{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:16:29Z","timestamp":1790057789384,"version":"4.0.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR300155"],"award-info":[{"award-number":["NIHR300155"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["CL-2022-11-001"],"award-info":[{"award-number":["CL-2022-11-001"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["CL-2017-11-003"],"award-info":[{"award-number":["CL-2017-11-003"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019256","name":"NIHR Great Ormond Street Hospital Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N004566\/1"],"award-info":[{"award-number":["MR\/N004566\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajo.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ajo.2024.08.021","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T20:25:32Z","timestamp":1725049532000},"page":"136-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Optic Nerve Head Morphological Variation in Craniosynostosis: A Cohort Study"],"prefix":"10.1016","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8134-6393","authenticated-orcid":false,"given":"Sohaib R.","family":"Rufai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervyn G.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2022-3669","authenticated-orcid":false,"given":"Oliver R.","family":"Marmoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Panteli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy A.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-3713","authenticated-orcid":false,"given":"Catey","family":"Bunce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri","family":"Gore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Gottlob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Dunaway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hayward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4913-2330","authenticated-orcid":false,"given":"Frank A.","family":"Proudlock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor ul Owase","family":"Jeelani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ajo.2024.08.021_bib0001","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ejhg.2010.235","article-title":"Craniosynostosis","volume":"19","author":"Johnson","year":"2011","journal-title":"Eur J Hum Genet"},{"issue":"9","key":"10.1016\/j.ajo.2024.08.021_bib0002","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.jcms.2016.07.007","article-title":"Increase of prevalence of craniosynostosis","volume":"44","author":"Cornelissen","year":"2016","journal-title":"J Craniomaxillofac Surg"},{"issue":"3","key":"10.1016\/j.ajo.2024.08.021_bib0003","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3171\/jns.1982.57.3.0370","article-title":"Intracranial pressure in craniostenosis","volume":"57","author":"Renier","year":"1982","journal-title":"J Neurosurg"},{"issue":"4","key":"10.1016\/j.ajo.2024.08.021_bib0004","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3390\/jcm11041060","article-title":"Prevalence of ocular anomalies in craniosynostosis: a systematic review and meta-analysis","volume":"11","author":"Rostamzad","year":"2022","journal-title":"J Clin Med"},{"issue":"5","key":"10.1016\/j.ajo.2024.08.021_bib0005","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/s41433-021-01458-5","article-title":"Visual outcomes in children with syndromic craniosynostosis: a review of 165 cases","volume":"36","author":"Hinds","year":"2022","journal-title":"Eye (Lond)"},{"issue":"8","key":"10.1016\/j.ajo.2024.08.021_bib0006","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/bjo.87.8.999","article-title":"Visual outcomes and amblyogenic risk factors in craniosynostotic syndromes: a review of 141 cases","volume":"87","author":"Khan","year":"2003","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajo.2024.08.021_bib0007","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/MOP.0000000000000542","article-title":"Clinical genetics of craniosynostosis","volume":"29","author":"Wilkie","year":"2017","journal-title":"Curr Opin Pediatr"},{"issue":"3","key":"10.1016\/j.ajo.2024.08.021_bib0008","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3171\/jns.2001.94.3.0377","article-title":"Enigma of raised intracranial pressure in patients with complex craniosynostosis: the role of abnormal intracranial venous drainage","volume":"94","author":"Taylor","year":"2001","journal-title":"J Neurosurg"},{"issue":"5","key":"10.1016\/j.ajo.2024.08.021_bib0009","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF00301758","article-title":"Subdural intracranial pressure monitoring in craniosynostosis: its role in surgical management","volume":"11","author":"Thompson","year":"1995","journal-title":"Childs Nerv Syst"},{"issue":"5","key":"10.1016\/j.ajo.2024.08.021_bib0010","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000120907","article-title":"Intracranial pressure in single-suture craniosynostosis","volume":"22","author":"Thompson","year":"1995","journal-title":"Pediatr Neurosurg"},{"key":"10.1016\/j.ajo.2024.08.021_bib0011","series-title":"GeneReviews\u00ae","article-title":"FGFR