{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:15:12Z","timestamp":1788207312228,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K11344"],"award-info":[{"award-number":["15K11344"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K10199"],"award-info":[{"award-number":["20K10199"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajodo.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.ajodo.2022.04.016","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:49:19Z","timestamp":1671670159000},"page":"531-539.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of short-term orthodontic force application on the root at different developmental stages in rat maxillary molars"],"prefix":"10.1016","volume":"163","author":[{"given":"Lu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Iseki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajodo.2022.04.016_bib1","series-title":"Contemporary orthodontics","first-page":"2","article-title":"Malocclusion and dentofacial deformity in contemporary society","author":"Proffit","year":"2018"},{"key":"10.1016\/j.ajodo.2022.04.016_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S8756-3282(99)00009-5","article-title":"Histomorphometric study of bone reactions during orthodontic tooth movement in rats","volume":"24","author":"Verna","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.ajodo.2022.04.016_bib3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.7150\/ijbs.5476","article-title":"Disruption of Wnt\/\u03b2-catenin signaling in odontoblasts and cementoblasts arrests tooth root development in postnatal mouse teeth","volume":"9","author":"Zhang","year":"2013","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.ajodo.2022.04.016_bib4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.archoralbio.2019.03.010","article-title":"Effects of mechanical force application on the developing root apex in rat maxillary molars","volume":"101","author":"Zhao","year":"2019","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.ajodo.2022.04.016_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4041\/kjod.2018.48.5.339","article-title":"Effects of continuous force application for extrusive tipping movement on periapical root resorption in the rat mandibular first molar","volume":"48","author":"Matsumoto","year":"2018","journal-title":"Korean J Orthod"},{"key":"10.1016\/j.ajodo.2022.04.016_bib6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/ejo\/cjv071","article-title":"Critical roles of periostin in the process of orthodontic tooth movement","volume":"38","author":"Rangiani","year":"2016","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2022.04.016_bib7","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ajodo.2014.07.007","article-title":"Accelerated orthodontic tooth movement: molecular mechanisms","volume":"146","author":"Huang","year":"2014","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2022.04.016_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00429-002-0276-3","article-title":"Behavior of epithelial root sheath during tooth root formation in porcine molars: TUNEL, TEM, and immunohistochemical studies","volume":"206","author":"Suzuki","year":"2002","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.ajodo.2022.04.016_bib9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ydbio.2009.06.034","article-title":"Fate of HERS during tooth root development","volume":"334","author":"Huang","year":"2009","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajodo.2022.04.016_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/0022034512470137","article-title":"\u03b2-catenin is required in odontoblasts for tooth root formation","volume":"92","author":"Kim","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2022.04.016_bib11","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1242\/dev.137216","article-title":"Cellular and molecular mechanisms of tooth root development","volume":"144","author":"Li","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.ajodo.2022.04.016_bib12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/ejo\/24.1.91","article-title":"Changes in root length during orthodontic treatment: advantages for immature teeth","volume":"24","author":"Mavragani","year":"2002","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2022.04.016_bib13","doi-asserted-by":"crossref","first-page":"768","DOI":"10.2319\/083015-584.1","article-title":"The treatment timing of labial inversely impacted maxillary central incisors: a prospective study","volume":"86","author":"Sun","year":"2016","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2022.04.016_bib14","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1600-9657.2010.00937.x","article-title":"Management of root dilaceration of an impacted maxillary central incisor following orthodontic treatment: an unusual therapeutic outcome","volume":"26","author":"Topouzelis","year":"2010","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.ajodo.2022.04.016_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/ortho\/29.2.129","article-title":"Experimental tooth movement under light orthodontic forces: rates of tooth movement and changes of the periodontium","volume":"29","author":"Kohno","year":"2002","journal-title":"J