{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:04:03Z","timestamp":1790024643265,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajodo.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.ajodo.2012.05.019","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T04:32:55Z","timestamp":1351571575000},"page":"625-634.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Bisphosphonates as a risk factor for adverse orthodontic outcomes: A retrospective cohort study"],"prefix":"10.1016","volume":"142","author":[{"given":"Raj B.","family":"Lotwala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey M.","family":"Greenlee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanton H.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg J.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajodo.2012.05.019_bib1","doi-asserted-by":"crossref","first-page":"864","DOI":"10.14219\/jada.archive.2009.0280","article-title":"Bisphosphonate and nonbisphosphonate-associated osteonecrosis of the jaw. A review","volume":"140","author":"Almazrooa","year":"2009","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.ajodo.2012.05.019_bib2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.jdent.2010.05.012","article-title":"Influence of bisphosphonates in orthodontic therapy: systematic review","volume":"38","author":"Iglesias-Linares","year":"2010","journal-title":"J Dent"},{"key":"10.1016\/j.ajodo.2012.05.019_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/SCS.0b013e3181c347a0","article-title":"Bisphosphonate-related osteonecrosis of the jaw: tip of the iceberg","volume":"21","author":"Knight","year":"2010","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.ajodo.2012.05.019_bib4","first-page":"25","article-title":"The top 200 brand drugs in 2005","volume":"150","author":"Ukens","year":"2006","journal-title":"Drug Topics"},{"key":"10.1016\/j.ajodo.2012.05.019_bib5","first-page":"8","article-title":"Oral bisphosphonates and osteonecrosis of the jaws","volume":"55","author":"Wynn","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajodo.2012.05.019_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jcms.2007.06.008","article-title":"\u201cBis-phossy jaws\u201d\u2014high and low risk factors for bisphosphonate-induced osteonecrosis of the jaw","volume":"36","author":"Abu-Id","year":"2008","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.ajodo.2012.05.019_bib7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1196\/annals.1346.041","article-title":"Bisphosphonates: from bench to bedside","volume":"1068","author":"Russell","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ajodo.2012.05.019_bib8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.joms.2007.09.019","article-title":"Outcomes of placing dental implants in patients taking oral bisphosphonates: a review of 115 cases","volume":"66","author":"Grant","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ajodo.2012.05.019_bib9","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (aredia) and zoledronate (zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ajodo.2012.05.019_bib10","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases","volume":"62","author":"Ruggiero","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ajodo.2012.05.019_bib11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/cncr.21130","article-title":"Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone\u2014an emerging oral complication of supportive cancer therapy","volume":"104","author":"Migliorati","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.ajodo.2012.05.019_bib12","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment","volume":"63","author":"Marx","year":"2005","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ajodo.2012.05.019_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/8756-3282(95)00445-9","article-title":"Bisphosphonates: a review of the pharmokinetic properties","volume":"18","author":"Lin","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.ajodo.2012.05.019_bib14","doi-asserted-by":"crossref","DOI":"10.7326\/0003-4819-145-10-200611210-00023","article-title":"Systematic review: bisphosphonates and osteonecrosis of the jaws","volume":"145","author":"Woo","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajodo.2012.05.019_bib15","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1016\/j.joms.2011.03.051","article-title":"Nationwide survey for bisphosphonate-related osteonecrosis of the jaws in Japan","volume":"69","author":"Urade","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ajodo.2012.05.019_bib16","first-page":"594","article-title":"A survey of bisphosphonate-related osteomyelitis\/osteonecrosis of the jaws","volume":"53","author":"Shimahara","year":"2007","journal-title":"Jpn J Oral Maxillfac Surg"},{"key":"10.1016\/j.ajodo.2012.05.019_bib17","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1177\/00220345960750090501","article-title":"Inhibitory effect of the topical administraion of a bisphosphonate (risedronate) on root resorption incident to orthodontic tooth movement in rats","volume":"75","author":"Igarashi","year":"1996","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2012.05.019_bib18","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.ajodo.2007.11.035","article-title":"Effect of alendronate on orthodontic tooth movement in rats","volume":"136","author":"Karras","year":"2009","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2012.05.019_bib19","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0889-5406(99)70290-8","article-title":"An ultrastructural study of the effects of bisphosphonate administration on osteoclastic bone resorption during relapse of experimentally moved rat molars","volume":"115","author":"Kim","year":"1999","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2012.05.019_bib20","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/ejo\/cjp068","article-title":"Influence of bisphosphonates on orthodontic tooth movement in mice","volume":"31","author":"Fujimura","year":"2009","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2012.05.019_bib21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ajodo.2008.08.017","article-title":"Optimizing orthodontic treatment in patients taking bisphosphonates for osteoporosis","volume":"135","author":"Zahrowski","year":"2009","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2012.05.019_bib22","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ajodo.2006.11.002","article-title":"Orthodontic treatment of patients using bisphosphonates: a report of 2 cases","volume":"131","author":"Rinchuse","year":"2007","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2012.05.019_bib23","first-page":"625","article-title":"2009 orthodontic practice