{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T08:00:16Z","timestamp":1772092816620,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007670","name":"Dalhousie Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007817","name":"Alcon Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007817","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008071","name":"Glaucoma Research Society of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010313","name":"Heidelberg Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.ajo.2019.07.009","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T19:28:32Z","timestamp":1563996512000},"page":"94-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Influence of Bruch's Membrane Opening Area in Diagnosing Glaucoma With Neuroretinal Parameters From Optical Coherence Tomography"],"prefix":"10.1016","volume":"208","author":[{"given":"Lucas A.","family":"Torres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen P.","family":"Sharpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M.","family":"Hutchison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila S.","family":"Zangalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard O.","family":"Burk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre S.C.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vital P.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo T.","family":"Nicolela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balwantray C.","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayme R.","family":"Vianna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ajo.2019.07.009_bib1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ophtha.2012.09.055","article-title":"Enhanced detection of open-angle glaucoma with an anatomically accurate optical coherence tomography-derived neuroretinal rim parameter","volume":"120","author":"Chauhan","year":"2013","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.ajo.2019.07.009_bib2","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.ophtha.2016.01.052","article-title":"Diagnostic accuracy of optical coherence tomography and scanning laser tomography for identifying glaucoma in myopic eyes","volume":"123","author":"Malik","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2019.07.009_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ajo.2018.04.022","article-title":"Glaucoma specialist optic disc margin, rim margin, and rim width discordance in glaucoma and glaucoma suspect eyes","volume":"192","author":"Hong","year":"2018","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajo.2019.07.009_bib4","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.ophtha.2006.08.046","article-title":"Determinants of normal retinal nerve fiber layer thickness measured by Stratus OCT","volume":"114","author":"Budenz","year":"2007","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ajo.2019.07.009_bib5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1001\/archopthalmol.2011.1576","article-title":"Effect of race, age, and axial length on optic nerve head parameters and retinal nerve fiber layer thickness measured by Cirrus HD-OCT","volume":"130","author":"Knight","year":"2012","journal-title":"Arch Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajo.2019.07.009_bib6","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1167\/iovs.17-22057","article-title":"Determinants and characteristics of Bruch\u2019s membrane opening and Bruch\u2019s membrane opening-minimum rim width in a normal Japanese population","volume":"58","author":"Araie","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"15","key":"10.1016\/j.ajo.2019.07.009_bib7","doi-asserted-by":"crossref","first-page":"6596","DOI":"10.1167\/iovs.16-20561","article-title":"Novel Bruch\u2019s membrane opening minimum rim area equalizes disc size dependency and offers high diagnostic power for glaucoma","volume":"57","author":"Enders","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.ajo.2019.07.009_bib8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/eye.2017.306","article-title":"Bruch\u2019s membrane opening-based optical coherence tomography of the optic nerve head: a useful diagnostic tool to detect glaucoma in macrodiscs","volume":"32","author":"Enders","year":"2018","journal-title":"Eye"},{"issue":"4","key":"10.1016\/j.ajo.2019.07.009_bib9","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1136\/bjophthalmol-2016-308957","article-title":"The use of Bruch\u2019s membrane opening-based optical coherence tomography of the optic nerve head for glaucoma detection in microdiscs","volume":"101","author":"Enders","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2019.07.009_bib10","series-title":"Glaucoma Module Premium Edition User Manual Software Version 6.7","year":"2016"},{"issue":"10","key":"10.1016\/j.ajo.2019.07.009_bib11","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1001\/archopht.119.10.1492","article-title":"Optic disc and visual field changes in a prospective longitudinal study of patients with glaucoma: comparison of scanning laser tomography with conventional perimetry and optic disc photography","volume":"119","author":"Chauhan","year":"2001","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajo.2019.07.009_bib12","first-page":"841","article-title":"Bruch\u2019s membrane opening minimum rim width in healthy Brazilian