{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:36:26Z","timestamp":1776688586026,"version":"3.51.2"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology Case Reports"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.ajoc.2023.101831","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T04:27:20Z","timestamp":1679372840000},"page":"101831","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Symptomatic familial primary iris cysts at the pupillary margin in three consecutive generations: A case series"],"prefix":"10.1016","volume":"30","author":[{"given":"Mohammad","family":"Alyahya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Zaher Addeen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mhd Firas","family":"Safadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2478-7007","authenticated-orcid":false,"given":"Somar M.","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajoc.2023.101831_bib1","first-page":"771","article-title":"Primary cysts of the iris","volume":"79","author":"Shields","year":"1981","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"1","key":"10.1016\/j.ajoc.2023.101831_bib2","first-page":"64","article-title":"Cysts of the Iris pigment epithelium. What is new and interesting? The 2016 jose rizal international medal lecture","volume":"6","author":"Shields","year":"2017","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"issue":"2","key":"10.1016\/j.ajoc.2023.101831_bib3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3390\/jcm10020189","article-title":"Clinical features of Iris cysts in long-term follow-up","volume":"10","author":"Konopi\u0144ska","year":"2021","journal-title":"J Clin Med"},{"issue":"10","key":"10.1016\/j.ajoc.2023.101831_bib4","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/S0161-6420(98)91034-X","article-title":"Primary cysts of the iris pigment epithelium. Clinical features and natural course in 234 patients","volume":"105","author":"Lois","year":"1998","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.ajoc.2023.101831_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10020189","article-title":"Clinical features of Iris cysts in long-term follow-up","volume":"10","author":"Konopinska","year":"2021","journal-title":"J Clin Med"},{"issue":"4","key":"10.1016\/j.ajoc.2023.101831_bib6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0002-9394(36)91208-4","article-title":"Congenital and familial cysts and flocculi of the Iris","volume":"19","author":"Cowan","year":"1936","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajoc.2023.101831_bib7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0002-9394(01)01332-0","article-title":"Recurring transitory blindness caused by primary marginal pigment epithelial iris cysts","volume":"133","author":"Sallo","year":"2002","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajoc.2023.101831_bib8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0002-9394(86)90216-3","article-title":"Lack of association between iris color and primary iris cysts","volume":"102","author":"Kliman","year":"1986","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajoc.2023.101831_bib9","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0161-6420(84)34287-7","article-title":"The heredity and treatment of angle-closure glaucoma secondary to iris and ciliary body cysts","volume":"91","author":"Vela","year":"1984","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.ajoc.2023.101831_bib10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000504432","article-title":"Chronological observations of Iris flocculi in a Japanese family with thoracic aortic aneurysm and dissections","volume":"10","author":"Mori","year":"2019","journal-title":"Case Rep Ophthalmol"},{"issue":"10","key":"10.1016\/j.ajoc.2023.101831_bib11","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/S0161-6420(96)30444-2","article-title":"Autosomal-dominant anomalies of the iris pigment epithelium","volume":"103","author":"Lee","year":"1996","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajoc.2023.101831_bib12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.35119\/asjoo.v17i1.438","article-title":"Laser puncture of symptomatic primary iris pigment epithelial cyst causing hemeralopia: a rare case","volume":"17","author":"Sharma","year":"2020","journal-title":"Asian J Ophthalmol"},{"issue":"12","key":"10.1016\/j.ajoc.2023.101831_bib13","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/ng.2007.6","article-title":"Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections","volume":"39","author":"Guo","year":"2007","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.ajoc.2023.101831_bib14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/hrt.2010.204388","article-title":"Risk of dissection in thoracic aneurysms associated with mutations of smooth muscle alpha-actin 2 (ACTA2)","volume":"97","author":"Disabella","year":"2011","journal-title":"Heart"},{"issue":"4","key":"10.1016\/j.ajoc.2023.101831_bib15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1136\/bjophthalmol-2018-312306","article-title":"Iris anomalies and the incidence of ACTA2 mutation","volume":"103","author":"Taubenslag","year":"2019","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"10.1016\/j.ajoc.2023.101831_bib16","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1016\/0002-9394(52)91457-8","article-title":"Embryonic intraepithelial cyst of the ciliary processes","volume":"35","author":"Vail","year":"1952","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"10.1016\/j.ajoc.2023.101831_bib17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.survophthal.2017.08.009","article-title":"Iris