{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:15:04Z","timestamp":1785204904907,"version":"3.55.0"},"reference-count":12,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology Case Reports"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.ajoc.2020.100695","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T20:16:42Z","timestamp":1586549802000},"page":"100695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Bilateral optic nerve and retinal infiltration as an initial site of relapse in a child with T-cell acute lymphoblastic leukemia"],"prefix":"10.1016","volume":"18","author":[{"given":"Adam E.","family":"Pflugrath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram S.","family":"Brar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ajoc.2020.100695_bib1","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1002\/1097-0142(197610)38:4<1744::AID-CNCR2820380449>3.0.CO;2-3","article-title":"Leukemic ophthalmopathy in children","volume":"38","author":"Ridgway","year":"1976","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/j.ajoc.2020.100695_bib2","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/1097-0142(19890415)63:8<1616::AID-CNCR2820630829>3.0.CO;2-Y","article-title":"The optic nerve as the site of initial relapse in childhood acute lymphoblastic leukemia","volume":"63","author":"Schwartz","year":"1989","journal-title":"Cancer"},{"key":"10.1016\/j.ajoc.2020.100695_bib3","doi-asserted-by":"crossref","first-page":"lll","DOI":"10.1007\/BF00133423","article-title":"Leukemic optic neuropathy","volume":"3","author":"Brown","year":"1981","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.ajoc.2020.100695_bib4","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/0002-9394(73)90893-3","article-title":"Leukemic infiltration of the optic nerve head","volume":"75","author":"Ellis","year":"1973","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajoc.2020.100695_bib5","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1001\/archopht.1989.01070010715033","article-title":"Ophthalmic manifestations of leukemia","volume":"107","author":"Schachat","year":"1989","journal-title":"Arch Ophthalmol"},{"issue":"8","key":"10.1016\/j.ajoc.2020.100695_bib6","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.ophtha.2012.03.042","article-title":"T-cell leukemia","volume":"119","author":"Chalam","year":"2012","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.ajoc.2020.100695_bib7","doi-asserted-by":"crossref","first-page":"E114","DOI":"10.1111\/j.1442-9071.2011.02616.x","article-title":"Devastating bilateral optic nerve leukaemic infiltration","volume":"40","author":"Shah","year":"2012","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajoc.2020.100695_bib8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/sj.eye.6700701","article-title":"Leukaemic infiltration of the optic nerve as the initial manifestation of leukaemic relapse","volume":"18","author":"Lin","year":"2004","journal-title":"Eye"},{"key":"10.1016\/j.ajoc.2020.100695_bib9","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/eye.2009.204","article-title":"Dramatic visual recovery after prompt radiotherapy and chemotherapy for leukaemic infiltration of the optic nerve in a child","volume":"24","author":"Puvanachandra","year":"2010","journal-title":"Eye"},{"key":"10.1016\/j.ajoc.2020.100695_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/(SICI)1096-911X(199602)26:2<101::AID-MPO6>3.0.CO;2-P","article-title":"Optic nerve head infiltration in acute leukemia in children: an indication for emergency optic nerve radiation therapy","volume":"26","author":"Kaikov","year":"1996","journal-title":"Med Pediatr Oncol"},{"issue":"6","key":"10.1016\/j.ajoc.2020.100695_bib11","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/ICU.0000000000000309","article-title":"Ophthalmic manifestations of leukemia","volume":"27","author":"Talcott","year":"2016","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.ajoc.2020.100695_bib12","first-page":"237","article-title":"Optical coherence tomography findings of bilateral foveal leukemic infiltration","volume":"9","author":"Le","year":"2016","journal-title":"Int Med Case Rep J"}],"container-title":["American Journal of Ophthalmology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993618303384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993618303384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:58:06Z","timestamp":1762527486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451993618303384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":12,"alternative-id":["S2451993618303384"],"URL":"https:\/\/doi.org\/10.1016\/j.ajoc.2020.100695","relation":{},"ISSN":["2451-9936"],"issn-type":[{"value":"2451-9936","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bilateral optic nerve and retinal infiltration as an initial site of relapse in a child with T-cell acute lymphoblastic leukemia","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajoc.2020.100695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100695"}}