subjects","volume":"57","author":"Zangalli","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"10.1016\/j.ajo.2019.07.009_bib13","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.ophtha.2015.06.001","article-title":"Bruch\u2019s membrane opening minimum rim width and retinal nerve fiber layer thickness in a normal white population: a multicenter study","volume":"122","author":"Chauhan","year":"2015","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ajo.2019.07.009_bib14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3174\/ajnr.A2425","article-title":"Analysis by categorizing or dichotomizing continuous variables is inadvisable: an example from the natural history of unruptured aneurysms","volume":"32","author":"Naggara","year":"2011","journal-title":"AJNR Am J Neuroradiol"},{"issue":"3","key":"10.1016\/j.ajo.2019.07.009_bib15","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1167\/iovs.05-1133","article-title":"Influence of disease severity and optic disc size on the diagnostic performance of imaging instruments in glaucoma","volume":"47","author":"Medeiros","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.ajo.2019.07.009_bib16","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1167\/iovs.10-5546","article-title":"Effect of disease severity and optic disc size on diagnostic accuracy of RTVue spectral domain optical coherence tomograph in glaucoma","volume":"52","author":"Rao","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"10.1016\/j.ajo.2019.07.009_bib17","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.1167\/iovs.10-6698","article-title":"The effects of race, optic disc area, age, and disease severity on the diagnostic performance of spectral-domain optical coherence tomography","volume":"52","author":"Girkin","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"10.1016\/j.ajo.2019.07.009_bib18","first-page":"CD008803","article-title":"Optic nerve head and fibre layer imaging for diagnosing glaucoma","volume":"93","author":"Michelessi","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"10.1016\/j.ajo.2019.07.009_bib19","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1001\/archopht.1991.01080100121056","article-title":"Larger optic nerve heads have more nerve fibers in normal monkey eyes","volume":"109","author":"Quigley","year":"1991","journal-title":"Arch Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajo.2019.07.009_bib20","first-page":"2012","article-title":"Human optic nerve fiber count and optic disc size","volume":"33","author":"Jonas","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"10.1016\/j.ajo.2019.07.009_bib21","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","article-title":"Microglia: a sensor for pathological events in the CNS","volume":"19","author":"Kreutzberg","year":"1996","journal-title":"Trends Neurosci"},{"issue":"8","key":"10.1016\/j.ajo.2019.07.009_bib22","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1001\/archopht.117.8.1050","article-title":"Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma","volume":"117","author":"Neufeld","year":"1999","journal-title":"Arch Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2019.07.009_bib23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00061198-199710000-00007","article-title":"Astrocyte responses in human optic nerve head with primary open-angle glaucoma","volume":"6","author":"Varela","year":"1997","journal-title":"J Glaucoma"},{"key":"10.1016\/j.ajo.2019.07.009_bib24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.exer.2016.01.014","article-title":"Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma","volume":"150","author":"Bosco","year":"2016","journal-title":"Exp Eye Res"},{"issue":"5","key":"10.1016\/j.ajo.2019.07.009_bib25","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1167\/iovs.13-13482","article-title":"Structure-function relationships with spectral-domain optical coherence tomography retinal nerve fiber layer and optic nerve head measurements","volume":"55","author":"Pollet-Villard","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"10.1016\/j.ajo.2019.07.009_bib26","doi-asserted-by":"crossref","first-page":"OCT575","DOI":"10.1167\/iovs.15-18906","article-title":"Comparison of Bruch\u2019s membrane opening minimum rim width and peripapillary retinal nerve fiber layer thickness in early glaucoma assessment","volume":"57","author":"Gmeiner","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.ajo.2019.07.009_bib27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/aos.13698","article-title":"Evaluation of two-dimensional Bruch\u2019s membrane opening minimum rim area for glaucoma diagnostics in a large patient cohort","volume":"97","author":"Enders","year":"2019","journal-title":"Acta Ophthalmol"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939419303459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939419303459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:40:37Z","timestamp":1757598037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939419303459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":27,"alternative-id":["S0002939419303459"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2019.07.009","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of Bruch's Membrane Opening Area in Diagnosing Glaucoma With Neuroretinal Parameters From Optical Coherence Tomography","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2019.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}