{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:29:08Z","timestamp":1791354548750,"version":"4.3.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1016\/j.ajog.2004.06.065","type":"journal-article","created":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T23:15:39Z","timestamp":1106694939000},"page":"146-152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["Effects into adulthood of single or repeated antenatal corticosteroids in sheep"],"prefix":"10.1016","volume":"192","author":[{"given":"Timothy J.M.","family":"Moss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota A.","family":"Doherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Nitsos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M.","family":"Sloboda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Newnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2004.06.065_bib1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1677\/joe.0.0450515","article-title":"Premature delivery of foetal lambs infused with glucocorticoids","volume":"45","author":"Liggins","year":"1969","journal-title":"J Endocrinol"},{"key":"10.1016\/j.ajog.2004.06.065_bib2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1542\/peds.50.4.515","article-title":"A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants","volume":"50","author":"Liggins","year":"1972","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2004.06.065_bib3","unstructured":"Crowley P. Prophylactic corticosteroids for preterm birth (Cochrane Review). In: The Cochrane Library; 2001;4."},{"key":"10.1016\/j.ajog.2004.06.065_bib4","first-page":"413","article-title":"Effect of corticosteroids for fetal maturation on perinatal outcomes, February 28-March 2, 1994","volume":"173","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2004.06.065_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0140-6736(99)00448-1","article-title":"Antenatal corticosteroids: is more better?","volume":"355","author":"Smith","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2004.06.065_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1479-828X.1998.tb02947.x","article-title":"Use of corticosteroids by Australian obstetricians\u2014a survey of clinical practice","volume":"38","author":"Quinlivan","year":"1998","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2004.06.065_bib7","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/00001703-200212000-00006","article-title":"Antenatal corticosteroids: the good, the bad and the unknown","volume":"14","author":"Newnham","year":"2002","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.ajog.2004.06.065_bib8","first-page":"144","article-title":"Antenatal corticosteroids revisited: repeat courses\u2014National Institutes of Health Consensus Development Conference Statement, August 17-18, 2000","volume":"98","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2004.06.065_bib9","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0002-9378(98)70518-6","article-title":"Single and repetitive maternal glucocorticoid exposures reduce fetal growth in sheep","volume":"178","author":"Jobe","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2004.06.065_bib10","first-page":"81","article-title":"Maternal, but not fetal, administration of corticosteroids restricts fetal growth","volume":"8","author":"Newnham","year":"1999","journal-title":"J Matern Fetal Med"},{"key":"10.1016\/j.ajog.2004.06.065_bib11","first-page":"485","article-title":"Antenatal dexamethasone and decreased birth weight","volume":"97","author":"Bloom","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2004.06.065_bib12","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0002-9378(99)70517-X","article-title":"Multiple courses of antenatal corticosteroids and outcome of premature neonates. North American Thyrotropin-Releasing Hormone Study Group","volume":"181","author":"Banks","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2004.06.065_bib13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0002-9378(99)70160-2","article-title":"Repeated antenatal corticosteroids: size at birth and subsequent development","volume":"180","author":"French","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2004.06.065_bib14","first-page":"309","article-title":"Repeated prenatal corticosteroids delay myelination in the ovine central nervous system","volume":"6","author":"Dunlop","year":"1997","journal-title":"J Matern Fetal Med"},{"key":"10.1016\/j.ajog.2004.06.065_bib15","first-page":"213","article-title":"Effect of corticosteroids on brain growth in fetal sheep","volume":"94","author":"Huang","year":"1999","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2004.06.065_bib16","first-page":"757","article-title":"Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome?","volume":"83","author":"Phillips","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2004.06.065_bib17","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/00004872-199608000-00002","article-title":"Is blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature","volume":"14","author":"Law","year":"1996","journal-title":"J Hypertens"},{"key":"10.1016\/j.ajog.2004.06.065_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0303-7207(01)00633-5","article-title":"Glucocorticoid programming of the fetus; adult phenotypes and molecular mechanisms","volume":"185","author":"Seckl","year":"2001","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.ajog.2004.06.065_bib19","first-page":"R960","article-title":"Programming effects in sheep of prenatal growth restriction and glucocorticoid exposure","volume":"281","author":"Moss","year":"2001","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ajog.2004.06.065_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1677\/joe.0.1720071","article-title":"The effect of prenatal betamethasone administration on postnatal ovine hypothalamic-pituitary-adrenal function","volume":"172","author":"Sloboda","year":"2002","journal-title":"J Endocrinol"},{"key":"10.1016\/j.ajog.2004.06.065_bib21","series-title":"Effects of betamethasone upon the ovine fetus","author":"Quinlivan","year":"2000"},{"key":"10.1016\/j.ajog.2004.06.065_bib22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0736-5748(01)00026-0","article-title":"Repeated prenatal corticosteroid administration delays myelination of the corpus callosum in fetal sheep","volume":"19","author":"Huang","year":"2001","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.ajog.2004.06.065_bib23","first-page":"47","article-title":"Repeated, but not single, maternal administration of corticosteroids delays myelination in the brain of fetal