{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:30:48Z","timestamp":1786984248706,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology Case Reports"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.ajoc.2018.01.026","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T21:37:56Z","timestamp":1516138676000},"page":"106-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Two cases of differentiation syndrome with ocular manifestations in patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and arsenic trioxide"],"prefix":"10.1016","volume":"9","author":[{"given":"A.R.","family":"Newman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.G.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wellwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.R.","family":"Imrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajoc.2018.01.026_bib1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2165\/00002018-199818040-00003","article-title":"Retinoic acid syndrome. Recognition, prevention and management","volume":"18","author":"Fenaux","year":"1998","journal-title":"Drug Saf"},{"key":"10.1016\/j.ajoc.2018.01.026_bib2","doi-asserted-by":"crossref","first-page":"7140","DOI":"10.1038\/sj.onc.1204763","article-title":"All trans retinoic acid in acute promyelocytic leukemia","volume":"20","author":"Degos","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.ajoc.2018.01.026_bib3","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1182\/blood.V94.4.1192","article-title":"A randomized comparison of all transretinoic acid (ATRA) followed by chemotherapy and ATRA plus chemotherapy and the role of maintenance therapy in newly diagnosed acute promyelocytic leukemia. The European APL Group","volume":"94","author":"Fenaux","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.ajoc.2018.01.026_bib4","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1182\/blood-2009-02-204834","article-title":"Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome","volume":"114","author":"Luesink","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ajoc.2018.01.026_bib5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0168-9525(99)01710-2","article-title":"Molecular genetics of acute promyelocytic leukemia","volume":"15","author":"Lin","year":"1999","journal-title":"Trends Genet"},{"key":"10.1016\/j.ajoc.2018.01.026_bib6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0268-960X(02)00075-9","article-title":"The molecular pathogenesis of acute promyelocytic leukaemia: implications for the clinical management of the disease","volume":"17","author":"Mistry","year":"2003","journal-title":"Blood Rev"},{"key":"10.1016\/j.ajoc.2018.01.026_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0268-960X(05)80018-9","article-title":"The molecular genetics of acute promyelocytic leukemia","volume":"7","author":"Grignani","year":"1993","journal-title":"Blood Rev"},{"key":"10.1016\/j.ajoc.2018.01.026_bib8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF02703936","article-title":"Mechanisms of all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells","volume":"25","author":"Zhang","year":"2000","journal-title":"J Biosci"},{"key":"10.1016\/j.ajoc.2018.01.026_bib9","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.leukres.2013.05.007","article-title":"Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death","volume":"37","author":"Altman","year":"2013","journal-title":"Leuk Res"},{"key":"10.1016\/j.ajoc.2018.01.026_bib10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.leukres.2012.09.004","article-title":"High efficacy of arsenic trioxide plus all-trans retinoic acid based induction and maintenance therapy in newly diagnosed acute promyelocytic leukemia","volume":"37","author":"Lou","year":"2013","journal-title":"Leuk Res"},{"key":"10.1016\/j.ajoc.2018.01.026_bib11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.leukres.2013.03.001","article-title":"All-trans retinoic acid and late relapses in acute promyelocytic leukemia: very long-term follow-up of the North American Intergroup Study I0129","volume":"37","author":"Douer","year":"2013","journal-title":"Leuk Res"},{"key":"10.1016\/j.ajoc.2018.01.026_bib12","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/leu.2012.57","article-title":"How to manage acute promyelocytic leukemia","volume":"26","author":"Mi","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.ajoc.2018.01.026_bib13","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.leukres.2013.04.011","article-title":"Predictive factors for all-trans retinoic