{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:10:54Z","timestamp":1784747454514,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MCT 41550"],"award-info":[{"award-number":["MCT 41550"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000241","name":"Physicians' Services Incorporated Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.ajog.2006.10.868","type":"journal-article","created":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T07:18:45Z","timestamp":1169191125000},"page":"37.e1-37.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm labor"],"prefix":"10.1016","volume":"196","author":[{"given":"Graeme N.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Ohlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Windrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2006.10.868_bib1","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM199811123392004","article-title":"Determinants of preterm birth rates in Canada from 1981 through 1983 and from 1992 through 1994","volume":"339","author":"Joseph","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2006.10.868_bib2","series-title":"Effective prevention of preterm birth: the French experience measured at Haguenau","first-page":"195","article-title":"Long term development of preterms: the state of health at age 6 years","author":"Bouyer","year":"1989"},{"issue":"Suppl 20","key":"10.1016\/j.ajog.2006.10.868_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1046\/j.1471-0528.2003.00021.x","article-title":"Classification and heterogeneity of preterm birth","volume":"110","author":"Moutquin","year":"2003","journal-title":"BJOG"},{"issue":"Suppl 20","key":"10.1016\/j.ajog.2006.10.868_bib4","first-page":"56","article-title":"Socio-economic and psychosocial factors in the management and prevention of preterm labour","volume":"110","author":"Moutquin","year":"2003","journal-title":"BJOG"},{"issue":"Suppl 20","key":"10.1016\/j.ajog.2006.10.868_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1046\/j.1471-0528.2003.00013.x","article-title":"Economic consequences of preterm birth and low birthweight","volume":"110","author":"Petrou","year":"2003","journal-title":"BJOG"},{"issue":"Suppl 20","key":"10.1016\/j.ajog.2006.10.868_bib6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1471-0528.2003.00053.x","article-title":"What are the realistic expectations of tocolytics?","volume":"110","author":"Smith","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2006.10.868_bib7","first-page":"869","article-title":"Tocolytics for preterm labor: a systematic review","volume":"94","author":"Gyetvai","year":"1999","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.10.868_bib8","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0140-6736(94)92468-6","article-title":"Arrest of preterm labour and prolongation of gestation with glyceryl trinitrate, a nitric oxide donor","volume":"343","author":"Lees","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2006.10.868_bib9","first-page":"403","article-title":"Glyceryl trinitrate and ritodrine in tocolysis: an international multicenter randomized study","volume":"94","author":"Lees","year":"1999","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.10.868_bib10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1479-828X.1996.tb02174.x","article-title":"Treatment of preterm cervical dilatation with glyceryl trinitrate, a nitric oxide donor","volume":"36","author":"Rowlands","year":"1996","journal-title":"Aust NZ J Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2006.10.868_bib11","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1471-0528.1999.tb08376.x","article-title":"Randomized, double-blind, placebo controlled trial assessing nitroglycerin as a tocolytic","volume":"106","author":"Smith","year":"1999","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2006.10.868_bib12","series-title":"The biology of nitric oxide","first-page":"201","article-title":"Glyceryl trinitrate stops active labour in sheep","author":"Heymann","year":"1994"},{"key":"10.1016\/j.ajog.2006.10.868_bib13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3109\/14767059309017336","article-title":"Nitric oxide inhibits preterm labour in Rhesus monkeys","volume":"2","author":"Jennings","year":"1993","journal-title":"J Maternal Fetal Med"},{"key":"10.1016\/j.ajog.2006.10.868_bib14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00006254-199809000-00023","article-title":"The use of nitroglycerin for uterine relaxation","volume":"53","author":"Smith","year":"1998","journal-title":"Obstet Gynecol Survey"},{"key":"10.1016\/j.ajog.2006.10.868_bib15","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.ajog.2004.02.019","article-title":"The randomized nitric oxide tocolysis trial (RNOTT) for the treatment of preterm labor","volume":"191","author":"Bisits","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.10.868_bib16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1542\/peds.82.4.527","article-title":"Abnormal pulmonary outcomes in premature infants; prediction from oxygen requirement in the neonatal period","volume":"82","author":"Sheennan","year":"1988","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2006.10.868_bib17","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM196702162760701","article-title":"Pulmonary disease following respirator therapy of hyaline membrane disease","volume":"276","author":"Northway","year":"1967","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2006.10.868_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal necrotizing enterocolitis","volume":"187","author":"Bell","year":"1978","journal-title":"Ann Surg"},{"key":"10.1016\/j.ajog.2006.10.868_bib19","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1056\/NEJM199207303270503","article-title":"Treatment of preterm labor with the beta-adrenergic agonist ritodrine","volume":"327","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2006.10.868_bib20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2307\/2530245","article-title":"A