{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:43:19Z","timestamp":1792086199524,"version":"4.4.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305299\/2015-8"],"award-info":[{"award-number":["305299\/2015-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008353","name":"Funda\u00e7\u00e3o de Apoio ao Ensino, Pesquisa e Assist\u00eancia do Hospital das Cl\u00ednicas da Faculdade de Medicina de Ribeir\u00e3o Preto da Universidade de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016145","name":"Ministerio de Sanidad, Consumo y Bienestar Social","doi-asserted-by":"publisher","award":["863140\/2017"],"award-info":[{"award-number":["863140\/2017"]}],"id":[{"id":"10.13039\/100016145","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology Case Reports"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.ajoc.2021.101093","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T10:06:52Z","timestamp":1618826812000},"page":"101093","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Use of a slow-release intravitreal clindamycin implant for the management of ocular toxoplasmosis"],"prefix":"10.1016","volume":"22","author":[{"given":"Rodrigo","family":"Jorge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9987-6886","authenticated-orcid":false,"given":"Igor Neves","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Silva-Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella Maria","family":"Fernandes Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid U.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Lig\u00f3rio","family":"Fialho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Marcello","family":"Furtado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajoc.2021.101093_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.preteyeres.2013.12.005","article-title":"Ocular toxoplasmosis past, present and new aspects of an old disease","volume":"39","author":"Maenz","year":"2014","journal-title":"Prog Retin Eye Res"},{"issue":"9425","key":"10.1016\/j.ajoc.2021.101093_bib2","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","volume":"363","author":"Montoya","year":"2004","journal-title":"Toxoplasmosis. Lancet."},{"issue":"2","key":"10.1016\/j.ajoc.2021.101093_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212375","article-title":"Socioeconomic vulnerability associated to Toxoplasma gondii exposure in southern Brazil","volume":"14","author":"Mareze","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.ajoc.2021.101093_bib4","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.ajo.2003.09.040","article-title":"Ocular toxoplasmosis: a global reassessment","volume":"136","author":"Holland","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajoc.2021.101093_bib5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0002-9394(14)73976-5","article-title":"An unusually high prevalence of ocular toxoplasmosis in southern Brazil","volume":"114","author":"Glasner","year":"1992","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajoc.2021.101093_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/09273948.2016.1215471","article-title":"Current practices in ocular toxoplasmosis: a survey of Brazilian uveitis specialists","volume":"26","author":"Morais","year":"2016","journal-title":"Ocul Immunol Inflamm"},{"issue":"4","key":"10.1016\/j.ajoc.2021.101093_bib7","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1055\/s-0042-123717","article-title":"Ocular toxoplasmosis: therapy-related adverse drug reactions and their management","volume":"234","author":"Helfenstein","year":"2017","journal-title":"Klin Monbl Augenheilkd"},{"issue":"11","key":"10.1016\/j.ajoc.2021.101093_bib8","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/j.clinthera.2008.10.021","article-title":"Adverse drug reactions to treatments for ocular toxoplasmosis: a retrospective chart review","volume":"30","author":"Iaccheri","year":"2008","journal-title":"Clin Therapeut"},{"issue":"3","key":"10.1016\/j.ajoc.2021.101093_bib9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3928\/1542-8877-20010501-03","article-title":"Intravitreal clindamycin and dexamethasone for toxoplasmic retinochoroiditis","volume":"32","author":"Kishore","year":"2001","journal-title":"Ophthalmic Surg Laser"},{"issue":"5","key":"10.1016\/j.ajoc.2021.101093_bib10","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1046\/j.1365-2958.2002.02825.x","article-title":"An rRNA mutation identifies the apicoplast as the target for clindamycin in Toxoplasma gondii","volume":"43","author":"Camps","year":"2002","journal-title":"Mol Microbiol"},{"issue":"1","key":"10.1016\/j.ajoc.2021.101093_bib11","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/ICB.0000000000000413","article-title":"Safety and feasibility OF a novel 25-GAUGE biodegradable implant OF dexamethasone for treatment OF macular edema associated with retinal vein occlusion: a phase I clinical trial","volume":"12","author":"Cunha","year":"2018","journal-title":"Retin Cases Brief Rep"},{"key":"10.1016\/j.ajoc.2021.101093_bib12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3109\/09273948.2014.964422","article-title":"The effect of long-term intermittent trimethoprim\/sulfamethoxazole treatment on recurrences of toxoplasmic retinochoroiditis: 10 years of follow-up","volume":"23","author":"Silveira","year":"2015","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.ajoc.2021.101093_bib13","doi-asserted-by":"crossref","unstructured":"Fernandes-Cunha, G. M et al. Ocular safety of intravitreal clindamycin hydrochloride released by PLGA implants. Pharmaceut Res. 201734(5), 1083\u20131092.","DOI":"10.1007\/s11095-017-2118-2"},{"issue":"4","key":"10.1016\/j.ajoc.2021.101093_bib14","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.ajo.2013.12.022","article-title":"Trimethoprim-sulfamethoxazole versus placebo to reduce the risk of recurrences of toxoplasma gondii retinochoroiditis: randomized controlled clinical trial","volume":"157","author":"Felix","year":"2014","journal-title":"Am J Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajoc.2021.101093_bib15","article-title":"Anti-toxoplasma activity and impact evaluation of lyophilization, hot molding process, and gamma irradiation techniques on CLH-PLGA intravitreal implants","volume":"27","author":"Fernandes-Cunha","year":"2016","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.ajoc.2021.101093_bib16","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jpba.2014.08.023","article-title":"Development of a method to quantify clindamycin in vitreous humor of rabbits' eyes by UPLC\u2013MS\/MS: application to a comparative pharmacokinetic study and in vivo ocular biocompatibility evaluation","volume":"102","author":"Fernandes-Cunha","year":"2015","journal-title":"J Pharmaceut Biomed Anal"}],"container-title":["American Journal of Ophthalmology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245199362100102X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245199362100102X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:57:57Z","timestamp":1762527477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S245199362100102X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":16,"alternative-id":["S245199362100102X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajoc.2021.101093","relation":{},"ISSN":["2451-9936"],"issn-type":[{"value":"2451-9936","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of a slow-release intravitreal clindamycin implant for the management of ocular toxoplasmosis","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajoc.2021.101093","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101093"}}