{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T20:37:59Z","timestamp":1764794279916,"version":"build-2065373602"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology Case Reports"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.ajoc.2022.101390","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T03:33:47Z","timestamp":1644032027000},"page":"101390","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Role of intravitreal brolucizumab with intravitreal rtPA and pneumatic displacement for submacular hemorrhage: A case series"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9693-7882","authenticated-orcid":false,"given":"Debdulal","family":"Chakraborty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3590-7759","authenticated-orcid":false,"given":"Jay U.","family":"Sheth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumen","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhendu","family":"Boral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ajoc.2022.101390_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0039-6257(97)00089-1","article-title":"Pathophysiology and management of subretinal hemorrhage","volume":"42","author":"Hochman","year":"1997","journal-title":"Surv Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajoc.2022.101390_bib2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s10384-017-0549-2","article-title":"Quantification of retinal changes after resolution of submacular hemorrhage secondary to polypoidal choroidal vasculopathy","volume":"62","author":"Kim","year":"2018","journal-title":"Jpn J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ajoc.2022.101390_bib3","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1001\/archopht.1991.01080050139046","article-title":"Fibrin directs early retinal damage after experimental subretinal hemorrhage","volume":"109","author":"Toth","year":"1991","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajoc.2022.101390_bib4","article-title":"Management of acute submacular hemorrhage using intravitreal injection of tissue plasminogen activator and gas: a case series","volume":"8","author":"Karamitsos","year":"2020","journal-title":"SAGE Open Med Case Rep"},{"issue":"1","key":"10.1016\/j.ajoc.2022.101390_bib5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.survophthal.2015.04.004","article-title":"Submacular hemorrhage in neovascular age-related macular degeneration: a synthesis of the literature","volume":"61","author":"Stanescu-Segall","year":"2016","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ajoc.2022.101390_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40942-020-00228-x","article-title":"Surgical management of submacular hemorrhage due to n-AMD: a comparison of three surgical methods","volume":"6","author":"Grohmann","year":"2020","journal-title":"Int J Retina Vitreous"},{"issue":"6","key":"10.1016\/j.ajoc.2022.101390_bib7","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.ajo.2013.01.012","article-title":"Management of submacular hemorrhage secondary to neovascular age-related macular degeneration with anti-vascular endothelial growth factor monotherapy","volume":"155","author":"Shienbaum","year":"2013","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajoc.2022.101390_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00417-019-04474-0","article-title":"Intravitreal aflibercept for submacular hemorrhage secondary to neovascular age-related macular degeneration and polypoidal choroidal vasculopathy","volume":"258","author":"Kim","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajoc.2022.101390_bib9","article-title":"Off-label intravitreal brolucizumab for recalcitrant diabetic macular edema: a real-world case series","volume":"24","author":"Chakraborty","year":"2021","journal-title":"Am J Ophthalmol Case Rep"},{"issue":"1","key":"10.1016\/j.ajoc.2022.101390_bib10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ophtha.2020.06.028","article-title":"HAWK and HARRIER: ninety-six-week outcomes from the phase 3 trials of brolucizumab for neovascular age-related macular degeneration","volume":"128","author":"Dugel","year":"2021","journal-title":"Ophthalmology"},{"issue":"11","key":"10.1016\/j.ajoc.2022.101390_bib11","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.ophtha.2004.07.023","article-title":"Surgery for hemorrhagic choroidal neovascular lesions of age-related macular degeneration: ophthalmic findings: SST report no. 13","volume":"111","author":"Bressler","year":"2004","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1016\/j.ajoc.2022.101390_bib12","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0161-6420(01)00648-0","article-title":"Intravitreous injection of tissue plasminogen activator and gas in the treatment of submacular hemorrhage under various conditions","volume":"108","author":"Hattenbach","year":"2001","journal-title":"Ophthalmology"},{"issue":"7","key":"10.1016\/j.ajoc.2022.101390_bib13","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1089\/jop.2013.0135","article-title":"Long-term visual outcome and its predictive factors following treatment of acute submacular hemorrhage with intravitreous injection of tissue plasminogen factor and gas","volume":"30","author":"Sobolewska","year":"2014","journal-title":"J Ocul Pharmacol Therapeut"},{"issue":"6","key":"10.1016\/j.ajoc.2022.101390_bib14","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1136\/bjophthalmol-2014-306454","article-title":"Compatibility of recombinant tissue plasminogen activator (rtPA) and aflibercept or ranibizumab coapplied for neovascular age-related macular degeneration with submacular haemorrhage","volume":"99","author":"Klettner","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajoc.2022.101390_bib16","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.2147\/OPTH.S328160","article-title":"Brolucizumab in neovascular age-related macular degeneration - Indian real-world experience: the BRAILLE study","volume":"15","author":"Chakraborty","year":"2021","journal-title":"Clin Ophthalmol"}],"container-title":["American Journal of Ophthalmology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993622001360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993622001360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:03:09Z","timestamp":1762527789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451993622001360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":15,"alternative-id":["S2451993622001360"],"URL":"https:\/\/doi.org\/10.1016\/j.ajoc.2022.101390","relation":{},"ISSN":["2451-9936"],"issn-type":[{"type":"print","value":"2451-9936"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of intravitreal brolucizumab with intravitreal rtPA and pneumatic displacement for submacular hemorrhage: A case series","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajoc.2022.101390","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101390"}}