{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:29:17Z","timestamp":1790792957194,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ajo.2019.02.001","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T18:30:13Z","timestamp":1549909813000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["The Genetic Influence on Corticosteroid-Induced Ocular Hypertension: A Field Positioned for Discovery"],"prefix":"10.1016","volume":"202","author":[{"given":"Weilin","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janey L.","family":"Wiggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Sobrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ajo.2019.02.001_bib1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1159\/000328630","article-title":"Steroid-induced iatrogenic glaucoma","volume":"47","author":"Razeghinejad","year":"2012","journal-title":"Ophthalmic Res"},{"issue":"2","key":"10.1016\/j.ajo.2019.02.001_bib2","first-page":"163","article-title":"Corticosteroid-induced ocular hypertension and glaucoma: a brief review and update of the literature","volume":"17","author":"Jones","year":"2006","journal-title":"Curr Opin Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2019.02.001_bib3","first-page":"198","article-title":"Intraocular pressure response to topical corticosteroids","volume":"4","author":"Becker","year":"1965","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.ajo.2019.02.001_bib4","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1001\/archopht.1963.00960050484010","article-title":"Effect of corticosteroids on intraocular pressure and fluid dynamics: I. the effect of dexamethasone in the normal eye","volume":"70","author":"Armaly","year":"1963","journal-title":"Arch Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2019.02.001_bib5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/bjo.67.7.487","article-title":"Steroid responsiveness in connective tissue diseases","volume":"67","author":"Gaston","year":"1983","journal-title":"Br J Ophthalmol"},{"issue":"8","key":"10.1016\/j.ajo.2019.02.001_bib6","doi-asserted-by":"crossref","first-page":"e102972","DOI":"10.1371\/journal.pone.0102972","article-title":"Diabetes mellitus as a risk factor for open-angle glaucoma: a systematic review and meta-analysis","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.ajo.2019.02.001_bib7","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/0002-9394(66)92551-7","article-title":"High myopia and primary open-angle glaucoma","volume":"62","author":"Podos","year":"1966","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2019.02.001_bib8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1001\/archopht.1966.00970050034007","article-title":"The heritable nature of dexamethasone-induced ocular hypertension","volume":"75","author":"Armaly","year":"1966","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajo.2019.02.001_bib9","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0002-9394(64)92500-0","article-title":"Topical corticosteroids and heredity in primary open-angle glaucoma","volume":"57","author":"Becker","year":"1964","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2019.02.001_bib10","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1001\/archopht.1966.03850010486004","article-title":"Topical corticosteroid testing in glaucoma siblings","volume":"76","author":"Becker","year":"1966","journal-title":"Arch Ophthalmol"},{"issue":"R1","key":"10.1016\/j.ajo.2019.02.001_bib11","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1093\/hmg\/ddx184","article-title":"Genetics of glaucoma","volume":"26","author":"Wiggs","year":"2017","journal-title":"Hum Mol Genet"},{"issue":"4","key":"10.1016\/j.ajo.2019.02.001_bib12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1001\/archopht.1973.01000050283006","article-title":"Twin study on ocular pressure following topically applied dexamethasone. II. Inheritance of variation in pressure response","volume":"90","author":"Schwartz","year":"1973","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajo.2019.02.001_bib13","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1001\/archopht.1963.00960050502012","article-title":"Corticosteroids and intraocular pressure","volume":"70","author":"Becker","year":"1963","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2019.02.001_bib14","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1038\/s41467-018-04555-4","article-title":"A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci","volume":"9","author":"Choquet","year":"2018","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.ajo.2019.02.001_bib15","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00439-018-1943-7","article-title":"Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations","volume":"137","author":"Bonnemaijer","year":"2018","journal-title":"Hum Genet"},{"issue":"1","key":"10.1016\/j.ajo.2019.02.001_bib16","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1038\/s41467-017-01913-6","article-title":"A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure","volume":"8","author":"Choquet","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajo.2019.02.001_bib17","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1001\/archopht.1963.00960050494011","article-title":"Effect of corticosteroids on intraocular pressure and fluid dynamics. II. The effect of dexamethasone in the glaucomatous eye","volume":"70","author":"Armaly","year":"1963","journal-title":"Arch Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2019.02.001_bib18","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0002-9394(88)90595-8","article-title":"Intraocular