acid-related differentiation syndrome in patients with acute promyelocytic leukemia","volume":"37","author":"Leblebjian","year":"2013","journal-title":"Leuk Res"},{"key":"10.1016\/j.ajoc.2018.01.026_bib14","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1182\/blood-2008-07-168617","article-title":"Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors","volume":"113","author":"Montesinos","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ajoc.2018.01.026_bib15","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2011.059","article-title":"The differentiation syndrome in patients with acute promyelocytic leukemia: experience of the pethema group and review of the literature","volume":"3","author":"Montesinos","year":"2011","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"10.1016\/j.ajoc.2018.01.026_bib16","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1182\/blood-2013-10-512640","article-title":"How we prevent and treat differentiation syndrome in patients with acute promyelocytic leukemia","volume":"123","author":"Sanz","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.ajoc.2018.01.026_bib17","doi-asserted-by":"crossref","first-page":"292","DOI":"10.7326\/0003-4819-117-4-292","article-title":"The \"retinoic acid syndrome\" in acute promyelocytic leukemia","volume":"117","author":"Frankel","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajoc.2018.01.026_bib18","first-page":"90","article-title":"Clinical description of 44 patients with acute promyelocytic leukemia who developed the retinoic acid syndrome","volume":"95","author":"Tallman","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.ajoc.2018.01.026_bib19","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1182\/blood.V92.8.2712","article-title":"Incidence, clinical features, and outcome of all trans-retinoic acid syndrome in 413 cases of newly diagnosed acute promyelocytic leukemia. The European APL Group","volume":"92","author":"De Botton","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.ajoc.2018.01.026_bib20","first-page":"421","article-title":"Relationship between cytokines and leukocytosis in patients with APL induced by all-trans retinoic acid or arsenic trioxide","volume":"3","author":"Bi","year":"2006","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.ajoc.2018.01.026_bib21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/ICB.0b013e3182618d6c","article-title":"Lambert Maberley DA. All-trans retinoic Acid differentiation syndrome chorioretinopathy: a case of multifocal serous neurosensory detachments in a patient with acute promyelocytic leukemia treated with all-trans retinoic Acid","volume":"7","author":"Levasseur","year":"2013","journal-title":"Retin Cases Brief Rep"},{"key":"10.1016\/j.ajoc.2018.01.026_bib22","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood-2012-02-410746","article-title":"All-trans-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4)","volume":"120","author":"Iland","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ajoc.2018.01.026_bib23","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/sj.eye.6701308","article-title":"Ophthalmic manifestations of acute leukaemias: the ophthalmologist's role","volume":"18","author":"Sharma","year":"2004","journal-title":"Eye"},{"key":"10.1016\/j.ajoc.2018.01.026_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ajoc.2016.08.004","article-title":"A case of Acute Myeloid Leukemia masquerading as unilateral exudative detachment","volume":"4","author":"Sharma","year":"2016","journal-title":"Am J Ophthalmol Case Rep"},{"key":"10.1016\/j.ajoc.2018.01.026_bib25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3341\/kjo.2010.24.4.245","article-title":"Bilateral serous retinal detachment as a presenting sign of acute lymphoblastic leukemia","volume":"24","author":"Kim","year":"2010","journal-title":"Kor J Ophthalmol"},{"key":"10.1016\/j.ajoc.2018.01.026_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.24966\/CSMC-8801\/100007","article-title":"Bilateral serous retinal detachment as a presenting sign of acute lymphoblastic leukemia in an adult","volume":"2","author":"Liang","year":"2015","journal-title":"J Clin Stud Med Case Rep"},{"key":"10.1016\/j.ajoc.2018.01.026_bib27","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1442-9071.2006.01291.x","article-title":"Bilateral exudative retinal detachment as the first sign of relapsing acute myelogenous leukaemia","volume":"34","author":"Wu","year":"2006","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajoc.2018.01.026_bib28","doi-asserted-by":"crossref","first-page":"410","DOI":"10.4103\/0974-9233.102762","article-title":"Bilateral