{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:49:11Z","timestamp":1788900551609,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajodo.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.ajodo.2014.06.002","type":"journal-article","created":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T09:15:43Z","timestamp":1409303743000},"page":"346-354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Morphologic variability of nonsyndromic operated patients affected by cleft lip and palate: A geometric morphometric study"],"prefix":"10.1016","volume":"146","author":[{"given":"Viviana","family":"Toro-Ibacache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cort\u00e9s Araya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"D\u00edaz Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germ\u00e1n","family":"Manr\u00edquez Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajodo.2014.06.002_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.ajodo.2014.06.002_bib2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.4067\/S0034-98872001000300008","article-title":"Incidencia de labio leporino y paladar hendido en la Maternidad del Hospital Cl\u00ednico de la Universidad de Chile y en las maternidades chilenas participantes en el Estudio Colaborativo Latino Americano de Malformaciones Cong\u00e9nitas (ECLAMC) per\u00edodo 1991-1999","volume":"129","author":"Nazer","year":"2001","journal-title":"Rev Med Chil"},{"key":"10.1016\/j.ajodo.2014.06.002_bib3","first-page":"17","article-title":"Prevalencia de fisura labiopalatina e indicadores de riesgo: estudio de la poblaci\u00f3n atendida en el Hospital Cl\u00ednico F\u00e9lix Bulnes de Santiago de Chile","volume":"30","author":"Sep\u00falveda Troncoso","year":"2008","journal-title":"Rev Esp Cir Oral y Maxilofac"},{"key":"10.1016\/j.ajodo.2014.06.002_bib4","first-page":"216","article-title":"Incidence of cleft lip, cleft palate, and cleft lip and palate among races: a review","volume":"24","author":"Vanderas","year":"1987","journal-title":"Cleft Palate J"},{"key":"10.1016\/j.ajodo.2014.06.002_bib5","series-title":"Cleft lip and palate. Epidemiology, aetiology and treatment","first-page":"1","article-title":"Epidemiology of oral clefts 2012: an international perspective","author":"Mossey","year":"2012"},{"key":"10.1016\/j.ajodo.2014.06.002_bib6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1034\/j.1399-0004.2002.610402.x","article-title":"Gene\/environment causes of cleft lip and\/or palate","volume":"61","author":"Murray","year":"2002","journal-title":"Clin Genet"},{"key":"10.1016\/j.ajodo.2014.06.002_bib7","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1046\/j.1469-1809.2001.6560505.x","article-title":"Nonsyndromic cleft lip and palate: complex genetics and environmental effects","volume":"65","author":"Prescott","year":"2001","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.ajodo.2014.06.002_bib8","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/(SICI)1096-8628(19980113)75:2<126::AID-AJMG2>3.0.CO;2-R","article-title":"Classification and birth prevalence of orofacial clefts","volume":"75","author":"Tolarov\u00e1","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.ajodo.2014.06.002_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00006534-195907000-00007","article-title":"Cephalometric measurements on adult patients with nonoperated cleft palates","volume":"24","author":"Ortiz-Monasterio","year":"1959","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.ajodo.2014.06.002_bib10","first-page":"239","article-title":"Cephalometric evaluation of facial growth in operated and non-operated individuals with isolated clefts of the palate","volume":"10","author":"Bishara","year":"1973","journal-title":"Cleft Palate J"},{"key":"10.1016\/j.ajodo.2014.06.002_bib11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1597\/1545-1569(1996)033<0051:IIOLAP>2.3.CO;2","article-title":"Isolated influences of lip and palate surgery on facial growth: comparison of operated and unoperated male adults with UCLP","volume":"33","author":"Capelozza Filho","year":"1996","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.ajodo.2014.06.002_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1010-5182(05)80092-7","article-title":"Influence of surgery on maxillary growth in cleft lip and\/or palate patients","volume":"20","author":"Corre\u02dca Normando","year":"1992","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.ajodo.2014.06.002_bib13","first-page":"270","article-title":"Influence of the nasal septum on maxillonasal growth in patients with congenital labiomaxillary