{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:35:30Z","timestamp":1793316930440,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"am","delay-in-days":292,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012617","name":"Moorfields Eye Hospital City Road Campus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"MRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002426","name":"Telethon Italy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Governo Italiano Ministero dell&apos;Istruzione dell&apos;Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.ajo.2022.12.014","type":"journal-article","created":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T17:17:13Z","timestamp":1671383833000},"page":"99-107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Childhood-Onset Leber Hereditary Optic Neuropathy\u2014Clinical and Prognostic Insights"],"prefix":"10.1016","volume":"249","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0118-4177","authenticated-orcid":false,"given":"Piero","family":"Barboni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4639-8929","authenticated-orcid":false,"given":"Chiara","family":"La Morgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia","family":"Cascavilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8413-1929","authenticated-orcid":false,"given":"Eun Hee","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5940-6177","authenticated-orcid":false,"given":"Marco","family":"Battista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7145-063X","authenticated-orcid":false,"given":"Anna","family":"Majander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Caporali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Starace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Amore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Di","family":"Renzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6034-5295","authenticated-orcid":false,"given":"Michele","family":"Carbonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4036-703X","authenticated-orcid":false,"given":"Paolo","family":"Nucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3092-7451","authenticated-orcid":false,"given":"Neringa","family":"Jurkute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8214-0186","authenticated-orcid":false,"given":"Benson S.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Panebianco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"De Negri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Sadun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-9682","authenticated-orcid":false,"given":"Francesco","family":"Bandello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo A.","family":"Sadun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Carelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7847-9320","authenticated-orcid":false,"given":"Patrick","family":"Yu-Wai-Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajo.2022.12.014_bib0001","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.preteyeres.2003.10.003","article-title":"Mitochondrial dysfunction as a cause of optic neuropathies","volume":"23","author":"Carelli","year":"2004","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ajo.2022.12.014_bib0002","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/jmg.39.3.162","article-title":"Leber hereditary optic neuropathy","volume":"39","author":"Yu-Wai-Man","year":"2002","journal-title":"J Med Genet"},{"key":"10.1016\/j.ajo.2022.12.014_bib0003","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.ajhg.2016.05.015","article-title":"The epidemiology of Leber hereditary optic neuropathy in the North East of England","volume":"98","author":"Yu-Wai-Man","year":"2016","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajo.2022.12.014_bib0004","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5301\/ejo.5000055","article-title":"Meta-analysis of the prevalence of Leber hereditary optic neuropathy mtDNA mutations in Europe","volume":"2","author":"Mascialino","year":"2012","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0005","doi-asserted-by":"crossref","first-page":"985","DOI":"10.2174\/1566524014666141010132627","article-title":"Genetic basis of mitochondrial optic neuropathies","volume":"14","author":"Maresca","year":"2014","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.ajo.2022.12.014_bib0006","first-page":"77","article-title":"Pedigree analysis in Leber hereditary optic neuropathy families with a pathogenic mtDNA mutation","volume":"57","author":"Harding","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajo.2022.12.014_bib0007","series-title":"Mitochondrial Disorders in Neurology","first-page":"115","article-title":"Leber's hereditary optic neuropathy","author":"Carelli","year":"2002"},{"key":"10.1016\/j.ajo.2022.12.014_bib0008","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/WNO.0000000000000570","article-title":"International consensus statement on the clinical and therapeutic management of Leber hereditary optic neuropathy","volume":"37","author":"Carelli","year":"2017","journal-title":"J Neuroophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0009","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ajo.2005.11.007","article-title":"Influence of mutation type on clinical expression of Leber hereditary optic neuropathy","volume":"141","author":"Spruijt","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0010","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ophtha.2019.11.014","article-title":"Demographics of a large international population of patients affected by Leber's