{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T09:03:02Z","timestamp":1779786182591,"version":"3.53.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201142"],"award-info":[{"award-number":["82201142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371021"],"award-info":[{"award-number":["82371021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010091"],"award-info":[{"award-number":["2023A1515010091"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018634","name":"State Key Laboratory of Ophthalmology","doi-asserted-by":"publisher","award":["2025QZSPT45"],"award-info":[{"award-number":["2025QZSPT45"]}],"id":[{"id":"10.13039\/501100018634","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajo.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ajo.2026.02.048","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T20:24:36Z","timestamp":1772483076000},"page":"174-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Systemic Immunosuppressant Cessation\/Tapering Linked to MGD Progression Post-HSCT"],"prefix":"10.1016","volume":"286","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7148-6807","authenticated-orcid":false,"given":"Wenxin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9651-567X","authenticated-orcid":false,"given":"Xiaohui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5125-3735","authenticated-orcid":false,"given":"Yinglin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8629-2408","authenticated-orcid":false,"given":"Ling","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2971-4827","authenticated-orcid":false,"given":"Lingyi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ajo.2026.02.048_bib0001","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1038\/bmt.2015.187","article-title":"Incidence and risk factors for ocular GVHD after allogeneic hematopoietic stem cell transplantation","volume":"50","author":"Na","year":"2015","journal-title":"Bone Marrow Transplant"},{"issue":"8","key":"10.1016\/j.ajo.2026.02.048_bib0002","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.ophtha.2015.04.011","article-title":"Vision-related quality of life in patients with ocular graft-versus-host disease","volume":"122","author":"Saboo","year":"2015","journal-title":"Ophthalmology"},{"issue":"9","key":"10.1016\/j.ajo.2026.02.048_bib0003","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.bbmt.2015.05.020","article-title":"Impact of ocular chronic graft-versus-host disease on quality of life","volume":"21","author":"Sun","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"issue":"10","key":"10.1016\/j.ajo.2026.02.048_bib0004","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1136\/bjo.83.10.1125","article-title":"Dry eye after haematopoietic stem cell transplantation","volume":"83","author":"Ogawa","year":"1999","journal-title":"Br J Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajo.2026.02.048_bib0005","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/bmt.2015.72","article-title":"Meibography and meibomian gland measurements in ocular graft-versus-host disease","volume":"50","author":"Engel","year":"2015","journal-title":"Bone Marrow Transplant"},{"issue":"10","key":"10.1016\/j.ajo.2026.02.048_bib0006","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1097\/ICO.0000000000001585","article-title":"Meibomian gland dropout in hematological patients before hematopoietic stem cell transplantation","volume":"37","author":"Giannaccare","year":"2018","journal-title":"Cornea"},{"issue":"7","key":"10.1016\/j.ajo.2026.02.048_bib0007","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/ICO.0000000000002271","article-title":"Longitudinal analysis of infrared meibography in patients undergoing hematopoietic stem cell transplantation","volume":"39","author":"Bernabei","year":"2020","journal-title":"Cornea"},{"key":"10.1016\/j.ajo.2026.02.048_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtos.2022.04.002","article-title":"Comparable meibomian gland changes in patients with and without ocular graft-versus-host disease after hematopoietic stem cell transplantation","volume":"25","author":"Zhao","year":"2022","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ajo.2026.02.048_bib0009","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jtos.2024.10.002","article-title":"Cytarabine chemotherapy induces meibomian gland dysfunction","volume":"34","author":"Liu","year":"2024","journal-title":"Ocul Surf"},{"issue":"3","key":"10.1016\/j.ajo.2026.02.048_bib0010","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jtos.2019.04.009","article-title":"Longitudinal analysis of meibomian gland dropout in patients with ocular graft-versus-host