{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:19:29Z","timestamp":1787865569532,"version":"build-2784847793"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Ophthalmology Case Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ajoc.2026.102605","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:22:33Z","timestamp":1779726153000},"page":"102605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Iris metastasis from lung adenocarcinoma diagnosed solely through aqueous humor cytology: A case report"],"prefix":"10.1016","volume":"43","author":[{"given":"Atsushi","family":"Okubo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiko","family":"Okinaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1766-4773","authenticated-orcid":false,"given":"Shuichiro","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohdai","family":"Kitamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6182-4343","authenticated-orcid":false,"given":"Ryo","family":"Terao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9998-7448","authenticated-orcid":false,"given":"Keiko","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajoc.2026.102605_bib1","series-title":"StatPearls","article-title":"Benign and malignant iris tumors","author":"Moshirfar","year":"2025"},{"key":"10.1016\/j.ajoc.2026.102605_bib2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/ICO.0000000000000285","article-title":"Iris metastasis from systemic cancer in 104 patients: the 2014 Jerry A. Shields Lecture","volume":"34","author":"Shields","year":"2015","journal-title":"Cornea"},{"key":"10.1016\/j.ajoc.2026.102605_bib3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4103\/0974-620X.122269","article-title":"Review of cystic and solid tumors of the iris","volume":"6","author":"Shields","year":"2013","journal-title":"Oman J Ophthalmol"},{"key":"10.1016\/j.ajoc.2026.102605_bib4","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0161-6420(97)30148-1","article-title":"Survey of 520 eyes with uveal metastases","volume":"104","author":"Shields","year":"1997","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajoc.2026.102605_bib5","first-page":"19","article-title":"Problems in the differential diagnosis of choroidal nevi and malignant melanoma. XXXIII Edward Jackson Memorial lecture","volume":"83","author":"Gass","year":"1977","journal-title":"Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol"},{"key":"10.1016\/j.ajoc.2026.102605_bib6","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0002-9394(14)71227-9","article-title":"Metastatic tumors to the iris in 40 patients","volume":"119","author":"Shields","year":"1995","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajoc.2026.102605_bib7","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1001\/archopht.1974.01010010286003","article-title":"Carcinoma metastatic to the eye and orbit. I. A clinicopathologic study of 227 cases","volume":"92","author":"Ferry","year":"1974","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajoc.2026.102605_bib8","article-title":"Non-small cell lung cancer with iris metastasis controlled with osimertinib and monthly intravitreal bevacizumab","volume":"25","author":"Wong","year":"2022","journal-title":"Am J Ophthalmol Case Rep"},{"key":"10.1016\/j.ajoc.2026.102605_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0002-9394(55)92652-0","article-title":"Metastatic carcinoma of the iris and ciliary body","volume":"39","author":"Mayer","year":"1955","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajoc.2026.102605_bib10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.oftal.2018.02.007","article-title":"Iris metastasis as a first manifestation of lung adenocarcinoma","volume":"93","author":"Hern\u00e1ndez-Da Mota","year":"2018","journal-title":"Arch Soc Esp Oftalmol"},{"key":"10.1016\/j.ajoc.2026.102605_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000542905","article-title":"A case of metastatic iris tumor from adenocarcinoma of the cecum diagnosed by combined tumor markers in aqueous humor and fine needle aspiration cytology","volume":"18","author":"Mitamura","year":"2025","journal-title":"Case Rep Oncol"},{"key":"10.1016\/j.ajoc.2026.102605_bib12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.14744\/bej.2023.39200","article-title":"Bilateral iris metastasis in a patient with small cell lung carcinoma: a case report","volume":"9","author":"Ciftci","year":"2024","journal-title":"Beyoglu Eye J"},{"key":"10.1016\/j.ajoc.2026.102605_bib13","first-page":"215","article-title":"A case report of intravitreal aflibercept for iris metastasis from small cell lung carcinoma with neovascular glaucoma, Case Rep","volume":"16","author":"Goto","year":"2025","journal-title":"Ophthalmol Times"},{"key":"10.1016\/j.ajoc.2026.102605_bib14","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s13000-024-01553-7","article-title":"A case of masquerade syndrome caused by metastatic iris tumor diagnosed by a high CEA level in the aqueous humor and iris biopsy","volume":"19","author":"Konno","year":"2024","journal-title":"Diagn Pathol"},{"key":"10.1016\/j.ajoc.2026.102605_bib15","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3341\/jkos.2023.64.8.749","article-title":"Iris metastasis of non-small-cell lung cancer confirmed via aqueous humor cytology","author":"Han","year":"2023","journal-title":"Journal of Korean Ophthalmological Society"},{"issue":"12","key":"10.1016\/j.ajoc.2026.102605_bib16","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3341\/jkos.2024.65.12.810","article-title":"Iris metastasis of non-small-cell lung cancer inducing anterior uveitis and secondary glaucoma","volume":"65","author":"Moon","year":"2024","journal-title":"Journal of the Korean Ophthalmological Society"},{"issue":"4","key":"10.1016\/j.ajoc.2026.102605_bib17","first-page":"266","article-title":"Metastatic carcinoma of the iris and ciliary body simulating iridocyclitis","volume":"188","author":"Takahashi","year":"1984","journal-title":"Ophthalmologica"},{"issue":"4","key":"10.1016\/j.ajoc.2026.102605_bib18","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.21873\/invivo.12023","article-title":"A case of metastatic Iris Tumor observed with anterior segment optical coherence tomography before and after radiation therapy","volume":"34","author":"Mitamura","year":"2020","journal-title":"In Vivo"},{"issue":"12","key":"10.1016\/j.ajoc.2026.102605_bib19","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/S0161-6420(83)34375-X","article-title":"Metastatic carcinoma to the iris. Diagnosis by aqueous paracentesis and response to irradiation and chemotherapy","volume":"90","author":"Scholz","year":"1983","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajoc.2026.102605_bib20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/092739490500165","article-title":"The contribution of aqueous humor cytology in the differential diagnosis of anterior uvea inflammations","volume":"12","author":"Kalogeropoulos","year":"2004","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.ajoc.2026.102605_bib21","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/cncy.22384","article-title":"Ocular cytology: diagnostic features and ongoing practices","volume":"129","author":"Laver","year":"2021","journal-title":"Cancer Cytopathol"}],"container-title":["American Journal of Ophthalmology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993626000939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451993626000939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:31:40Z","timestamp":1787862700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451993626000939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":21,"alternative-id":["S2451993626000939"],"URL":"https:\/\/doi.org\/10.1016\/j.ajoc.2026.102605","relation":{},"ISSN":["2451-9936"],"issn-type":[{"value":"2451-9936","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iris metastasis from lung adenocarcinoma diagnosed solely through aqueous humor cytology: A case report","name":"articletitle","label":"Article Title"},{"value":"American Journal of Ophthalmology Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajoc.2026.102605","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102605"}}