hereditary optic neuropathy","volume":"127","author":"Poincenot","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2022.12.014_bib0011","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0002-9394(14)76784-4","article-title":"The clinical characteristics of pedigrees of Leber's hereditary optic neuropathy with the 11778 mutation","volume":"111","author":"Newman","year":"1991","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0012","first-page":"1218","article-title":"A variant of Leber hereditary optic neuropathy characterized by recovery of vision and by an unusual mitochondrial genetic etiology","volume":"51","author":"Mackey","year":"1992","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajo.2022.12.014_bib0013","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1001\/archopht.1992.01080230077025","article-title":"Leber's hereditary optic neuropathy. Clinical manifestations of the 3460 mutation","volume":"110","author":"Johns","year":"1992","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0014","first-page":"197","article-title":"Nonfamilial and unusual cases of Leber's hereditary optic neuropathy identified by mitochondrial DNA analysis","volume":"36","author":"Isashiki","year":"1992","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0015","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1001\/archopht.1993.01090040087038","article-title":"Leber's hereditary optic neuropathy: clinical manifestations of the 14484 mutation","volume":"111","author":"Johns","year":"1993","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0016","first-page":"96","article-title":"Clinical features of Japanese Leber's hereditary optic neuropathy with 11778 mutation of mitochondrial DNA","volume":"39","author":"Hotta","year":"1995","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0017","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/brain\/118.2.319","article-title":"The clinical features of Leber's hereditary optic neuropathy defined by the presence of a pathogenic mitochondrial DNA mutation","volume":"118","author":"Riordan-Eva","year":"1995","journal-title":"Brain"},{"key":"10.1016\/j.ajo.2022.12.014_bib0018","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0161-6420(96)30665-9","article-title":"Ophthalmologic findings in Leber hereditary optic neuropathy, with special reference to mtDNA mutations","volume":"103","author":"Nikoskelainen","year":"1996","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2022.12.014_bib0019","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s003470050479","article-title":"[Leber optic neuropathy in women and children]","volume":"96","author":"Leo-Kottler","year":"1999","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.ajo.2022.12.014_bib0020","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/ana.10177","article-title":"Mitochondrial DNA C4171A\/ND1 is a novel primary causative mutation of Leber's hereditary optic neuropathy with a good prognosis","volume":"51","author":"Kim","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0021","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1167\/iovs.06-0520","article-title":"Leber's hereditary optic neuropathy with childhood onset","volume":"47","author":"Barboni","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2022.12.014_bib0022","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1136\/bjophthalmol-2016-310072","article-title":"Childhood-onset Leber hereditary optic neuropathy","volume":"101","author":"Majander","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0023","article-title":"Genetic and clinical analyses of DOA and LHON in 304 Chinese patients with suspected childhood-onset hereditary optic neuropathy","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ajo.2022.12.014_bib0024","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s00417-020-04757-x","article-title":"Genotypic and phenotypic characteristics of Korean children with childhood-onset Leber's hereditary optic neuropathy","volume":"258","author":"Ahn","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0025","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s10038-006-0032-2","article-title":"Molecular epidemiology of mtDNA mutations in 903 Chinese families suspected with Leber hereditary optic neuropathy","volume":"51","author":"Jia","year":"2006","journal-title":"J Hum Genet"},{"key":"10.1016\/j.ajo.2022.12.014_bib0026","first-page":"15","article-title":"Evidence for a metabolic trigger for Leber's hereditary optic neuropathy: a case report","volume":"12","author":"DuBois","year":"1992","journal-title":"J Clin Neuroophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0027","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1001\/archneur.1993.00540050082021","article-title":"Leber's hereditary optic neuropathy: new genetic considerations","volume":"50","author":"Newman","year":"1993","journal-title":"Arch Neurol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0028","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1001\/archneur.1993.00540050022009","article-title":"Atypical Leber's hereditary optic neuropathy with molecular confirmation","volume":"50","author":"Weiner","year":"1993","journal-title":"Arch Neurol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0029","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1542\/peds.91.5.988","article-title":"Leber's hereditary optic neuropathy as a cause of severe visual loss in childhood","volume":"91","author":"Moorman","year":"1993","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajo.2022.12.014_bib0030","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s004170050301","article-title":"A