disease","volume":"17","author":"Hwang","year":"2019","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ajo.2026.02.048_bib0011","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jtos.2025.01.014","article-title":"Effect of hematopoietic stem cell transplantation on meibomian gland structure","volume":"36","author":"Novo-Diez","year":"2025","journal-title":"Ocul Surf"},{"issue":"10","key":"10.1016\/j.ajo.2026.02.048_bib0012","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/eye.2017.78","article-title":"Ocular surface analysis in hematological patients before and after allogeneic hematopoietic stem cell transplantation: implication for daily clinical practice","volume":"31","author":"Giannaccare","year":"2017","journal-title":"Eye (Lond)"},{"issue":"3","key":"10.1016\/j.ajo.2026.02.048_bib0013","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/ICO.0000000000000340","article-title":"Onset of ocular graft-versus-host disease symptoms after allogeneic hematopoietic stem cell transplantation","volume":"34","author":"Shikari","year":"2015","journal-title":"Cornea"},{"issue":"4","key":"10.1016\/j.ajo.2026.02.048_bib0014","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbmt.2008.12.493","article-title":"First-line therapy for chronic graft-versus-host disease that includes low-dose methotrexate is associated with a high response rate","volume":"15","author":"Wang","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.ajo.2026.02.048_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.leukres.2021.106642","article-title":"Ruxolitinib for chronic steroid-refractory graft versus host disease: a single center experience","volume":"109","author":"Xue","year":"2021","journal-title":"Leuk Res"},{"key":"10.1016\/j.ajo.2026.02.048_bib0016","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.exer.2017.07.013","article-title":"Changes of meibomian glands in the early stage of post hematopoietic stem cell transplantation","volume":"163","author":"Kim","year":"2017","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajo.2026.02.048_bib0017","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1038\/srep03419","article-title":"International Chronic ocular Graft-vs-host-disease (GVHD) consensus group: proposed diagnostic criteria for chronic GVHD (Part I)","volume":"3","author":"Ogawa","year":"2013","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.ajo.2026.02.048_bib0018","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1167\/iovs.10-6997f","article-title":"The International Workshop on Meibomian Gland Dysfunction: report of the diagnosis subcommittee","volume":"52","author":"Tomlinson","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.ajo.2026.02.048_bib0019","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/bmt.2009.238","article-title":"Determinants of functional performance in long-term survivors of allogeneic hematopoietic stem cell transplantation with Chronic Graft-versus-host Disease (cGVHD)","volume":"45","author":"Mitchell","year":"2010","journal-title":"Bone Marrow Transplant"},{"issue":"5","key":"10.1016\/j.ajo.2026.02.048_bib0020","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archopht.118.5.615","article-title":"Reliability and validity of the ocular surface disease index","volume":"118","author":"Schiffman","year":"2000","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajo.2026.02.048_bib0021","first-page":"221","article-title":"Report of the National Eye Institute\/Industry Workshop on clinical trials in dry eyes","volume":"21","author":"Lemp","year":"1995","journal-title":"CLAO J"},{"issue":"5","key":"10.1016\/j.ajo.2026.02.048_bib0022","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.ophtha.2007.06.031","article-title":"Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population","volume":"115","author":"Arita","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajo.2026.02.048_bib0023","first-page":"2533","article-title":"Morphologic evaluation of meibomian glands in chronic graft-versus-host disease using in vivo laser confocal microscopy","volume":"17","author":"Ban","year":"2011","journal-title":"Mol Vis."