{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:04:37Z","timestamp":1790024677406,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ajodo.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ajodo.2026.06.029","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:26:51Z","timestamp":1790022411000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of clear aligner treatment in patients with cleft lip and palate: A 3-dimensional linear, angular, and morphometric study of the maxillary arch"],"prefix":"10.1016","author":[{"given":"Giorgio","family":"Oliva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1695-0927","authenticated-orcid":false,"given":"Vincenzo","family":"D\u2019Ant\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6784-0975","authenticated-orcid":false,"given":"Leonardo Paolo","family":"Demonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"De Gennaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9596-570X","authenticated-orcid":false,"given":"Maria Costanza","family":"Meazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajodo.2026.06.029_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-79346-7","article-title":"Maternal factors increase risk of orofacial cleft: a meta-analysis","volume":"14","author":"\u00c1cs","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajodo.2026.06.029_bib2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1515\/ijamh-2020-0117","article-title":"Comparison of the psychosocial impact on patients affected by cranio facial anomalies between traditional orthodontic brackets and aligners","volume":"34","author":"Meazzini","year":"2022","journal-title":"Int J Adolesc Med Health"},{"key":"10.1016\/j.ajodo.2026.06.029_bib3","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1597\/12-211","article-title":"Long-term follow-up of UCLP patients: surgical and orthodontic burden of care during growth and final orthognathic surgery need","volume":"52","author":"Meazzini","year":"2015","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.ajodo.2026.06.029_bib4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/ejo\/cjq078","article-title":"Malocclusion characteristics of patients with cleft lip and\/or palate","volume":"33","author":"Vettore","year":"2011","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2026.06.029_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jormas.2019.06.004","article-title":"Maxillary shape at the end of puberty in operated unilateral cleft lip and palate: a geometric morphometric assessment using computer tomography","volume":"121","author":"Segna","year":"2020","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"10.1016\/j.ajodo.2026.06.029_bib6","article-title":"Overview of systematic reviews and meta-analyses assessing the predictability and clinical effectiveness of clear aligner therapy","volume":"3:100074","author":"Alwafi","year":"2023","journal-title":"Dent Rev"},{"key":"10.1016\/j.ajodo.2026.06.029_bib7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40510-025-00575-1","article-title":"Indications and limits of clear aligner therapy: an international modified Delphi consensus study","volume":"26","author":"D\u2019Ant\u00f2","year":"2025","journal-title":"Prog Orthod"},{"key":"10.1016\/j.ajodo.2026.06.029_bib8","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ajodo.2025.07.012","article-title":"Clear aligner orthodontic treatment: an international modified Delphi consensus study","volume":"168","author":"Arveda","year":"2025","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2026.06.029_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/ejo\/cjaf091","article-title":"Quality and stability of orthodontic treatment outcomes with clear aligners versus fixed appliances: a systematic review and meta-analysis","volume":"47","author":"Alhafi","year":"2025","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.ajodo.2026.06.029_bib10","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1186\/s12903-023-03681-w","article-title":"Comparison of pain intensity and impacts on oral health-related quality of life between orthodontic patients treated with clear aligners and fixed appliances: a systematic review and meta-analysis","volume":"23","author":"Li","year":"2023","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.ajodo.2026.06.029_bib11","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1186\/s12903-023-03257-8","article-title":"White spot lesions, plaque accumulation and salivary caries-associated bacteria in clear aligners compared to fixed orthodontic treatment. A systematic review and meta-analysis","volume":"23","author":"Raghavan","year":"2023","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.ajodo.2026.06.029_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/1055665619861780","article-title":"Comparison of pain perception in patients affected by cleft and cranio facial anomalies treated with traditional fixed appliances or Invisalign","volume":"57","author":"Meazzini","year":"2020","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.ajodo.2026.06.029_bib13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40510-022-00453-0","article-title":"Predictability of orthodontic tooth movement with aligners: effect of treatment design","volume":"24","author":"Castroflorio","year":"2023","journal-title":"Prog Orthod"},{"key":"10.1016\/j.ajodo.2026.06.029_bib14","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.3390\/ma15072646","article-title":"Evaluation of tooth movement accuracy with aligners: a prospective study","volume":"15","author":"D\u2019Ant\u00f2","year":"2022","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.ajodo.2026.06.029_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-61594-2","article-title":"Predictability of tooth rotations in patients treated with clear aligners","volume":"14","author":"D\u2019Ant\u00f2","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajodo.2026.06.029_bib16","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.3390\/ma16051910","article-title":"The predictability of transverse changes in patients treated with clear aligners","volume":"16","author":"D\u2019Ant\u00f2","year":"2023","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.ajodo.2026.06.029_bib17","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.3390\/ijerph20042941","article-title":"Predictability of maxillary molar distalization and derotation with clear aligners: a prospective study","volume":"20","author":"D\u2019Ant\u00f2","year":"2023","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.ajodo.2026.06.029_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2196-1042-14-19","article-title":"Evaluation