craniosynostosis syndromes overview","author":"Wenger","year":"1998"},{"issue":"12","key":"10.1016\/j.ajo.2024.08.021_bib0012","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1136\/bjo.2005.075978","article-title":"Expression of FGFR-2 and FGFR-3 in the normal human fetal orbit","volume":"89","author":"Khan","year":"2005","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajo.2024.08.021_bib0013","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mcn.2006.05.009","article-title":"Anosmin-1 modulates the FGF-2-dependent migration of oligodendrocyte precursors in the developing optic nerve","volume":"33","author":"Bribi\u00e1n","year":"2006","journal-title":"Mol Cell Neurosci"},{"issue":"7624","key":"10.1016\/j.ajo.2024.08.021_bib0014","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"335","author":"von Elm","year":"2007","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.ajo.2024.08.021_bib0015","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/01.prs.0000220873.72953.3e","article-title":"Prevalence of abnormal pattern reversal visual evoked potentials in craniosynostosis","volume":"118","author":"Thompson","year":"2006","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"10.1016\/j.ajo.2024.08.021_bib0016","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41433-021-01839-w","article-title":"Electrophysiological and fundoscopic detection of intracranial hypertension in craniosynostosis","volume":"37","author":"Rufai","year":"2023","journal-title":"Eye (Lond)"},{"issue":"10","key":"10.1016\/j.ajo.2024.08.021_bib0017","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.ophtha.2016.06.057","article-title":"Optic nerve head development in healthy infants and children using handheld spectral-domain optical coherence tomography","volume":"123","author":"Patel","year":"2016","journal-title":"Ophthalmology"},{"issue":"7","key":"10.1016\/j.ajo.2024.08.021_bib0018","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.ajo.2024.08.021_bib0019","unstructured":"Wiki. ID. Active contour (snake). Available at: https:\/\/imagejdocu.list.lu\/plugin\/segmentation\/active_contour\/start. Accessed 26 July 2024."},{"issue":"12","key":"10.1016\/j.ajo.2024.08.021_bib0021","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/tvst.12.12.16","article-title":"Feasibility and repeatability of handheld optical coherence tomography in children with craniosynostosis","volume":"12","author":"Rufai","year":"2023","journal-title":"Transl Vis Sci Technol"},{"issue":"4","key":"10.1016\/j.ajo.2024.08.021_bib0022","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/00006123-199610000-00007","article-title":"The beaten copper cranium: a correlation between intracranial pressure, cranial radiographs, and computed tomographic scans in children with craniosynostosis","volume":"39","author":"Tuite","year":"1996","journal-title":"Neurosurgery"},{"issue":"12","key":"10.1016\/j.ajo.2024.08.021_bib0023","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jcms.2021.06.017","article-title":"Optic canal characteristics in pediatric syndromic craniosynostosis","volume":"49","author":"Hariri","year":"2021","journal-title":"J Craniomaxillofac Surg"},{"issue":"8","key":"10.1016\/j.ajo.2024.08.021_bib0024","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-046935","article-title":"Detection of intracranial hypertension in children using optical coherence tomography: a systematic review","volume":"11","author":"Rufai","year":"2021","journal-title":"BMJ Open"},{"issue":"4","key":"10.1016\/j.ajo.2024.08.021_bib0025","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1001\/jamaophthalmol.2017.0025","article-title":"Evaluation of optical coherence tomography to detect elevated intracranial pressure in children","volume":"135","author":"Swanson","year":"2017","journal-title":"JAMA Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajo.2024.08.021_bib0026","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/PRS.0000000000008821","article-title":"Elevated intracranial pressure in patients with craniosynostosis by optical coherence tomography","volume":"149","author":"Kalmar","year":"2022","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"10.1016\/j.ajo.2024.08.021_bib0027","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1055\/s-0032-1320064","article-title":"Syndromic craniosynostosis","volume":"26","author":"Derderian","year":"2012","journal-title":"Semin Plast Surg"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939424003829?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939424003829?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T22:21:06Z","timestamp":1738621266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939424003829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":26,"alternative-id":["S0002939424003829"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2024.08.021","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optic Nerve Head Morphological Variation in Craniosynostosis: A Cohort Study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2024.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}