{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:42:22Z","timestamp":1791250942532,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ajo.2025.06.045","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T07:02:07Z","timestamp":1751007727000},"page":"356-368","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Early Structural Changes in Keratoconic Eyes After Corneal Crosslinking Detected by Polarization-Sensitive Optical Coherence Tomography"],"prefix":"10.1016","volume":"278","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6218-5317","authenticated-orcid":false,"given":"Jan","family":"Lammer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1880-8345","authenticated-orcid":false,"given":"Julia","family":"Aschauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Beer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Pircher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6303-828X","authenticated-orcid":false,"given":"Stephan","family":"Holzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Schmidinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6608-8821","authenticated-orcid":false,"given":"Christoph K.","family":"Hitzenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pircher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajo.2025.06.045_bib0001","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"Wollensak","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2025.06.045_bib0002","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jcrs.2005.12.092","article-title":"Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet a light","volume":"2","author":"Kohlhaas","year":"2006","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.ajo.2025.06.045_bib0003","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1167\/iovs.09-3738","article-title":"Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and Long-wavelength ultraviolet radiation (UVA)","volume":"51","author":"McCall","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2025.06.045_bib0004","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/exer.1997.0410","article-title":"Induction of cross-links in corneal tissue","volume":"66","author":"Spoerl","year":"1998","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajo.2025.06.045_bib0005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/02713680490513182","article-title":"Increased resistance of crosslinked cornea against enzymatic digestion","volume":"29","author":"Spoerl","year":"2004","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.ajo.2025.06.045_bib0006","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/S0886-3350(03)00407-3","article-title":"Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking","volume":"29","author":"Wollensak","year":"2003","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.ajo.2025.06.045_bib0007","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/01.icu.0000233954.86723.25","article-title":"Crosslinking treatment of progressive keratoconus: new hope","volume":"17","author":"Wollensak","year":"2006","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.ajo.2025.06.045_bib0008","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1097\/01.ico.0000225720.38748.58","article-title":"Corneal cross-linking-induced stromal demarcation line","volume":"25","author":"Seiler","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.ajo.2025.06.045_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajo.2009.06.031","article-title":"Use of anterior segment optical coherence tomography to study corneal changes after collagen cross-linking","volume":"148","author":"Doors","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2025.06.045_bib0010","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/ICO.0b013e318030df5a","article-title":"Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans","volume":"26","author":"Mazzotta","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.ajo.2025.06.045_bib0011","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1167\/iovs.11-8281","article-title":"Brillouin optical microscopy for corneal biomechanics","volume":"53","author":"Scarcelli","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2025.06.045_bib0012","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1167\/iovs.11-7184","article-title":"Multiphoton microscopy of ex vivo corneas after collagen cross-linking","volume":"52","author":"Bueno","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2025.06.045_bib0013","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1364\/BOE.8.001838","article-title":"Polarization sensitive optical coherence tomography - a review","volume":"8","author":"de Boer","year":"2017","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.ajo.2025.06.045_bib0014","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.preteyeres.2011.06.003","article-title":"Polarization sensitive optical coherence tomography in the human eye","volume":"30","author":"Pircher","year":"2011","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ajo.2025.06.045_bib0015","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1167\/iovs.06-0727","article-title":"Imaging of birefringent properties of keratoconus corneas hy polarization-sensitive optical coherence tomography","volume":"48","author":"G\u00f6tzinger","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2025.06.045_bib0016","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/j.jcrs.0000000000000898","article-title":"Mapping of corneal birefringence in thin and asymmetric keratoconus corneas with ultrahigh-resolution polarization-sensitive