{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:08:06Z","timestamp":1793862486354,"version":"4.6.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.ajog.2007.05.029","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T08:24:22Z","timestamp":1189671862000},"page":"84.e1-84.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["BMP15 mutations in XX gonadal dysgenesis and premature ovarian failure"],"prefix":"10.1016","volume":"198","author":[{"given":"Susanne","family":"Ledig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"R\u00f6pke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Haeusler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Hinney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wieacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2007.05.029_bib1","first-page":"604","article-title":"Incidence of premature ovarian failure","volume":"67","author":"Coulam","year":"1986","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2007.05.029_bib2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/humupd\/dmi012","article-title":"Premature ovarian failure","volume":"11","author":"Goswami","year":"2005","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ajog.2007.05.029_bib3","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0092-8674(95)90275-9","article-title":"Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure","volume":"82","author":"Aittomaki","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ajog.2007.05.029_bib4","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1172\/JCI3795","article-title":"A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor","volume":"102","author":"Beau","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajog.2007.05.029_bib5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/77033","article-title":"Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner","volume":"25","author":"Galloway","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajog.2007.05.029_bib6","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1095\/biolreprod.103.023093","article-title":"Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries)","volume":"70","author":"Hanrahan","year":"2004","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajog.2007.05.029_bib7","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1210\/mend.13.6.0310","article-title":"Paracrine actions of growth differentiation factor-9 in the mammalian ovary","volume":"13","author":"Elvin","year":"1999","journal-title":"Mol Endo"},{"key":"10.1016\/j.ajog.2007.05.029_bib8","doi-asserted-by":"crossref","first-page":"39523","DOI":"10.1074\/jbc.M007428200","article-title":"Bone morphogenetic protein-15: identification of target cells and biological function","volume":"275","author":"Otsuka","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajog.2007.05.029_bib9","doi-asserted-by":"crossref","first-page":"11387","DOI":"10.1074\/jbc.M010043200","article-title":"Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression","volume":"276","author":"Otsuka","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajog.2007.05.029_bib10","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1016\/S0021-9258(18)53714-5","article-title":"GDF-3 and GDF-9: two novel members of the transforming growth factor-\u03b2 superfamily containing a novel pattern of cysteines","volume":"268","author":"McPherron","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajog.2007.05.029_bib11","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1210\/mend.12.12.0206","article-title":"The bone morphogenetic protein is X-linked and expressed in oocytes","volume":"12","author":"Dube","year":"1998","journal-title":"Mol Endo"},{"key":"10.1016\/j.ajog.2007.05.029_bib12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1086\/422103","article-title":"Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene","volume":"75","author":"Di Pasquale","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajog.2007.05.029_bib13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s00439-006-0150-0","article-title":"Missense mutations in the BMP15 gene are associated with ovarian failure","volume":"119","author":"Dixit","year":"2006","journal-title":"Hum Genet"},{"key":"10.1016\/j.ajog.2007.05.029_bib14","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1210\/jc.2006-0548","article-title":"Editorial: BMP15\u2014the first true ovarian determinant gene on the X-chromosome?","volume":"91","author":"Layman","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2007.05.029_bib15","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajog.2007.05.029_bib16","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1073\/pnas.83.15.5703","article-title":"Characterization of two related Epstein-Barr virus-encoded membrane proteins that are differentially expressed in Burkitt lymphoma and vitro-transformed cell lines","volume":"83","author":"Modrow","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajog.2007.05.029_bib17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0092-8674(86)90778-6","article-title":"Identification and characterization of conserved and variable regions in the envelope gene of human T cell lymphotrophic virus type III-lymhadenopathy-associated virus, the retrovirus of AIDS","volume":"45","author":"Starcich","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.ajog.2007.05.029_bib18","first-page":"1229","article-title":"Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation","volume":"51","author":"Allen","year":"1992","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajog.2007.05.029_bib19","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1210\/mend.15.6.0662","article-title":"Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function","volume":"15","author":"Yan","year":"2001","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.ajog.2007.05.029_bib20","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/383531a0","article-title":"Growth differentiation factor-9 is required during early ovarian folliculogenesis","volume":"383","author":"Dong","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2007.05.029_bib21","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1210\/jc.2005-2650","article-title":"Identification of new variants of human BMP15 gene in a large cohort of women with premature ovarian failure","volume":"91","author":"Di Pasquale","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2007.05.029_bib22","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.fertnstert.2005.02.031","article-title":"Single-nucleotide polymorphisms in the promoter region influence the expression of the human follicle-stimulating hormone receptor","volume":"84","author":"Wunsch","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2007.05.029_bib23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-2265.1999.00745.x","article-title":"Mutation screening and isoform prevalence of the follicle stimulating hormone receptor gene in women with premature ovarian failure, resistant ovary syndrome and polycystic ovary syndrome","volume":"51","author":"Conway","year":"1999","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937807006692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937807006692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:25:57Z","timestamp":1757586357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937807006692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0002937807006692"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2007.05.029","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BMP15 mutations in XX gonadal dysgenesis and premature ovarian failure","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2007.05.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}