume":"1497","author":"Michiels","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajo.2018.01.030_bib31","doi-asserted-by":"crossref","first-page":"7738","DOI":"10.1073\/pnas.0802857105","article-title":"Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7","volume":"105","author":"Wang","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajo.2018.01.030_bib32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1161\/01.RES.85.3.247","article-title":"Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cdelta activity","volume":"85","author":"Shizukuda","year":"1999","journal-title":"Circ Res"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939418300424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939418300424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:36:50Z","timestamp":1757597810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939418300424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":32,"alternative-id":["S0002939418300424"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2018.01.030","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vancomycin-Associated Hemorrhagic Occlusive Retinal Vasculitis: A Clinical-Pathophysiological Analysis","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2018.01.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}