{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:11:29Z","timestamp":1787731889996,"version":"build-2784847793"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology Case Reports"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.ajoc.2020.100592","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T06:48:57Z","timestamp":1578379737000},"page":"100592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Cavernous sinus thrombosis caused by Streptococcus constellatus-associated Lemierre syndrome presenting as an isolated abducens nerve palsy"],"prefix":"10.1016","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5403-421X","authenticated-orcid":false,"given":"Landon J.","family":"Rohowetz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Gratton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6973-9597","authenticated-orcid":false,"given":"Daniel","family":"Dansdill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9764-2074","authenticated-orcid":false,"given":"Cory J.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-333X","authenticated-orcid":false,"given":"Sarah","family":"Dubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ajoc.2020.100592_bib1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/WNO.0b013e31825e42ae","article-title":"Lemierre syndrome causing bilateral cavernous sinus thrombosis","volume":"32","author":"Miller","year":"2012","journal-title":"J Neuro Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajoc.2020.100592_bib2","doi-asserted-by":"crossref","first-page":"782","DOI":"10.5692\/clinicalneurol.52.782","article-title":"A case of Lemierre syndrome associated with infectious cavernous sinus thrombosis and septic meningitis","volume":"52","author":"Shibuya","year":"2012","journal-title":"Rinsho Shinkeigaku"},{"issue":"1","key":"10.1016\/j.ajoc.2020.100592_bib3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.otorri.2011.08.005","article-title":"Lemierre syndrome: thrombosis of the cavernous sinus and internal carotid artery occlusion secondary to acute sphenoid sinusitis","volume":"64","author":"Rudski Ricondo","year":"2013","journal-title":"Acta Otorrinolaringol"},{"issue":"6","key":"10.1016\/j.ajoc.2020.100592_bib4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jaapos.2011.06.010","article-title":"Isolated abducens nerve palsy secondary to Lemierre syndrome","volume":"15","author":"Bababeygy","year":"2011","journal-title":"J AAPOS"},{"key":"10.1016\/j.ajoc.2020.100592_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2015-209777","article-title":"Clival osteomyelitis and hypoglossal nerve palsy-rare complications of Lemierre's syndrome","volume":"2015","author":"He","year":"2015","journal-title":"BMJ Case Rep"},{"issue":"26","key":"10.1016\/j.ajoc.2020.100592_bib6","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000011228","article-title":"The co-existence of Lemierre's syndrome and Bezold's abscesses due to Streptococcus constellatus","volume":"97","author":"Yaita","year":"2018","journal-title":"Medicine"},{"issue":"8","key":"10.1016\/j.ajoc.2020.100592_bib7","first-page":"260","article-title":"Lemierre's syndrome caused by Klebsiella pneumoniae in a diabetic patient: a case report and review of the literature","volume":"74","author":"Chuncharunee","year":"2015","journal-title":"Hawaii J Med Public Heal"},{"key":"10.1016\/j.ajoc.2020.100592_bib8","doi-asserted-by":"crossref","DOI":"10.1186\/1752-1947-6-97","article-title":"Lemierre's syndrome due to Klebsiella pneumoniae in a 63-year-old man with diabetes: a case report","volume":"6","author":"Garbati","year":"2012","journal-title":"J Med Case Rep"},{"issue":"4","key":"10.1016\/j.ajoc.2020.100592_bib9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/INF.0000000000001460","article-title":"Methicillin-resistant Staphylococcus aureus as a cause of Lemierre's syndrome","volume":"36","author":"Jariwala","year":"2017","journal-title":"Pediatr Infect Dis J"},{"issue":"13","key":"10.1016\/j.ajoc.2020.100592_bib10","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1212\/WNL.0b013e3182a55f30","article-title":"Lemierre syndrome: more than the forgotten disease","volume":"81","author":"Morelli","year":"2013","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.ajoc.2020.100592_bib11","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jocn.2013.02.020","article-title":"Endoscopic sphenoid sinus drainage in Lemierre syndrome","volume":"21","author":"Golan","year":"2014","journal-title":"J Clin Neurosci"},{"issue":"3","key":"10.1016\/j.ajoc.2020.100592_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3341\/kjo.2013.27.3.219","article-title":"Differential