{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T13:48:28Z","timestamp":1766065708826,"version":"3.44.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.ajog.2006.05.019","type":"journal-article","created":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T15:17:14Z","timestamp":1157728634000},"page":"1636-1645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Serum and urine inhibin A but not free activin A are endocrine biomarkers of severe pre-eclampsia"],"prefix":"10.1016","volume":"195","author":[{"given":"Benjamin D.","family":"Hamar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina A.","family":"Buhimschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna K.","family":"Sfakianaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian M.","family":"Pettker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lissa K.","family":"Magloire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund F.","family":"Funai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua A.","family":"Copel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalin S.","family":"Buhimschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2006.05.019_bib1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2006.05.019_bib2","first-page":"533","article-title":"Pregnancy-related mortality from pre-eclampsia and eclampsia","volume":"97","author":"MacKay","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.05.019_bib3","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1001\/jama.294.21.2751","article-title":"Manifestations of chronic disease during pregnancy","volume":"294","author":"Kaaja","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2006.05.019_bib4","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1067\/mob.2002.127305","article-title":"The myometrial junctional zone spiral arteries in normal and abnormal pregnancies: a review of the literature","volume":"187","author":"Brosens","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.05.019_bib5","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1056\/NEJM198909213211210","article-title":"Inhibin: from hypothesis to clinical application","volume":"321","author":"Bremner","year":"1989","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2006.05.019_bib6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1095\/biolreprod40.1.33","article-title":"The isolation and physiology of inhibin and related proteins","volume":"40","author":"de Kretser","year":"1989","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajog.2006.05.019_bib7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3181\/00379727-186-42611A","article-title":"Inhibins and activins: chemical properties and biological activity","volume":"186","author":"Ying","year":"1987","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.ajog.2006.05.019_bib8","first-page":"915","article-title":"Identification of activins and follistatin proteins in human follicular fluid and placenta","volume":"80","author":"Yokoyama","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2006.05.019_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0022-1759(91)90311-3","article-title":"Ultrasensitive two-site assays for inhibin-A and activin-A using monoclonal antibodies raised to synthetic peptides","volume":"145","author":"Groome","year":"1991","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.ajog.2006.05.019_bib10","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1365-2265.1994.tb02504.x","article-title":"Detection of dimeric inhibin throughout the human menstrual cycle by two-site enzyme immunoassay","volume":"40","author":"Groome","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.ajog.2006.05.019_bib11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0301-2115(98)00179-1","article-title":"Advance in the study of inhibin, activin and follistatin production in pregnant women","volume":"81","author":"Qu","year":"1998","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2006.05.019_bib12","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-2265.1995.tb02648.x","article-title":"Measurement of serum concentrations of inhibin-A (alpha-beta A dimer) during human pregnancy","volume":"42","author":"Muttukrishna","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.ajog.2006.05.019_bib13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-0897.1998.tb00386.x","article-title":"Inhibin-A and pro-alpha C\u00a0are elevated in preeclamptic pregnancy and correlate with human chorionic gonadotropin","volume":"40","author":"Fraser","year":"1998","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.ajog.2006.05.019_bib14","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0002-9378(99)70606-X","article-title":"Comparison of maternal serum total activin A and inhibin A in normal, preeclamptic, and nonproteinuric gestationally hypertensive pregnancies","volume":"180","author":"Silver","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.05.019_bib15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1081\/PRG-120016794","article-title":"Women with pre-eclampsia have increased serum levels of pregnancy-associated plasma protein A (PAPP-A), inhibin A, activin A and soluble E-selectin","volume":"22","author":"Bersinger","year":"2003","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.ajog.2006.05.019_bib16","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1210\/jc.2002-021924","article-title":"Endothelial cells and peripheral blood mononuclear cells are a\u00a0potential source of extraplacental activin a in pre-eclampsia","volume":"88","author":"Tannetta","year":"2003","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2006.05.019_bib17","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0140-6736(96)09264-1","article-title":"Activin A and inhibin A as possible endocrine markers for pre-eclampsia","volume":"349","author":"Muttukrishna","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2006.05.019_bib18","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/humrep\/15.7.1640","article-title":"Serum inhibin A and activin A are elevated prior to the onset of