{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:28:54Z","timestamp":1790166534152,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajodo.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.ajodo.2010.01.031","type":"journal-article","created":{"date-parts":[[2010,11,4]],"date-time":"2010-11-04T04:18:12Z","timestamp":1288844292000},"page":"548.e1-548.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of clodronate on early alveolar bone remodeling and root resorption related to orthodontic forces: A histomorphometric analysis"],"prefix":"10.1016","volume":"138","author":[{"given":"Josefina","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hak","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Il","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Il","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajodo.2010.01.031_bib1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S8756-3282(01)00655-X","volume":"30","author":"Van Beek","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.ajodo.2010.01.031_bib2","doi-asserted-by":"crossref","first-page":"945","DOI":"10.2165\/00003495-199447060-00007","article-title":"Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease","volume":"47","author":"Plosker","year":"1994","journal-title":"Drugs"},{"key":"10.1016\/j.ajodo.2010.01.031_bib3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S8756-3282(03)00229-1","article-title":"Long-term analgesic effect of clodronate in rodents","volume":"33","author":"Bonabello","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.ajodo.2010.01.031_bib4","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1172\/JCI118722","article-title":"Bisphosphonates: mechanisms of action","volume":"97","author":"Rodan","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajodo.2010.01.031_bib5","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0149-2918(99)80022-8","article-title":"Diagnosis and management of osteoporosis in postmenopausal women: clinical guidelines. International Committee for Osteoporosis Clinical Guidelines","volume":"21","author":"Meunier","year":"1999","journal-title":"Clin Ther"},{"key":"10.1016\/j.ajodo.2010.01.031_bib6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S8756-3282(96)00285-2","article-title":"Clodronate decreases the frequency of skeletal metastases in women with breast cancer","volume":"19","author":"Kanis","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.ajodo.2010.01.031_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/8756-3282(95)00442-4","article-title":"Cyclical intravenous clodronate in postmenopausal osteoporosis: results of a long-term clinical trial","volume":"18","author":"Filipponi","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.ajodo.2010.01.031_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s001980050010","article-title":"Vertebral Efficacy with Risedronate Therapy (VERT) Study Group","volume":"11","author":"Reginster","year":"2000","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.ajodo.2010.01.031_bib9","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1046\/j.1365-2141.2001.02851.x","article-title":"Long-term follow-up of a prospective, double-blind, placebo-controlled randomized trial of clodronate in multiple myeloma","volume":"113","author":"McCloskey","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ajodo.2010.01.031_bib10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/BF02555852","article-title":"Inhibition of bone resorption by bisphosphonates: interactions between bisphosphonates, osteoclasts, and bone","volume":"49","author":"Flanagan","year":"1991","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.ajodo.2010.01.031_bib11","first-page":"121","article-title":"Clodronate stimulates bone formation as well as inhibits bone resorption and increases bone mineral density in rats fed a low-calcium diet","volume":"50","author":"Horie","year":"2003","journal-title":"J Med Dent Sci"},{"key":"10.1016\/j.ajodo.2010.01.031_bib12","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1177\/00220345940730081301","article-title":"Effects of topical administration of a bisphosphonate (risedronate) on orthodontic tooth movements in rats","volume":"73","author":"Adachi","year":"1994","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2010.01.031_bib13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0889-5406(94)70048-6","article-title":"Anchorage and retentive effects of a bisphosphonate (AHBuBP) on tooth movements in rats","volume":"106","author":"Igarashi","year":"1994","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2010.01.031_bib14","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1177\/00220345960750090501","article-title":"Inhibitory effect of the topical administration of a bisphosphonate (risedronate) on root resorption incident to orthodontic tooth movement in rats","volume":"75","author":"Igarashi","year":"1996","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.ajodo.2010.01.031_bib15","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/ejo\/26.5.469","article-title":"Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats","volume":"26","author":"Liu","year":"2004","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2010.01.031_bib16","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1002\/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.0.CO;2-L","article-title":"Cellular and molecular mechanisms of action of bisphosphonates","volume":"88","author":"Rogers","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ajodo.2010.01.031_bib17","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1002\/1529-0131(200109)44:9<2201::AID-ART374>3.0.CO;2-E","article-title":"The molecular mechanism of action of the antiresorptive and anti-inflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis","volume":"44","author":"Frith","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ajodo.2010.01.031_bib18","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0889-5406(95)70035-8","article-title":"The effects of exogenous prostaglandins on orthodontic tooth movement in rats","volume":"108","author":"Leiker","year":"1995","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2010.01.031_bib19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1067\/mod.2001.118623","article-title":"Osteoclast recruitment to sites of compression in orthodontic tooth movement","volume":"120","author":"Rody","year":"2001","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2010.01.031_bib20","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1359\/jbmr.2003.18.5.852","article-title":"Sustained antiresorptive effects after a single treatment with human recombinant osteoprotegerin (OPG): a pharmacodynamic and pharmacokinetic analysis in