diagnosis of Lemierre's syndrome in a patient with acute paresis of the abducens and oculomotor nerves","volume":"27","author":"Gutzeit","year":"2013","journal-title":"Korean J Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajoc.2020.100592_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jemermed.2012.02.075","article-title":"Lemierre syndrome secondary to community-acquired methicillin-resistant Staphylococcus aureus infection associated with cavernous sinus thromboses","volume":"44","author":"Stauffer","year":"2013","journal-title":"J Emerg Med"},{"issue":"1","key":"10.1016\/j.ajoc.2020.100592_bib14","first-page":"38","article-title":"Lemierre syndrome: a pediatric case series and review of literature","volume":"31","author":"Ridgway","year":"2010","journal-title":"Am J Otolaryngol - Head Neck Med Surg"},{"issue":"1","key":"10.1016\/j.ajoc.2020.100592_bib15","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.anl.2009.02.012","article-title":"Lemierre syndrome caused by acute isolated sphenoid sinusitis and its intracranial complications","volume":"37","author":"Lim","year":"2010","journal-title":"Auris Nasus Larynx"},{"issue":"4","key":"10.1016\/j.ajoc.2020.100592_bib16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1468-1331.2006.01155.x","article-title":"Hemiplegia in Lemierre syndrome: a neuroimaging strategy","volume":"13","author":"Touitou","year":"2006","journal-title":"Eur J Neurol"},{"issue":"8","key":"10.1016\/j.ajoc.2020.100592_bib17","doi-asserted-by":"crossref","first-page":"753","DOI":"10.2169\/internalmedicine.49.2779","article-title":"Lemierre syndrome with blepharoptosis","volume":"49","author":"Yamaguchi","year":"2010","journal-title":"Intern Med"},{"issue":"1","key":"10.1016\/j.ajoc.2020.100592_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3171\/ped.2007.106.1.53","article-title":"Lemierre syndrome complicated by cavernous sinus thrombosis, the development of subdural empyemas, and internal carotid artery narrowing without cerebral infarction","volume":"106","author":"Westhout","year":"2008","journal-title":"J Neurosurg Pediatr"},{"issue":"7","key":"10.1016\/j.ajoc.2020.100592_bib19","doi-asserted-by":"crossref","first-page":"483","DOI":"10.5692\/clinicalneurol.cn-000676","article-title":"A case with both infectious cavernous sinus thrombosis and Lemierre syndrome due to intraoral resident flora","volume":"55","author":"Nishida","year":"2015","journal-title":"Rinsho Shinkeigaku"},{"issue":"2","key":"10.1016\/j.ajoc.2020.100592_bib20","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1080\/01676830.2017.1383458","article-title":"Septic thrombosis of cavernous sinus extended to the ipsilateral internal jugular vein and transversal sinus with favorable outcome: clinical and radiological features of a Lemierre syndrome","volume":"37","author":"Martel","year":"2018","journal-title":"Orbit"},{"issue":"9","key":"10.1016\/j.ajoc.2020.100592_bib21","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/23744235.2017.1331465","article-title":"A review of eight cases of cavernous sinus thrombosis secondary to sphenoid sinusitis, including a12-year-old girl at the present department","volume":"49","author":"Wang","year":"2017","journal-title":"Infect Dis"},{"issue":"4","key":"10.1016\/j.ajoc.2020.100592_bib22","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1017\/cjn.2016.438","article-title":"Bilateral cavernous sinus thrombosis in Lemierre's syndrome","volume":"44","author":"Budhram","year":"2017","journal-title":"Can J Neurol Sci"},{"issue":"1","key":"10.1016\/j.ajoc.2020.100592_bib23","first-page":"73","article-title":"Diagnosis and management of cerebral venous diseases in neuro-ophthalmology: ongoing controversies","volume":"8","author":"Dinkin","year":"2019","journal-title":"Asia-Pacific J Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajoc.2020.100592_bib24","first-page":"733","article-title":"Septic cavernous sinus thrombosis due to Streptococcus constellatus infection","volume":"102","author":"Chang","year":"2003","journal-title":"J Formos Med Assoc"},{"issue":"6","key":"10.1016\/j.ajoc.2020.100592_bib25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2169\/internalmedicine.46.6202","article-title":"Septic cavernous sinus thrombosis complicated by narrowing of the internal carotid artery, subarachnoid abscess and multiple pulmonary septic emboli","volume":"46","author":"Hoshino","year":"2007","journal-title":"Intern Med"},{"issue":"2","key":"10.1016\/j.ajoc.2020.100592_bib26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/01676830600675418","article-title":"Septic cavernous sinus