{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:44:24Z","timestamp":1790063064519,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology Case Reports"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ajoc.2019.100519","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T11:35:44Z","timestamp":1563276944000},"page":"100519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Keratoconus progression associated with hormone replacement therapy"],"prefix":"10.1016","volume":"15","author":[{"given":"Giulia","family":"Coco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Kheirkhah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7088-605X","authenticated-orcid":false,"given":"William","family":"Foulsham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Dana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Ciolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajoc.2019.100519_bib1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","volume":"42","author":"Rabinowitz","year":"1998","journal-title":"Keratoconus. Surv Ophthalmol"},{"key":"10.1016\/j.ajoc.2019.100519_bib2","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.ophtha.2015.08.017","article-title":"Keratoplasty in the United States","volume":"122","author":"Park","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajoc.2019.100519_bib3","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1097\/ICO.0b013e3182068adc","article-title":"Pregnancy-induced progression of keratoconus","volume":"30","author":"Bilgihan","year":"2011","journal-title":"Cornea"},{"key":"10.1016\/j.ajoc.2019.100519_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/ICO.0b013e3181ac0518","article-title":"The influence of gender and hormone status on the severity and progression of keratoconus","volume":"29","author":"Fink","year":"2010","journal-title":"Cornea"},{"key":"10.1016\/j.ajoc.2019.100519_bib5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/BF03345600","article-title":"Acute keratoconus induced by hypothyroxinemia during pregnancy","volume":"31","author":"Gatzioufas","year":"2008","journal-title":"J Endocrinol Investig"},{"key":"10.1016\/j.ajoc.2019.100519_bib6","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1136\/bjo.2007.124388","article-title":"Oestrogen-induced changes in biomechanics in the cornea as a possible reason for keratectasia","volume":"91","author":"Spoerl","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajoc.2019.100519_bib7","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1097\/ICO.0000000000000988","article-title":"Role of thyroxine in the development of keratoconus","volume":"35","author":"Thanos","year":"2016","journal-title":"Cornea"},{"key":"10.1016\/j.ajoc.2019.100519_bib8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/OPX.0b013e318238c3f2","article-title":"Two cases of keratoconus diagnosed after pregnancy","volume":"89","author":"Soeters","year":"2012","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.ajoc.2019.100519_bib9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3928\/1081597X-20151207-10","article-title":"Keratoconus progression induced by in vitro fertilization treatment","volume":"32","author":"Yuksel","year":"2016","journal-title":"J Refract Surg"},{"key":"10.1016\/j.ajoc.2019.100519_bib10","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1098\/rsif.2010.0108","article-title":"Characterization of age-related variation in corneal biomechanical properties","volume":"7","author":"Elsheikh","year":"2010","journal-title":"J R Soc Interface"},{"key":"10.1016\/j.ajoc.2019.100519_bib11","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1167\/iovs.09-4798","article-title":"Age-related differences in the elasticity of the human cornea","volume":"52","author":"Knox Cartwright","year":"2011","journal-title":"Investig Opthalmology Vis Sci"},{"key":"10.1016\/j.ajoc.2019.100519_bib12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.optom.2015.05.001","article-title":"Effect of ageing on keratoconic corneas","volume":"9","author":"Millodot","year":"2016","journal-title":"J Opt"},{"key":"10.1016\/j.ajoc.2019.100519_bib13","first-page":"644","article-title":"Collagen fibrils in the human corneal stroma: structure and aging","volume":"39","author":"Daxer","year":"1998","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajoc.2019.100519_bib14","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/00006324-198011000-00008","article-title":"Effects of oral contraceptive steroids on the thickness of human cornea","volume":"57","author":"Soni","year":"1980","journal-title":"Am J Optom Physiol Opt"},{"key":"10.1016\/j.ajoc.2019.100519_bib15","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/0002-9394(88)90006-2","article-title":"Maternal corneal thickness during pregnancy","volume":"105","author":"Weinreb","year":"1988","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajoc.2019.100519_bib16","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1097\/00006324-198310000-00003","article-title":"Menstrual cycle variations of corneal topography and thickness","volume":"60","author":"Kiely","year":"1983","journal-title":"Am J Optom Physiol Opt"},{"key":"10.1016\/j.ajoc.2019.100519_bib17","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/j.jcrs.2014.02.042","article-title":"Ocular anterior segment changes in pregnancy","volume":"40","author":"Goldich","year":"2014","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.ajoc.2019.100519_bib18","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.jcrs.2008.02.036","article-title":"Pregnancy-related exacerbation of iatrogenic keratectasia despite corneal collagen crosslinking","volume":"34","author":"Hafezi","year":"2008","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.ajoc.2019.100519_bib19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.survophthal.2005.02.005","article-title":"Sex hormone receptors in the human eye","volume":"50","author":"Gupta","year":"2005","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ajoc.2019.100519_bib20","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1076\/ceyr.22.1.28.6980","article-title":"Expression of sex steroid hormone receptors in human cornea","volume":"22","author":"Suzuki","year":"2001","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.ajoc.2019.100519_bib21","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.exer.2003.07.003","article-title":"The organization of collagen in the corneal stroma","volume":"78","author":"Meek","year":"2004","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajoc.2019.100519_bib22","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1097\/01.ico.0000160973.04072.a5","article-title":"Estrogen stimulation of proinflammatory cytokine and matrix metalloproteinase gene expression in human corneal epithelial cells","volume":"24","author":"Suzuki","year":"2005","journal-title":"Cornea"},{"key":"10.1016\/j.ajoc.2019.100519_bib23","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJM197409122911105","volume":"291","author":"Harris","year":"1974","journal-title":"Collagenases. N Engl J Med"},{"key":"10.1016\/j.ajoc.2019.100519_bib24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1093-3263(02)00145-6","article-title":"Collagen stability, hydration and native state","volume":"21","author":"Mogilner","year":"2002","journal-title":"J Mol Graph Model"},{"key":"10.1016\/j.ajoc.2019.100519_bib25","first-page":"151","article-title":"Dynamic mechanical spectroscopy of the cornea for measurement of its viscoelastic properties in vitro","volume":"4","author":"Soergel","year":"1995","journal-title":"Ger J Ophthalmol"},{"key":"10.1016\/j.ajoc.2019.100519_bib26","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1136\/bjophthalmol-2016-308682","article-title":"The natural history of corneal topographic progression of keratoconus after age 30\u2005years in non-contact lens wearers","volume":"101","author":"Gokul","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajoc.2019.100519_bib27","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1136\/bjo.84.8.834","article-title":"Atopy and keratoconus: a multivariate analysis","volume":"84","author":"Bawazeer","year":"2000","journal-title":"Br J Ophthalmol"}],"container-title":["American Journal of Ophthalmology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993618304407?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993618304407?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:59:03Z","timestamp":1762527543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451993618304407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":27,"alternative-id":["S2451993618304407"],"URL":"https:\/\/doi.org\/10.1016\/j.ajoc.2019.100519","relation":{},"ISSN":["2451-9936"],"issn-type":[{"value":"2451-9936","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Keratoconus progression associated with hormone replacement therapy","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajoc.2019.100519","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100519"}}