{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T16:42:27Z","timestamp":1758040947599,"version":"3.44.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.ajog.2008.10.003","type":"journal-article","created":{"date-parts":[[2008,12,26]],"date-time":"2008-12-26T04:17:26Z","timestamp":1230265046000},"page":"198.e1-198.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hyperhomocysteinemia is not sufficient to cause preeclampsia in an animal model: the importance of folate intake"],"prefix":"10.1016","volume":"200","author":[{"given":"St\u00e9phanie","family":"Falcao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Bisotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanta","family":"Gutkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie L.","family":"Lavoie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2008.10.003_bib1","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/35080570","article-title":"Placental development: lessons from mouse mutants","volume":"2","author":"Rossant","year":"2001","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.ajog.2008.10.003_bib2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1023\/A:1012085713898","article-title":"Use of transgenic mice model for understanding the placentation: towards clinical applications in human obstetrical pathologies?","volume":"10","author":"Sapin","year":"2001","journal-title":"Transgenic Res"},{"key":"10.1016\/j.ajog.2008.10.003_bib3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1071\/RD05121","article-title":"Placental function in development and disease","volume":"18","author":"Cross","year":"2006","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.ajog.2008.10.003_bib4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/hy02t2.102904","article-title":"Discovery of a spontaneous genetic mouse model of preeclampsia","volume":"39","author":"Davisson","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.ajog.2008.10.003_bib5","doi-asserted-by":"crossref","first-page":"H918","DOI":"10.1152\/ajpheart.00641.2001","article-title":"Maternal cardiovascular changes during pregnancy and postpartum in mice","volume":"282","author":"Wong","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ajog.2008.10.003_bib6","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1126\/science.274.5289.995","article-title":"Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen","volume":"274","author":"Takimoto","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ajog.2008.10.003_bib7","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1161\/01.HYP.0000154785.50570.63","article-title":"Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia","volume":"45","author":"Dechend","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.ajog.2008.10.003_bib8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1034\/j.1399-0004.2003.00127.x","article-title":"The genetics of pre-eclampsia: a feto-placental or maternal problem?","volume":"64","author":"Cross","year":"2003","journal-title":"Clin Genet"},{"key":"10.1016\/j.ajog.2008.10.003_bib9","first-page":"383","article-title":"Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemia","volume":"122","author":"Granger","year":"2006","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.ajog.2008.10.003_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mvr.2007.04.009","article-title":"Molecular mechanisms of preeclampsia","volume":"75","author":"Mutter","year":"2008","journal-title":"Microvasc Res"},{"key":"10.1016\/j.ajog.2008.10.003_bib11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1521-6934(03)00009-9","article-title":"Homocysteine and pregnancy","volume":"17","author":"Hague","year":"2003","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2008.10.003_bib12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/01.AOG.0000151117.52952.b6","article-title":"Mapping the theories of preeclampsia: the role of homocysteine","volume":"105","author":"Mignini","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2008.10.003_bib13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/hmg\/10.5.433","article-title":"Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition","volume":"10","author":"Chen","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ajog.2008.10.003_bib14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1051\/medsci\/2007233297","article-title":"Molecular genetics of MTHFR: polymorphisms are not all benign","volume":"23","author":"Leclerc","year":"2007","journal-title":"Med Sci (Paris)"},{"key":"10.1016\/j.ajog.2008.10.003_bib15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/ajcn\/82.1.188","article-title":"Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice","volume":"82","author":"Li","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ajog.2008.10.003_bib16","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1182\/blood-2003-09-3078","article-title":"Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice","volume":"103","author":"Devlin","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.ajog.2008.10.003_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/bdra.20223","article-title":"Impact of methylenetetrahydrofolate reductase deficiency and low dietary folate on the development of neural tube defects in splotch mice","volume":"76","author":"Li","year":"2006","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.ajog.2008.10.003_bib18","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1161\/01.ATV.0000083297.47245.DA","article-title":"Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice","volume":"23","author":"Virdis","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ajog.2008.10.003_bib19","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/00004872-200405000-00018","article-title":"Small artery mechanics in hyperhomocysteinemic mice: effects of angiotensin II","volume":"22","author":"Neves","year":"2004","journal-title":"J Hypertens"},{"key":"10.1016\/j.ajog.2008.10.003_bib20","first-page":"1","article-title":"Pression art\u00e9rielle chez la souris avec un nouveau transmetteur miniaturis\u00e9","volume":"4","author":"Lavoie","year":"2006","journal-title":"Sci Tech Anim Lab"},{"key":"10.1016\/j.ajog.2008.10.003_bib21","unstructured":"Hoppe CC, Moritz KM, Fitzgerald SM, Bertram JF, Evans RG. Transient hypertension and sustained tachycardia in mice housed individually in metabolism cages. Physiol Res In press."},{"key":"10.1016\/j.ajog.2008.10.003_bib22","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/ajcn\/83.5.993","article-title":"Folate and human reproduction","volume":"83","author":"Tamura","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ajog.2008.10.003_bib23","doi-asserted-by":"crossref","first-page":"598S","DOI":"10.1093\/ajcn\/85.2.598S","article-title":"In utero physiology: role of folic acid in nutrient delivery and fetal development","volume":"85","author":"Antony","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ajog.2008.10.003_bib24","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ki.1997.359","article-title":"Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure","volume":"52","author":"Guttormsen","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajog.2008.10.003_bib25","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1097\/01.hjh.0000244947.80287.74","article-title":"Elevation of plasma homocysteine by methionine loading increases the diastolic blood pressure response to exercise","volume":"24","author":"Brett","year":"2006","journal-title":"J Hypertens"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937808020073?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937808020073?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:29:16Z","timestamp":1757586556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937808020073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0002937808020073"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2008.10.003","relation":{},"ISSN":["0002-9378"],"issn-type":[{"type":"print","value":"0002-9378"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperhomocysteinemia is not sufficient to cause preeclampsia in an animal model: the importance of folate intake","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2008.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}