{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T03:52:37Z","timestamp":1787111557257,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.ajo.2018.02.001","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T12:19:59Z","timestamp":1518437999000},"page":"173-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"special_numbering":"C","title":["Comparing Treatment of Acute Retinal Necrosis With Either Oral Valacyclovir or Intravenous Acyclovir"],"prefix":"10.1016","volume":"188","author":[{"given":"Julijana","family":"Baltinas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Lightman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1015-1641","authenticated-orcid":false,"given":"Oren","family":"Tomkins-Netzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ajo.2018.02.001_bib1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/eye.2011.338","article-title":"Acute retinal necrosis in the United Kingdom: results of a prospective surveillance study","volume":"26","author":"Cochrane","year":"2012","journal-title":"Eye (Lond)"},{"issue":"11","key":"10.1016\/j.ajo.2018.02.001_bib2","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1136\/bjo.2007.114884","article-title":"Acute retinal necrosis: a national population-based study to assess the incidence, methods of diagnosis, treatment strategies and outcomes in the UK","volume":"91","author":"Muthiah","year":"2007","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2018.02.001_bib3","first-page":"607","article-title":"Unilateral acute uveitis with retinal periarteritis and detachment","volume":"25","author":"Urayama","year":"1971","journal-title":"Jpn J Clin Ophthalmol"},{"issue":"9","key":"10.1016\/j.ajo.2018.02.001_bib4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1136\/bjo.62.9.581","article-title":"Bilateral acute retinal necrosis","volume":"62","author":"Young","year":"1978","journal-title":"Br J Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2018.02.001_bib5","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0161-6420(82)34638-2","article-title":"The acute retinal necrosis syndrome: part 2: histopathology and etiology","volume":"89","author":"Culbertson","year":"1982","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ajo.2018.02.001_bib6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0161-6420(86)33740-0","article-title":"Treatment of the acute retinal necrosis syndrome with intravenous acyclovir","volume":"93","author":"Blumenkranz","year":"1986","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2018.02.001_bib7","volume":"Vol 4","author":"Nussenblatt","year":"2010"},{"issue":"5","key":"10.1016\/j.ajo.2018.02.001_bib8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0039-6257(91)90183-G","article-title":"Diagnosis and management of the acute retinal necrosis (ARN) syndrome","volume":"35","author":"Duker","year":"1991","journal-title":"Surv Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2018.02.001_bib9","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.ophtha.2009.09.001","article-title":"Treatment of acute retinal necrosis","volume":"117","author":"Tibbetts","year":"2010","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ajo.2018.02.001_bib10","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3109\/09273948.2013.819928","article-title":"Acute retinal necrosis: clinical features, management and outcomes\u2013a 10 year consecutive case series","volume":"22","author":"Roy","year":"2014","journal-title":"Ocul Immunol Inflamm"},{"issue":"10","key":"10.1016\/j.ajo.2018.02.001_bib11","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/j.ophtha.2009.03.029","article-title":"Acute retinal necrosis: clinical features, early vitrectomy, and outcomes","volume":"116","author":"Hillenkamp","year":"2009","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.ajo.2018.02.001_bib12","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.ophtha.2006.08.037","article-title":"Acute retinal necrosis: features, management, and outcomes","volume":"114","author":"Lau","year":"2007","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ajo.2018.02.001_bib13","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0002-9394(14)76725-X","article-title":"Decrease in the risk of bilateral acute retinal necrosis by acyclovir therapy","volume":"112","author":"Palay","year":"1991","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2018.02.001_bib14","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1136\/bjophthalmol-2012-301983","article-title":"Emerging concepts in the management of acute retinal necrosis","volume":"97","author":"Wong","year":"2013","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2018.02.001_bib15","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ophtha.2016.11.007","article-title":"Diagnosis and treatment of acute retinal necrosis","volume":"124","author":"Schoenberger","year":"2017","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1016\/j.ajo.2018.02.001_bib16","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/j.ophtha.2014.07.007","article-title":"Long-term clinical outcome and causes of vision loss in patients with uveitis","volume":"121","author":"Tomkins-Netzer","year":"2014","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.ajo.2018.02.001_bib17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0002-9394(01)00912-6","article-title":"Rate of visual field loss and long-term visual outcome in primary open-angle glaucoma","volume":"132","author":"Kwon","year":"2001","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2018.02.001_bib18","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ajo.2005.03.057","article-title":"Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop","volume":"140","author":"Jabs","year":"2005","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2018.02.001_bib19","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00006982-200206000-00016","article-title":"Oral