study, part I: trends","volume":"43","author":"Keim","year":"2009","journal-title":"J Clin Orthod"},{"key":"10.1016\/j.ajodo.2012.05.019_bib24","doi-asserted-by":"crossref","first-page":"545","DOI":"10.14219\/jada.archive.2008.0214","article-title":"Osteoporosis and its implications for dental patients","volume":"139","author":"Edwards","year":"2008","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.ajodo.2012.05.019_bib25","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.14219\/jada.archive.2008.0110","article-title":"Updated recommendations for managing the care of patients receiving oral bisphosphonate therapy: an advisory statement from the American Dental Association Council on Scientific Affairs","volume":"139","author":"Edwards","year":"2008","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.ajodo.2012.05.019_bib26","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.14219\/jada.archive.2011.0108","article-title":"Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis: executive summary of recommendations from the American Dental Association Council on Scientific Affairs","volume":"142","author":"Hellstein","year":"2011","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.ajodo.2012.05.019_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/pds.1273","article-title":"Changes in pattern of use, clinical characteristics and persistence rate of hormone replacement therapy among postmenopausal women after the WHI publication","volume":"16","author":"Guay","year":"2007","journal-title":"Pharmacoepidemiol Drug Safety"},{"key":"10.1016\/j.ajodo.2012.05.019_bib28","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1093\/oxfordjournals.aje.a009609","article-title":"International variability in ages at menarche, first livebirth, and menopause","volume":"148","author":"Morabia","year":"1998","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ajodo.2012.05.019_bib29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00776-007-1133-2","article-title":"The osteoporosis revolution marches on","volume":"12","author":"Raisz","year":"2007","journal-title":"J Orthop Sci"},{"key":"10.1016\/j.ajodo.2012.05.019_bib30","first-page":"484","article-title":"Adverse events and intravenous versus oral bisphosphonate use in patients with osteoporosis and cancer in the U.S","volume":"58","author":"Skrepnek","year":"2010","journal-title":"Gen Dent"},{"key":"10.1016\/j.ajodo.2012.05.019_bib31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jbmr.189","article-title":"Estimating bisphosphonate use and fracture reduction among US women aged 45 years and older, 2001-2008","volume":"26","author":"Siris","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ajodo.2012.05.019_bib32","first-page":"94","article-title":"Extraction-nonextraction dilemma","volume":"5","author":"Gera","year":"2011","journal-title":"J Indian Dent Assoc"},{"key":"10.1016\/j.ajodo.2012.05.019_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.14219\/jada.archive.2008.0016","article-title":"Bisphosphonate use and the risk of adverse jaw outcomes","volume":"139","author":"Cartsos","year":"2008","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.ajodo.2012.05.019_bib34","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1834-7819.2010.01283.x","article-title":"A review of the clinical implications of bisphosphonates in dentistry","volume":"56","author":"Borromeo","year":"2011","journal-title":"Aust Dent J"},{"key":"10.1016\/j.ajodo.2012.05.019_bib35","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1056\/NEJMp068157","article-title":"Osteonecrosis of the jaw\u2014do bisphosphonates pose a risk?","volume":"355","author":"Bilezikian","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajodo.2012.05.019_bib36","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.joms.2006.10.061","article-title":"Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia","volume":"65","author":"Mavrokokki","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ajodo.2012.05.019_bib37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.joms.2009.03.050","article-title":"Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure","volume":"68","author":"Lo","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ajodo.2012.05.019_bib38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.14219\/jada.archive.2009.0019","article-title":"Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw: an institutional inquiry","volume":"140","author":"Sedghizadeh","year":"2009","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.ajodo.2012.05.019_bib39","doi-asserted-by":"crossref","first-page":"e505","DOI":"10.1016\/j.ajodo.2010.11.019","article-title":"Influence of root parallelism on the stability of extraction-site closures","volume":"139","author":"Chiqueto","year":"2011","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2012.05.019_bib40","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1067\/mod.2002.119435","article-title":"The accuracy of 4 panoramic units in the projection of mesiodistal tooth angulations","volume":"121","author":"McKee","year":"2002","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2012.05.019_bib41","article-title":"Some drugs affect tooth movement","volume":"127","author":"Schwartz","year":"2005","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"12 Suppl","key":"10.1016\/j.ajodo.2012.05.019_bib42","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1002\/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.0.CO;2-L","article-title":"Cellular and molecular mechanisms of action of bisphosphonates","volume":"88","author":"Rogers","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ajodo.2012.05.019_bib43","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3949\/ccjm.78a.11022","article-title":"What is the optimal duration of bisphosphonate therapy?","volume":"78","author":"Ott","year":"2011","journal-title":"Cleve Clin J Med"}],"container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088954061200755X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088954061200755X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:54:51Z","timestamp":1760172891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088954061200755X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S088954061200755X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajodo.2012.05.019","relation":{},"ISSN":["0889-5406"],"issn-type":[{"value":"0889-5406","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bisphosphonates as a risk factor for adverse orthodontic outcomes: A retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Orthodontics and Dentofacial Orthopedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajodo.2012.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}