{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:19:03Z","timestamp":1778275143285,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.ajog.2005.06.031","type":"journal-article","created":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T07:05:27Z","timestamp":1136099127000},"page":"239-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Circulating angiogenic proteins in trisomy 13"],"prefix":"10.1016","volume":"194","author":[{"given":"Yuval","family":"Bdolah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn E.","family":"Palomaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Yaron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tali","family":"Bdolah-Abram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlene","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin P.","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Haddow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Ananth","family":"Karumanchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2005.06.031_bib1","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S0140-6736(00)02800-2","article-title":"Pre-eclampsia","volume":"356","author":"Walker","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2005.06.031_bib2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0146-0005(03)00022-3","article-title":"What we have learned about preeclampsia","volume":"27","author":"Sibai","year":"2003","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.ajog.2005.06.031_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/pd.814","article-title":"Trisomy 13 mosaicism: study of serial cytogenetic changes in a case from early pregnancy to infancy","volume":"24","author":"Chen","year":"2004","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2005.06.031_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1447-0756.2004.00191.x","article-title":"Chromosome abnormalities identified in 347 spontaneous abortions collected in Japan","volume":"30","author":"Nagaishi","year":"2004","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.ajog.2005.06.031_bib5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1542\/peds.111.4.777","article-title":"Population-based analyses of mortality in trisomy 13 and trisomy 18","volume":"111","author":"Rasmussen","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2005.06.031_bib6","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1471-0528.1992.tb14436.x","article-title":"Pre-eclampsia and trisomy 13","volume":"99","author":"Tuohy","year":"1992","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2005.06.031_bib7","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0140-6736(87)92602-X","article-title":"Pre-eclampsia and trisomy 13","volume":"2","author":"Bower","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2005.06.031_bib8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(87)90960-3","article-title":"Pre-eclampsia and trisomy 13: a possible association","volume":"2","author":"Boyd","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2005.06.031_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1399-0004.1995.tb03915.x","article-title":"Maternal 3;13 chromosome insertion, with severe pre-eclampsia","volume":"47","author":"Boyd","year":"1995","journal-title":"Clin Genet"},{"key":"10.1016\/j.ajog.2005.06.031_bib10","first-page":"395","article-title":"Severe toxemia, hydramnios and trisomy 13-15","volume":"67","author":"Evers","year":"1967","journal-title":"Ned Tijdschr Verloskd Gynaecol"},{"key":"10.1016\/j.ajog.2005.06.031_bib11","first-page":"505","article-title":"Preeclampsia, trisomy 13, and the placental bed","volume":"78","author":"Feinberg","year":"1991","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2005.06.031_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0028-2243(95)02055-W","article-title":"Pre-eclampsia and trisomy 13","volume":"60","author":"Heydanus","year":"1995","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2005.06.031_bib13","first-page":"2108","article-title":"[Severe pre-eclampsia and fetal trisomy 13 in a multiparous woman]","volume":"165","author":"Pedersen","year":"2003","journal-title":"Ugeskr Laeger"},{"key":"10.1016\/j.ajog.2005.06.031_bib14","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0140-6736(87)92519-0","article-title":"Pre-eclampsia and trisomy 13","volume":"2","author":"Thornton","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2005.06.031_bib15","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajog.2005.06.031_bib16","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1210\/jc.2003-030528","article-title":"Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequences","volume":"88","author":"Tsatsaris","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2005.06.031_bib17","doi-asserted-by":"crossref","first-page":"12605","DOI":"10.1074\/jbc.C300012200","article-title":"Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria","volume":"278","author":"Sugimoto","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajog.2005.06.031_bib18","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1210\/jc.2002-021942","article-title":"Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia","volume":"88","author":"Koga","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2005.06.031_bib19","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.ajog.2004.03.043","article-title":"Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia: young investigator award","volume":"190","author":"Chaiworapongsa","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2005.06.031_bib20","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1373\/clinchem.2004.036715","article-title":"Maternal serum sFlt1 concentration is an early and reliable predictive marker of preeclampsia","volume":"50","author":"Hertig","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.ajog.2005.06.031_bib21","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2005.06.031_bib22","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1210\/jc.2003-031244","article-title":"First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia","volume":"89","author":"Thadhani","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2005.06.031_bib23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1001\/jama.293.1.77","article-title":"Urinary