cysts: a comprehensive review on diagnosis and treatment","volume":"63","author":"Georgalas","year":"2018","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.ajoc.2023.101831_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.704200","article-title":"Analysis of primary Iris and ciliary body cysts in Chinese patients with primary angle closure disease","volume":"8","author":"Wei","year":"2021","journal-title":"Front Med"},{"key":"10.1016\/j.ajoc.2023.101831_bib19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4236\/cm.2011.21003","article-title":"Primary pupillary margin cyst of the Iris pigment epithelium","volume":"2","author":"Dammacco","year":"2011","journal-title":"Chin Med"},{"issue":"10","key":"10.1016\/j.ajoc.2023.101831_bib20","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1001\/archopht.1995.01100100118041","article-title":"Iris flocculi and familial aortic dissection","volume":"113","author":"Lewis","year":"1995","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajoc.2023.101831_bib21","article-title":"Iris pigment epithelial (IPE) cysts secondary to Hodgkin's lymphoma: a case report","volume":"27","author":"Willekens","year":"2022","journal-title":"Am J Ophthalmol Case Rep"},{"key":"10.1016\/j.ajoc.2023.101831_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9053737","article-title":"The effectiveness of ultrasound biomicroscopic and anterior segment optical coherence tomography in the assessment of anterior segment tumors: long-term follow-up","volume":"2020","author":"Konopi\u0144ska","year":"2020","journal-title":"Journal of Ophthalmology"},{"issue":"7","key":"10.1016\/j.ajoc.2023.101831_bib23","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.ophtha.2010.11.011","article-title":"Assessment of anterior segment tumors with ultrasound biomicroscopy versus anterior segment optical coherence tomography in 200 cases","volume":"118","author":"Bianciotto","year":"2011","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.ajoc.2023.101831_bib24","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4103\/sjopt.sjopt_228_21","article-title":"Iris cysts: varied presentations and review of literature","volume":"35","author":"Dubey","year":"2021","journal-title":"Saudi J Ophthalmol"},{"issue":"1","key":"10.1016\/j.ajoc.2023.101831_bib25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4274\/tjo.galenos.2019.20633","article-title":"Iris cysts: clinical features, imaging findings, and treatment results","volume":"50","author":"K\u00f6se","year":"2020","journal-title":"Turk J Ophthalmol"},{"issue":"4","key":"10.1016\/j.ajoc.2023.101831_bib26","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000445719","article-title":"Dissecting aortic aneurysm 55 Years after diagnosis of Iris flocculi","volume":"2","author":"Shields","year":"2016","journal-title":"Ocul Oncol Pathol"},{"issue":"9","key":"10.1016\/j.ajoc.2023.101831_bib27","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/S0161-6420(84)34184-7","article-title":"Argon laser destruction of anterior chamber implantation cysts","volume":"91","author":"Sugar","year":"1984","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.ajoc.2023.101831_bib28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3928\/1542-8877-20040101-17","article-title":"Free iris cyst in the anterior chamber","volume":"35","author":"Baykara","year":"2004","journal-title":"Ophthalmic Surg Laser Imag"},{"key":"10.1016\/j.ajoc.2023.101831_bib29","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0002-9394(99)00392-X","article-title":"Laser iridocystotomy for bilateral acute angle-closure glaucoma secondary to iris cysts","volume":"129","author":"Kuchenbecker","year":"2000","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"10.1016\/j.ajoc.2023.101831_bib30","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1136\/bjo.84.7.799b","article-title":"Treatment of recurrent giant iris cyst with intracyst administration of mitomycin C","volume":"84","author":"Kawaguchi","year":"2000","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"10.1016\/j.ajoc.2023.101831_bib31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0002-9394(00)00707-8","article-title":"Needle aspiration and endodiathermy treatment of epithelial inclusion cyst of the iris","volume":"131","author":"Tsai","year":"2001","journal-title":"Am J Ophthalmol"},{"issue":"8","key":"10.1016\/j.ajoc.2023.101831_bib32","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/S0161-6420(03)00543-8","article-title":"Epithelial iris cyst treatment with intracystic ethanol irrigation","volume":"110","author":"Behrouzi","year":"2003","journal-title":"Ophthalmology"}],"container-title":["American Journal of Ophthalmology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993623000397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993623000397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:00:28Z","timestamp":1762527628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451993623000397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":32,"alternative-id":["S2451993623000397"],"URL":"https:\/\/doi.org\/10.1016\/j.ajoc.2023.101831","relation":{},"ISSN":["2451-9936"],"issn-type":[{"value":"2451-9936","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Symptomatic familial primary iris cysts at the pupillary margin in three consecutive generations: A case series","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajoc.2023.101831","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101831"}}