valacyclovir in the treatment of acute retinal necrosis syndrome","volume":"22","author":"Aslanides","year":"2002","journal-title":"Retina"},{"key":"10.1016\/j.ajo.2018.02.001_bib20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1471-2415-12-48","article-title":"Valacyclovir in the treatment of acute retinal necrosis","volume":"12","author":"Taylor","year":"2012","journal-title":"BMC Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2018.02.001_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ophtha.2006.06.058","article-title":"Treatment of acute retinal necrosis syndrome with oral antiviral medications","volume":"114","author":"Aizman","year":"2007","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1016\/j.ajo.2018.02.001_bib22","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.ophtha.2006.05.063","article-title":"Primary treatment of acute retinal necrosis with oral antiviral therapy","volume":"113","author":"Emerson","year":"2006","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.ajo.2018.02.001_bib23","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1093\/jac\/47.6.855","article-title":"Comparable aciclovir exposures produced by oral valaciclovir and intravenous aciclovir in immunocompromised cancer patients","volume":"47","author":"H\u00f6glund","year":"2001","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"10.1016\/j.ajo.2018.02.001_bib24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/clpt.1993.196","article-title":"Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteers","volume":"54","author":"Weller","year":"1993","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.ajo.2018.02.001_bib25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0002-9394(99)00316-5","article-title":"Viral causes of the acute retinal necrosis syndrome","volume":"129","author":"Ganatra","year":"2000","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2018.02.001_bib26","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0161-6420(01)00556-5","article-title":"Herpes simplex virus type 2 as a cause of acute retinal necrosis syndrome in young patients","volume":"108","author":"Van Gelder","year":"2001","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.ajo.2018.02.001_bib27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0002-9394(14)73077-6","article-title":"Detection of intraocular antibody production to herpesviruses in acute retinal necrosis syndrome","volume":"117","author":"de Boer","year":"1994","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2018.02.001_bib28","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1442-9071.2009.02083.x","article-title":"Acute retinal necrosis: a case series with clinical features and treatment outcomes","volume":"37","author":"Sims","year":"2009","journal-title":"Clin Exp Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2018.02.001_bib29","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0161-6420(84)34107-0","article-title":"Retinal detachment following the acute retinal necrosis syndrome","volume":"91","author":"Clarkson","year":"1984","journal-title":"Ophthalmology"},{"issue":"7","key":"10.1016\/j.ajo.2018.02.001_bib30","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s003470050299","article-title":"Argon-Laser-Koagulation (ALK) zur Prophylaxe rhegmatogener Netzhautabl\u00f6sungen [Argon laser photocoagulation to prevent rhegmatogenous retinal detachment in patients with acute retinal necrosis (ARN) syndrome]","volume":"95","author":"Hudde","year":"1998","journal-title":"Ophthalmologe"},{"issue":"8","key":"10.1016\/j.ajo.2018.02.001_bib31","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1001\/archopht.1987.01060080053027","article-title":"Laser photocoagulation in the acute retinal necrosis syndrome","volume":"105","author":"Han","year":"1987","journal-title":"Arch Ophthalmol"},{"issue":"8","key":"10.1016\/j.ajo.2018.02.001_bib32","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1136\/bjo.75.8.455","article-title":"Surgical management of retinal detachment associated with the acute retinal necrosis syndrome","volume":"75","author":"McDonald","year":"1991","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2018.02.001_bib33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3928\/23258160-20140908-02","article-title":"Combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis syndrome","volume":"45","author":"Yeh","year":"2014","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"issue":"3","key":"10.1016\/j.ajo.2018.02.001_bib34","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ophtha.2009.08.003","article-title":"Acute retinal necrosis: the effects of intravitreal foscarnet and virus type on outcome","volume":"117","author":"Wong","year":"2010","journal-title":"Ophthalmology"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939418300503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939418300503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:37:13Z","timestamp":1757597833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939418300503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":34,"alternative-id":["S0002939418300503"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2018.02.001","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparing Treatment of Acute Retinal Necrosis With Either Oral Valacyclovir or Intravenous Acyclovir","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2018.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}