{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:29:58Z","timestamp":1780637398969,"version":"3.54.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["451-03-9\/2021-14\/200129"],"award-info":[{"award-number":["451-03-9\/2021-14\/200129"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajodo.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.ajodo.2021.09.016","type":"journal-article","created":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T06:54:43Z","timestamp":1660460083000},"page":"e246-e251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Single nucleotide polymorphisms MYO1H 1001 C>T SNP (rs3825393) is a strong risk factor for mandibular prognathism"],"prefix":"10.1016","volume":"162","author":[{"given":"Olga","family":"Milosevic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8513-9313","authenticated-orcid":false,"given":"Nadja","family":"Nikolic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-7589","authenticated-orcid":false,"given":"Jelena","family":"Carkic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1998-8026","authenticated-orcid":false,"given":"Jovana","family":"Juloski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2617-7926","authenticated-orcid":false,"given":"Ljiljana","family":"Vucic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1420-6790","authenticated-orcid":false,"given":"Branislav","family":"Glisic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Milasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajodo.2021.09.016_bib1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ajodo.2015.04.012","article-title":"Evolution of Class III treatment in orthodontics","volume":"148","author":"Ngan","year":"2015","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2021.09.016_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4236\/ojepi.2012.24012","article-title":"Prevalence of angle Class III malocclusion: A systematic review and meta-analysis","volume":"02","author":"Hardy","year":"2012","journal-title":"Open J Epidemiol"},{"key":"10.1016\/j.ajodo.2021.09.016_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/ocr.12356","article-title":"A multilevel analysis of craniofacial growth in subjects with untreated Class III malocclusion","volume":"23","author":"Rutili","year":"2020","journal-title":"Orthod Craniofac Res"},{"key":"10.1016\/j.ajodo.2021.09.016_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/ajmg.a.32062","article-title":"Major gene and multifactorial inheritance of mandibular prognathism","volume":"146A","author":"Cruz","year":"2008","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.ajodo.2021.09.016_bib5","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/154405910208100714","article-title":"Quantitative trait loci on chromosomes 10 and 11 influencing mandible size of SMXA RI mouse strains","volume":"81","author":"Dohmoto","year":"2002","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2021.09.016_bib6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/154405910508400309","article-title":"Genome-wide linkage analysis of mandibular prognathism in Korean and Japanese patients","volume":"84","author":"Yamaguchi","year":"2005","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2021.09.016_bib7","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1177\/0022034510375962","article-title":"Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans","volume":"89","author":"Jang","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2021.09.016_bib8","article-title":"Genome scan for locus involved in mandibular prognathism in pedigrees from China","volume":"5","author":"Li","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ajodo.2021.09.016_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/0022034510382546","article-title":"The identification of a novel locus for mandibular prognathism in the Han Chinese population","volume":"90","author":"Li","year":"2011","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2021.09.016_bib10","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/0022034513502790","article-title":"A missense mutation in DUSP6 is associated with Class III malocclusion","volume":"92","author":"Nikopensius","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2021.09.016_bib11","article-title":"Identification of a mutation in FGF23 involved in mandibular prognathism","volume":"5","author":"Chen","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajodo.2021.09.016_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/0022034508327817","article-title":"Evidence of linkage in a Hispanic cohort with a Class III dentofacial phenotype","volume":"88","author":"Frazier-Bowers","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2021.09.016_bib13","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1177\/0022034515589957","article-title":"The ADAMTS1 gene is associated with familial mandibular prognathism","volume":"94","author":"Guan","year":"2015","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2021.09.016_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/cge.13519","article-title":"ADAMTSL1 and mandibular prognathism","volume":"95","author":"Kantaputra","year":"2019","journal-title":"Clin Genet"},{"key":"10.1016\/j.ajodo.2021.09.016_bib15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ajodo.2018.08.020","article-title":"Three novel genes tied to mandibular prognathism in eastern Mediterranean families","volume":"156","author":"Genno","year":"2019","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2021.09.016_bib16","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1177\/0022034515581643","article-title":"Candidate gene analyses of skeletal variation in malocclusion","volume":"94","author":"da Fontoura","year":"2015","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2021.09.016_bib17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.archoralbio.2018.09.018","article-title":"Genetic variants in ACTN3 and MYO1H are associated with sagittal and vertical craniofacial skeletal patterns","volume":"97","author":"Cunha","year":"2019","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.ajodo.2021.09.016_bib18","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00784-020-03731-5","article-title":"Genetic factors contributing to skeletal Class III malocclusion: a systematic review and meta-analysis","volume":"25","author":"Dehesa-Santos","year":"2021","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.ajodo.2021.09.016_bib19","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ajodo.2016.09.013","article-title":"Genetic polymorphisms underlying the skeletal Class III phenotype","volume":"151","author":"Cruz","year":"2017","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2021.09.016_bib20","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1177\/0022034518784936","article-title":"Identification and functional studies of