cleft","volume":"23","author":"Delaire","year":"1986","journal-title":"Cleft Palate J"},{"key":"10.1016\/j.ajodo.2014.06.002_bib14","first-page":"193","article-title":"La cheilo-rhinoplastie primaire pour fente labio-maxillaire congenitale unilaterale. Essai de schematisation d\u2019une technique","volume":"76","author":"Delaire","year":"1975","journal-title":"Rev Stomatol Chir Maxillofac"},{"key":"10.1016\/j.ajodo.2014.06.002_bib15","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0278-2391(95)90119-1","article-title":"Nasal symmetry after primary cleft lip repair: comparison between Delaire cheilorhinoplasty and modified rotation-advancement","volume":"53","author":"Horswell","year":"1995","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ajodo.2014.06.002_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0266-4356(95)90285-6","article-title":"Skeletal growth after muscular reconstruction for cleft lip, alveolus, and palate","volume":"33","author":"Joos","year":"1995","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.ajodo.2014.06.002_bib17","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/ejo\/cjp140","article-title":"Three-dimensional geometric morphometrics applied to the study of children with cleft lip and\/or palate from the north east of England","volume":"32","author":"Bugaighis","year":"2010","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2014.06.002_bib18","first-page":"34","article-title":"Transverse maxillary growth in combined cleft lip and palate","volume":"16","author":"Dahl","year":"1979","journal-title":"Cleft Palate J"},{"key":"10.1016\/j.ajodo.2014.06.002_bib19","first-page":"114","article-title":"Craniofacial growth in unilateral cleft lip and palate: skeletal growth from eight to eighteen years","volume":"25","author":"Horswell","year":"1988","journal-title":"Cleft Palate J"},{"key":"10.1016\/j.ajodo.2014.06.002_bib20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0035-1768(06)77062-0","article-title":"Caract\u00e9ristiques cranio-faciales chez un groupe de patients chiliens atteints de fente labio-maxillo-palatine unilat\u00e9rale op\u00e9r\u00e9e","volume":"107","author":"Cort\u00e9s Araya","year":"2006","journal-title":"Rev Stomatol Chir Maxillofac"},{"key":"10.1016\/j.ajodo.2014.06.002_bib21","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1597\/1545-1569_2003_040_0403_dotmci_2.0.co_2","article-title":"Deformations of the midfacial complex in twins with orofacial clefts","volume":"40","author":"Singh","year":"2003","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.ajodo.2014.06.002_bib22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev.anthro.34.081804.120613","article-title":"Geometric morphometrics","volume":"36","author":"Slice","year":"2007","journal-title":"Annu Rev Anthropol"},{"key":"10.1016\/j.ajodo.2014.06.002_bib23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1469-7580.2000.19710103.x","article-title":"The study of morphological variation in the hominid fossil record: biology, landmarks and geometry","volume":"197","author":"O'Higgins","year":"2000","journal-title":"J Anat"},{"key":"10.1016\/j.ajodo.2014.06.002_bib24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11692-009-9055-x","article-title":"Advances in geometric morphometrics","volume":"36","author":"Mitteroecker","year":"2009","journal-title":"Evol Biol"},{"key":"10.1016\/j.ajodo.2014.06.002_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1601-6343.2007.00390.x","article-title":"Three-dimensional facial morphology following surgical repair of unilateral cleft lip and palate in patients after nasoalveolar molding","volume":"10","author":"Singh","year":"2007","journal-title":"Orthod Craniofac Res"},{"key":"10.1016\/j.ajodo.2014.06.002_bib26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1601-6343.2009.01462.x","article-title":"Face shape of unaffected parents with cleft affected offspring: combining three-dimensional surface imaging and geometric morphometrics","volume":"12","author":"Weinberg","year":"2009","journal-title":"Orthod Craniofac Res"},{"key":"10.1016\/j.ajodo.2014.06.002_bib27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1597\/02-166","article-title":"Longitudinal craniofacial growth patterns in patients with orofacial clefts: geometric morphometrics","volume":"41","author":"Singh","year":"2004","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.ajodo.2014.06.002_bib28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.0021-8782.2004.00356.x","article-title":"Craniofacial variability and morphological integration in mice susceptible to cleft lip and palate","volume":"205","author":"Hallgr\u00edmsson","year":"2004","journal-title":"J