{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:58:18Z","timestamp":1758124698708,"version":"3.44.0"},"reference-count":12,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.ajog.2007.04.018","type":"journal-article","created":{"date-parts":[[2007,12,6]],"date-time":"2007-12-06T17:56:49Z","timestamp":1196963809000},"page":"606.e1-606.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Changes in the maternal serum concentration of proearly placenta insulin-like growth factor peptides in normal vs abnormal pregnancy"],"prefix":"10.1016","volume":"197","author":[{"given":"Luca","family":"Bruni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Luisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Janneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariachiara","family":"Quadrifoglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Richon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Dangles-Marie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Bellet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felice","family":"Petraglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2007.04.018_bib1","first-page":"156","article-title":"Peptide signaling in human placenta and membranes: autocrine, paracrine, and endocrine mechanisms","volume":"17","author":"Petraglia","year":"1996","journal-title":"Endocr Rev"},{"key":"10.1016\/j.ajog.2007.04.018_bib2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1006\/geno.1995.9980","article-title":"Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta","volume":"29","author":"Chassin","year":"1995","journal-title":"Genomics"},{"key":"10.1016\/j.ajog.2007.04.018_bib3","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1095\/biolreprod.105.039859","article-title":"Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth","volume":"73","author":"Millar","year":"2005","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajog.2007.04.018_bib4","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1210\/jcem.82.9.4359","article-title":"Identification of pro-EPIL and EPIL peptides translated from insulin-like 4 (INSL4) mRNA in human placenta","volume":"82","author":"Bellet","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2007.04.018_bib5","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1210\/jcem.84.6.5888","article-title":"Pro-EPIL forms are present in amniotic fluid and maternal serum during normal pregnancy","volume":"84","author":"Mock","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2007.04.018_bib6","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1210\/jcem-63-6-1319","article-title":"Sensitive and specific assay for human chorionic gonadotropin (hCG) based on anti-peptide and anti-hCG monoclonal antibodies: construction and clinical implications","volume":"63","author":"Bellet","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2007.04.018_bib7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0161-5890(87)90175-1","article-title":"The immune response to a synthetic peptide analogous to the 109-145 beta hCG carboxyl-terminus is directed against two major and two minor regions","volume":"24","author":"Bidart","year":"1987","journal-title":"Mol Immunol"},{"issue":"Suppl 2","key":"10.1016\/j.ajog.2007.04.018_bib8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/humrep\/14.suppl_2.90","article-title":"Role of the IGF system in trophoblast invasion and pre-eclampsia","volume":"14","author":"Irwin","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2007.04.018_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0002-9378(97)70438-1","article-title":"Placental apoptosis in normal human pregnancy","volume":"177","author":"Smith","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2007.04.018_bib10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.placenta.2003.10.016","article-title":"Large variability of trophoblast gene expression within and between human normal term placentae","volume":"25","author":"Pidoux","year":"2004","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2007.04.018_bib11","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jsgi.2004.04.001","article-title":"The role of matrix degrading enzymes and apoptosis in rupture of membranes","volume":"11","author":"Menon","year":"2004","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.ajog.2007.04.018_bib12","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1677\/erc.1.00975","article-title":"Expression of early placenta insulin-like growth factor in breast cancer cells provides an autocrine loop that predominantly enhances invasiveness and motility","volume":"12","author":"Brandt","year":"2005","journal-title":"Endocr Relat Cancer"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293780700539X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293780700539X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:22:54Z","timestamp":1757586174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000293780700539X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S000293780700539X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2007.04.018","relation":{},"ISSN":["0002-9378"],"issn-type":[{"type":"print","value":"0002-9378"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in the maternal serum concentration of proearly placenta insulin-like growth factor peptides in normal vs abnormal pregnancy","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2007.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}