MYO1H for mandibular prognathism","volume":"97","author":"Sun","year":"2018","journal-title":"J Dent Res"},{"issue":"2","key":"10.1016\/j.ajodo.2021.09.016_bib21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.21315\/aos2020.15.2.446","article-title":"Application of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique in the analysis of MYO1H single nucleotide polymorphism in Malay mandibular prognathism patients","volume":"15","author":"Mohd Yusoff","year":"2020","journal-title":"Arch Orofac Sci"},{"key":"10.1016\/j.ajodo.2021.09.016_bib22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/SCS.0000000000003287","article-title":"Genetic etiology in nonsyndromic mandibular prognathism","volume":"28","author":"Liu","year":"2017","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.ajodo.2021.09.016_bib23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/ocr.12433","article-title":"Potential interactions among single nucleotide polymorphisms in bone- and cartilage-related genes in skeletal malocclusions","volume":"24","author":"K\u00fcchler","year":"2021","journal-title":"Orthod Craniofac Res"},{"key":"10.1016\/j.ajodo.2021.09.016_bib24","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0002-9416(53)90082-7","article-title":"Cephalometrics for you and me","volume":"39","author":"Steiner","year":"1953","journal-title":"Am J Orthod"},{"key":"10.1016\/j.ajodo.2021.09.016_bib25","first-page":"350","article-title":"Classification of malocclusion","volume":"41","author":"Angle","year":"1899","journal-title":"Dental Cosmos"},{"key":"10.1016\/j.ajodo.2021.09.016_bib26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"10.1016\/j.ajodo.2021.09.016_bib27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ajodo.2011.06.033","article-title":"Genetic variation in myosin 1H contributes to mandibular prognathism","volume":"141","author":"Tassopoulou-Fishell","year":"2012","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2021.09.016_bib28","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/JLB.1MR0918-350RRR","article-title":"Class I myosins: highly versatile proteins with specific functions in the immune system","volume":"105","author":"Gir\u00f3n-P\u00e9rez","year":"2019","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ajodo.2021.09.016_bib29","first-page":"281","article-title":"Myo1H gene single nucleotide polymorphism rs10850110 and the risk of malocclusion in the Romanian population","volume":"2","author":"Ghergie","year":"2013","journal-title":"Acta Med Transilvanica"},{"key":"10.1016\/j.ajodo.2021.09.016_bib30","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.ajodo.2015.10.028","article-title":"Role of myosin 1H gene polymorphisms in mandibular retrognathism","volume":"149","author":"Arun","year":"2016","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2021.09.016_bib31","first-page":"79","article-title":"Masseter function and skeletal malocclusion","volume":"114","author":"Sciote","year":"2013","journal-title":"Rev Stomatol Chir Maxillofac Chir Orale"},{"key":"10.1016\/j.ajodo.2021.09.016_bib32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrendo.2016.12","article-title":"BMP signalling in skeletal development, disease and repair","volume":"12","author":"Salazar","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.ajodo.2021.09.016_bib33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/00006534-200101000-00018","article-title":"Expression of bone morphogenetic proteins during membranous bone healing","volume":"107","author":"Spector","year":"2001","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.ajodo.2021.09.016_bib34","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1359\/jbmr.2000.15.4.663","article-title":"Essential requirement of BMPs-2\/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin","volume":"15","author":"Abe","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ajodo.2021.09.016_bib35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00006534-200301000-00035","article-title":"Expression of bone morphogenetic proteins during mandibular distraction osteogenesis","volume":"111","author":"Campisi","year":"2003","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.ajodo.2021.09.016_bib36","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1053\/joms.2003.50116","article-title":"Expression of bone morphogenetic proteins during mandibular distraction osteogenesis in rabbits","volume":"61","author":"Yazawa","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"issue":"Suppl 1 Pt 2","key":"10.1016\/j.ajodo.2021.09.016_bib37","first-page":"S146","article-title":"Application of bone morphogenetic proteins in the treatment of clinical oral and maxillofacial osseous defects","volume":"83-A","author":"Boyne","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.ajodo.2021.09.016_bib38","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1093\/hmg\/ddt231","article-title":"Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height\u00a0and craniofacial distances","volume":"22","author":"Fatemifar","year":"2013","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ajodo.2021.09.016_bib39","article-title":"Joint testing of genotypic and gene-environment interaction identified novel association for BMP4 with non-syndromic CL\/P in an Asian population using data from an International Cleft Consortium","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ajodo.2021.09.016_bib40","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.archoralbio.2016.08.019","article-title":"BMP2 and BMP4 variations and risk of non-syndromic cleft lip and palate","volume":"72","author":"Saket","year":"2016","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.ajodo.2021.09.016_bib41","article-title":"Genetic variants of BMP2 and their association with the risk of non-syndromic tooth agenesis","volume":"11","author":"Lu","year":"2016","journal-title":"PLoS One"}],"container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540622004693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540622004693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:14:59Z","timestamp":1760174099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889540622004693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0889540622004693"],"URL":"https:\/\/doi.org\/10.1016\/j.ajodo.2021.09.016","relation":{},"ISSN":["0889-5406"],"issn-type":[{"value":"0889-5406","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single nucleotide polymorphisms MYO1H 1001 C>T SNP (rs3825393) is a strong risk factor for mandibular prognathism","name":"articletitle","label":"Article Title"},{"value":"American Journal of Orthodontics and Dentofacial Orthopedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajodo.2021.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American Association of Orthodontists. All rights reserved.","name":"copyright","label":"Copyright"}]}}