Anat"},{"key":"10.1016\/j.ajodo.2014.06.002_bib29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/(SICI)1520-6300(1997)9:2<225::AID-AJHB9>3.0.CO;2-Z","article-title":"Facial clefting and Amerindian admixture in populations of Santiago, Chile","volume":"9","author":"Palomino","year":"1997","journal-title":"Am J Hum Biol"},{"key":"10.1016\/j.ajodo.2014.06.002_bib30","series-title":"Cleft craft","author":"Millard","year":"1980"},{"key":"10.1016\/j.ajodo.2014.06.002_bib31","series-title":"Morphometric tools for landmark data: geometry and biology","author":"Bookstein","year":"1991"},{"key":"10.1016\/j.ajodo.2014.06.002_bib32","series-title":"Statistical shape analysis","author":"Dryden","year":"1998"},{"key":"10.1016\/j.ajodo.2014.06.002_bib33","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0030-4220(81)90252-8","article-title":"An architectural and structural craniofacial analysis: a new lateral cephalometric analysis","volume":"52","author":"Delaire","year":"1981","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.ajodo.2014.06.002_bib34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF02458311","article-title":"Biometrics, biomathematics and the morphometric synthesis","volume":"58","author":"Bookstein","year":"1996","journal-title":"Bull Math Biol"},{"key":"10.1016\/j.ajodo.2014.06.002_bib35","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.0014-3820.2002.tb01367.x","article-title":"Geometric estimates of heritability in biological shape","volume":"56","author":"Monteiro","year":"2002","journal-title":"Evolution"},{"key":"10.1016\/j.ajodo.2014.06.002_bib36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1046\/j.1469-7580.1998.19320251.x","article-title":"Facial growth in cercocebus torquatus: an application of three-dimensional geometric morphometric techniques to the study of morphological variation","volume":"193","author":"O'Higgins","year":"1998","journal-title":"J Anat"},{"key":"10.1016\/j.ajodo.2014.06.002_bib37","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1111\/j.0014-3820.2002.tb00117.x","article-title":"Shape analysis of symmetric structures: quantifying variation among individuals and asymmetry","volume":"56","author":"Klingenberg","year":"2002","journal-title":"Evolution"},{"key":"10.1016\/j.ajodo.2014.06.002_bib38","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.alcohol.2009.10.016","article-title":"Prenatal alcohol exposure alters the patterns of facial asymmetry","volume":"44","author":"Klingenberg","year":"2010","journal-title":"Alcohol"},{"key":"10.1016\/j.ajodo.2014.06.002_bib39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1469-7580.2002.00092.x","article-title":"A geometric morphometric study of regional differences in the ontogeny of the modern human facial skeleton","volume":"201","author":"Strand Vi\u00f0arsd\u00f3ttir","year":"2002","journal-title":"J Anat"},{"key":"10.1016\/j.ajodo.2014.06.002_bib40","series-title":"Geometric morphometrics for biologists: a primer","author":"Zelditch","year":"2012"},{"key":"10.1016\/j.ajodo.2014.06.002_bib41","first-page":"71","article-title":"The pace of morphological change: historical transformation of skull shape in St Bernard dogs","volume":"275","author":"Drake","year":"2008","journal-title":"Proc Biol Sci"},{"key":"10.1016\/j.ajodo.2014.06.002_bib42","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/sysbio\/syt025","article-title":"Evolutionary covariation in geometric morphometric data: analyzing integration, modularity, and allometry in a phylogenetic context","volume":"62","author":"Klingenberg","year":"2013","journal-title":"Syst Biol"},{"key":"10.1016\/j.ajodo.2014.06.002_bib43","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1080\/106351500750049806","article-title":"Use of two-block partial least-squares to study covariation in shape","volume":"49","author":"Rohlf","year":"2000","journal-title":"Syst Biol"},{"key":"10.1016\/j.ajodo.2014.06.002_bib44","doi-asserted-by":"crossref","first-page":"751","DOI":"10.2307\/2529140","article-title":"Le traitement des variables vectorielles","volume":"29","author":"Escoufier","year":"1973","journal-title":"Biometrics"},{"key":"10.1016\/j.ajodo.2014.06.002_bib45","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1755-0998.2010.02924.x","article-title":"MorphoJ: an integrated software package for geometric morphometrics","volume":"11","author":"Klingenberg","year":"2011","journal-title":"Mol Ecol Resour"},{"key":"10.1016\/j.ajodo.2014.06.002_bib46","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1469-7580.2006.00644.x","article-title":"Craniofacial levels