{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T05:51:45Z","timestamp":1764827505373,"version":"3.44.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.ajog.2006.02.046","type":"journal-article","created":{"date-parts":[[2006,5,25]],"date-time":"2006-05-25T20:15:23Z","timestamp":1148588123000},"page":"1379-1387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Screening for Down syndrome using first-trimester combined screening followed by second-trimester ultrasound examination in an unselected population"],"prefix":"10.1016","volume":"195","author":[{"given":"Patrick","family":"Rozenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Bussi\u00e8res","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Chevret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Pierre","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Malagrida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Cuckle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Chabry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Durand-Zaleski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Bidat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Lacroix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Moulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Roger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Christine","family":"Jacquemot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Philippe","family":"Bault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Boukobza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Boccara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Vialard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Giudicelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Ville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2006.02.046_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/096914139700400402","article-title":"Antenatal screening for Down's syndrome","volume":"4","author":"Wald","year":"1997","journal-title":"J Med Screen"},{"key":"10.1016\/j.ajog.2006.02.046_bib2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0140-6736(97)11280-6","article-title":"UK multicenter project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation","volume":"351","author":"Snijders","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2006.02.046_bib3","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1056\/NEJM199804023381404","article-title":"Screening of maternal serum for fetal Down's syndrome in the first trimester","volume":"338","author":"Haddow","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2006.02.046_bib4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0146-0005(99)80002-0","article-title":"First trimester serum screening for aneuploidy: serum biochemical markers","volume":"23","author":"Canick","year":"1999","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.ajog.2006.02.046_bib5","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/(SICI)1097-0223(199904)19:4<360::AID-PD556>3.0.CO;2-U","article-title":"First-trimester screening for Down syndrome using nuchal translucency measurement with free [beta]-hCG and PAPP-A between 10 and 13 weeks of pregnancy\u2014the combined test","volume":"19","author":"De Biasio","year":"1999","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2006.02.046_bib6","first-page":"207","article-title":"First-trimester Down syndrome screening using dried blood biochemistry and nuchal translucency","volume":"96","author":"Krantz","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib7","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/sj.ejhg.5200655","article-title":"Evaluation of first trimester maternal serum and ultrasound screening for Down's syndrome in Eastern and Northern Finland","volume":"9","author":"Niemimaa","year":"2001","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ajog.2006.02.046_bib8","first-page":"211","article-title":"The first trimester \u2018combined test\u2019 for the detection of Down syndrome pregnancies in 4939 unselected pregnancies","volume":"22","author":"Schuchter","year":"2002","journal-title":"Prenat\u00a0Diagn"},{"key":"10.1016\/j.ajog.2006.02.046_bib9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1471-0528.2002.01394.x","article-title":"Combined ultrasound and biochemical screening for Down's syndrome in the first trimester: a Scottish multicenter study","volume":"109","author":"Crossley","year":"2002","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2006.02.046_bib10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1469-0705.2002.00808.x","article-title":"One-stop clinic for assessment of risk for trisomy 21 at 11-14 weeks: a prospective study of 15,030 pregnancies","volume":"20","author":"Bindra","year":"2002","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib11","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1056\/NEJMoa025273","article-title":"First Trimester Maternal Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study Group. First-trimester screening for trisomies 21 and 18","volume":"349","author":"Wapner","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2006.02.046_bib12","first-page":"56","article-title":"First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS)","volume":"10","author":"Wald","year":"2003","journal-title":"J Med Screen"},{"key":"10.1016\/j.ajog.2006.02.046_bib13","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1056\/NEJMoa043693","article-title":"First- and