{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:33:35Z","timestamp":1789205615802,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajodo.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.ajodo.2006.03.043","type":"journal-article","created":{"date-parts":[[2008,5,9]],"date-time":"2008-05-09T05:45:58Z","timestamp":1210311958000},"page":"690-698","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Substance P increases production of proinflammatory cytokines and formation of osteoclasts in dental pulp fibroblasts in patients with severe orthodontic root resorption"],"prefix":"10.1016","volume":"133","author":[{"given":"Masaru","family":"Yamaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Mishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihito","family":"Aihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajodo.2006.03.043_bib1","first-page":"180","article-title":"Orthodontically induced inflammatory root resorption","volume":"72","author":"Brezniak","year":"2002","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2006.03.043_bib2","first-page":"30","article-title":"Apical root resorption in patients treated with comprehensive orthodontics","volume":"81","author":"Harris","year":"2001","journal-title":"J Tenn Dent Assoc"},{"key":"10.1016\/j.ajodo.2006.03.043_bib3","first-page":"395","article-title":"Continuous versus interrupted continuous orthodontic force related to early tooth movement and root resorption","volume":"65","author":"Owman-Moll","year":"1995","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2006.03.043_bib4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0889-5406(96)80015-1","article-title":"Time-related root resorption after application of a controlled continuous orthodontic force","volume":"110","author":"Kurol","year":"1996","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2006.03.043_bib5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0889-5406(97)70189-6","article-title":"A heritable component for external apical root resorption in patients treated orthodontically","volume":"111","author":"Harris","year":"1997","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2006.03.043_bib6","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0889-5406(99)70187-3","article-title":"External apical root resorption of posterior teeth in asthmatics after orthodontic treatment","volume":"116","author":"McNab","year":"1999","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2006.03.043_bib7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0002-9416(86)90001-1","article-title":"Activation of the vascular system: a main mediator of periodontal fiber remodeling in orthodontic tooth movement","volume":"89","author":"Rygh","year":"1986","journal-title":"Am J Orthod"},{"key":"10.1016\/j.ajodo.2006.03.043_bib8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0889-5406(05)81677-4","article-title":"Iatrogenic pulpal reactions to orthodontic extrusion","volume":"99","author":"Mostafa","year":"1991","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2006.03.043_bib9","first-page":"404","article-title":"Root resorption and pulpal changes due to intrusive force","volume":"2","author":"Kucukkeles","year":"1994","journal-title":"J Marmara Univ Dent Fac"},{"key":"10.1016\/j.ajodo.2006.03.043_bib10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0889-5406(90)70086-R","article-title":"A comparison of apical root resorption during orthodontic treatment in endodontically treated and vital teeth","volume":"97","author":"Spurrier","year":"1990","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2006.03.043_bib11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/ejo\/17.2.93","article-title":"Prevalence and severity of apical root resorption of maxillary anterior teeth in adult orthodontic patients","volume":"17","author":"Mirabella","year":"1995","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2006.03.043_bib12","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0099-2399(97)80353-6","article-title":"Periapical replacement resorption of permanent, vital, endodontically treated incisors after orthodontic movement: report of two cases","volume":"23","author":"Bender","year":"1997","journal-title":"J Endod"},{"key":"10.1016\/j.ajodo.2006.03.043_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/00016357709055992","article-title":"Effects of adrenaline and felypressin (octapressin) on blood flow and sensory nerve activity in the tooth","volume":"35","author":"Olgart","year":"1977","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.ajodo.2006.03.043_bib14","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0003-9969(85)90136-0","article-title":"The distribution and origin of substance P-like immunoreactivity in the rat molar pulp and periodontal tissues","volume":"30","author":"Wakisaka","year":"1985","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.ajodo.2006.03.043_bib15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/07367228709144624","article-title":"An interpretation of dental innervation based upon the pattern of calcitonin gene-related peptide (CGRP)-immunoreactive thin sensory axons","volume":"5","author":"Silverman","year":"1987","journal-title":"Somatosens Res"},{"key":"10.1016\/j.ajodo.2006.03.043_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0006-8993(87)90598-1","article-title":"Numerous nerves with calcitonin