{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T01:20:38Z","timestamp":1769217638777,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.ajo.2022.02.020","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T10:52:31Z","timestamp":1646218351000},"page":"205-216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The three-dimensional structural configuration of the central retinal vessel trunk and branches as a glaucoma biomarker"],"prefix":"10.1016","volume":"240","author":[{"given":"Satish K.","family":"Panda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8856-8319","authenticated-orcid":false,"given":"Haris","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tin A.","family":"Tun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanadet","family":"Chuangsuwanich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiste","family":"Kadziauskiene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayalakshmi","family":"Senthil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0764-3204","authenticated-orcid":false,"given":"Ramaswami","family":"Krishnadas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-3358","authenticated-orcid":false,"given":"Martin L.","family":"Buist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamira","family":"Perera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Yu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tin","family":"Aung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9542-509X","authenticated-orcid":false,"given":"Alexandre H.","family":"Thiery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4408-5918","authenticated-orcid":false,"given":"Micha\u00ebl J.A.","family":"Girard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajo.2022.02.020_bib0001","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/jama.2020.21899","article-title":"Glaucoma in adults-screening, diagnosis, and management: a review","volume":"325","author":"Stein","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.ajo.2022.02.020_bib0002","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/S0161-6420(98)91133-2","article-title":"The probability of blindness from open-angle glaucoma","volume":"105","author":"Hattenhauer","year":"1998","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2022.02.020_bib0003","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2022.02.020_bib0004","first-page":"25","article-title":"Economics of glaucoma care","volume":"1","author":"Lee","year":"2009","journal-title":"Glaucoma"},{"key":"10.1016\/j.ajo.2022.02.020_bib0005","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/bs.pbr.2015.03.001","article-title":"Strategies to improve early diagnosis in glaucoma","volume":"221","author":"Tatham","year":"2015","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.ajo.2022.02.020_bib0006","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1364\/BOE.2.001097","article-title":"Method for comparing visual field defects to local RNFL and RGC damage seen on frequency domain OCT in patients with glaucoma","volume":"2","author":"Hood","year":"2011","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.ajo.2022.02.020_bib0007","first-page":"1937","article-title":"Open-angle glaucoma","volume":"67","author":"Distelhorst","year":"2003","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.ajo.2022.02.020_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00002512-200522010-00001","article-title":"Management of glaucoma: focus on pharmacological therapy","volume":"22","author":"Marquis","year":"2005","journal-title":"Drugs Aging"},{"key":"10.1016\/j.ajo.2022.02.020_bib0009","doi-asserted-by":"crossref","first-page":"9755","DOI":"10.1038\/s41598-021-87844-1","article-title":"The influence of different intraocular pressure on lamina cribrosa parameters in glaucoma and the relation clinical implication","volume":"11","author":"Wu","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajo.2022.02.020_bib0010","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00441-013-1554-5","article-title":"The potential of annexin-labelling for the diagnosis and follow-up of glaucoma","volume":"353","author":"Normando","year":"2013","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ajo.2022.02.020_bib0011","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1136\/bjo.82.12.1366","article-title":"Neuroretinal rim width ratios in morphological glaucoma diagnosis","volume":"82","author":"Jonas","year":"1998","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.02.020_bib0012","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ajo.2021.06.010","article-title":"Describing the structural phenotype of the glaucomatous optic nerve head using artificial intelligence","volume":"236","author":"Panda","year":"2021","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.02.020_bib0013","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0161-6420(01)00571-1","article-title":"Central retinal vessel trunk exit and location of glaucomatous parapapillary atrophy in glaucoma","volume":"108","author":"Jonas","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2022.02.020_bib0014","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/OPX.0b013e31817841cb","article-title":"The mechanical environment of the optic nerve head in glaucoma","volume":"85","author":"Downs","year":"2008","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.ajo.2022.02.020_bib0015","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.coph.2012.09.001","article-title":"Altering the way the optic nerve head responds to intraocular pressure-a potential approach to glaucoma therapy","volume":"13","author":"Strouthidis","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.ajo.2022.02.020_bib0016","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0002-9394(14)74101-7","article-title":"Positional changes in the vasculature of the optic disk in glaucoma","volume":"104","author":"Varma","year":"1987","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.02.020_bib0017","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.ophtha.2013.11.002","article-title":"Retinal blood vessel positional shifts and glaucoma progression","volume":"121","author":"Radcliffe","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2022.02.020_bib0018","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/ije\/dyaa238","article-title":"Cohort profile: the Singapore epidemiology of eye diseases study (seed)","volume":"50","author":"Majithia","year":"2021","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ajo.2022.02.020_bib0019","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/ceo.13836","article-title":"Asian-specific vertical cup-to-disc ratio cut-off for glaucoma screening: an evidence-based recommendation from a multi-ethnic asian population","volume":"48","author":"Soh","year":"2020","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajo.2022.02.020_bib0020","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1167\/iovs.12-11327","article-title":"Enhancement of lamina cribrosa visibility in optical coherence tomography images using adaptive compensation","volume":"54","author":"Mari","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2022.02.020_bib0021","series-title":"Paper presented at: 27th Signal Processing and Communications Applications Conference","first-page":"1","article-title":"Semantic segmentation with extended DeepLabv3 