and the morphological maturation of the human skull","volume":"209","author":"Bastir","year":"2006","journal-title":"J Anat"},{"key":"10.1016\/j.ajodo.2014.06.002_bib47","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1359\/JBMR.0301251","article-title":"Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety","volume":"19","author":"Rubin","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ajodo.2014.06.002_bib48","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/ar.a.10119","article-title":"Bone's mechanostat: a 2003 update","volume":"275","author":"Frost","year":"2003","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"10.1016\/j.ajodo.2014.06.002_bib49","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0889-5406(97)70267-1","article-title":"The functional matrix hypothesis revisited. 1. The role of mechanotransduction","volume":"112","author":"Moss","year":"1997","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2014.06.002_bib50","series-title":"Bones: structure and mechanics","author":"Currey","year":"2006"},{"key":"10.1016\/j.ajodo.2014.06.002_bib51","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.bone.2011.08.020","article-title":"A Wolff in sheep's clothing: trabecular bone adaptation in response to changes in joint loading orientation","volume":"49","author":"Barak","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.ajodo.2014.06.002_bib52","doi-asserted-by":"crossref","first-page":"19546","DOI":"10.1073\/pnas.1113050108","article-title":"Global human mandibular variation reflects differences in agricultural and hunter-gatherer subsistence strategies","volume":"108","author":"von Cramon-Taubadel","year":"2011","journal-title":"Proc Natl Sci Acad U S A"},{"key":"10.1016\/j.ajodo.2014.06.002_bib53","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/ajpa.21550","article-title":"The relative efficacy of functional and developmental cranial modules for reconstructing global human population history","volume":"146","author":"von Cramon-Taubadel","year":"2011","journal-title":"Am J Phys Anthropol"},{"key":"10.1016\/j.ajodo.2014.06.002_bib54","series-title":"Morphological integration of upper and lower jaws in extant hominids. Proceedings of the Third Annual Meeting of the European Society for the Study of Human Evolution","author":"Stelzer","year":"2013"},{"key":"10.1016\/j.ajodo.2014.06.002_bib55","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/0002-9416(69)90034-7","article-title":"The primary role of functional matrices in facial growth","volume":"55","author":"Moss","year":"1969","journal-title":"Am J Orthod"},{"key":"10.1016\/j.ajodo.2014.06.002_bib56","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1177\/00220345920710060301","article-title":"A comparison of jaw muscle cross-sections of long-face and normal adults","volume":"71","author":"van Spronsen","year":"1992","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2014.06.002_bib57","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/ejo\/25.3.265","article-title":"Maximum bite force, muscle efficiency and mechanical advantage in children with vertical growth patterns","volume":"25","author":"Garc\u00eda-Morales","year":"2003","journal-title":"Eur J Orhod"},{"key":"10.1016\/j.ajodo.2014.06.002_bib58","first-page":"244","article-title":"Feeding infants with cleft lip, cleft palate, or cleft lip and palate","volume":"24","author":"Clarren","year":"1987","journal-title":"Cleft Palate J"},{"key":"10.1016\/j.ajodo.2014.06.002_bib59","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/02699200410001663362","article-title":"Abnormal patterns of tongue-palate contact in the speech of individuals with cleft palate","volume":"18","author":"Gibbon","year":"2004","journal-title":"Clin Linguist Phon"}],"container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540614005368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540614005368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:58:11Z","timestamp":1760173091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889540614005368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0889540614005368"],"URL":"https:\/\/doi.org\/10.1016\/j.ajodo.2014.06.002","relation":{},"ISSN":["0889-5406"],"issn-type":[{"value":"0889-5406","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Morphologic variability of nonsyndromic operated patients affected by cleft lip and palate: A geometric morphometric study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Orthodontics and Dentofacial Orthopedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajodo.2014.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}