{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:38:01Z","timestamp":1775695081143,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.ajog.2008.01.052","type":"journal-article","created":{"date-parts":[[2008,5,4]],"date-time":"2008-05-04T03:13:12Z","timestamp":1209870792000},"page":"553.e1-553.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects"],"prefix":"10.1016","volume":"198","author":[{"given":"Maria P.","family":"Canter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Heit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda S.","family":"Blackwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel W.","family":"Wilkey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon B.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Merchant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2008.01.052_bib1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0022-5347(01)61947-5","article-title":"Epidemiology of interstitial cystitis: a population based study","volume":"161","author":"Curhan","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.ajog.2008.01.052_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0090-4295(01)01127-X","article-title":"Sensitivity and specificity of antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor as urine markers for interstitial cystitis","volume":"57","author":"Keay","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.ajog.2008.01.052_bib3","first-page":"169","article-title":"The use of urine proteomic and metabonomic patterns for the diagnosis of interstitial cystitis and bacterial cystitis","volume":"19","author":"Van","year":"2004","journal-title":"Dis Marker 2003"},{"key":"10.1016\/j.ajog.2008.01.052_bib4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1023\/A:1008974420049","article-title":"A health related quality of life measure for use in patients with urge urinary incontinence: a validation study","volume":"8","author":"Lubeck","year":"1999","journal-title":"Qual Life Res"},{"key":"10.1016\/j.ajog.2008.01.052_bib5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0090-4295(99)80333-1","article-title":"the interstitial cystitis symptom index and problem index","volume":"49","author":"O'Leary","year":"1997","journal-title":"Urology"},{"key":"10.1016\/j.ajog.2008.01.052_bib6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0090-4295(01)01126-8","article-title":"Psychometric validation of the O'Leary-Sant interstitial cystitis symptom index in a clinical trial of pentosan polysulfate sodium","volume":"57","author":"Lubeck","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.ajog.2008.01.052_bib7","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0090-4295(02)01829-0","article-title":"Increased prevalence of interstitial cystitis: previously unrecognized urologic and gynecologic cases identified using a new symptom questionnaire and intravesical potassium sensitivity","volume":"60","author":"Parsons","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.ajog.2008.01.052_bib8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/bmj.305.6846.160","article-title":"Validating the SF-36 health survey questionnaire: new outcome measure for primary care","volume":"305","author":"Brazier","year":"1992","journal-title":"BMJ"},{"key":"10.1016\/j.ajog.2008.01.052_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF00647843","article-title":"Criterion validity and reliability of the SF-36 in a population sample","volume":"3","author":"Jenkinson","year":"1994","journal-title":"Qual Life Res"},{"key":"10.1016\/j.ajog.2008.01.052_bib10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/01.ju.0000146466.71311.ab","article-title":"Do the National Institute of Diabetes and Digestive and Kidney Diseases Cystoscopic criteria associate with other clinical and objective features of interstitial cystitis?","volume":"173","author":"Erickson","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.ajog.2008.01.052_bib11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0022-5347(01)61948-7","article-title":"The diagnosis of interstitial cystitis revisited: lessons learned from the National Institutes of Health Interstitial Cystitis Database study","volume":"161","author":"Hanno","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.ajog.2008.01.052_bib12","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0022-5347(01)62376-0","article-title":"Cystoscopic findings consistent with interstitial cystitis in normal women undergoing tubal ligation","volume":"160","author":"Waxman","year":"1998","journal-title":"J Urol"},{"key":"10.1016\/j.ajog.2008.01.052_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00240-003-0374-6","article-title":"Tamm-Horsfall protein in patients with kidney damage and diabetes","volume":"32","author":"Chakraborty","year":"2004","journal-title":"Urol Res"},{"key":"10.1016\/j.ajog.2008.01.052_bib14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00418-004-0638-4","article-title":"Selectively reduced expression of thick ascending limb Tamm Horsfall protein in hypothyroid kidneys","volume":"121","author":"Schmitt","year":"2004","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.ajog.2008.01.052_bib15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0167-0115(97)01058-6","article-title":"Urinary excretion of epidermal growth factor and Tamm-Horsfall protein in three rat models with increased renal excretion of urine","volume":"72","author":"Thuleson","year":"1997","journal-title":"Regul Pept"},{"key":"10.1016\/j.ajog.2008.01.052_bib16","doi-asserted-by":"crossref","first-page":"F559","DOI":"10.1152\/ajprenal.00143.2004","article-title":"Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice","volume":"288","author":"Bachmann","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ajog.2008.01.052_bib17","doi-asserted-by":"crossref","first-page":"f49","DOI":"10.1152\/ajprenal.00134.2004","article-title":"Defective expression of Tamm-Horsfall protein\/uromodulin in COX-2-deficient Me increases their susceptibility to urinary tract infections","volume":"289","author":"Duo","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ajog.2008.01.052_bib18","doi-asserted-by":"crossref","first-page":"F795","DOI":"10.1152\/ajprenal.00357.2003","article-title":"Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli","volume":"286","author":"Mo","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ajog.2008.01.052_bib19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1046\/j.1442-2042.2000.00165.x","article-title":"Urothelial cytoprotective activity of Tamm-Horsfall protein isolated from the urine of healthy subjects and patients with interstitial cystitis","volume":"7","author":"Akiyama","year":"2000","journal-title":"Int J Urol"},{"key":"10.1016\/j.ajog.2008.01.052_bib20","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/pmic.200300661","article-title":"Characterization of the human urinary proteome: a method for high-resolution display of urinary proteins on two-dimensional electrophoresis gels with a yield of nearly 1400 distinct protein spots","volume":"4","author":"Pieper","year":"2004","journal-title":"Proteomics"},{"key":"10.1016\/j.ajog.2008.01.052_bib21","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1189\/jlb.1103546","article-title":"Stimulated human neutrophils from biologically active kinin peptides from high and low molecular weight kininogens","volume":"75","author":"Stuardo","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ajog.2008.01.052_bib22","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1128\/IAI.72.7.3777-3782.2004","article-title":"ITIH4 (inter-alpha-trypsin inhibitor heavy chai 4) is a new acute-phase protein isolated from cattle during experimental infection","volume":"72","author":"Pineiro","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajog.2008.01.052_bib23","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1158\/0008-5472.CAN-04-0746","article-title":"Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer","volume":"64","author":"Zhang","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajog.2008.01.052_bib24","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1006\/geno.1999.5795","article-title":"A novel set of hepatic mRNAs preferentially expressed during an acute inflammation in rat represents mostly intracellular proteins","volume":"57","author":"Olivier","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.ajog.2008.01.052_bib25","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1046\/j.1432-1327.2000.01195.x","article-title":"Pig MAP\/ITIH4 and Haptoglobin are Interleukin-6-dependent acute-phase plasma proteins in porcine primary cultured hepatocytes","volume":"267","author":"Gonzalez-Ramon","year":"2000","journal-title":"Eur J Biochem"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937808001129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937808001129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:27:03Z","timestamp":1757586423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937808001129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0002937808001129"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2008.01.052","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2008.01.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}