architecture","author":"Yurtkulu","year":"2019"},{"key":"10.1016\/j.ajo.2022.02.020_bib0022","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.patcog.2019.01.006","article-title":"Wider or deeper: revisiting the resnet model for visual recognition","volume":"90","author":"Wu","year":"2019","journal-title":"Pattern Recognit"},{"key":"10.1016\/j.ajo.2022.02.020_bib0023","series-title":"Paper presented at: 31st AAAI Conference on Artificial Intelligence","article-title":"Inception-v4, inception-ResNet and the impact of residual connections on learning","author":"Szegedy","year":"2017"},{"key":"10.1016\/j.ajo.2022.02.020_bib0024","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1038\/s41598-020-60355-1","article-title":"Nasalization of central retinal vessel trunk predicts rapid progression of central visual field in open-angle glaucoma","volume":"10","author":"Shon","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajo.2022.02.020_bib0025","doi-asserted-by":"crossref","first-page":"9930","DOI":"10.1038\/s41598-017-10042-5","article-title":"Location of the central retinal vessel trunk in the laminar and prelaminar tissue of healthy and glaucomatous eyes","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajo.2022.02.020_bib0026","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ajo.2017.01.001","article-title":"Relationship between central retinal vessel trunk location and visual field loss in glaucoma","volume":"176","author":"Wang","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.02.020_bib0027","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3341\/kjo.1998.12.1.51","article-title":"Retinal vessel diameter in normal and primary open-angle glaucoma","volume":"12","author":"Lee","year":"1998","journal-title":"Korean J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.02.020_bib0028","first-page":"1599","article-title":"Parapapillary retinal vessel diameter in normal and glaucoma eyes: I. Morphometric data","volume":"30","author":"Jonas","year":"1989","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2022.02.020_bib0029","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3390\/jcm8091446","article-title":"Aiding the diagnosis of diabetic and hypertensive retinopathy using artificial intelligence-based semantic segmentation","volume":"8","author":"Arsalan","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.ajo.2022.02.020_bib0030","series-title":"Paper presented at: International Work-Conference on the Interplay Between Natural and Artificial Computation","first-page":"3","article-title":"Automatic detection of blood vessels in retinal OCT images","author":"Moura","year":"2017"},{"key":"10.1016\/j.ajo.2022.02.020_bib0031","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10916-008-9195-z","article-title":"Automated diagnosis of glaucoma using digital fundus images","volume":"33","author":"Nayak","year":"2009","journal-title":"J Med Syst"},{"key":"10.1016\/j.ajo.2022.02.020_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.artmed.2019.101758","article-title":"Ophthalmic diagnosis using deep learning with fundus images-a critical review","volume":"102","author":"Sengupta","year":"2020","journal-title":"Artif Intell Med"},{"key":"10.1016\/j.ajo.2022.02.020_bib0033","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/08820538.2019.1620807","article-title":"A review of OCT angiography in glaucoma","volume":"34","author":"Werner","year":"2019","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.ajo.2022.02.020_bib0034","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.20.10.100901","article-title":"Methods and algorithms for optical coherence tomography-based angiography: a review and comparison","volume":"20","author":"Zhang","year":"2015","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.ajo.2022.02.020_bib0035","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s00417-015-3095-y","article-title":"Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study","volume":"253","author":"Wang","year":"2015","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajo.2022.02.020_bib0036","doi-asserted-by":"crossref","DOI":"10.1364\/3D.2020.JTu2A.43","article-title":"3D reconstruction of retinal vascular structure from 2D OCT-A images for glaucoma diagnosis","author":"Akter","year":"2020","journal-title":"Adapt Opt Anal Methods Syst"},{"key":"10.1016\/j.ajo.2022.02.020_bib0037","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.5301\/ejo.5000717","article-title":"Vessel density calculated from OCT angiography in 3 peripapillary sectors in normal, ocular hypertensive, and glaucoma eyes","volume":"26","author":"Hollo","year":"2016","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.02.020_bib0038","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1097\/IJG.0000000000000527","article-title":"Influence of large intraocular pressure reduction on peripapillary OCT vessel density in ocular hypertensive and glaucoma eyes","volume":"26","author":"Hollo","year":"2017","journal-title":"J Glaucoma"},{"key":"10.1016\/j.ajo.2022.02.020_bib0039","doi-asserted-by":"crossref","first-page":"e252","DOI":"10.1111\/aos.12298","article-title":"Ocular perfusion pressure in glaucoma","volume":"92","author":"Costa","year":"2014","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.ajo.2022.02.020_bib0040","article-title":"Use of artificial intelligence to describe the structural signature of the glaucomatous optic nerve head","volume":"62","author":"Panda","year":"2021","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2022.02.020_bib0041","article-title":"Image restoration algorithms for OCT images of the optic nerve head: performance comparison between OCT-GAN and compensation","volume":"62","author":"Cheong","year":"2021","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2022.02.020_bib0042","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1167\/tvst.9.2.23","article-title":"DeshadowGAN: a deep learning approach to remove shadows from optical coherence tomography images","volume":"9","author":"Cheong","year":"2020","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.ajo.2022.02.020_bib0043","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.1364\/BOE.395934","article-title":"Towards label-free 3D segmentation of optical coherence tomography images of the optic nerve head using deep learning","volume":"11","author":"Devalla","year":"2020","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.ajo.2022.02.020_bib0044","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.ophtha.2018.02.002","article-title":"Positional change of optic nerve head vasculature during axial elongation as evidence of lamina cribrosa shifting: Boramae Myopia Cohort Study Report 2","volume":"125","author":"Lee","year":"2018","journal-title":"Ophthalmology"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293942200085X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293942200085X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:51:20Z","timestamp":1757598680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000293942200085X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":44,"alternative-id":["S000293942200085X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2022.02.020","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The three-dimensional structural configuration of the central retinal vessel trunk and branches as a glaucoma biomarker","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2022.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}