{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:52:43Z","timestamp":1793368363917,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.ajog.2007.11.057","type":"journal-article","created":{"date-parts":[[2008,4,4]],"date-time":"2008-04-04T11:18:51Z","timestamp":1207307931000},"page":"474.e1-474.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"title":["Mechanical homeostasis is altered in uterine leiomyoma"],"prefix":"10.1016","volume":"198","author":[{"given":"Rebecca","family":"Rogers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Norian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minnie","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Christman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mones","family":"Abu-Asab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faye","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Korecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Iatridis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Catherino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocky S.","family":"Tuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namisha","family":"Dhillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Leppert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Segars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2007.11.057_bib1","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1126\/science.1112063","article-title":"Uterine fibroids: the elephant in the room","volume":"308","author":"Walker","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ajog.2007.11.057_bib2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/gcc.20035","article-title":"Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids","volume":"40","author":"Catherino","year":"2004","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.ajog.2007.11.057_bib3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0015-0282(02)03191-6","article-title":"Insights from gene arrays on the development and growth regulation of uterine leiomyomata","volume":"78","author":"Tsibris","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2007.11.057_bib4","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.fertnstert.2004.04.030","article-title":"Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium","volume":"82","author":"Leppert","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2007.11.057_bib5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrm809","article-title":"Myofibroblasts and mechano-regulation of connective tissue remodeling","volume":"3","author":"Tomasek","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajog.2007.11.057_bib6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10911-004-1404-x","article-title":"The tension mounts: mechanics meets morphogenesis and malignancy","volume":"9","author":"Paszek","year":"2004","journal-title":"J Mam Gland Biol Neopl"},{"key":"10.1016\/j.ajog.2007.11.057_bib7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000072074","article-title":"Different proliferative and apoptotic activity in peripheral versus central parts of human uterine leiomyomas","volume":"55","author":"Bourlev","year":"2003","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.ajog.2007.11.057_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1055\/s-2004-828615","article-title":"Apoptosis in human uterine leiomyomas","volume":"22","author":"Martel","year":"2004","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.ajog.2007.11.057_bib9","doi-asserted-by":"crossref","first-page":"E439","DOI":"10.1152\/ajpendo.00275.2003","article-title":"Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells","volume":"287","author":"Mitchell","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ajog.2007.11.057_bib10","doi-asserted-by":"crossref","first-page":"C1530","DOI":"10.1152\/ajpcell.00607.2001","article-title":"Mitogen-activated protein kinases mediate stretch-induced cfos mRNA expression in myometrial smooth muscle cells","volume":"283","author":"Oldenhof","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajog.2007.11.057_bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000061025","article-title":"Role of mechanical signals in the onset of term and preterm labor","volume":"27","author":"Lye","year":"2001","journal-title":"Front Horm Res"},{"key":"10.1016\/j.ajog.2007.11.057_bib12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ccr.2005.08.009","article-title":"Cell tension, matrix mechanics, and cancer development","volume":"8","author":"Huang","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ajog.2007.11.057_bib13","first-page":"PE6","article-title":"Mechanotransduction: all signals point to cytoskeleton, matrix and integrins","volume":"119","author":"Alenghat","year":"2002","journal-title":"Sci STKE"},{"key":"10.1016\/j.ajog.2007.11.057_bib14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0092-8674(02)00831-0","article-title":"Exploring the neighborhood: adhesion-coupled cell mechanosensors","volume":"110","author":"Geiger","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.ajog.2007.11.057_bib15","doi-asserted-by":"crossref","first-page":"31111","DOI":"10.1074\/jbc.M300725200","article-title":"Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae","volume":"278","author":"Kawamura","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajog.2007.11.057_bib16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0008-6363(00)00076-6","article-title":"Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways","volume":"47","author":"Ruwhof","year":"2000","journal-title":"Cardiovascular Res"},{"key":"10.1016\/j.ajog.2007.11.057_bib17","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/ncb1001-867","article-title":"Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca+2 release in cardiomyocytes","volume":"3","author":"Petroff","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajog.2007.11.057_bib18","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1101\/gad.1003302","article-title":"Guanine nucleotide exchange factors for the Rho GTPases: turning on the switch","volume":"16","author":"Schmidt","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajog.2007.11.057_bib19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s00109-002-0370-2","article-title":"Rho\/Rho-kinase mediated signaling in physiology and pathophysiology","volume":"80","author":"Wettschureck","year":"2002","journal-title":"J Mol Med"},{"key":"10.1016\/j.ajog.2007.11.057_bib20","unstructured":"Davis BJ. The NIEHS Uterine Fibroid Study: preliminary results. Presented at: Advances in Leiomyoma Research: 2nd NIH International Congress, Bethesda, MD, February 24-25, 2005."