{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:42:17Z","timestamp":1760236937182,"version":"build-2065373602"},"reference-count":56,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajodo.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.ajodo.2009.10.032","type":"journal-article","created":{"date-parts":[[2010,5,7]],"date-time":"2010-05-07T06:20:50Z","timestamp":1273213250000},"page":"584.e1-584.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Patterns of tooth agenesis in patients with Down syndrome in relation to hypothyroidism and congenital heart disease: An aid for treatment planning"],"prefix":"10.1016","volume":"137","author":[{"given":"Wimke","family":"Reuland-Bosma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merijn C.","family":"Reuland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewald","family":"Bronkhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khee Hian","family":"Phoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5696","key":"10.1016\/j.ajodo.2009.10.032_bib1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1126\/science.1098992","article-title":"A chromosome 21 critical region does not cause specific Down syndrome phenotypes","volume":"306","author":"Olson","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ajodo.2009.10.032_bib2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1079-2104(97)90343-7","article-title":"Down syndrome: a review of the literature","volume":"84","author":"Desai","year":"1997","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.ajodo.2009.10.032_bib3","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1210\/jc.2005-0130","article-title":"The effect of thyroxine treatment started in the neonatal period on development and growth of two-year-old Down syndrome children: a randomized clinical trial","volume":"90","author":"van Trotsenburg","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajodo.2009.10.032_bib4","first-page":"539","article-title":"Growth and development of selected hard tissues in Down syndrome: a review","volume":"55","author":"Barden","year":"1983","journal-title":"Hum Biol"},{"issue":"Suppl","key":"10.1016\/j.ajodo.2009.10.032_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/00220345650440011601","article-title":"Dental and facial characteristics in Down's syndrome (mongolism)","volume":"44","author":"Cohen","year":"1965","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2009.10.032_bib6","article-title":"Congenitally absent permanent teeth among mongols and their sibs","author":"Orner","year":"1971","journal-title":"J Ment Defic Res"},{"key":"10.1016\/j.ajodo.2009.10.032_bib7","first-page":"133","article-title":"Distribution of missing teeth and tooth morphology in patients with oligodontia","volume":"59","author":"Schalk-van der Weide","year":"1992","journal-title":"ASDC J Dent Child"},{"key":"10.1016\/j.ajodo.2009.10.032_bib8","first-page":"290","article-title":"Prevalence of tooth transposition, third molar agenesis, and maxillary canine impaction in\u00a0individuals with Down syndrome","volume":"70","author":"Shapira","year":"2000","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2009.10.032_bib9","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0002-9416(73)90291-1","article-title":"Dentoalveolar morphology and developmental changes in Down's syndrome (trisomy 21)","volume":"64","author":"Jensen","year":"1973","journal-title":"Am J Orthod"},{"key":"10.1016\/j.ajodo.2009.10.032_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0003-9969(83)90123-1","article-title":"Tooth size in children and young adults with trisomy 21 (Down) syndrome","volume":"28","author":"Townsend","year":"1983","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.ajodo.2009.10.032_bib11","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/ajhb.1107","article-title":"Effect of Down syndrome on the dimensions of dental crowns and tissues","volume":"13","author":"Bell","year":"2001","journal-title":"Am J Hum Biol"},{"key":"10.1016\/j.ajodo.2009.10.032_bib12","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1590\/S0103-64402007000400014","article-title":"Dental anomalies in patients with Down syndrome","volume":"18","author":"de Moraes","year":"2007","journal-title":"Braz Dent J"},{"key":"10.1016\/j.ajodo.2009.10.032_bib13","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/ajmg.1320550415","article-title":"Tooth agenesis in Down syndrome","volume":"55","author":"Russell","year":"1995","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.ajodo.2009.10.032_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/ejo\/8.1.12","article-title":"Position of the maxillary permanent canine in relation to anomalous or missing lateral incisors: a\u00a0population study","volume":"8","author":"Brin","year":"1986","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2009.10.032_bib15","doi-asserted-by":"crossref","first-page":"996","DOI":"10.2319\/082905-303","article-title":"Hypodontia patterns and variations in craniofacial morphology in Japanese orthodontic patients","volume":"76","author":"Endo","year":"2006","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2009.10.032_bib16","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1600-051X.1986.tb02225.x","article-title":"Experimental gingivitis around deciduous teeth in children with Down's syndrome","volume":"13","author":"Reuland-Bosma","year":"1986","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.ajodo.2009.10.032_bib17","first-page":"234","article-title":"\u2018Emily goes to the dentist.