Second-Trimester Evaluation of Risk (FASTER) Research Consortium. First-trimester or second-trimester screening, or both, for Down's syndrome","volume":"353","author":"Malone","year":"2005","journal-title":"N Engl J\u00a0Med"},{"key":"10.1016\/j.ajog.2006.02.046_bib14","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1471-0528.2004.00192.x","article-title":"Down's Syndrome screening: confusion or consensus?","volume":"111","author":"Goldberg","year":"2004","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2006.02.046_bib15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1046\/j.1469-0705.1998.12010008.x","article-title":"Age-adjusted ultrasound risk assessment for fetal Down's syndrome during the second trimester: description of the method and analysis of 142 cases","volume":"12","author":"Nyberg","year":"1998","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib16","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/0002-9378(85)90385-0","article-title":"A sonographic sign for the detection in the second trimester of the fetus with Down's syndrome","volume":"151","author":"Benacerraf","year":"1985","journal-title":"Am J Obstet Gynecol"},{"year":"1999","series-title":"The 11-14 week scan","author":"Nicolaides","key":"10.1016\/j.ajog.2006.02.046_bib17"},{"key":"10.1016\/j.ajog.2006.02.046_bib18","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1471-0528.1999.tb08317.x","article-title":"Ultrasonography in the detection of fetal anomalies in early pregnancy","volume":"106","author":"Economides","year":"1999","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2006.02.046_bib19","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/j.1471-0528.1999.tb08432.x","article-title":"The value of sonography in early pregnancy for the detection of fetal abnormalities in an unselected population","volume":"106","author":"Whitlow","year":"1999","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2006.02.046_bib20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1469-0705.2000.00203.x","article-title":"Trisomy 21: 91% detection rate using second-trimester ultrasound markers","volume":"16","author":"DeVore","year":"2000","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib21","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1046\/j.1469-0705.1998.12060398.x","article-title":"Nuchal translucency audit: a novel image-scoring method","volume":"12","author":"Herman","year":"1998","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib22","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1046\/j.1469-0705.1997.09040244.x","article-title":"The effect of nuchal translucency measurement on second-trimester biochemical screening for Down's syndrome","volume":"9","author":"Kadir","year":"1997","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib23","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/pd.131","article-title":"Inaccurate estimation of risk in second trimester serum screening for Down syndrome among women who have already had first trimester screening","volume":"21","author":"Hackshaw","year":"2001","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2006.02.046_bib24","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/(SICI)1097-0223(199805)18:5<519::AID-PD398>3.0.CO;2-U","article-title":"Correct estimation of parameters for ultrasound nuchal translucency screening","volume":"18","author":"Nicolaides","year":"1998","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2006.02.046_bib25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2307\/2530820","article-title":"Assessment of diagnostic tests when disease verification is subject to selection bias","volume":"39","author":"Begg","year":"1983","journal-title":"Biometrics"},{"key":"10.1016\/j.ajog.2006.02.046_bib26","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0895-4356(96)00014-5","article-title":"The importance of work-up (verification) bias correction in assessing the accuracy of SPECT thallium-201 testing for the diagnosis of coronary artery disease","volume":"49","author":"Cecil","year":"1996","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.ajog.2006.02.046_bib27","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1002\/sim.1517","article-title":"A global sensitivity analysis of performance of a medical diagnostic test when verification bias is present","volume":"22","author":"Kosinski","year":"2003","journal-title":"Stat Med"},{"key":"10.1016\/j.ajog.2006.02.046_bib28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1469-0705.1999.13030167.x","article-title":"Maternal age- and gestation-specific risk for trisomy 21","volume":"13","author":"Snijders","year":"1999","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1148\/radiology.193.1.8090881","article-title":"Identification of second-trimester fetuses with autosomal trisomy by use of a sonographic scoring index","volume":"193","author":"Benacerraf","year":"1994","journal-title":"Radiology"},{"key":"10.1016\/j.ajog.2006.02.046_bib30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1469-0705.1997.10050321.x","article-title":"The incorporation of maternal age into the sonographic scoring index for the detection at 14-20 weeks of fetuses with Down's syndrome","volume":"10","author":"Bromley","year":"1997","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib31","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1053\/j.semperi.2005.05.004","article-title":"Down syndrome screening in the