{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:37:40Z","timestamp":1785235060088,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Medical Practice Plan","award":["CUF 22425"],"award-info":[{"award-number":["CUF 22425"]}]},{"name":"University Research Board","award":["103185"],"award-info":[{"award-number":["103185"]}]},{"DOI":"10.13039\/100007688","name":"American University of Beirut","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajodo.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.ajodo.2018.08.020","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T14:32:49Z","timestamp":1561645969000},"page":"104-112.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Three novel genes tied to mandibular prognathism in eastern Mediterranean families"],"prefix":"10.1016","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2866-4445","authenticated-orcid":false,"given":"Pamela G.","family":"Genno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges M.","family":"Nemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3301-5367","authenticated-orcid":false,"given":"Savo Bou","family":"Zein Eddine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony T.","family":"Macari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph G.","family":"Ghafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajodo.2018.08.020_bib1","first-page":"153","article-title":"Who seeks surgical-orthodontic treatment?","volume":"5","author":"Proffit","year":"1990","journal-title":"Int J Adult Orthodon Orthognath Surg"},{"key":"10.1016\/j.ajodo.2018.08.020_bib2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0030-4220(76)90287-5","article-title":"Surgical correction of mandibular prognathism","volume":"42","author":"Shira","year":"1976","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.ajodo.2018.08.020_bib3","first-page":"293","article-title":"The role of dental compensations in the orthodontic treatment of mandibular prognathism","volume":"47","author":"Sperry","year":"1977","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2018.08.020_bib4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0002-9416(59)90076-4","article-title":"Heredity and the craniofacial complex","volume":"45","author":"Kraus","year":"1959","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2018.08.020_bib5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/jmg.30.2.112","article-title":"On the genetics of mandibular prognathism: analysis of large European noble families","volume":"30","author":"Wolff","year":"1993","journal-title":"J Med Genet"},{"key":"10.1016\/j.ajodo.2018.08.020_bib6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1177\/154405910308200707","article-title":"Segregation analysis of mandibular prognathism in Libya","volume":"82","author":"El-Gheriani","year":"2003","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2018.08.020_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/154405910508400309","article-title":"Genome-wide linkage analysis of mandibular prognathism in Korean and Japanese patients","volume":"84","author":"Yamaguchi","year":"2005","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2018.08.020_bib8","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1177\/0022034510375962","article-title":"Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans","volume":"89","author":"Jang","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2018.08.020_bib9","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.archoralbio.2010.07.018","article-title":"Identification of SNP markers on 1p36 and association analysis of EPB41 with mandibular prognathism in a Chinese population","volume":"55","author":"Xue","year":"2010","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.ajodo.2018.08.020_bib10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/ocr.12038","article-title":"Analysis of the association of COL2A1 and IGF-1 with mandibular prognathism in a Chinese population","volume":"17","author":"Xue","year":"2014","journal-title":"Orthod Craniofac Res"},{"key":"10.1016\/j.ajodo.2018.08.020_bib11","doi-asserted-by":"crossref","first-page":"e12678","DOI":"10.1371\/journal.pone.0012678","article-title":"Genome scan for locus involved in mandibular prognathism in pedigrees from China","volume":"5","author":"Li","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ajodo.2018.08.020_bib12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/0022034510382546","article-title":"The identification of a novel locus for mandibular prognathism in the Han Chinese population","volume":"90","author":"Li","year":"2011","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2018.08.020_bib13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ajodo.2011.06.033","article-title":"Genetic variation in Myosin 1H contributes to mandibular prognathism","volume":"141","author":"Tassopoulou-Fishell","year":"2012","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2018.08.020_bib14","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/0022034513502790","article-title":"A missense mutation in DUSP6 is associated with Class III malocclusion","volume":"92","author":"Nikopensius","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2018.08.020_bib15","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.ajodo.2014.01.022","article-title":"Microsatellite genome-wide association study for mandibular prognathism","volume":"145","author":"Ikuno","year":"2014","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2018.08.020_bib16","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1177\/0022034515589957","article-title":"The