sheep","volume":"4","author":"Quinlivan","year":"1999","journal-title":"Prenat Neonatal Med"},{"key":"10.1016\/j.ajog.2004.06.065_bib24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1113\/jphysiol.2002.025700","article-title":"Glucocorticoid exposure at the dose used clinically alters cytoskeletal proteins and presynaptic terminals in the fetal baboon brain","volume":"547","author":"Antonow-Schlorke","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.ajog.2004.06.065_bib25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1113\/jphysiol.2003.043414","article-title":"A single course of prenatal betamethasone in the rat alters postnatal brain cell proliferation but not apoptosis","volume":"552","author":"Scheepens","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.ajog.2004.06.065_bib26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1006\/hbeh.1994.1030","article-title":"Neurotoxicity of glucocorticoids in the primate brain","volume":"28","author":"Uno","year":"1994","journal-title":"Horm Behav"},{"key":"10.1016\/j.ajog.2004.06.065_bib27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0165-3806(90)90002-G","article-title":"Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques. I. Hippocampus","volume":"53","author":"Uno","year":"1990","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.ajog.2004.06.065_bib28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1053\/siny.2001.0066","article-title":"Antenatal glucocorticoids and the developing brain: mechanisms of action","volume":"6","author":"Matthews","year":"2001","journal-title":"Semin Neonatol"},{"key":"10.1016\/j.ajog.2004.06.065_bib29","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1203\/00006450-200003000-00003","article-title":"Antenatal glucocorticoids and programming of the developing CNS","volume":"47","author":"Matthews","year":"2000","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ajog.2004.06.065_bib30","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.1542\/peds.106.1.e2","article-title":"Antenatal corticosteroids and outcome at 14 years of age in children with birth weight less than 1501 grams","volume":"106","author":"Doyle","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2004.06.065_bib31","doi-asserted-by":"crossref","first-page":"E77","DOI":"10.1542\/peds.105.6.e77","article-title":"Twenty-year follow-up of antenatal corticosteroid treatment","volume":"105","author":"Dessens","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2004.06.065_bib32","first-page":"S24","article-title":"Multiple courses of antenatal steroids are associated with a delay in long-term psychomotor development in children with birth weights <1,500 grams","volume":"182","author":"Esplin","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2004.06.065_bib33","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ajog.2003.12.016","article-title":"Repeated antenatal corticosteroids: effects on cerebral palsy and childhood behaviour","volume":"190","author":"French","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2004.06.065_bib34","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0378-3782(77)90015-9","article-title":"Head circumference as an index of brain weight in the fetus and newborn","volume":"1","author":"Cooke","year":"1977","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.ajog.2004.06.065_bib35","first-page":"101","article-title":"Does antenatal corticosteroid therapy affect birth weight and head circumference?","volume":"99","author":"Thorp","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2004.06.065_bib36","first-page":"109","article-title":"Effect of antenatal and postnatal corticosteroid therapy on weight gain and head circumference growth in the nursery","volume":"99","author":"Thorp","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2004.06.065_bib37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1084-2756(02)00189-6","article-title":"Corticosteroids in the prevention and management of bronchopulmonary dysplasia","volume":"8","author":"Grier","year":"2003","journal-title":"Semin Neonatol"},{"key":"10.1016\/j.ajog.2004.06.065_bib38","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/cs0980137","article-title":"Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children","volume":"98","author":"Doyle","year":"2000","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.ajog.2004.06.065_bib39","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/S0895-7061(98)00090-9","article-title":"The impact of birth weight and gestational age on blood pressure in adult life: a population-based study of 49-year-old men","volume":"11","author":"Siewert-Delle","year":"1998","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.ajog.2004.06.065_bib40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/cs0940149","article-title":"An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep","volume":"94","author":"Dodic","year":"1998","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.ajog.2004.06.065_bib41","first-page":"R343","article-title":"No evidence for HPA reset in adult sheep with high blood pressure due to short prenatal exposure to dexamethasone","volume":"282","author":"Dodic","year":"2002","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ajog.2004.06.065_bib42","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1042\/cs0980553","article-title":"Differential timing for programming of glucose homoeostasis, sensitivity to insulin and blood pressure by in utero exposure to dexamethasone in sheep","volume":"98","author":"Gatford","year":"2000","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.ajog.2004.06.065_bib43","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1172\/JCI1567","article-title":"Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring","volume":"101","author":"Nyirenda","year":"1998","journal-title":"J Clin Invest"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937804006659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937804006659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T09:57:15Z","timestamp":1757584635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937804006659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S0002937804006659"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2004.06.065","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1023738.281702","asserted-by":"object"}]},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects into adulthood of single or repeated antenatal corticosteroids in sheep","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2004.06.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}