pressure response to topical dexamethasone as a predictor for the development of primary open-angle glaucoma","volume":"106","author":"Lewis","year":"1988","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2019.02.001_bib19","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/archopht.1981.03930010819005","article-title":"The prognosis of corticosteroid-responsive individuals","volume":"99","author":"Kitazawa","year":"1981","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2019.02.001_bib20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1089\/jop.1993.9.35","article-title":"Identification of high intraocular pressure responders to topical ophthalmic corticosteroids","volume":"9","author":"Bartlett","year":"1993","journal-title":"J Ocul Pharmacol"},{"issue":"12","key":"10.1016\/j.ajo.2019.02.001_bib21","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1016\/S0161-6420(99)90530-4","article-title":"Inhaled corticosteroids, family history, and risk of glaucoma","volume":"106","author":"Mitchell","year":"1999","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2019.02.001_bib22","first-page":"2001","article-title":"Proteomic similarities in steroid responsiveness in normal and glaucomatous trabecular meshwork cells","volume":"18","author":"Bollinger","year":"2012","journal-title":"Mol Vis"},{"issue":"5","key":"10.1016\/j.ajo.2019.02.001_bib23","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1167\/iovs.07-0414","article-title":"Gene expression profiles of human trabecular meshwork cells induced by triamcinolone and dexamethasone","volume":"49","author":"Fan","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.ajo.2019.02.001_bib24","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1167\/iovs.02-0444","article-title":"Tissue differential microarray analysis of dexamethasone induction reveals potential mechanisms of steroid glaucoma","volume":"44","author":"Lo","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"42","key":"10.1016\/j.ajo.2019.02.001_bib25","doi-asserted-by":"crossref","first-page":"11199","DOI":"10.1073\/pnas.1706193114","article-title":"CRISPR-Cas9-based treatment of myocilin-associated glaucoma","volume":"114","author":"Jain","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"10.1016\/j.ajo.2019.02.001_bib26","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1056\/NEJMra0804630","article-title":"Primary open-angle glaucoma","volume":"360","author":"Kwon","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajo.2019.02.001_bib27","first-page":"125","article-title":"Gene expression profile of human trabecular meshwork cells in response to long-term dexamethasone exposure","volume":"12","author":"Rozsa","year":"2006","journal-title":"Mol Vis"},{"issue":"8","key":"10.1016\/j.ajo.2019.02.001_bib28","first-page":"1769","article-title":"Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues","volume":"42","author":"Clark","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"10.1016\/j.ajo.2019.02.001_bib29","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0039-6257(02)00353-3","article-title":"Myocilin glaucoma","volume":"47","author":"Fingert","year":"2002","journal-title":"Surv Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2019.02.001_bib30","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ajpath.2016.12.003","article-title":"Dexamethasone-induced ocular hypertension in mice: effects of myocilin and route of administration","volume":"187","author":"Patel","year":"2017","journal-title":"Am J Pathol"},{"issue":"6","key":"10.1016\/j.ajo.2019.02.001_bib31","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41588-018-0126-8","article-title":"Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma","volume":"50","author":"Khawaja","year":"2018","journal-title":"Nat Genet"},{"issue":"10","key":"10.1016\/j.ajo.2019.02.001_bib32","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/ng.3087","article-title":"Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma","volume":"46","author":"Hysi","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajo.2019.02.001_bib33","first-page":"596","article-title":"Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders","volume":"16","author":"Fingert","year":"2010","journal-title":"Mol Vis"},{"issue":"4","key":"10.1016\/j.ajo.2019.02.001_bib34","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1167\/iovs.14-14803","article-title":"Identification of a novel mucin gene HCG22 associated with steroid-induced ocular hypertension","volume":"56","author":"Jeong","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2019.02.001_bib35","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.preteyeres.2016.09.003","article-title":"Steroid-induced ocular hypertension\/glaucoma: focus on pharmacogenomics and implications for precision medicine","volume":"56","author":"Fini","year":"2017","journal-title":"Prog Retin Eye Res"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939419300522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939419300522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:39:23Z","timestamp":1757597963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939419300522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":35,"alternative-id":["S0002939419300522"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2019.02.001","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Genetic Influence on Corticosteroid-Induced Ocular Hypertension: A Field Positioned for Discovery","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2019.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}