\u2019 Oral care for individuals with Down syndrome","volume":"113","author":"Bouvy-Berends","year":"2006","journal-title":"Ned Tijdschr Tandheelkd"},{"key":"10.1016\/j.ajodo.2009.10.032_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/ejo\/8.1.35","article-title":"Craniofacial development in patients with Down's syndrome from birth to 14 years of age","volume":"8","author":"Fischer-Brandies","year":"1986","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2009.10.032_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1754-4505.2008.00020.x","article-title":"Skeletal age of individuals with Down syndrome","volume":"28","author":"de Moraes","year":"2008","journal-title":"Spec Care Dentist"},{"key":"10.1016\/j.ajodo.2009.10.032_bib20","first-page":"63","article-title":"Observations from longitudinal data on growth in stature and sitting height of children with Down's syndrome","volume":"18","author":"Rarick","year":"1974","journal-title":"J Ment Defic Res"},{"key":"10.1016\/j.ajodo.2009.10.032_bib21","first-page":"316","article-title":"Tooth size and tooth formation in children with advanced hypodontia","volume":"44","author":"Rune","year":"1974","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2009.10.032_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/000163500429280","article-title":"Dental maturity in Finns and the problem of missing teeth","volume":"58","author":"Nystrom","year":"2000","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.ajodo.2009.10.032_bib23","first-page":"83","article-title":"Tooth numbering progress","volume":"66","author":"Peck","year":"1996","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2009.10.032_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1600-0722.2006.00340.x","article-title":"A numeric code for identifying patterns of human tooth agenesis: a new approach","volume":"114","author":"van Wijk","year":"2006","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.ajodo.2009.10.032_bib25","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1754-4505.2001.tb00230.x","article-title":"Prevalence of numeric anomalies in the permanent dentition of patients with Down syndrome","volume":"2","author":"Acerbi","year":"2001","journal-title":"Spec Care Dentist"},{"key":"10.1016\/j.ajodo.2009.10.032_bib26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1754-4505.1997.tb00884.x","article-title":"Oligodontia: a radiographic comparison of subjects with Down syndrome and normal subjects","volume":"17","author":"Kumasaka","year":"1997","journal-title":"Spec Care Dentist"},{"issue":"Suppl","key":"10.1016\/j.ajodo.2009.10.032_bib27","first-page":"69","article-title":"Hypodontia in patients with Down's syndrome","volume":"22","author":"Mestrovic","year":"1998","journal-title":"Coll Antropol"},{"key":"10.1016\/j.ajodo.2009.10.032_bib28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/sj.bmt.1703330","article-title":"Long-term adverse effects on dentition in children with poor-risk neuroblastoma treated with high-dose chemotherapy and autologous stem cell transplantation with or without total body irradiation","volume":"29","author":"Holtta","year":"2002","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.ajodo.2009.10.032_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1834-7819.2005.tb00347.x","article-title":"Epigenetic influences may explain dental differences in monozygotic twin pairs","volume":"50","author":"Townsend","year":"2005","journal-title":"Aust Dent J"},{"key":"10.1016\/j.ajodo.2009.10.032_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1600-0528.2004.00158.x","article-title":"A meta-analysis of the prevalence of dental agenesis of permanent teeth","volume":"32","author":"Polder","year":"2004","journal-title":"Community Dent Oral Epidemiol"},{"key":"10.1016\/j.ajodo.2009.10.032_bib31","first-page":"197","article-title":"Differential cellular growth in the organs of hypothyroid rats","volume":"34","author":"Brasel","year":"1970","journal-title":"Growth"},{"key":"10.1016\/j.ajodo.2009.10.032_bib32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000087648","article-title":"Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat","volume":"81","author":"Ambrogini","year":"2005","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ajodo.2009.10.032_bib33","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.mod.2007.09.003","article-title":"Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning","volume":"124","author":"Kettunen","year":"2007","journal-title":"Mech Dev"},{"key":"10.1016\/j.ajodo.2009.10.032_bib34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0003-9969(94)90107-4","article-title":"Osteogenesis of the mandibular arch in Ts16 mice","volume":"39","author":"Di Stefano","year":"1994","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.ajodo.2009.10.032_bib35","first-page":"394","article-title":"A review of the intraosseous course of the nerves of the mandible","volume":"17","author":"Anderson","year":"1991","journal-title":"J Oral Implantol"},{"key":"10.1016\/j.ajodo.2009.10.032_bib36","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1177\/00220345960750080401","article-title":"The human mandibular canal arises from three separate canals innervating different tooth groups","volume":"75","author":"Chavez-Lomeli","year":"1996","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2009.10.032_bib37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1179\/bjo.21.2.169","article-title":"The palatal canine and the adjacent lateral incisor: a study of a west of Scotland population","volume":"21","author":"Mossey","year":"1994","journal-title":"Br J Orthod"},{"key":"10.1016\/j.ajodo.2009.10.032_bib38","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/00220345540330011601","article-title":"Hormonal control of tooth eruption. I. The effect of thyroidectomy of the upper rat incisor and the response to growth hormone, thyroxin, or the combination of both","volume":"33","author":"Baume","year":"1954","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2009.10.032_bib39","first-page":"167","article-title":"Dental changes in juvenile hypothyrodism","volume":"33","author":"Hinrichs","year":"1966","journal-title":"J Dent Child"},{"key":"10.1016\/j.ajodo.2009.10.032_bib40","first-page":"64","article-title":"Mandibular