{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:37:07Z","timestamp":1792661827554,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.ajo.2018.07.033","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T22:47:59Z","timestamp":1533336479000},"page":"83-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Do Largest Basal Tumor Diameter and the American Joint Committee on Cancer's Cancer Staging Influence Prognostication by Gene Expression Profiling in Choroidal Melanoma"],"prefix":"10.1016","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1593-1476","authenticated-orcid":false,"given":"Hakan","family":"Demirci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie M.","family":"Niziol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Ozkurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naziha","family":"Slimani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Ozgonul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Musch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Materin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ajo.2018.07.033_bib1","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1001\/jamaophthalmol.2015.0887","article-title":"Long-term risk of melanoma-related mortality for patients with uveal melanoma treated with proton beam therapy","volume":"133","author":"Lane","year":"2015","journal-title":"JAMA Ophthalmol"},{"issue":"11","key":"10.1016\/j.ajo.2018.07.033_bib2","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1167\/iovs.03-0538","article-title":"Very long-term prognosis of patients with malignant uveal melanoma","volume":"44","author":"Kujala","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.ajo.2018.07.033_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4103\/0301-4738.154367","article-title":"Uveal melanoma: estimating prognosis","volume":"63","author":"Kaliki","year":"2015","journal-title":"Indian J Ophthalmol"},{"issue":"9010","key":"10.1016\/j.ajo.2018.07.033_bib4","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0140-6736(96)90736-9","article-title":"Prognostic implications of monosomy 3 in uveal melanoma","volume":"347","author":"Prescher","year":"1996","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.ajo.2018.07.033_bib5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/gcc.2870020307","article-title":"Cytogenetic findings in six posterior uveal melanomas: involvement of chromosomes 3, 6, and 8","volume":"2","author":"Sisley","year":"1990","journal-title":"Genes Chromosomes Cancer"},{"issue":"1","key":"10.1016\/j.ajo.2018.07.033_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/(SICI)1098-2264(199705)19:1<22::AID-GCC4>3.0.CO;2-2","article-title":"Abnormalities of chromosomes 3 and 8 in posterior uveal melanoma correlate with prognosis","volume":"19","author":"Sisley","year":"1997","journal-title":"Genes Chromosomes Cancer"},{"issue":"20","key":"10.1016\/j.ajo.2018.07.033_bib7","doi-asserted-by":"crossref","first-page":"7205","DOI":"10.1158\/0008-5472.CAN-04-1750","article-title":"Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death","volume":"64","author":"Onken","year":"2004","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.ajo.2018.07.033_bib8","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.ophtha.2013.12.014","article-title":"A molecular revolution in uveal melanoma: implications for patient care and targeted therapy","volume":"121","author":"Harbour","year":"2014","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1016\/j.ajo.2018.07.033_bib9","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.ophtha.2012.02.017","article-title":"Collaborative ocular oncology group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma","volume":"119","author":"Onken","year":"2012","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.ajo.2018.07.033_bib10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ajo.2014.10.026","article-title":"Frequency and implications of discordant gene expression profile class in posterior uveal melanomas sampled by fine needle biopsy","volume":"159","author":"Augsburger","year":"2015","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"10.1016\/j.ajo.2018.07.033_bib11","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1001\/jamaophthalmol.2015.1790","article-title":"Variable results for uveal melanoma-specific gene expression profile prognostic test in choroidal metastasis","volume":"133","author":"Klufas","year":"2015","journal-title":"JAMA Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2018.07.033_bib12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000453616","article-title":"Uveal melanoma with histopathologic intratumoral heterogeneity associated with gene expression profile discordance","volume":"3","author":"Miller","year":"2017","journal-title":"Ocul Oncol Pathol"},{"issue":"5","key":"10.1016\/j.ajo.2018.07.033_bib13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3928\/23258160-20140806-01","article-title":"Uveal melanoma gene expression profile test result provided for uveal metastasis","volume":"45","author":"Seider","year":"2014","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"issue":"2","key":"10.1016\/j.ajo.2018.07.033_bib14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ajo.2015.11.019","article-title":"Independent prognostic significance of gene expression profile class and largest basal diameter of posterior uveal melanomas","volume":"162","author":"Correa","year":"2016","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2018.07.033_bib15","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1001\/jamaophthalmol.2016.0913","article-title":"Prognostic implications of tumor diameter in association with gene expression profile for uveal melanoma","volume":"134","author":"Walter","year":"2016","journal-title":"JAMA Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2018.07.033_bib16","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1038\/eye.2009.235","article-title":"A reappraisal of the significance of largest basal diameter of posterior uveal melanoma","volume":"23","author":"Damato","year":"2009","journal-title":"Eye"},{"issue":"5","key":"10.1016\/j.ajo.2018.07.033_bib17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.preteyeres.2011.05.003","article-title":"Estimating prognosis for survival after treatment of choroidal melanoma","volume":"30","author":"Damato","year":"2011","journal-title":"Prog Retin Eye Res"},{"issue":"8","key":"10.1016\/j.ajo.2018.07.033_bib18","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1167\/iovs.13-12195","article-title":"Genomic profile of 320 uveal melanoma cases: chromosome 8p-loss and metastatic outcome","volume":"54","author":"Ewens","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"10.1016\/j.ajo.2018.07.033_bib19","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/sj.eye.6702779","article-title":"Significance of gene expression analysis in uveal melanoma in comparison to standard risk factors for risk assessment of subsequent metastases","volume":"22","author":"Petrausch","year":"2008","journal-title":"Eye"},{"issue":"7","key":"10.1016\/j.ajo.2018.07.033_bib20","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1016\/j.ophtha.2013.03.036","article-title":"Molecular analysis of uveal melanoma","volume":"120","author":"Coupland","year":"2013","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.ajo.2018.07.033_bib21","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.ophtha.2012.12.019","article-title":"Gene