pre-eclampsia","volume":"15","author":"Muttukrishna","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2006.05.019_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1677\/joe.0.1650157","article-title":"Increased maternal serum activin A but not follistatin levels in pregnant women with hypertensive disorders","volume":"165","author":"D'Antona","year":"2000","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.ajog.2006.05.019_bib20","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/j.1471-0528.1998.tb09943.x","article-title":"Maternal serum inhibin A can predict pre-eclampsia","volume":"105","author":"Cuckle","year":"1998","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2006.05.019_bib21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0002-9378(99)70448-5","article-title":"Second-trimester maternal serum inhibin A concentration as an early marker for pre-eclampsia","volume":"181","author":"Aquilina","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.05.019_bib22","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1471-0528.2000.tb13343.x","article-title":"Raised maternal serum inhibin A concentration at 10 to 14 weeks of gestation is associated with pre-eclampsia","volume":"107","author":"Sebire","year":"2000","journal-title":"BJOG"},{"issue":"Suppl A","key":"10.1016\/j.ajog.2006.05.019_bib23","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1053\/plac.1999.0524","article-title":"Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen\u2014a review","volume":"21","author":"Ahmed","year":"2000","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2006.05.019_bib24","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1600-0897.2004.00154.x","article-title":"Determinants of placental vascularity","volume":"51","author":"Torry","year":"2004","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.ajog.2006.05.019_bib25","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in pre-eclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajog.2006.05.019_bib26","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of pre-eclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2006.05.019_bib27","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.ajog.2004.12.052","article-title":"Urinary angiogenic factors cluster hypertensive disorders and identify women with severe pre-eclampsia","volume":"192","author":"Buhimschi","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.05.019_bib28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1001\/jama.293.1.77","article-title":"Urinary placental growth factor and risk of pre-eclampsia","volume":"293","author":"Levine","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2006.05.019_bib29","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/01.AOG.0000207698.74104.4f","article-title":"Fractional excretion of angiogenic factors in women with severe pre-eclampsia","volume":"107","author":"Buhimschi","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.05.019_bib30","first-page":"159","article-title":"ACOG practice bulletin. Diagnosis and management of pre-eclampsia and eclampsia. Number 33, January 2002","volume":"99","author":"ACOG Committee on Practice Bulletins\u2013Obstetrics","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.05.019_bib31","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/01.grf.0000160315.67359.e6","article-title":"Expectant management of severe pre-eclampsia: proper candidates and pregnancy outcome","volume":"48","author":"Haddad","year":"2005","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.05.019_bib32","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0143-4004(95)90102-7","article-title":"Hypertension in pregnancy: changes in activin A maternal serum concentration","volume":"16","author":"Petraglia","year":"1995","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2006.05.019_bib33","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/14767050410001668275","article-title":"First-trimester maternal serum activin A in pre-eclampsia and fetal\u00a0growth restriction","volume":"15","author":"Ong","year":"2004","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2006.05.019_bib34","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/gye.16.5.365.372","article-title":"Pre-eclampsia with fetal growth restriction: placental and serum activin A and inhibin A levels","volume":"16","author":"Florio","year":"2002","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.ajog.2006.05.019_bib35","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1046\/j.1471-0528.2003.02190.x","article-title":"Maternal serum activin A levels in association with intrauterine fetal growth restriction","volume":"110","author":"Wallace","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2006.05.019_bib36","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1067\/mob.2001.117349","article-title":"Use of a random urinary protein-to-creatinine ratio for the diagnosis of significant proteinuria during pregnancy","volume":"185","author":"Rodriguez-Thompson","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.05.019_bib37","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.ogc.2004.08.010","article-title":"Biochemical screening for congenital defects","volume":"31","author":"Bahado-Singh","year":"2004","journal-title":"Obstet Gynecol Clin North Am"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937806006582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937806006582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:18:29Z","timestamp":1757585909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937806006582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0002937806006582"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2006.05.019","relation":{},"ISSN":["0002-9378"],"issn-type":[{"type":"print","value":"0002-9378"}],"subject":[],"published":{"date-parts":[[2006,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum and urine inhibin A but not free activin A are endocrine biomarkers of severe pre-eclampsia","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2006.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}