multiple testing procedure for clinical trials","volume":"35","author":"O\u2019Brien","year":"1979","journal-title":"Biometrics"},{"key":"10.1016\/j.ajog.2006.10.868_bib21","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0140-6736(00)02626-X","article-title":"Search for best tocolytic for preterm labour","volume":"356","author":"Hannah","year":"2000","journal-title":"Lancet"},{"issue":"Suppl 20","key":"10.1016\/j.ajog.2006.10.868_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1046\/j.1471-0528.2003.00012.x","article-title":"Neonatal complications following preterm birth","volume":"110","author":"Ward","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2006.10.868_bib23","first-page":"134","article-title":"Clinical effect and mechanism of nitroglycerin patch on arresting preterm labor","volume":"37","author":"He","year":"2002","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"10.1016\/j.ajog.2006.10.868_bib24","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0849-5831(16)30184-7","article-title":"The Canadian Consensus on the Use of Tocolytics for Preterm Labour","volume":"17","author":"Hannah","year":"1995","journal-title":"J SOGC"},{"key":"10.1016\/j.ajog.2006.10.868_bib25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ijgo.2003.09.001","article-title":"Glyceryl trinitrate vs. ritodrine for the treatment of preterm labor","volume":"85","author":"Wani","year":"2004","journal-title":"Int J Gynecol Obstet"},{"key":"10.1016\/j.ajog.2006.10.868_bib26","first-page":"572","article-title":"Maternal and fetal cardiovascular effects of transdermal glyceryl trinitrate and intravenous ritodrine","volume":"94","author":"Black","year":"1999","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.10.868_bib27","first-page":"79","article-title":"Randomized comparison of intravenous nitroglycerin and magnesium sulfate for treatment of preterm labour","volume":"93","author":"El-Sayed","year":"1999","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.10.868_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0301-2115(02)00197-5","article-title":"Maternal and fetal side effects of tocolysis using transdermal nitroglycerin or intravenous fenoterol combined with magnesium sulfate","volume":"106","author":"Schleussner","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2006.10.868_bib29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1472-8206.2003.00231.x","article-title":"Tocolytic effects of intravenous nitroglycerin","volume":"18","author":"de Spirlet","year":"2004","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.ajog.2006.10.868_bib30","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0020-7292(01)00362-9","article-title":"Nitric oxide for treatment of threatend preterm labor","volume":"73","author":"Leszczynska-Gorzelak","year":"2001","journal-title":"Int J Gynecol Obstet"},{"key":"10.1016\/j.ajog.2006.10.868_bib31","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1471-0528.1999.tb08300.x","article-title":"The effect of indomethacin tocolysis for preterm labour on perinatal outcome: a randomized placebo controlled trial","volume":"106","author":"Panter","year":"1999","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2006.10.868_bib32","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1139\/y03-085","article-title":"Steady-state maternal and fetal plasma concentrations of glyceryl trinitrate (GTN) in the preterm sheep","volume":"81","author":"Bustard","year":"2003","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.ajog.2006.10.868_bib33","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0002-9378(97)70563-5","article-title":"Fetal and maternal hemodynamic and metabolic effects of maternal nitroglycerin infusions in sheep","volume":"176","author":"Bootstaylor","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.10.868_bib34","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/S0002-9378(03)00866-4","article-title":"Human maternal and fetal plasma glyceryl trinate concentrations","volume":"189","author":"Bustard","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.10.868_bib35","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1067\/mob.2002.123033","article-title":"The pharmacokinetics of glyceryl trinitrate with the use of the in vitro term human placental perfusion setup","volume":"187","author":"Bustard","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2006.10.868_bib36","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0301-2115(02)00429-3","article-title":"Nitric oxide donors: effects on fetoplacental blood flow","volume":"115","author":"Kahler","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2006.10.868_bib37","first-page":"756","article-title":"The influence of transdermal nitroglycerin patches on fetal blood flow parameters in threatened preterm labor","volume":"73","author":"Leszczynska-Gorzelak","year":"2002","journal-title":"Ginekol Pol"},{"key":"10.1016\/j.ajog.2006.10.868_bib38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1469-0705.1999.14020101.x","article-title":"Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild pre-eclampsia and threatened preterm labor","volume":"14","author":"Luzi","year":"1999","journal-title":"Ultras Obstet Gynecol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937806021338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937806021338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:31:30Z","timestamp":1762079490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937806021338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0002937806021338"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2006.10.868","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1090427.544389","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1090427.543685","asserted-by":"object"}]},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm labor","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2006.10.868","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}