expression profiling versus TNM classification","volume":"120","author":"Kivela","year":"2013","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ajo.2018.07.033_bib22","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jcjo.2012.03.038","article-title":"Uveal melanoma prognostication: from lesion size and cell type to molecular class","volume":"47","author":"Gill","year":"2012","journal-title":"Can J Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2018.07.033_bib23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ophtha.2010.05.023","article-title":"Prognosis of uveal melanoma in 500 cases using genetic testing of fine-needle aspiration biopsy specimens","volume":"118","author":"Shields","year":"2011","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.ajo.2018.07.033_bib24","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2353\/jmoldx.2010.090220","article-title":"An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanoma","volume":"12","author":"Onken","year":"2010","journal-title":"J Mol Diagn"},{"issue":"10","key":"10.1016\/j.ajo.2018.07.033_bib25","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.ophtha.2007.06.012","article-title":"Cytogenetics of uveal melanoma: a 7-year clinical experience","volume":"114","author":"Damato","year":"2007","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.ajo.2018.07.033_bib26","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/cncr.11113","article-title":"A prognostic model and staging for metastatic uveal melanoma","volume":"97","author":"Eskelin","year":"2003","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.ajo.2018.07.033_bib27","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0161-6420(95)30864-0","article-title":"Risk factors for growth and metastasis of small choroidal melanocytic lesions","volume":"102","author":"Shields","year":"1995","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ajo.2018.07.033_bib28","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/archopht.118.3.360","article-title":"Combination of clinical factors predictive of growth of small melanocytic tumors","volume":"118","author":"Shields","year":"2000","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2018.07.033_bib29","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1001\/archopht.1997.01100160707007","article-title":"The collaborative ocular melanoma study group: factors predictive of growth and treatment of small choroidal melanoma. COMS report no 5","volume":"115","year":"1997","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2018.07.033_bib30","first-page":"1268","article-title":"Accuracy of diagnosis of choroidal melanomas in the collaborative ocular melanoma study. COMS report no. 1","volume":"108","year":"1990","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajo.2018.07.033_bib31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/978-1-62703-727-3_22","article-title":"A prognostic test to predict the risk of metastasis in uveal melanoma based on a 15-gene expression profile","volume":"1102","author":"Harbour","year":"2014","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.ajo.2018.07.033_bib32","series-title":"AJCC Cancer Staging Manual","first-page":"547","article-title":"Malignant melanoma of the uvea","year":"2010"},{"issue":"6","key":"10.1016\/j.ajo.2018.07.033_bib33","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.ophtha.2015.01.026","article-title":"American Joint Committee on Cancer classification of uveal melanoma (anatomic stage) predicts prognosis in 7731 patients: The 2013 Zimmerman Lecture","volume":"122","author":"Shields","year":"2015","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.ajo.2018.07.033_bib34","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1167\/iovs.16-20212","article-title":"The prognostic value of AJCC staging in uveal melanoma is enhanced by adding chromosome 3 and 8q status","volume":"58","author":"Dogrusoz","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.ajo.2018.07.033_bib35","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1167\/iovs.14-15571","article-title":"The prognostic effect of American Joint Committee on Cancer staging and genetic status in patients with choroidal and ciliary body melanoma","volume":"56","author":"Bagger","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.ajo.2018.07.033_bib36","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1001\/archophthalmol.2009.40","article-title":"Translating uveal melanoma cytogenetics into clinical care","volume":"127","author":"Damato","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2018.07.033_bib37","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/archopht.119.7.969","article-title":"The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma, III: initial mortality findings: COMS report No: 18","volume":"119","year":"2001","journal-title":"Arch Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2018.07.033_bib38","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1001\/archopht.1986.01050170045019","article-title":"Enucleation vs cobalt plaque radiotherapy for malignant melanomas of the choroid and ciliary body","volume":"104","author":"Augsburger","year":"1986","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2018.07.033_bib39","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1136\/bjo.78.2.109","article-title":"Impact of enucleation versus plaque radiotherapy in the management of juxtapapillary choroidal melanoma on patient survival","volume":"78","author":"De Potter","year":"1994","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"10.1016\/j.ajo.2018.07.033_bib40","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/S0161-6420(03)00661-4","article-title":"Iodine brachytherapy as an alternative to enucleation for large uveal melanomas","volume":"110","author":"Puusaari","year":"2003","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.ajo.2018.07.033_bib41","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0002-9394(98)00039-7","article-title":"The Collaborative Ocular Melanoma Study Group (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma II: initial mortality findings. COMS report no. 10","volume":"125","year":"1998","journal-title":"Am J Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajo.2018.07.033_bib42","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/S0161-6420(02)01181-8","article-title":"Plaque radiotherapy for large posterior uveal melanomas (> or\u00a0= 8\u00a0mm thick) in 354 consecutive patients","volume":"109","author":"Shields","year":"2002","journal-title":"Ophthalmology"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939418304264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939418304264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:38:09Z","timestamp":1757597889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939418304264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":42,"alternative-id":["S0002939418304264"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2018.07.033","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733764866.793585172","asserted-by":"object"}]},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Do Largest Basal Tumor Diameter and the American Joint Committee on Cancer's Cancer Staging Influence Prognostication by Gene Expression Profiling in Choroidal Melanoma","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2018.07.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}