{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:32:30Z","timestamp":1792211550476,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"am","delay-in-days":327,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007337","name":"Massachusetts Eye and Ear","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.ajo.2020.05.035","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T22:09:03Z","timestamp":1595628543000},"page":"296-303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Prevalence of Persistent Corneal Epithelial Defects in Chronic Ocular Graft-Versus-Host Disease"],"prefix":"10.1016","volume":"218","author":[{"given":"Shruti","family":"Sinha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2426-3900","authenticated-orcid":false,"given":"Rohan Bir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-4541","authenticated-orcid":false,"given":"Thomas H.","family":"Dohlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukako","family":"Taketani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-6758","authenticated-orcid":false,"given":"Jia","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Dana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajo.2020.05.035_bib1","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1001\/jama.2010.491","article-title":"Hematopoietic stem cell transplantation: a global perspective","volume":"303","author":"Gratwohl","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.ajo.2020.05.035_bib2","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.bbmt.2017.05.035","article-title":"Current use and trends in hematopoietic cell transplantation in the United States","volume":"23","author":"D\u2019Souza","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.ajo.2020.05.035_bib3","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1182\/blood-2014-01-514752","article-title":"Current issues in chronic graft-versus-host disease","volume":"124","author":"Soci\u00e9","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.ajo.2020.05.035_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.survophthal.2012.08.004","article-title":"Ocular graft-versus-host disease: a review","volume":"58","author":"Shikari","year":"2013","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ajo.2020.05.035_bib5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/ICO.0000000000000340","article-title":"Onset of ocular graft-versus-host disease symptoms after allogeneic hematopoietic stem cell transplantation","volume":"34","author":"Shikari","year":"2015","journal-title":"Cornea"},{"key":"10.1016\/j.ajo.2020.05.035_bib6","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41409-018-0340-0","article-title":"Ocular graft-versus-host disease after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT","volume":"54","author":"Inamoto","year":"2019","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.ajo.2020.05.035_bib7","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.ophtha.2015.04.011","article-title":"Vision-related quality of life in patients with ocular graft-versus-host disease","volume":"122","author":"Saboo","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2020.05.035_bib8","first-page":"351","article-title":"Ocular graft versus host disease following allogeneic stem cell transplantation: a review of current knowledge and recommendations","volume":"8","author":"Nassiri","year":"2013","journal-title":"J Ophthalmic Vis Res"},{"key":"10.1016\/j.ajo.2020.05.035_bib9","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/srep03419","article-title":"International chronic ocular graft-vs-host-disease (GVHD) consensus group: proposed diagnostic criteria for chronic GVHD (Part I)","volume":"3","author":"Ogawa","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajo.2020.05.035_bib10","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0929-6646(09)60125-X","article-title":"Recurrent corneal perforation and acute calcareous corneal degeneration in chronic graft-versus-host disease","volume":"105","author":"Yeh","year":"2006","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.ajo.2020.05.035_bib11","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1016\/S0161-6420(99)90412-8","article-title":"Treatment of persistent corneal epithelial defect by autologous serum application","volume":"106","author":"Tsubota","year":"1999","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2020.05.035_bib12","series-title":"Albert Jakobiec\u2019s Principles and Practice of Ophthalmology","author":"Albert","year":"2008"},{"key":"10.1016\/j.ajo.2020.05.035_bib13","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1097\/ICO.0b013e3181a2a7f6","article-title":"Autologous serum 50% eyedrops in the treatment of persistent corneal epithelial defects","volume":"28","author":"Jeng","year":"2009","journal-title":"Cornea"},{"key":"10.1016\/j.ajo.2020.05.035_bib14","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jtos.2020.05.002","article-title":"Pigment epithelium-derived factor secreted by corneal epithelial cells regulates dendritic cell maturation in dry eye