gene-related peptide-like immunoreactivity innervate junctional epithelium of rats","volume":"419","author":"Byers","year":"1987","journal-title":"Brain Res"},{"key":"10.1016\/j.ajodo.2006.03.043_bib17","first-page":"339","article-title":"Immunohistochemical study of neuronal markers in human gingiva with phenytoin-induced overgrowth","volume":"96","author":"Luthman","year":"1988","journal-title":"Scand J Dent Res"},{"key":"10.1016\/j.ajodo.2006.03.043_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00266583","article-title":"Peptidergic nerves in human dental pulp","volume":"95","author":"Casasco","year":"1990","journal-title":"Histochemistry"},{"key":"10.1016\/j.ajodo.2006.03.043_bib19","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1749-6632.1998.tb11195.x","article-title":"Main sensory neuropeptides, but not VIP and NPY, are involved in bone remodeling during orthodontic tooth movement in the rat","volume":"865","author":"Norevall","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ajodo.2006.03.043_bib20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/ejo\/17.4.311","article-title":"Expression of neuropeptides (CGRP, substance P) during and after orthodontic tooth movement in the rat","volume":"17","author":"Norevall","year":"1995","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2006.03.043_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00011-003-1243-z","article-title":"Neuropeptides stimulate production of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha in human dental pulp cells","volume":"53","author":"Yamaguchi","year":"2004","journal-title":"Inflamm Res"},{"key":"10.1016\/j.ajodo.2006.03.043_bib22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0002-9416(82)90317-7","article-title":"Root resorption after orthodontic treatment of traumatized teeth","volume":"82","author":"Malmgren","year":"1982","journal-title":"Am J Orthod"},{"key":"10.1016\/j.ajodo.2006.03.043_bib23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/bmme.1996.0079","article-title":"Stimulation of interleukin-1beta-independent interleukin-6 production in human dental pulp cells by lipopolysaccharide","volume":"59","author":"Hosoya","year":"1996","journal-title":"Biochem Mol Med"},{"key":"10.1016\/j.ajodo.2006.03.043_bib24","doi-asserted-by":"crossref","first-page":"12511","DOI":"10.1074\/jbc.271.21.12511","article-title":"Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts","volume":"271","author":"Drake","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajodo.2006.03.043_bib25","first-page":"159","article-title":"Continuous vs. discontinuous force application and root resorption","volume":"69","author":"Acar","year":"1999","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2006.03.043_bib26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/ejo\/23.1.35","article-title":"Ultrastructure of cementum and periodontal ligament after continuous intrusion in humans: a transmission electron microscopy study","volume":"23","author":"Faltin","year":"2001","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2006.03.043_bib27","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0003-9969(83)90064-X","article-title":"Prolyl-hydroxylase activity in odontoblasts from bovine incisor and premolar teeth","volume":"28","author":"Takei","year":"1983","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.ajodo.2006.03.043_bib28","first-page":"416","article-title":"Interleukin-1 and bone metabolism","volume":"64","author":"Tatakis","year":"1993","journal-title":"J Periodontol"},{"key":"10.1016\/j.ajodo.2006.03.043_bib29","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1210\/endo-121-3-1164","article-title":"Comparison of the bone-resorbing activity in the supernatants from phytohemagglutinin-stimulated human peripheral blood mononuclear cells with that of cytokines through the use of an antiserum to interleukin 1","volume":"121","author":"Lorenzo","year":"1987","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajodo.2006.03.043_bib30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0065-2776(08)60642-2","article-title":"Interleukin-1 and its biologically related cytokines","volume":"44","author":"Dinarello","year":"1989","journal-title":"Adv Immunol"},{"key":"10.1016\/j.ajodo.2006.03.043_bib31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF02557686","article-title":"Pig interleukin 1 (catabolin) is a potent stimulator of bone resorption in vitro","volume":"37","author":"Heath","year":"1985","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.ajodo.2006.03.043_bib32","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.4049\/jimmunol.145.10.3297","article-title":"IL-6 is produced by osteoblasts and induces bone resorption","volume":"145","author":"Ishimi","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.ajodo.2006.03.043_bib33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0196-0709(91)90041-D","article-title":"The role of tumor necrosis factor-alpha in bone resorption of cholesteatoma","volume":"12","author":"Yan","year":"1991","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.ajodo.2006.03.043_bib34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cytogfr.2003.10.005","article-title":"IL-6, RANKL, TNF-alpha\/IL-1: interrelations in bone resorption pathophysiology","volume":"15","author":"Kwan