pedigree of Leber's hereditary optic neuropathy with visual loss in childhood, primarily in girls","volume":"237","author":"Thieme","year":"1999","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0031","first-page":"1063","article-title":"Childhood Leber hereditary optic neuropathy: a case of a 6-year-old girl with loss of vision","volume":"26","author":"Balayre","year":"2003","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0032","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10384-004-0140-5","article-title":"Unilateral manifestation of Leber's hereditary optic neuropathy after blunt ocular trauma","volume":"49","author":"Nagai","year":"2005","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0033","unstructured":"Barboni P. Sadun AA. Atlas of LHON. MEDonline; 2019."},{"key":"10.1016\/j.ajo.2022.12.014_bib0034","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/s41433-021-01535-9","article-title":"Natural history of patients with Leber hereditary optic neuropathy-results from the REALITY study","volume":"36","author":"Yu-Wai-Man","year":"2022","journal-title":"Eye (Lond)"},{"issue":"42","key":"10.1016\/j.ajo.2022.12.014_bib0035","doi-asserted-by":"crossref","first-page":"8362","DOI":"10.1523\/JNEUROSCI.2422-18.2019","article-title":"Maturation of brain microstructure and metabolism associates with increased capacity for self-regulation during the transition from childhood to adolescence","volume":"39","author":"Baron Nelson","year":"2019","journal-title":"J Neurosci"},{"key":"10.1016\/j.ajo.2022.12.014_bib0036","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/WNO.0000000000000346","article-title":"Atypical Leber hereditary optic neuropathy: 18 year interval between eyes","volume":"36","author":"Ohden","year":"2016","journal-title":"J Neuroophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0037","first-page":"1208","article-title":"Segregation patterns and heteroplasmy prevalence in Leber's hereditary optic neuropathy","volume":"42","author":"Jacobi","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2022.12.014_bib0038","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1177\/112067210201200615","article-title":"Ladies with Leber's hereditary optic neuropathy: an atypical disease","volume":"12","author":"Dandekar","year":"2002","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0039","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/sj.eye.6701388","article-title":"Late onset of Leber's hereditary optic neuropathy precipitated by anaemia","volume":"18","author":"Goyal","year":"2004","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.ajo.2022.12.014_bib0040","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1167\/iovs.13-13365","article-title":"Retinal ganglion cell dysfunction in asymptomatic G11778A: Leber hereditary optic neuropathy","volume":"55","author":"Guy","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2022.12.014_bib0041","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/BF00194478","article-title":"Interocular asymmetry of optic disc size and its relevance to visual field loss in normal-tension glaucoma","volume":"232","author":"Tomita","year":"1994","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0042","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/j.1528-1157.1992.tb01765.x","article-title":"Facial asymmetry in partial epilepsies","volume":"33","author":"Tinuper","year":"1992","journal-title":"Epilepsia"},{"key":"10.1016\/j.ajo.2022.12.014_bib0043","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00041327-199509000-00012","article-title":"Vasculature and morphometry of the optic canal and intracanalicular optic nerve","volume":"15","author":"Chou","year":"1995","journal-title":"J Neuroophthalmol"},{"key":"10.1016\/j.ajo.2022.12.014_bib0044","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.visres.2017.01.004","article-title":"Interocular suppression in children with deprivation amblyopia","volume":"133","author":"Hamm","year":"2017","journal-title":"Vision Res"},{"key":"10.1016\/j.ajo.2022.12.014_bib0045","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1167\/iovs.16-20964","article-title":"Unilateral amblyopia affects two eyes: fellow eye deficits in amblyopia","volume":"58","author":"Meier","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2022.12.014_bib0046","first-page":"481","article-title":"Primary pathogenic mtDNA mutations in multigeneration pedigrees with Leber hereditary optic neuropathy","volume":"59","author":"Mackey","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajo.2022.12.014_bib0047","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1442-9071.2007.01628.x","article-title":"Woman with atypical unilateral Leber's hereditary optic neuropathy with visual improvement","volume":"35","author":"Sugisaka","year":"2007","journal-title":"Clin Exp Ophthalmol"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939422005013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939422005013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:52:54Z","timestamp":1757598774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939422005013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":47,"alternative-id":["S0002939422005013"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2022.12.014","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Childhood-Onset Leber Hereditary Optic Neuropathy\u2014Clinical and Prognostic Insights","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2022.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}