rats","volume":"18","author":"Capparelli","year":"2003","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.ajodo.2010.01.031_bib21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ajodo.2004.02.024","article-title":"Peri-implant bone response to orthodontic loading: part 2. Implant surface geometry and its effect on regional bone remodeling","volume":"128","author":"Oyonarte","year":"2005","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2010.01.031_bib22","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1600-0714.1982.tb00172.x","article-title":"A method for the study of undecalcified bones and teeth with attached soft tissues. The S\u00e4ge-Schliff (sawing and grinding) technique","volume":"11","author":"Donath","year":"1982","journal-title":"J Oral Pathol"},{"key":"10.1016\/j.ajodo.2010.01.031_bib23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/ejo\/25.2.199","article-title":"The effect of prostaglandin E2 and calcium gluconate on orthodontic tooth movement and root resorption in rats","volume":"25","author":"Seifi","year":"2003","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2010.01.031_bib24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/8756-3282(88)90029-4","article-title":"Bone histomorphometry: standardization of nomenclature, symbols and units (summary of proposed system)","volume":"9","author":"Parfitt","year":"1988","journal-title":"Bone"},{"key":"10.1016\/j.ajodo.2010.01.031_bib25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00008505-199807040-00009","article-title":"Overview of surface variability of metallic endosseous dental implants: textured and porous surface-structured designs","volume":"7","author":"Pilliar","year":"1998","journal-title":"Implant Dent"},{"key":"10.1016\/j.ajodo.2010.01.031_bib26","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ajodo.2004.11.030","article-title":"Inhibition of orthodontically induced root resorption with echistatin, an RGD-containing peptide","volume":"129","author":"Talic","year":"2006","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2010.01.031_bib27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/ejo\/25.4.359","article-title":"Bone turnover rate in rats does not influence root resorption induced by orthodontic treatment","volume":"25","author":"Verna","year":"2003","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2010.01.031_bib28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1034\/j.1600-0544.2000.030202.x","article-title":"Orthodontically stressed periodontium of transgenic mouse as a model for studying mechanical response in bone: the effect on the number of osteoblasts","volume":"3","author":"Pavlin","year":"2000","journal-title":"Clin Orthod Res"},{"key":"10.1016\/j.ajodo.2010.01.031_bib29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1600-0722.2007.00433.x","article-title":"Inhibition of tooth movement by osteoprotegerin vs. pamidronate under conditions of constant orthodontic force","volume":"115","author":"Keles","year":"2007","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.ajodo.2010.01.031_bib30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/8756-3282(91)90029-I","article-title":"Histomorphometric study of alveolar bone turnover in orthodontic tooth movement","volume":"12","author":"King","year":"1991","journal-title":"Bone"},{"key":"10.1016\/j.ajodo.2010.01.031_bib31","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S8756-3282(01)00615-9","article-title":"Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis","volume":"29","author":"Halasy-Nagy","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.ajodo.2010.01.031_bib32","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1177\/154405910608500813","article-title":"Clodronate inhibits PGE(2) production in compressed periodontal ligament cells","volume":"85","author":"Liu","year":"2006","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2010.01.031_bib33","first-page":"425","article-title":"Bisphosphonates and orthodontics: clinical implications","volume":"40","author":"Graham","year":"2006","journal-title":"J Clin Orthod"},{"key":"10.1016\/j.ajodo.2010.01.031_bib34","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ajodo.2006.09.035","article-title":"Bisphosphonate treatment: an orthodontic concern calling for a proactive approach","volume":"131","author":"Zahrowski","year":"2007","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2010.01.031_bib35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ajodo.2008.08.017","article-title":"Optimizing orthodontic treatment in patients taking bisphosphonates for osteoporosis","volume":"135","author":"Zahrowski","year":"2009","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2010.01.031_bib36","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1359\/jbmr.040116","article-title":"Clodronate reduces vertebral fracture risk in women with postmenopausal or secondary osteoporosis: results of a double-blind, placebo-controlled 3-year study","volume":"19","author":"McCloskey","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ajodo.2010.01.031_bib37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/8756-3282(93)90240-B","article-title":"Effects of one-year cyclical treatment with clodronate on postmenopausal bone loss","volume":"14","author":"Giannini","year":"1993","journal-title":"Bone"},{"key":"10.1016\/j.ajodo.2010.01.031_bib38","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/1097-0142(20010401)91:7<1191::AID-CNCR1119>3.0.CO;2-0","article-title":"Zoledronic acid reduces skeletal-related events in patients with osteolytic metastases","volume":"91","author":"Berenson","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.ajodo.2010.01.031_bib39","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1056\/NEJMoa011807","article-title":"Intravenous zoledronic acid in postmenopausal women with low bone mineral density","volume":"346","author":"Reid","year":"2002","journal-title":"N Eng J Med"}],"container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088954061000613X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088954061000613X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:50:14Z","timestamp":1760172614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088954061000613X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S088954061000613X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajodo.2010.01.031","relation":{},"ISSN":["0889-5406"],"issn-type":[{"value":"0889-5406","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of clodronate on early alveolar bone remodeling and root resorption related to orthodontic forces: A histomorphometric analysis","name":"articletitle","label":"Article Title"},{"value":"American Journal of Orthodontics and Dentofacial Orthopedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajodo.2010.01.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ajodo.2010.07.003","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}