OCT","volume":"48","author":"Patil","year":"2022","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.ajo.2025.06.045_bib0017","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40662-024-00391-4","article-title":"Insights into atypical segmental layer thicknesses and phase retardation in thick corneas using ultrahigh-resolution polarization-sensitive optical coherence tomography","volume":"11","author":"Patil","year":"2024","journal-title":"Eye Vis"},{"key":"10.1016\/j.ajo.2025.06.045_bib0018","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ajo.2019.05.025","article-title":"Large field of view corneal epithelium and Bowman\u2019s layer thickness maps in keratoconic and healthy eyes","volume":"209","author":"Pircher","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2025.06.045_bib0019","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00417-025-06750-8","article-title":"Diagnostic performance of corneal epithelium- and Bowman\u2019s layer thickness mapping in patients with unilateral keratoconus","volume":"263","author":"Pircher","year":"2025","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajo.2025.06.045_bib0020","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1167\/iovs.12-10979","article-title":"Keratoconus diagnosis using anterior segment polarization-sensitive optical coherence tomography","volume":"54","author":"Fukuda","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2025.06.045_bib0021","first-page":"85670F","article-title":"Non-invasive assessment of corneal crosslinking changes using polarization sensitive optical coherence tomography","volume":"XXIII","author":"Alonso-Caneiro","year":"2013","journal-title":"Proc. SPIE 8567, Ophthalmic Technologies"},{"key":"10.1016\/j.ajo.2025.06.045_bib0022","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1364\/BOE.8.002906","article-title":"Conical scan pattern for enhanced visualization of the human cornea using polarization-sensitive OCT","volume":"8","author":"Beer","year":"2017","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.ajo.2025.06.045_bib0023","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1364\/BOE.5.002798","article-title":"Single input state polarization sensitive swept source optical coherence tomography based on an all single mode fiber interferometer","volume":"5","author":"Trasischker","year":"2014","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.ajo.2025.06.045_bib0024","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1167\/iovs.18-25311","article-title":"Mapping of corneal layer thicknesses with polarization-sensitive optical coherence tomography using a conical scan pattern","volume":"59","author":"Beer","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajo.2025.06.045_bib0025","unstructured":"Rasband WS. ImageJ, U. S. National Institutes of Health, Bethesda, Maryland, USA, 1997-2018. https:\/\/imagej.net\/ij\/. Accessed January 25, 2018."},{"key":"10.1016\/j.ajo.2025.06.045_bib0026","unstructured":"Macro to radial reslice for ImageJ 1.52a. http:\/\/microscopynotes.com\/imagej\/radialreslice\/."},{"key":"10.1016\/j.ajo.2025.06.045_bib0027","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ajo.2015.05.019","article-title":"Current protocols of corneal collagen cross-linking: visual, refractive, and tomographic outcomes","volume":"160","author":"Shetty","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajo.2025.06.045_bib0028","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/tvst.12.5.18","article-title":"How modifications of corneal cross-linking protocols influence corneal resistance to enzymatic digestion and treatment depth","volume":"12","author":"Kowalska","year":"2023","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.ajo.2025.06.045_bib0029","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ajo.2013.09.010","article-title":"Correlation of the corneal collagen cross-linking demarcation line using confocal microscopy and anterior segment optical coherence tomography in keratoconic patients","volume":"157","author":"Kymionis","year":"2014","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajo.2025.06.045_bib0030","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3390\/jcm11020393","article-title":"In vivo confocal microscopy evaluation in patients with keratoconus","volume":"11","author":"Teo","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.ajo.2025.06.045_bib0031","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00417-018-3922-z","article-title":"Correlation between central stromal demarcation line depth and changes in K values after corneal cross-linking (CXL)","volume":"256","author":"Pircher","year":"2018","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajo.2025.06.045_bib0032","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.2147\/OPTH.S117372","article-title":"Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature","volume":"10","author":"Spadea","year":"2016","journal-title":"Clin. Ophthalmol"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939425003411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939425003411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T02:55:47Z","timestamp":1757818547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939425003411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":32,"alternative-id":["S0002939425003411"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2025.06.045","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Structural Changes in Keratoconic Eyes After Corneal Crosslinking Detected by Polarization-Sensitive Optical Coherence Tomography","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2025.06.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}