},{"issue":"12","key":"10.1016\/j.ajo.2026.02.048_bib0024","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1097\/ICO.0b013e31823cc098","article-title":"A randomized double-masked study of 0.05% cyclosporine ophthalmic emulsion in the treatment of meibomian gland dysfunction","volume":"31","author":"Prabhasawat","year":"2012","journal-title":"Cornea"},{"issue":"8","key":"10.1016\/j.ajo.2026.02.048_bib0025","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1089\/jop.2012.0265","article-title":"Treatment of refractory dry eye associated with graft versus host disease with 0.03% tacrolimus eyedrops","volume":"29","author":"Sanz-Marco","year":"2013","journal-title":"J Ocul Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.ajo.2026.02.048_bib0026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0245329","article-title":"Efficacy of 0.05% cyclosporine a on the lipid layer and meibomian glands after cataract surgery: a randomized, double-masked study","volume":"16","author":"Kang","year":"2021","journal-title":"Plos One"},{"issue":"3","key":"10.1016\/j.ajo.2026.02.048_bib0027","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s10384-022-00906-3","article-title":"Efficacy of a 0.05% cyclosporine a topical nanoemulsion in dry eyes with obstructive meibomian gland dysfunction","volume":"66","author":"Rhim","year":"2022","journal-title":"Jpn J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajo.2026.02.048_bib0028","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.jaad.2005.09.041","article-title":"Sebaceous hyperplasia and skin cancer in patients undergoing renal transplant","volume":"55","author":"Salim","year":"2006","journal-title":"J Am Acad Dermatol"},{"issue":"5 Pt 1","key":"10.1016\/j.ajo.2026.02.048_bib0029","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0190-9622(96)90723-9","article-title":"Sebaceous hyperplasia in organ transplant recipients: shared aspects of hyperplastic and dysplastic processes?","volume":"35","author":"de Berker","year":"1996","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.ajo.2026.02.048_bib0030","doi-asserted-by":"crossref","first-page":"391","DOI":"10.47102\/annals-acadmedsg.V34N5p391","article-title":"Cyclosporin-induced sebaceous hyperplasia in renal transplant patients","volume":"34","author":"Pang","year":"2005","journal-title":"Ann Acad Med Singap"},{"issue":"3","key":"10.1016\/j.ajo.2026.02.048_bib0031","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0090-9556(25)06712-1","article-title":"Tissue distribution, disposition, and metabolism of cyclosporine in rats","volume":"15","author":"Wagner","year":"1987","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.ajo.2026.02.048_bib0032","article-title":"Meibomian gland dropout of upper eyelids as a novel biomarker for early diagnosis of primary Sj? Gren's Syndrome: a pilot study","volume":"16","author":"Wu","year":"2024","journal-title":"Ther Adv Musculoskel"},{"issue":"5","key":"10.1016\/j.ajo.2026.02.048_bib0033","doi-asserted-by":"crossref","first-page":"e800","DOI":"10.1111\/aos.14000","article-title":"Dry eye syndrome in thyroid eye disease patients: the role of increased incomplete blinking and meibomian gland loss","volume":"97","author":"Park","year":"2019","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.ajo.2026.02.048_bib0034","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jtos.2021.12.009","article-title":"A single institute validation study comparing the international chronic ocular graft-versus-host disease consensus group diagnostic criteria with clinical parameters","volume":"24","author":"Hiratsuka","year":"2022","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ajo.2026.02.048_bib0035","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jtos.2021.10.006","article-title":"Eyelid blood vessel and meibomian gland changes in a sclerodermatous chronic GVHD Mouse Model","volume":"26","author":"Yang","year":"2022","journal-title":"Ocul Surf"},{"issue":"3","key":"10.1016\/j.ajo.2026.02.048_bib0036","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jtos.2018.04.006","article-title":"Glycoprotein 340 in mucosal immunity and ocular surface","volume":"16","author":"Osei","year":"2018","journal-title":"Ocul Surf"},{"issue":"5","key":"10.1016\/j.ajo.2026.02.048_bib0037","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0014-4835(86)80005-7","article-title":"Naturally occurring IgA antibodies to ocular and oral microorganisms in tears saliva and colostrum: evidence for a common mucosal immune system and local immune response","volume":"43","author":"Gregory","year":"1986","journal-title":"Exp Eye Res"}],"container-title":["American Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939426001121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002939426001121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:09:49Z","timestamp":1779782989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002939426001121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":37,"alternative-id":["S0002939426001121"],"URL":"https:\/\/doi.org\/10.1016\/j.ajo.2026.02.048","relation":{},"ISSN":["0002-9394"],"issn-type":[{"value":"0002-9394","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic Immunosuppressant Cessation\/Tapering Linked to MGD Progression Post-HSCT","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajo.2026.02.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}