first and\/or second trimester: model predicted performance using meta-analysis parameters","volume":"29","author":"Cuckle","year":"2005","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.ajog.2006.02.046_bib32","first-page":"1168","article-title":"Combined second-trimester biochemical and ultrasound screening for Down syndrome","volume":"100","author":"Benn","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib33","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1046\/j.1471-0528.2003.01490.x","article-title":"Fetuses with Down's Syndrome detected by prenatal screening are more likely to abort spontaneously than fetuses with Down's Syndrome not detected by prenatal screening","volume":"110","author":"Leporrier","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2006.02.046_bib34","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/01.AOG.0000139832.79658.b9","article-title":"First Trimester Maternal Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study Group. Sequential pathways of testing after first-trimester screening for trisomy 21","volume":"104","author":"Platt","year":"2004","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib35","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1046\/j.1469-0705.2000.00141.x","article-title":"Should sonographic screening for fetal Down syndrome be applied to low risk women?","volume":"15","author":"Benacerraf","year":"2000","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib36","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1046\/j.1469-0705.1993.03010056.x","article-title":"Ultrasonographically detectable markers of fetal chromosomal defects","volume":"3","author":"Nicolaides","year":"1993","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib37","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0002-9378(95)90008-X","article-title":"Adjusting the risk for trisomy 21 on the basis of second-trimester ultrasonography","volume":"172","author":"Vintzileos","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib38","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/0029-7844(96)00053-1","article-title":"The use of second-trimester genetic sonogram in guiding clinical management of patients at increased risk for fetal\u00a0trisomy 21","volume":"87","author":"Vintzileos","year":"1996","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib39","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1148\/radiology.215.3.r00ma36775","article-title":"The \u201cgenetic sonogram\u201d: comparison of the index scoring system with the age-adjusted US risk assessment","volume":"215","author":"Winter","year":"2000","journal-title":"Radiology"},{"key":"10.1016\/j.ajog.2006.02.046_bib40","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1067\/mob.2001.117673","article-title":"Role of ultrasound for Down syndrome screening in advanced maternal age","volume":"185","author":"Egan","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.02.046_bib41","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1056\/NEJMe058189","article-title":"Choosing the best prenatal screening protocol","volume":"353","author":"Simpson","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2006.02.046_bib42","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1136\/bmj.1.6012.753","article-title":"Preventing the birth of infants with Down's syndrome: a cost-benefit analysis","volume":"1","author":"Hagard","year":"1976","journal-title":"BMJ"},{"key":"10.1016\/j.ajog.2006.02.046_bib43","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1399-0004.1990.tb04187.x","article-title":"A cost-benefit analysis of prenatal diagnosis by amniocentesis in Denmark","volume":"37","author":"Golstein","year":"1990","journal-title":"Clin Genetic"},{"key":"10.1016\/j.ajog.2006.02.046_bib44","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/00005650-199408000-00008","article-title":"A cost-effectiveness analysis of amniocentesis and chorionic villus sampling for prenatal genetic testing","volume":"32","author":"Heckerling","year":"1994","journal-title":"Med Care"},{"key":"10.1016\/j.ajog.2006.02.046_bib45","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/bmj.323.7310.423","article-title":"Screening for Down's syndrome: effects, safety, and cost effectiveness of first and second trimester strategies","volume":"323","author":"Gilbert","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.ajog.2006.02.046_bib46","first-page":"1066","article-title":"Society for Maternal-Fetal Medicine. First-trimester sonographic screening for Down syndrome","volume":"102","author":"Malone","year":"2003","journal-title":"Obstet Gynecol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937806002900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937806002900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:19:54Z","timestamp":1757585994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937806002900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0002937806002900"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2006.02.046","relation":{},"ISSN":["0002-9378"],"issn-type":[{"type":"print","value":"0002-9378"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Screening for Down syndrome using first-trimester combined screening followed by second-trimester ultrasound examination in an unselected population","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2006.02.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}