Orthod"},{"key":"10.1016\/j.ajodo.2022.04.016_bib16","doi-asserted-by":"crossref","first-page":"8753","DOI":"10.1038\/s41598-017-09326-7","article-title":"Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression","volume":"7","author":"Shoji-Matsunaga","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajodo.2022.04.016_bib17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2319\/081812-661.1","article-title":"Effects of long-term occlusal hypofunction and its recovery on the morphogenesis of molar roots and the periodontium in rats","volume":"83","author":"Motokawa","year":"2013","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2022.04.016_bib18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-1-62703-989-5_17","article-title":"Proliferation assays (BrdU and EdU) on skeletal tissue sections","volume":"1130","author":"Mead","year":"2014","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.ajodo.2022.04.016_bib19","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/03008207.2010.544429","article-title":"Characterization of rat apical tissues in different root development stage","volume":"52","author":"Xu","year":"2011","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.ajodo.2022.04.016_bib20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1267\/ahc.15006","article-title":"Hertwig\u2019s epithelial root sheath fate during initial cellular cementogenesis in rat molars","volume":"48","author":"Yamamoto","year":"2015","journal-title":"Acta Histochem Cytochem"},{"key":"10.1016\/j.ajodo.2022.04.016_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.14219\/jada.archive.2002.0022","article-title":"Surgical repositioning of an impacted dilacerated incisor in mixed dentition","volume":"133","author":"Tsai","year":"2002","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.ajodo.2022.04.016_bib22","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ajodo.2009.10.040","article-title":"Treatment of an impacted dilacerated maxillary central incisor","volume":"139","author":"Pavlidis","year":"2011","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2022.04.016_bib23","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ajodo.2014.07.026","article-title":"Root morphology and development of labial inversely impacted maxillary central incisors in the mixed dentition: a retrospective cone-beam computed tomography study","volume":"146","author":"Sun","year":"2014","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2022.04.016_bib24","first-page":"293","article-title":"Orthodontic management of a dilacerated maxillary central incisor with an unusual sequela","volume":"32","author":"McNamara","year":"1998","journal-title":"J Clin Orthod"},{"key":"10.1016\/j.ajodo.2022.04.016_bib25","doi-asserted-by":"crossref","first-page":"e4985","DOI":"10.1371\/journal.pone.0004985","article-title":"Distinct impacts of Eda and Edar loss of function on the mouse dentition","volume":"4","author":"Charles","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ajodo.2022.04.016_bib26","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1177\/0022034517725692","article-title":"The impact of the Eda pathway\u00a0on\u00a0tooth root development","volume":"96","author":"Fons Romero","year":"2017","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2022.04.016_bib27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/0022034513511247","article-title":"Contribution of mesenchymal proliferation in tooth root morphogenesis","volume":"93","author":"Sohn","year":"2014","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2022.04.016_bib28","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1177\/0022034517717478","article-title":"Signaling pathways critical for tooth root formation","volume":"96","author":"Wang","year":"2017","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajodo.2022.04.016_bib29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/0022034519897607","article-title":"Epithelial Wnt10a is essential for tooth root furcation morphogenesis","volume":"99","author":"Yu","year":"2020","journal-title":"J Dent Res"},{"issue":"Suppl 1","key":"10.1016\/j.ajodo.2022.04.016_bib30","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/ocr.12282","article-title":"Osteocytes and mechanical loading: the Wnt connection","volume":"22","author":"Bullock","year":"2019","journal-title":"Orthod Craniofac Res"},{"key":"10.1016\/j.ajodo.2022.04.016_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.116087","article-title":"The Wnt pathway: an important control mechanism in bone\u2019s response to mechanical loading","volume":"153","author":"Choi","year":"2021","journal-title":"Bone"}],"container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540622007740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540622007740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:14:29Z","timestamp":1760174069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889540622007740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0889540622007740"],"URL":"https:\/\/doi.org\/10.1016\/j.ajodo.2022.04.016","relation":{},"ISSN":["0889-5406"],"issn-type":[{"value":"0889-5406","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of short-term orthodontic force application on the root at different developmental stages in rat maxillary molars","name":"articletitle","label":"Article Title"},{"value":"American Journal of Orthodontics and Dentofacial Orthopedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajodo.2022.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American Association of Orthodontists. All rights reserved.","name":"copyright","label":"Copyright"}]}}