of tip and torque on virtual study models: a validation study","volume":"14","author":"Huanca Ghislanzoni","year":"2013","journal-title":"Prog Orthod"},{"key":"10.1016\/j.ajodo.2026.06.029_bib19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40510-017-0190-0","article-title":"Predictability of orthodontic movement with orthodontic aligners: a retrospective study","volume":"18","author":"Lombardo","year":"2017","journal-title":"Prog Orthod"},{"key":"10.1016\/j.ajodo.2026.06.029_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2319\/063023-458.1","article-title":"Comparison of labio-palatal incisor movement between two wear protocols: a retrospective cohort study","volume":"94","author":"Wei","year":"2024","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2026.06.029_bib21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2319\/032921-246.1","article-title":"Differences in finished case quality between Invisalign and traditional fixed appliances","volume":"92","author":"Lin","year":"2022","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2026.06.029_bib22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12903-018-0695-z","article-title":"A comparison of treatment effectiveness between clear aligner and fixed appliance therapies","volume":"19","author":"Ke","year":"2019","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.ajodo.2026.06.029_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2319\/032322-237.1","article-title":"Comparison between clear aligners and 2 \u00d7 4 mechanics in the mixed dentition: a randomized clinical trial","volume":"93","author":"da Silva","year":"2023","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2026.06.029_bib24","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3390\/sym7020843","article-title":"Analyzing fluctuating asymmetry with geometric morphometrics: concepts, methods, and applications","volume":"7","author":"Klingenberg","year":"2015","journal-title":"Symmetry"},{"key":"10.1016\/j.ajodo.2026.06.029_bib25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1042\/ETLS20210273","article-title":"Shape asymmetry\u2014what\u2019s new?","volume":"6","author":"Klingenberg","year":"2022","journal-title":"Emerg Top Life Sci"},{"key":"10.1016\/j.ajodo.2026.06.029_bib26","first-page":"e61","article-title":"Assessment of Invisalign treatment outcomes using the ABO Model Grading System","volume":"2","author":"Kassas","year":"2013","journal-title":"J World Fed Orthod"},{"key":"10.1016\/j.ajodo.2026.06.029_bib27","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.ajodo.2024.06.009","article-title":"Comparison of digital study model superimposition methods using implant-supported crowns and best-fit algorithms","volume":"166","author":"Meade","year":"2024","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2026.06.029_bib28","series-title":"Testing statistical hypotheses of equivalence","author":"Wellek","year":"2002"},{"key":"10.1016\/j.ajodo.2026.06.029_bib29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1755-0998.2010.02924.x","article-title":"MorphoJ: an integrated software package for geometric morphometrics","volume":"11","author":"Klingenberg","year":"2011","journal-title":"Mol Ecol Resour"},{"key":"10.1016\/j.ajodo.2026.06.029_bib30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A guideline of selecting and reporting intraclass correlation coefficients for reliability research","volume":"15","author":"Koo","year":"2016","journal-title":"J Chiropr Med"},{"key":"10.1016\/j.ajodo.2026.06.029_bib31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2319\/071520-630.1","article-title":"Effect of clear aligner wear protocol on the efficacy of tooth movement","volume":"91","author":"Al-Nadawi","year":"2021","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2026.06.029_bib32","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ajodo.2020.02.010","article-title":"Outcomes of clear aligner treatment with and without dental monitoring: a retrospective cohort study","volume":"159","author":"Hansa","year":"2021","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2026.06.029_bib33","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ajodo.2024.06.008","article-title":"Efficacy of planned moderate to severe torque changes in maxillary central incisors with the Invisalign appliance: a retrospective investigation","volume":"166","author":"Rajan","year":"2024","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ajodo.2026.06.029_bib34","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1472-6831-14-68","article-title":"Treatment outcome and efficacy of an aligner technique\u2014regarding incisor torque, premolar derotation and molar distalization","volume":"14","author":"Simon","year":"2014","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.ajodo.2026.06.029_bib35","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2319\/061614-436.1","article-title":"Efficacy of clear aligners in controlling orthodontic tooth movement: a systematic review","volume":"85","author":"Rossini","year":"2015","journal-title":"Angle Orthod"},{"key":"10.1016\/j.ajodo.2026.06.029_bib36","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40510-025-00587-x","article-title":"Accuracy comparison of orthodontic movements obtained with 3D printed and thermoformed aligners: a retrospective cohort study","volume":"26","author":"Migliorati","year":"2025","journal-title":"Prog Orthod"}],"container-title":["American Journal of Orthodontics and Dentofacial Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540626004099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889540626004099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:26:57Z","timestamp":1790022417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889540626004099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":36,"alternative-id":["S0889540626004099"],"URL":"https:\/\/doi.org\/10.1016\/j.ajodo.2026.06.029","relation":{},"ISSN":["0889-5406"],"issn-type":[{"value":"0889-5406","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of clear aligner treatment in patients with cleft lip and palate: A 3-dimensional linear, angular, and morphometric study of the maxillary arch","name":"articletitle","label":"Article Title"},{"value":"American Journal of Orthodontics and Dentofacial Orthopedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajodo.2026.06.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the American Association of Orthodontists.","name":"copyright","label":"Copyright"}]}}