placental growth factor and risk of preeclampsia","volume":"293","author":"Levine","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2005.06.031_bib24","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.semnephrol.2004.07.003","article-title":"Angiogenic imbalance in the pathophysiology of preeclampsia: newer insights","volume":"24","author":"Bdolah","year":"2004","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.ajog.2005.06.031_bib25","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1210\/en.2004-1028","article-title":"Hypoxia and sFlt-1 in preeclampsia: the \u201cchicken-and-egg\u201d question","volume":"145","author":"Karumanchi","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajog.2005.06.031_bib26","series-title":"Practical nonparametric statistics","author":"Conover","year":"1980"},{"key":"10.1016\/j.ajog.2005.06.031_bib27","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/pd.148","article-title":"First trimester maternal serum placenta growth factor (PIGF) concentrations in pregnancies with fetal trisomy 21 or trisomy 18","volume":"21","author":"Spencer","year":"2001","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2005.06.031_bib28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/pd.218","article-title":"Raised maternal serum placenta growth factor concentration during the second trimester is associated with Down syndrome","volume":"22","author":"Su","year":"2002","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2005.06.031_bib29","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/molehr\/7.8.765","article-title":"Vascular endothelial growth factor and placenta growth factor concentrations in Down's syndrome and control pregnancies","volume":"7","author":"Debieve","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.ajog.2005.06.031_bib30","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/pd.998","article-title":"Placenta growth factor levels in second-trimester maternal serum in Down syndrome pregnancy and in the prediction of preeclampsia","volume":"24","author":"Lambert-Messerlian","year":"2004","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2005.06.031_bib31","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/hmg\/8.9.1799","article-title":"A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13","volume":"8","author":"Arngrimsson","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ajog.2005.06.031_bib32","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/sj.ejhg.5200706","article-title":"A genome-wide scan for preeclampsia in the Netherlands","volume":"9","author":"Lachmeijer","year":"2001","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ajog.2005.06.031_bib33","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/sj.ejhg.5200951","article-title":"Microsatellite marker association at chromosome region 2p13 in Finnish patients with preeclampsia and obstetric cholestasis suggests a common risk locus","volume":"11","author":"Laasanen","year":"2003","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ajog.2005.06.031_bib34","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0301-2115(02)00208-7","article-title":"Searching for preeclampsia genes: the current position","volume":"105","author":"Lachmeijer","year":"2002","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2005.06.031_bib35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(00)03577-7","article-title":"Pathogenesis and genetics of pre-eclampsia","volume":"357","author":"Roberts","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2005.06.031_bib36","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/00003081-200209000-00014","article-title":"Application of the human genome to obstetrics and gynecology","volume":"45","author":"Woodage","year":"2002","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.ajog.2005.06.031_bib37","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1086\/316888","article-title":"A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2","volume":"67","author":"Moses","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajog.2005.06.031_bib38","first-page":"303","article-title":"The familial factor in toxemia of pregnancy","volume":"32","author":"Chesley","year":"1968","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2005.06.031_bib39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/ng0593-59","article-title":"A molecular variant of angiotensinogen associated with preeclampsia","volume":"4","author":"Ward","year":"1993","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajog.2005.06.031_bib40","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/ng0693-114","article-title":"Angiotensinogen: A candidate gene involved in preeclampsia?","volume":"4","author":"Arngrimsson","year":"1993","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajog.2005.06.031_bib41","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/sj.eye.6701454","article-title":"Buphthalmos in trisomy 13","volume":"19","author":"Bunting","year":"2005","journal-title":"Eye"},{"key":"10.1016\/j.ajog.2005.06.031_bib42","first-page":"614","article-title":"Partial trisomy 13 with features similar to c syndrome","volume":"41","author":"Phadke","year":"2004","journal-title":"Indian J Pediatr"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937805008756?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937805008756?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:02:24Z","timestamp":1757584944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937805008756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0002937805008756"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2005.06.031","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating angiogenic proteins in trisomy 13","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2005.06.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}