thrombosis with bilateral secondary orbital infection","volume":"26","author":"Goawalla","year":"2007","journal-title":"Orbit"},{"key":"10.1016\/j.ajoc.2020.100592_bib27","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1136\/bcr.03.2009.1671","article-title":"Sudden onset proptosis secondary to cavernous sinus thrombosis from underlying mandibular dental infection","volume":"2009","author":"Jones","year":"2009","journal-title":"BMJ Case Rep"},{"issue":"1","key":"10.1016\/j.ajoc.2020.100592_bib28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13256-017-1309-0","article-title":"Odontogenic orbital cellulitis associated with cavernous sinus thrombosis and pulmonary embolism: a case report","volume":"11","author":"Allegrini","year":"2017","journal-title":"J Med Case Rep"},{"issue":"2","key":"10.1016\/j.ajoc.2020.100592_bib29","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jocn.2013.02.020","article-title":"Endoscopic sphenoid sinus drainage in Lemierre syndrome","volume":"21","author":"Golan","year":"2014","journal-title":"J Clin Neurosci"},{"issue":"3","key":"10.1016\/j.ajoc.2020.100592_bib30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0165-5876(99)00264-5","article-title":"Lemierre syndrome in an immunocompromised patient","volume":"51","author":"Tewfik","year":"1999","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"4","key":"10.1016\/j.ajoc.2020.100592_bib31","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/014556130208100412","article-title":"Bilateral Lemierre's syndrome: a case report and literature review","volume":"81","author":"Moore","year":"2002","journal-title":"Ear Nose Throat J"},{"issue":"8","key":"10.1016\/j.ajoc.2020.100592_bib32","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/j.joms.2007.12.002","article-title":"Lemierre syndrome and descending necrotizing mediastinitis following dental extraction","volume":"66","author":"Malis","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"issue":"2","key":"10.1016\/j.ajoc.2020.100592_bib33","first-page":"160","article-title":"The six syndromes of the sixth cranial nerve","volume":"8","author":"Azarmina","year":"2013","journal-title":"J Ophthalmic Vis Res"},{"issue":"9","key":"10.1016\/j.ajoc.2020.100592_bib34","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1007\/s00405-018-5062-9","article-title":"Prognosis of septic cavernous sinus thrombosis remarkably improved: a case series of 12 patients and literature review","volume":"275","author":"van der Poel","year":"2018","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"23","key":"10.1016\/j.ajoc.2020.100592_bib35","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V126.23.2296.2296","article-title":"Lemierre's Syndrome: role of anticoagulation and thrombosis outcomes, a retrospective study","volume":"126","author":"Cupit","year":"2015","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.ajoc.2020.100592_bib36","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s11096-012-9684-5","article-title":"Use of anticoagulation therapy for jugular vein thrombus in pediatric patients with Lemierre's syndrome","volume":"34","author":"Phan","year":"2012","journal-title":"Int J Clin Pharm"},{"issue":"2","key":"10.1016\/j.ajoc.2020.100592_bib37","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/00005792-198603000-00002","article-title":"Septic thrombosis of the dural venous sinuses","volume":"65","author":"Southwick","year":"1986","journal-title":"Medicine"},{"issue":"4","key":"10.1016\/j.ajoc.2020.100592_bib38","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1212\/WNL.38.4.517","article-title":"The role of anticoagulation in cavernous sinus thrombosis","volume":"38","author":"Levine","year":"2012","journal-title":"Neurology"}],"container-title":["American Journal of Ophthalmology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993620300037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993620300037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:59:05Z","timestamp":1762527545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451993620300037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":38,"alternative-id":["S2451993620300037"],"URL":"https:\/\/doi.org\/10.1016\/j.ajoc.2020.100592","relation":{},"ISSN":["2451-9936"],"issn-type":[{"value":"2451-9936","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cavernous sinus thrombosis caused by Streptococcus constellatus-associated Lemierre syndrome presenting as an isolated abducens nerve palsy","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajoc.2020.100592","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100592"}}