},{"key":"10.1016\/j.ajog.2007.11.057_bib21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1023\/A:1006914301565","article-title":"Extracellular matrix components in uterine leiomyoma and their alteration during the tumour growth","volume":"189","author":"Wolanska","year":"1998","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ajog.2007.11.057_bib22","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0300-9084(01)01281-0","article-title":"Identification, quantification and fine structural characterization of glycosaminoglycans from uterine leiomyoma and normal myometrium","volume":"83","author":"Mitropoulou","year":"2001","journal-title":"Biochimie"},{"key":"10.1016\/j.ajog.2007.11.057_bib23","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1034\/j.1600-0412.2001.801202.x","article-title":"Identification of the major proteoglycans from human myometrium","volume":"80","author":"Hjelm","year":"2001","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2007.11.057_bib24","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0304-4165(02)00446-4","article-title":"A comparative analysis of structure and spatial distribution of decorin in human leiomyoma and normal myometrium","volume":"1619","author":"Berto","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajog.2007.11.057_bib25","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ccr.2005.08.010","article-title":"Tensional homeostasis and the malignant phenotype","volume":"8","author":"Paszek","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ajog.2007.11.057_bib26","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/ncb1037","article-title":"Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells","volume":"5","author":"Beil","year":"2003","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajog.2007.11.057_bib27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.bioeng.5.040202.121623","article-title":"Selected methods for imaging elastic properties of biological tissues","volume":"5","author":"Greenleaf","year":"2003","journal-title":"Annu Rev Biomed Eng"},{"key":"10.1016\/j.ajog.2007.11.057_bib28","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/(SICI)1097-0215(19990531)81:5<682::AID-IJC2>3.0.CO;2-B","article-title":"Rho GTPases are over-expressed in human tumors","volume":"81","author":"Fritz","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajog.2007.11.057_bib29","doi-asserted-by":"crossref","first-page":"8994","DOI":"10.1158\/0008-5472.CAN-04-2052","article-title":"Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis","volume":"64","author":"Croft","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajog.2007.11.057_bib30","doi-asserted-by":"crossref","first-page":"14821","DOI":"10.1073\/pnas.95.25.14821","article-title":"Reciprocal interactions between \u03b21-integrin and epidermal growth factor receptor in three-dimensional basement membrane cultures: a different perspective in epithelial biology","volume":"95","author":"Wang","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajog.2007.11.057_bib31","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1115\/1.429656","article-title":"Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels","volume":"122","author":"Mauck","year":"2000","journal-title":"J Biomech Eng"},{"key":"10.1016\/j.ajog.2007.11.057_bib32","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0009-9120(96)00003-6","article-title":"A simplified method for the analysis of hydroxyproline in biologic tissues","volume":"29","author":"Reddy","year":"1996","journal-title":"Clin Biochem"},{"key":"10.1016\/j.ajog.2007.11.057_bib33","first-page":"5737","article-title":"Human uterine leiomyoma express higher levels of peroxisome proliferator\u2013activated receptor \u03b3, retinoid receptor \u03b1 and all-trans retinoic acid than myometrium","volume":"59","author":"Tsibris","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajog.2007.11.057_bib34","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0015-0282(03)00953-1","article-title":"Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray","volume":"80","author":"Catherino","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2007.11.057_bib35","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1038\/sj.onc.1201783","article-title":"Characterization of Brx, a novel DBL family member that modulates estrogen action","volume":"16","author":"Rubino","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.ajog.2007.11.057_bib36","doi-asserted-by":"crossref","first-page":"45361","DOI":"10.1074\/jbc.M202447200","article-title":"Association of Lbc Rho guanine nucleotide exchange factor with \u03b1-catenin-related protein, \u03b1-catulin\/CTNNAL1, supports serum response factor activation","volume":"277","author":"Park","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajog.2007.11.057_bib37","doi-asserted-by":"crossref","first-page":"46792","DOI":"10.1074\/jbc.M106927200","article-title":"The proto-oncoprotein Brx activates estrogen receptor \u03b2 by a p38 mitogen-activated protein kinase pathway","volume":"276","author":"Driggers","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajog.2007.11.057_bib38","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.fertnstert.2006.08.111","article-title":"Novel method to characterize primary cultures of leiomyoma and myometrium with the use of confirmatory biomarker gene arrays","volume":"87","author":"Malik","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2007.11.057_bib39","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1080\/03008200390244069","article-title":"Subcutaneous tissue mechanical behavior is linear and viscoelastic under uniaxial tension","volume":"44","author":"Iatridis","year":"2003","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.ajog.2007.11.057_bib40","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ajog.2005.12.059","article-title":"A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays","volume":"195","author":"Leppert","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2007.11.057_bib41","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1071-55760300004-2","article-title":"Gene expression profile of leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy","volume":"10","author":"Chegini","year":"2003","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.ajog.2007.11.057_bib42","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nature05602","article-title":"p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload","volume":"446","author":"Sano","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2007.11.057_bib43","doi-asserted-by":"crossref","first-page":"9118","DOI":"10.1074\/jbc.M509339200","article-title":"Rho family guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system","volume":"281","author":"Kino","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajog.2007.11.057_bib44","first-page":"901","article-title":"The concentrations of collagen-associated amino acids are higher in GnRH agonist-treated uterine myomas","volume":"82","author":"Rein","year":"1993","journal-title":"Obstet Gynecol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937807022399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937807022399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:26:23Z","timestamp":1757586383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937807022399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0002937807022399"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2007.11.057","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanical homeostasis is altered in uterine leiomyoma","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2007.11.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}