disease","volume":"18","author":"Singh","year":"2020","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ajo.2020.05.035_bib15","first-page":"1963","article-title":"Growth factors modulate clonal growth and differentiation of cultured rabbit limbal and corneal epithelium","volume":"34","author":"Kruse","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2020.05.035_bib16","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.exer.2005.10.033","article-title":"Correlation of proliferative and anti-apoptotic effects of HGF, insulin, IGF-1, IGF-2, and EGF in SV40-transformed human corneal epithelial cells","volume":"83","author":"Yanai","year":"2006","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajo.2020.05.035_bib17","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jtos.2014.12.005","article-title":"Novel therapy to treat corneal epithelial defects: a hypothesis with growth hormone","volume":"13","author":"Wirostko","year":"2015","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ajo.2020.05.035_bib18","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.sjopt.2014.06.011","article-title":"Management strategies for persistent epithelial defects of the cornea","volume":"28","author":"Katzman","year":"2014","journal-title":"Saudi J Ophthalmol"},{"key":"10.1016\/j.ajo.2020.05.035_bib19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0002-9394(00)00379-2","article-title":"Treatment of persistent corneal epithelial defect with extended wear of a fluid-ventilated gas-permeable scleral contact lens","volume":"130","author":"Rosenthal","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2020.05.035_bib20","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1136\/bjo.85.12.1455","article-title":"Single and multilayer amniotic membrane transplantation for persistent corneal epithelial defect with and without stromal thinning and perforation","volume":"85","author":"Prabhasawat","year":"2001","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2020.05.035_bib21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0002-9394(14)70125-4","article-title":"Amniotic membrane transplantation for persistent epithelial defects with ulceration","volume":"123","author":"Lee","year":"1997","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2020.05.035_bib22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0161-6420(83)34604-2","article-title":"Ocular manifestations of graft-vs-host disease","volume":"90","author":"Bray","year":"1983","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2020.05.035_bib23","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4274\/tjo.09582","article-title":"Unusual course of crystalline keratopathy in a patient with graft-versus-host disease","volume":"47","author":"Bostanc\u0131","year":"2017","journal-title":"Turkish J Ophthalmol"},{"key":"10.1016\/j.ajo.2020.05.035_bib24","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/sj.eye.6702589","article-title":"Corneal grafting and aggressive medication for corneal defects in graft-versus-host disease following bone marrow transplantation","volume":"21","author":"Tarnawska","year":"2007","journal-title":"Eye"},{"key":"10.1016\/j.ajo.2020.05.035_bib25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/01.icu.0000143684.22362.46","article-title":"Ocular manifestations of graft versus host disease","volume":"15","author":"Anderson","year":"2004","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.ajo.2020.05.035_bib26","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/bjo.75.10.611","article-title":"Ocular complications of bone marrow transplantation","volume":"75","author":"Bray","year":"1991","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2020.05.035_bib27","first-page":"221","article-title":"Report of the National Eye Institute\/Industry workshop on clinical trials in dry eyes","volume":"21","author":"Lemp","year":"1995","journal-title":"CLAO J"},{"key":"10.1016\/j.ajo.2020.05.035_bib28","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","article-title":"National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease. I. The 2014 Diagnosis and Staging Working Group Report","volume":"21","author":"Jagasia","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.ajo.2020.05.035_bib29","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.bbmt.2015.05.020","article-title":"Impact of ocular chronic graft-versus-host disease on quality of life","volume":"21","author":"Sun","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.ajo.2020.05.035_bib30","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0161-6420(83)34604-2","article-title":"Ocular manifestations of graft-vs-host disease","volume":"90","author":"Franklin","year":"1983","journal-title":"Ophthalmology"},{"issue":"4\u20135","key":"10.1016\/j.ajo.2020.05.035_bib31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/08820538.2011.588663","article-title":"Keratoconjunctivitis sicca manifestations in ocular graft versus host disease: Pathogenesis, presentation, prevention, and