ADAMTS1 gene is associated with familial mandibular prognathism","volume":"94","author":"Guan","year":"2015","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2018.08.020_bib17","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1177\/0022034515572190","article-title":"Genetic association of ARHGAP21 gene variant with mandibular prognathism","volume":"94","author":"Perillo","year":"2015","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2018.08.020_bib18","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ajodo.2016.09.013","article-title":"Genetic polymorphisms underlying the skeletal Class III phenotype","volume":"151","author":"Cruz","year":"2017","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2018.08.020_bib19","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1093\/molbev\/msi222","article-title":"A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution","volume":"22","author":"Vandepoele","year":"2005","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.ajodo.2018.08.020_bib20","series-title":"Dental anthropology","first-page":"29","article-title":"Occlusion and malocclusion of the teeth of primates","author":"Mills","year":"1963"},{"key":"10.1016\/j.ajodo.2018.08.020_bib21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/ajmg.a.32062","article-title":"Major gene and multifactorial inheritance of mandibular prognathism","volume":"146","author":"Cruz","year":"2008","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.ajodo.2018.08.020_bib22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/0022034508327817","article-title":"Evidence of linkage in a Hispanic cohort with a Class III dentofacial phenotype","volume":"88","author":"Frazier-Bowers","year":"2009","journal-title":"J Dent Res"},{"issue":"1-2","key":"10.1016\/j.ajodo.2018.08.020_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/00016356809004580","article-title":"A method for tabulation and statistical evaluation of epidemiologic malocclusion data","volume":"26","author":"Solow","year":"1968","journal-title":"Acta Odont Scand"},{"key":"10.1016\/j.ajodo.2018.08.020_bib24","first-page":"399","article-title":"Skeletal malocclusion: a developmental disorder with a life-long morbidity","volume":"6","author":"Joshia","year":"2014","journal-title":"J Clin Med Res"},{"key":"10.1016\/j.ajodo.2018.08.020_bib25","first-page":"207","article-title":"Epidemiologic panorama of dental occlusion","volume":"60","author":"El-Mangoury","year":"1990","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2018.08.020_bib26","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0002-9416(71)90147-3","article-title":"Malocclusion in the modern Alaskan Eskimo","volume":"60","author":"Wood","year":"1971","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2018.08.020_bib27","first-page":"20","article-title":"A cephalometric roentgenographic appraisal of the facial pattern in Class III malocclusions","volume":"18","author":"Stapf","year":"1948","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2018.08.020_bib28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0278-2391(84)90109-5","article-title":"Components of adult Class III malocclusion","volume":"42","author":"Ellis","year":"1984","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ajodo.2018.08.020_bib29","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.ijom.2015.05.018","article-title":"No differences in morphological characteristics between hyperplastic condyle and class III condyle","volume":"44","author":"Goulart","year":"2015","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.ajodo.2018.08.020_bib30","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.joms.2016.09.002","article-title":"Comparative evaluation of condylar volume between patients with unilateral condylar hyperplasia and Class III dentofacial deformity","volume":"75","author":"Goulart","year":"2017","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ajodo.2018.08.020_bib32","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nrg3031","article-title":"Exome sequencing as a tool for mendelian disease gene discovery","volume":"12","author":"Bamshad","year":"2011","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.ajodo.2018.08.020_bib33","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/ejo\/cjq052","article-title":"Prediction of the outcome of orthodontic treatment of Class III malocclusions\u2014a systematic review","volume":"33","author":"Fudalej","year":"2010","journal-title":"Eur J Orthod"}],"container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540619301891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540619301891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:05:42Z","timestamp":1760173542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889540619301891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0889540619301891"],"URL":"https:\/\/doi.org\/10.1016\/j.ajodo.2018.08.020","relation":{},"ISSN":["0889-5406"],"issn-type":[{"value":"0889-5406","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Three novel genes tied to mandibular prognathism in eastern Mediterranean families","name":"articletitle","label":"Article Title"},{"value":"American Journal of Orthodontics and Dentofacial Orthopedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajodo.2018.08.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American Association of Orthodontists. All rights reserved.","name":"copyright","label":"Copyright"}]}}