Tat","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.ajodo.2006.03.043_bib35","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1067\/mod.2003.42","article-title":"Genetic predisposition to external apical root resorption","volume":"123","author":"Al-Qawasmi","year":"2003","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2006.03.043_bib36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00441-003-0753-x","article-title":"Sympathectomy causes increased root resorption after orthodontic tooth movement in rats: immunohistochemical study","volume":"313","author":"Haug","year":"2003","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ajodo.2006.03.043_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ejo\/cjh089","article-title":"Soluble cytokine receptor treatment in experimental orthodontic tooth movement in the rat","volume":"27","author":"J\u00e4ger","year":"2005","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2006.03.043_bib38","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF02411252","article-title":"Bone acid phosphatase: tartrate-resistant acid phosphatase as a marker of osteoclast function","volume":"34","author":"Minkin","year":"1982","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.ajodo.2006.03.043_bib39","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/BF00298591","article-title":"An ultrastructural evaluation of the effects of cysteine-proteinase inhibitors on osteoclastic resorptive functions","volume":"56","author":"Debari","year":"1995","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.ajodo.2006.03.043_bib40","doi-asserted-by":"crossref","first-page":"8109","DOI":"10.1074\/jbc.272.13.8109","article-title":"Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption","volume":"272","author":"Inui","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajodo.2006.03.043_bib41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0928-4931(98)00052-6","article-title":"How do osteoclasts resorb bone?","volume":"6","author":"V\u00e4\u00e4n\u00e4nen","year":"1998","journal-title":"Mat Sci Eng C"},{"key":"10.1016\/j.ajodo.2006.03.043_bib42","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/(SICI)1097-0185(199805)251:1<80::AID-AR13>3.0.CO;2-7","article-title":"Effect of orthodontic appliance reactivation during the period of peak expansion in the osteoclast population","volume":"251","author":"Hughes","year":"1998","journal-title":"Anat Rec"},{"key":"10.1016\/j.ajodo.2006.03.043_bib43","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0003-9969(99)00091-6","article-title":"In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing tissue induced by tooth movement","volume":"44","author":"Domon","year":"1999","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.ajodo.2006.03.043_bib44","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/00016480410017710","article-title":"Substance P upregulates osteoclastogenesis by activating nuclear factor kappa B in osteoclast precursors","volume":"125","author":"Sohn","year":"2005","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.ajodo.2006.03.043_bib45","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/000163501317153239","article-title":"Effect of denervation on healing after tooth replantation in the ferret","volume":"59","author":"Berggreen","year":"2001","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.ajodo.2006.03.043_bib46","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/ejo\/15.6.467","article-title":"Non-clast cells start orthodontic root resorption in the periphery of hyalinized zones","volume":"15","author":"Brudvik","year":"1993","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2006.03.043_bib47","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/ejo\/16.4.249","article-title":"Root resorption beneath the main hyalinized zone","volume":"16","author":"Brudvik","year":"1994","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2006.03.043_bib48","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1067\/mod.2001.110809","article-title":"Orthodontic tooth movement and de novo synthesis of proinflammatory cytokines","volume":"119","author":"Alhashimi","year":"2001","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2006.03.043_bib49","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0889-5406(95)70052-8","article-title":"Orthodontic forces increase tumor necrosis factor alpha in the human gingival sulcus","volume":"108","author":"Lowney","year":"1995","journal-title":"Am J Orthod Dentofacial Orthop"}],"container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540607012413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540607012413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:44:27Z","timestamp":1760172267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889540607012413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0889540607012413"],"URL":"https:\/\/doi.org\/10.1016\/j.ajodo.2006.03.043","relation":{},"ISSN":["0889-5406"],"issn-type":[{"value":"0889-5406","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Substance P increases production of proinflammatory cytokines and formation of osteoclasts in dental pulp fibroblasts in patients with severe orthodontic root resorption","name":"articletitle","label":"Article Title"},{"value":"American Journal of Orthodontics and Dentofacial Orthopedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajodo.2006.03.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}