treatment","volume":"26","author":"Townley","year":"2011","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.ajo.2020.05.035_bib32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1542-0124(12)70207-0","article-title":"Chronic ocular surface disease after allogeneic bone marrow transplantation","volume":"3","author":"Balaram","year":"2005","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ajo.2020.05.035_bib33","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ajo.2016.12.026","article-title":"Elevated neutrophil elastase in tears of ocular graft-versus-host disease patients","volume":"176","author":"Arafat","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2020.05.035_bib34","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jtos.2018.04.007","article-title":"Tear inflammatory mediators and protein in eyes of post allogenic hematopoeitic stem cell transplant patients","volume":"16","author":"Nair","year":"2018","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ajo.2020.05.035_bib35","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1007\/PL00007449","article-title":"Proteolytic mechanisms in corneal ulceration and repair","volume":"290","author":"Fini","year":"1998","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.ajo.2020.05.035_bib36","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/jcp.22306","article-title":"Comprehensive gene expression profiling and functional analysis of matrix metalloproteinases and TIMPs, and identification of ADAM-10 gene expression, in a corneal model of epithelial resurfacing","volume":"226","author":"Gordon","year":"2011","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajo.2020.05.035_bib37","first-page":"13","article-title":"Corneal innervation and sensation: the eye and beyond","volume":"91","author":"Yang","year":"2018","journal-title":"Yale J Biol Med"},{"key":"10.1016\/j.ajo.2020.05.035_bib38","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/bmt.2014.77","article-title":"Neuropathic dermatomes and cutaneous ulceration in patients with chronic GVHD","volume":"49","author":"Kamble","year":"2014","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.ajo.2020.05.035_bib39","doi-asserted-by":"crossref","first-page":"6430953","DOI":"10.1155\/2018\/6430953","article-title":"Manifestation of clinical categories of ocular graft-versus-host disease","volume":"2018","author":"Qiu","year":"2018","journal-title":"J Ophthalmol"},{"key":"10.1016\/j.ajo.2020.05.035_bib40","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fmed.2018.00276","article-title":"Glucocorticoid impaired the wound healing ability of endothelial progenitor cells by reducing the expression of CXCR4 in the PGE2 pathway","volume":"5","author":"Carolina","year":"2019","journal-title":"Front Med"},{"key":"10.1016\/j.ajo.2020.05.035_bib41","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMra050541","article-title":"Antiinflammatory action of glucocorticoids---New mechanisms for old drugs","volume":"353","author":"Rhen","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajo.2020.05.035_bib42","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/bjo.66.11.705","article-title":"Corticosteroids and corneal epithelial wound healing","volume":"66","author":"Petroutsos","year":"1982","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2020.05.035_bib43","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00003226-198404000-00007","article-title":"A randomized trial of topical corticosteroids in epithelial healing after keratoplasty","volume":"3","author":"Sugar","year":"1984","journal-title":"Cornea"},{"key":"10.1016\/j.ajo.2020.05.035_bib44","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1600-0420.2005.00632.x","article-title":"Effect of topical steroids on corneal epithelial healing after vitreoretinal surgery","volume":"84","author":"Y\u00fclek","year":"2006","journal-title":"Acta Ophthalmol Scand"},{"key":"10.1016\/j.ajo.2020.05.035_bib45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.sjopt.2013.06.007","article-title":"Ocular manifestations of graft-versus-host disease","volume":"27","author":"Nassar","year":"2013","journal-title":"Saudi J Ophthalmol"},{"key":"10.1016\/j.ajo.2020.05.035_bib46","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ajo.2018.02.020","article-title":"Subtarsal fibrosis is associated with ocular surface epitheliopathy in graft-versus-host disease","volume":"189","author":"Kheirkhah","year":"2018","journal-title":"Am J Ophthalmol"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939420302762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939420302762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:45:10Z","timestamp":1757598310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939420302762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":46,"alternative-id":["S0002939420302762"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2020.05.035","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence of Persistent Corneal Epithelial Defects in Chronic Ocular Graft-Versus-Host Disease","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2020.05.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}