and dental development subsequent to thyroid therapy in a boy with Down syndrome: report of case","volume":"58","author":"Reuland-Bosma","year":"1991","journal-title":"ASDC J Dent Child"},{"key":"10.1016\/j.ajodo.2009.10.032_bib41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1096-8628(19981116)80:3<213::AID-AJMG6>3.0.CO;2-8","article-title":"Population-based study of congenital heart defects in Down syndrome","volume":"80","author":"Freeman","year":"1998","journal-title":"Am J Med Genet"},{"issue":"7093","key":"10.1016\/j.ajodo.2009.10.032_bib42","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nature04678","article-title":"NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21","volume":"441","author":"Arron","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ajodo.2009.10.032_bib43","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1074\/jbc.M210250200","article-title":"NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells","volume":"278","author":"Johnson","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajodo.2009.10.032_bib44","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1242\/dev.128.9.1531","article-title":"A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects","volume":"128","author":"Dor","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ajodo.2009.10.032_bib45","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.aanat.2007.11.006","article-title":"Immunocytochemical localization of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 of the human deciduous molar tooth germ development in the human fetus","volume":"190","author":"Miwa","year":"2008","journal-title":"Ann Anat"},{"key":"10.1016\/j.ajodo.2009.10.032_bib46","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.joen.2007.08.019","article-title":"Vascular endothelial growth factor receptor-2 expression in the pulp of human primary and young permanent teeth","volume":"33","author":"Grando Mattuella","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.ajodo.2009.10.032_bib47","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/039463200501800319","article-title":"Vascular endothelial growth factor (VEGF) in human tooth germ center","volume":"18","author":"Mastrangelo","year":"2005","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.ajodo.2009.10.032_bib48","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1016\/j.febslet.2006.09.053","article-title":"Neurogenic effect of vascular endothelial growth factor during germ layer formation of human embryonic stem cells","volume":"580","author":"Kim","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.ajodo.2009.10.032_bib49","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/S0003-4975(02)04814-2","article-title":"Vascular endothelial growth factor in children with congenital heart disease","volume":"75","author":"Ootaki","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ajodo.2009.10.032_bib50","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/00220345540330010201","article-title":"Hormonal control of tooth eruption. III. The response of the incisors of hypophysectomized rats to growth hormone, thyroxin, or the combination of both","volume":"33","author":"Baume","year":"1954","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.ajodo.2009.10.032_bib51","first-page":"169","article-title":"Effect of thyroxine and growth hormone on dentin production in maxillary incisors in the rat","volume":"86","author":"Hansson","year":"1978","journal-title":"Scand J Dent Res"},{"key":"10.1016\/j.ajodo.2009.10.032_bib52","first-page":"181","article-title":"Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months","volume":"9","author":"Schmidt-Sidor","year":"1990","journal-title":"Clin Neuropathol"},{"issue":"Suppl 2","key":"10.1016\/j.ajodo.2009.10.032_bib53","doi-asserted-by":"crossref","first-page":"S439","DOI":"10.1007\/s00259-002-0905-3","article-title":"Thyroid disorders in children from birth to adolescence","volume":"29","author":"Bettendorf","year":"2002","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.ajodo.2009.10.032_bib54","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1177\/00220345690480052301","article-title":"The time-structure relationship to tooth development in human embryogenesis","volume":"48","author":"Tonge","year":"1969","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2009.10.032_bib55","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-3-642-68006-9_12","article-title":"Functional implications of gene dosage effects in trisomy 21","volume":"2","author":"Epstein","year":"1981","journal-title":"Hum Genet Suppl"},{"key":"10.1016\/j.ajodo.2009.10.032_bib56","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ydbio.2003.10.036","article-title":"DSCR1 gene expression is\u00a0dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice","volume":"266","author":"Lange","year":"2004","journal-title":"Dev Biol"}],"container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540610000211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540610000211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:48:56Z","timestamp":1760172536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889540610000211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0889540610000211"],"URL":"https:\/\/doi.org\/10.1016\/j.ajodo.2009.10.032","relation":{},"ISSN":["0889-5406"],"issn-type":[{"type":"print","value":"0889-5406"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patterns of tooth agenesis in patients with Down syndrome in relation to hypothyroidism and congenital heart disease: An aid for treatment planning","name":"articletitle","label":"Article Title"},{"value":"American Journal of Orthodontics and Dentofacial Orthopedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajodo.2009.10.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ajodo.2010.01.013","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}