exudative retinal detachment as a presenting sign of acute lymphoblastic leukemia","volume":"19","author":"Chinta","year":"2012","journal-title":"Middle East Afr J Ophthalmol"},{"key":"10.1016\/j.ajoc.2018.01.026_bib29","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.sjopt.2013.07.013","article-title":"Lymphocytic leukemia presenting as acute Vogt-Koyanagi-Harada disease","volume":"28","author":"AlZamil","year":"2014","journal-title":"Saudi J Ophthalmol"},{"key":"10.1016\/j.ajoc.2018.01.026_bib30","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3341\/kjo.2009.23.4.325","article-title":"Acute lymphoblastic leukemia manifesting as acute Vogt-Koyanagi-Harada disease","volume":"23","author":"Yang","year":"2009","journal-title":"Kor J Ophthalmol"},{"key":"10.1016\/j.ajoc.2018.01.026_bib31","doi-asserted-by":"crossref","first-page":"382","DOI":"10.5935\/0004-2749.20150101","article-title":"Acute lymphoblastic leukemia presenting with bilateral serous macular detachment","volume":"78","author":"Vieira","year":"2015","journal-title":"Arq Bras Oftalmol"},{"key":"10.1016\/j.ajoc.2018.01.026_bib32","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1001\/archopht.1992.01080240057030","article-title":"Posterior chorioretinopathy and retinal detachment after organ transplantation","volume":"110","author":"Gass","year":"1992","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajoc.2018.01.026_bib33","article-title":"A review of the inflammatory chorioretinopathies: the white dot syndromes","volume":"2013","author":"Crawford","year":"2013","journal-title":"ICA Inf"},{"key":"10.1016\/j.ajoc.2018.01.026_bib34","series-title":"Multifocal choroidopathy syndromes: medscape","author":"Mansour","year":"2015"},{"key":"10.1016\/j.ajoc.2018.01.026_bib35","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/ICB.0000000000000281","article-title":"Chorioretinal biopsy for the diagnosis of endogenous endophthalmitis due to escherichia coli","volume":"11","author":"Cheng","year":"2017","journal-title":"Retin Cases Brief Rep"},{"key":"10.1016\/j.ajoc.2018.01.026_bib36","first-page":"95","article-title":"Endogenous endophthalmitis caused by Escherichia coli","volume":"25","author":"Park","year":"1993","journal-title":"Ann Ophthalmol"},{"key":"10.1016\/j.ajoc.2018.01.026_bib37","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0039-6257(77)90044-3","article-title":"Endogenous E. coli endophthalmitis","volume":"21","author":"Shammas","year":"1977","journal-title":"Surv Ophthalmol"},{"issue":"Pt 1","key":"10.1016\/j.ajoc.2018.01.026_bib38","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/eye.1996.28","article-title":"Coli endophthalmitis","volume":"10","author":"Anand","year":"1996","journal-title":"Eye"},{"key":"10.1016\/j.ajoc.2018.01.026_bib39","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/clinids\/22.6.1107","article-title":"Endogenous endophthalmitis due to Escherichia coli: case report and review","volume":"22","author":"Tseng","year":"1996","journal-title":"Clin Infect Dis: An Official Publication Of The Infectious Diseases Society Of America"},{"key":"10.1016\/j.ajoc.2018.01.026_bib40","series-title":"Retinal and Choroidal Manifestations of Selected Systemic Diseases","author":"Ar\u00e9valo","year":"2013"},{"key":"10.1016\/j.ajoc.2018.01.026_bib41","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2016-216886","article-title":"Bilateral choroidal detachment with exudative retinal detachment in a patient with septicaemia","volume":"2016","author":"Rani","year":"2016","journal-title":"BMJ Case Rep"}],"container-title":["American Journal of Ophthalmology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993617300774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993617300774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:56:35Z","timestamp":1762527395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451993617300774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":41,"alternative-id":["S2451993617300774"],"URL":"https:\/\/doi.org\/10.1016\/j.ajoc.2018.01.026","relation":{},"ISSN":["2451-9936"],"issn-type":[{"value":"2451-9936","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Two cases of differentiation syndrome with ocular manifestations in patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and arsenic trioxide","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajoc.2018.01.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}