{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:21:48Z","timestamp":1767838908172,"version":"3.49.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.ajog.2005.03.065","type":"journal-article","created":{"date-parts":[[2005,8,12]],"date-time":"2005-08-12T07:37:55Z","timestamp":1123832275000},"page":"313-321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["The effects of intra-amniotic injection of periodontopathic lipopolysaccharides in sheep"],"prefix":"10.1016","volume":"193","author":[{"given":"John P.","family":"Newnham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Shub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan H.","family":"Jobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip S.","family":"Bird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machiko","family":"Ikegami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias","family":"Nitsos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.M.","family":"Moss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2005.03.065_bib1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1902\/annals.1996.1.1.821","article-title":"Periodontal diseases: pathogenesis","volume":"1","author":"Offenbacher","year":"1996","journal-title":"Ann Periodontol"},{"key":"10.1016\/j.ajog.2005.03.065_bib2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1902\/annals.1998.3.1.233","article-title":"Potential pathogenic mechanisms of periodontitis-associated pregnancy complications","volume":"3","author":"Offenbacher","year":"1998","journal-title":"Ann Periodontol"},{"key":"10.1016\/j.ajog.2005.03.065_bib3","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1902\/annals.1998.3.1.222","article-title":"Preterm birth: associations with genital and possibly oral microflora","volume":"3","author":"Hill","year":"1998","journal-title":"Ann Periodontol"},{"key":"10.1016\/j.ajog.2005.03.065_bib4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/002203450208100113","article-title":"High risk of preterm birth and low birth weight in women with periodontal disease","volume":"81","author":"Lopez","year":"2002","journal-title":"J Dent Res"},{"key":"10.1016\/j.ajog.2005.03.065_bib5","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1902\/jop.2002.73.8.911","article-title":"Periodontal therapy may reduce the risk of preterm low birth weight in women with periodontal disease: a randomized controlled trial","volume":"73","author":"Lopez","year":"2002","journal-title":"J Periodontol"},{"key":"10.1016\/j.ajog.2005.03.065_bib6","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJM200005183422007","article-title":"Intrauterine infection and preterm delivery","volume":"342","author":"Goldenberg","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2005.03.065_bib7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0002-9378(00)70231-6","article-title":"Effects of antenatal endotoxin and glucocorticoids on the lungs of preterm lambs","volume":"182","author":"Jobe","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2005.03.065_bib8","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1164\/ajrccm.165.6.2108053","article-title":"Early gestational intra-amniotic endotoxin: lung function, surfactant and morphometry","volume":"165","author":"Moss","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajog.2005.03.065_bib9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/107155760200900206","article-title":"Fetal responses to intra-amniotic endotoxin in sheep","volume":"9","author":"Nitsos","year":"2002","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.ajog.2005.03.065_bib10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-0757.1999.tb00162.x","article-title":"Virulence factors of Porphyromonas gingivalis","volume":"20","author":"Holt","year":"2000","journal-title":"Periodontology"},{"key":"10.1016\/j.ajog.2005.03.065_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.3336774","article-title":"Implantation of Bacteroides gingivalis in non-human primates initiates progression of periodontitis","volume":"239","author":"Holt","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.ajog.2005.03.065_bib12","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1902\/jop.2001.72.11.1491","article-title":"The association between Porphyromonas gingivalis-specific maternal serum IgG and low birth weight","volume":"72","author":"Dasanayake","year":"2001","journal-title":"J Periodontol"},{"key":"10.1016\/j.ajog.2005.03.065_bib13","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1600-0757.1999.tb00160.x","article-title":"Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in nonoral infections","volume":"20","author":"Van Winkelhoff","year":"2000","journal-title":"Periodontology"},{"key":"10.1016\/j.ajog.2005.03.065_bib14","first-page":"527","article-title":"Possible association between amniotic fluid micro-organism infection and microflora in the mouth","volume":"109","author":"Bearfield","year":"2002","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2005.03.065_bib15","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1902\/jop.2001.72.11.1527","article-title":"The effects of interleukin-10 depletion in vivo on the immune response to Porphyromonas gingivalis in a murine model","volume":"72","author":"Herminajeng","year":"2001","journal-title":"J Periodontol"},{"key":"10.1016\/j.ajog.2005.03.065_bib16","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1128\/IAI.66.6.2736-2742.1998","article-title":"Strain-dependent activation of monocytes and inflammatory macrophages by lipopolysaccharide of Porphyromonas gingivalis","volume":"66","author":"Shapira","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajog.2005.03.065_bib17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1399-302X.1996.tb00187.x","article-title":"Effect of host responses on the pathogenicity of strains of Porphyromonas gingivalis","volume":"11","author":"Katz","year":"1996","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.ajog.2005.03.065_bib18","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2005.03.065_bib19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ajog.2005.03.065_bib20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1046\/j.1365-2567.2002.01491.x","article-title":"Expression and regulation of the pattern recognition receptors Toll-like receptor-2 and Toll-like receptor-4 in the human placenta","volume":"107","author":"Holmlund","year":"2002","journal-title":"Immunology"},{"key":"10.1016\/j.ajog.2005.03.065_bib21","first-page":"308","article-title":"Biological activities of tritiated endotoxins: correlation of the Limulus lysate assay with rabbit pyrogen and complement-activation assays for endotoxin","volume":"89","author":"Tomasulo","year":"1977","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.ajog.2005.03.065_bib22","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1128\/iai.62.10.4356-4361.1994","article-title":"Effects of a Porphyromonas gingivalis infection on inflammatory mediator response and pregnancy outcome in hamsters","volume":"62","author":"Collins","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajog.2005.03.065_bib23","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1128\/IAI.71.9.5163-5168.2003","article-title":"Porphyromonas gingivalis infection in pregnant mice is associated with placental dissemination, an increase in the placental Th1\/Th2 cytokine ratio, and fetal growth restriction","volume":"71","author":"Lin","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajog.2005.03.065_bib24","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1128\/IAI.72.4.2272-2279.2004","article-title":"Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth","volume":"72","author":"Han","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajog.2005.03.065_bib25","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ajog.2004.09.001","article-title":"Chronic maternal and fetal Porphyromonas gingivalis exposure during pregnancy in rabbits","volume":"192","author":"Boggess","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2005.03.065_bib26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0002-9378(97)70432-0","article-title":"Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1\u03b2, and tumor necrosis factor-\u03b1), neonatal brain white matter lesions, and cerebral palsy","volume":"177","author":"Yoon","year":"1997","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293780500503X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293780500503X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T09:58:54Z","timestamp":1757584734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000293780500503X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S000293780500503X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2005.03.065","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of intra-amniotic injection of periodontopathic lipopolysaccharides in sheep","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2005.03.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}