{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:32:34Z","timestamp":1771540354806,"version":"3.50.1"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,4,3]],"date-time":"2016-04-03T00:00:00Z","timestamp":1459641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology Case Reports"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.ajoc.2016.08.005","type":"journal-article","created":{"date-parts":[[2016,9,3]],"date-time":"2016-09-03T01:52:33Z","timestamp":1472867553000},"page":"54-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Floaters and reduced contrast sensitivity after successful pharmacologic vitreolysis with ocriplasmin"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2250-8820","authenticated-orcid":false,"given":"Matin","family":"Khoshnevis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannie","family":"Nguyen-Cuu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sebag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajoc.2016.08.005_bib1","series-title":"Vitreous \u2013 in Health & Disease","first-page":"241","article-title":"Anomalous PVD and vitreoschisis","author":"Sebag","year":"2014"},{"key":"10.1016\/j.ajoc.2016.08.005_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00006982-199818010-00001","article-title":"Pharmacologic vitreolysis","volume":"18","author":"Sebag","year":"1998","journal-title":"Retina"},{"key":"10.1016\/j.ajoc.2016.08.005_bib3","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/IAE.0b013e3181ac7b3c","article-title":"Pharmacologic vitreolysis \u2013 premise and promise of the first decade","volume":"29","author":"Sebag","year":"2009","journal-title":"Retina"},{"key":"10.1016\/j.ajoc.2016.08.005_bib4","first-page":"473","article-title":"Molecular biology of pharmacologic vitreolysis","volume":"103","author":"Sebag","year":"2005","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.ajoc.2016.08.005_bib5","series-title":"Vitreous \u2013 in Health & Disease","first-page":"845","article-title":"Pharmacologic vitreolysis with ocriplasmin: basic science studies","author":"deSmet","year":"2014"},{"key":"10.1016\/j.ajoc.2016.08.005_bib6","series-title":"Vitreous \u2013 in Health & Disease","first-page":"853","article-title":"Pharmacologic vitreolysis with ocriplasmin \u2013 clinical studies","author":"Stalmans","year":"2014"},{"key":"10.1016\/j.ajoc.2016.08.005_bib7","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1056\/NEJMoa1110823","article-title":"Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes","volume":"367","author":"Stalmans","year":"2012","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.ajoc.2016.08.005_bib8","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/jamaophthalmol.2014.278","article-title":"Safety and complications of ocriplasmin: oh, how safe art thou?","volume":"132","author":"Kim","year":"2014","journal-title":"JAMA Ophthalmol"},{"issue":"6","key":"10.1016\/j.ajoc.2016.08.005_bib9","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1097\/IAE.0000000000000519","article-title":"Safety profile of ocriplasmin for symptomatic vitreomacular adhesion: a comprehensive analysis of premarketing and post-marketing experiences","volume":"35","author":"Hahn","year":"2015","journal-title":"Retina"},{"issue":"7","key":"10.1016\/j.ajoc.2016.08.005_bib10","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s00417-006-0474-4","article-title":"The freiburg visual acuity test \u2013 variability unchanged by post- hoc re analysis","volume":"245","author":"Bach","year":"2007","journal-title":"Graefe's Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajoc.2016.08.005_bib11","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1097\/IAE.0000000000000065","article-title":"Vitrectomy for floaters \u2013 prospective efficacy analyses and retrospective safety profile","volume":"34","author":"Sebag","year":"2014","journal-title":"Retina"},{"issue":"2","key":"10.1016\/j.ajoc.2016.08.005_bib12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.survophthal.2015.11.008","article-title":"Vitreous floaters \u2013 etiology, diagnostics, and management","volume":"61","author":"Milston","year":"2016","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ajoc.2016.08.005_bib13","series-title":"Vitreous \u2013 in Health & Disease","first-page":"771","article-title":"Vitreous floaters and vision: current concepts and management paradigms","author":"Huang","year":"2014"},{"key":"10.1016\/j.ajoc.2016.08.005_bib14","series-title":"Vitreous \u2013 in Health & Disease","first-page":"665","article-title":"The history of vitrectomy","author":"Parel","year":"2014"}],"container-title":["American Journal of Ophthalmology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993616300561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993616300561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:55:12Z","timestamp":1762527312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451993616300561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":14,"alternative-id":["S2451993616300561"],"URL":"https:\/\/doi.org\/10.1016\/j.ajoc.2016.08.005","relation":{},"ISSN":["2451-9936"],"issn-type":[{"value":"2451-9936","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Floaters and reduced contrast sensitivity after successful pharmacologic vitreolysis with ocriplasmin","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajoc.2016.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}